Search

U sklopu diplomskog rada ispitani su mehanokemijski postupci sinteze koordinacijskih spojeva bakra(II) i aminokiselina s alifatskim bočnim ograncima. Koristeći LAG metodu, odnosno otapalom potpomognuto mljevenje, uspješno su pripravljeni koordinacijski spojevi Cu(L-Ala)2, Cu(L-Leu)2, Cu(L-Ile)2, Cu(L-Val)2, Cu(L-Pro)2 i ternarni spojevi Cu(L-Ala)(L-Ile) i Cu(L-Ala)( L-Val). Prilikom sinteza ternarnih spojeva, u 8 od 10 sinteza su dobiveni koordinacijski spojevi bakra s istovrsnim aminokiselinama, što ukazuje na selektivnost Cu(II) iona prema aminokiselinama, koja prati sljedeći trend: L-Leu ≈ L-Pro > L-Ile ≈ L-Val > L-Ala. Produkti su karakterizirani koristeći spektroskopiju IR (tehnika ATR) i rendgensku difrakciju u polikristalnom uzorku. Produkti trans-Cu(L-Val)2 i cis-Cu(L-Ile)2(H2O) su karakterizirani i rendgenskom difrakcijom na monokristalnom uzorku te su određene molekulske i kristalne strukture. U slučaju trans-bis(L-valinato)bakra(II), metalni centar ima oktaedarsku koordinaciju uz deformaciju geometrije što je posljedica Jahn-Tellerovog efekta. Kod cisbis(L-izoleucinato)bakra(II) je metalni centar pentakoordiniran te je geometrija kvadratno piramidalna. This diploma thesis presents an investigation of mechanochemical synthesis of coordination compounds of copper(II) and amino acids containing aliphatic side chains. Using the LAG method (liquid assisted grinding), the following compounds were successfully obtained: Cu(L-Ala)2, Cu(L-Leu)2, Cu(L-Ile)2, Cu(L-Val)2, Cu(L-Pro)2, Cu(L-Ala)( L-Ile) and Cu(L-Ala)(L-Val). When trying the synthesis of ternary compounds, coordination compounds of copper with identical amino acids were obtained in 8 out of 10 syntheses, which indicates the selectivity of Cu(II) ions towards amino acids, which follows the trend: L-Leu ≈ L-Pro > L-Ile ≈ L-Val > L-Ala. Obtained complexes were identified using IR spectroscopy (ATR technique) and powder X-ray diffraction. Molecular and crystal structures of trans-Cu(L-Val)2 and cis-Cu(L-Ile)2(H2O) were deermined using single crystal X-ray diffraction. Jahn-Teller effect was noticed as the geometry of copper ion in trans-Cu(L-Val)2 is distorted octahedral, whereas in the case of cis-Cu(L-Ile)2(H2O) the copper ion is pentacoordinated and the geometry is square pyramidal.