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Psihofarmaci su lijekovi koji djeluju na psihičke funkcije, ponašanje i doživljavanje bolesnika. Nuspojava lijeka je svaka štetna pojava koja se javlja kod uporabe lijeka sukladno njegovim uputama za korištenje. One značajno utječu na kvalitetu života. Na temelju detaljne anamneze i kliničkog pregleda mogu se prepoznati manifestacije lijekova na sluznici usne šupljine. Psihofarmaci izazivaju promjene u vidu stomatitisa, poremećaja sekrecije sline – kserostomija i ptijalizam, poremećaja okusne osjetljivosti, sindroma pečenja usta, hiperplazije gingive te lihenoidne reakcije. Psychopharmaceuticals are drugs used in treatments of mental health disorders. They have an effect on psychological functions and behaviour of the patient. Side effect are any results of a drug or a theraphy that occurs in addition to the desired effect, regardless whether it is beneficial or undesirable. Their effect can be detrimental to the patients wellbeing. Detailed medical history and medical examination is necessary in recognising the effects of the given drug on the mucus membrane of the mouth. Psychopharmaceuticals cause alterations such as inflammation of the mouth (stomatitis), defects in secretion of saliva – xerostomia and hypersalivation, disorders of taste, burning mouth syndrome, gingival hyperplasia and lichenoid eruptions.