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Cilj: Cilj ovog diplomskog je pokazati potencijalni pozitivni ili negativni učinak taninske kiseline na srčani mišić hiperglikemičnih štakora i ekspresiju koneksina 43 upotrebom koncentracije koja je već pokazala korisne učinke. Materijal i metode: U ovom je istraživanju dvanaest muških Wistar štakora podijeljeno u tri skupine na temelju napitaka koje su konzumirali. U svakoj skupini bila su po četiri štakora, a ispitivanje je trajalo dvadeset tjedana. Prva skupina, odnosno kontrolna skupina konzumirala je čistu vodu za piće, a druga skupina 30%-tnu vodenu otopinu saharoze. Treća skupina konzumirala je 30%-tnu vodenu otopinu saharoze i 0,1% taninsku kiselinu. Mjerena im je težina, a koncentracije glukoze u plazmi određivane su s glukometrom. Životinje su eutanazirane te njihova srca su uklonjena. Tkivo je pripremljeno i zatim obojeno trikromnim bojanjem po Mallory-ju. Također je napravljeno imunofluorescencijsko bojanje pa su slikane mikrofotografije. Analizirane su pomoću Adobe Photoshop 7 i Image J (National Institutes of Health, Bethesda, MD, SAD) programa. GraphPad Prism 5 (McIntosh, CA, USA) korišten je za statističku analizu. Rezultati: Nakon 20 tjedana eksperimenta, razina glukoze u krvi u skupini koja je konzumirala 30%-tnu vodenu otopinu saharoze značajno je povećana u usporedbi s kontrolnom skupinom (p, Objectives: The aim of this thesis is to demonstrate the potential positive or negative effect of the tannic acid on the cardiac muscle of hyperglycemic rats and the expression of the connexins 43 using a concentration that has already shown beneficial effects. Material and Methods: In this trial twelve male Wistar rats were divided into three groups based on beverages they were consuming. There were four rats in each group and Trial lasted twenty weeks. The control group consumed clean drinking water and the second group consumed 30% aqueous sucrose solution. Third group consumed 30% aqueous solution of sucrose and 0,1% tannic acid. They were weighed on electronic balance and their glucose concentrations in plasma were determined with glucometer at the same time. Animals were euthanized and their hearts were removed. The tissue was prepared and then stained by Mallory's trichrome stain. Tissues were also analysed with immunohistochemistry and then microphotographies were taken. Microphotographies were analyzed by Adobe photoshop 7 and Image J (National Institutes of Health, Bethesda, MD, USA). GraphPad Prism 5 (McIntosh, CA, USA) was used for statistical analysis. Results: After 20 weeks of experiment blood glucose levels of group that had consumed 30% aqueous solution of sucrose significantly increased compared to the control group (p