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Objective To explore the application and efficacy of high-frequency brain magnetic field analysis in stereo-electroencephalography (SEEG) radiofrequency thermal coagulation treatment for drug-resistant epilepsy. Methods The data of 11 patients with drug-resistant epilepsy who were admitted to the sixth ward, Department of Neurosurgery, Sanjiu Brain Hospital of Guangdong Province, from January 2022 to December 2022 were analyzed retrospectively. CURRY8 software was utilized for fusion analysis and evaluation of various imaging and electrophysiological data to locate possible epileptogenic foci and develop a plan for SEEG electrode implantation and parallel deep brain electrode implantation was performed. Postoperative SEEG was performed to monitor and observe the patients' EEG changes during the seizure period, combined with the preoperative images and SEEG data. Deep brain electrode epileptic foci destruction was performed according to the analyzed results, and the surgical efficacy was evaluated by regular postoperative follow-up for 3-6 months. Results Eleven patients underwent deep brain electrode radiofrequency thermocoagulation disruption based on the seizure initiation sites observed by SEEG. The efficacy of postoperative follow- up was Engel grade I in 6 patients, grade II in 3, grade III in 1, and grade IV in 1. Conclusions High-frequency magnetoencephalography analysis is both safe and reliable, providing a more precise foundation for the localization of epileptogenic zones. When combined with multimodal fusion analysis and comprehensive evaluation of various imaging techniques and electrophysiology, it enables a more intuitive and accurate identification of epileptogenic zones while optimizing the SEEG implantation plan. This approach ensures maximum surgical efficacy with minimal trauma, thereby offering significant benefits to patients suffering from drug-resistant epilepsy [ABSTRACT FROM AUTHOR]

Objective To study the electro-clinical characteristics of intractable startle epilepsy, and to explore the epileptogenic network of startle seizures. Methods The electro- clinical characteristics of 4 patients admitted to Tsinghua University Yuquan Hospital from January 2014 to August 2020 with refractory startle epilepsy who had no seizures after operation were analyzed retrospectively. The seizure origin and epileptogenic network were studied by the data of stereotactic electroencephalography (SEEG). Results Four patients were mainly induced by voice. Except case 1, which was unilateral limb sensory aura-tonic seizure, the other 3 cases were characterized by transient axial muscle and proximal limb muscle rigidity. During the seizure period, the electroencephalogram (EEG) showed generalized voltage suppression or artifact masking EEG, without lateral and location cues. The onset of SEEG in 4 patients all started with relatively diffused low voltage fast activity. In case 1, multiple around peri-insular micro gyri were slightly advanced. In case 2, left posterior insula and transverse temporal gyrus was slightly advanced. In case 3, left. supplementary sensorimotor area (SMA) and middle cingulate gyrus were slightly advanced. And in case 4, left posterior insular-opercular cortex was slightly advanced. High frequency epileptogenicgraphy showed that the seizure network involved the medial frontal lobe, motor-premotor cortex and peri-insulaopercular cortes. Rhythmic sound stimulation or speech could induce the response of transverse temporal gyrus, and the amplitude of evoked potential of transverse temporal gyrus was 150-400 µ.V. Conclusions Startle seizure may originate from SMA in the medial frontal lobe, or from the cortes peri-insular auditory cortes. The epileptogenic network of startle seizure mainly involves the medial frontal lobe, the motor premotor cortex, and the insular-opercular cortex. There may be two different epileptogenic network mechanisms in startle seizure. [ABSTRACT FROM AUTHOR]

Objective To explore the value of stereotactic-electroencephalography（SEEG） in preoperation of patients with refractory epilepsy with negative MRI. Methods The clinical data of 7 patients who underwent SEEG-guided surgical resection of seizure onset zones in the Affiliated The 988th Hospital of PLA from January 2018 to September 2018 were analyzed retrospectively. According to the assessment of curative effect based on the Engel standard was used to evaluate postoperative epilepsy control. Results 7 patients underwent SEEG surgeries and 63 electrodes carrying 548 contacts were implanted. There was no complication such as electrode breakage or displacement，infection, cerebrospinal fluid leakage and so on.All patients underwent radiofrequency thermocoagulation for suspected epileptic foci. The following-up from 12 to 18 months showed that the mean seizure frequency decreased 92.8%(P=0.00), among which 5 in Engel gradeⅠ and 2 in grade Ⅱ． Conclusions SEEG has a wide range of monitoring, which can accurately locate the origin of MRI negative seizures. It is safe and feasible in preoperative evaluation of MRI negative epilepsy and can effectively guide surgical removal of epileptic foci and control of seizures. [ABSTRACT FROM AUTHOR]