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Objective To observe the blood flow density and morphological structure of choroid and retina in the macular region of patients with neovascular and non-neovascular central serous chorioretinopathy (CSC). Methods Forty-one patients with chronic CSC (41 eyes, observation group)were selected, including 19 cases of neovascular CSC (19 eyes, neovascular CSC)and 22 cases of non-neovascular CSC (22 eyes, non-neovascular CSC), and meanwhile, 41 normal subjects (41 eyes)were selected as the control group. The macular choroidal and retinal vascular density indicators [superficial retinal capillary layer vascular density (SVD), deep retinal capillary layer vascular density (DVD), choroidal blood capillary layer blood flow density (CFD), foveal density in a 300 μm region around foveal avascular zone (FD300)］and the macular choroidal and retinal morphological and structural indicators［foveal avascular zone (FAZ) area, FAZ circumference, acircularity index (AI), ganglion cell complex (GCC)thickness, retinal outer nuclear layer thickness, subfoveal choroidal thickness (SFCT), incidence of retinal pigment epithelial detachment (PED), and incidence of doublelayer sign］were compared in the two groups, and then we analyzed the correlations between indexes. Results Compared with the control group, the choroidal CFD and retinal FD300, GCC thickness, and outer nuclear layer thickness decreased, while the retinal FAZ area, FAZ circumference, AI and choroidal SFCT increased in the observation group (all P<0. 05). Compared with non-neovascular CSC patients, the thickness of the outer nuclear layer decreased, and the incidence of double-layer sign increased in the neovascular CSC patients (all P<0. 05). In the observation group, choroidal CFD was negatively correlated with retinal FD300, GCC thickness, and outer nuclear layer thickness；choroidal SFCT was negatively correlated with retinal outer nuclear layer thickness (all P<0. 05). Conclusions Compared with ordinary people, the choroid CFD, FD300, GCC thickness and outer nuclear layer thickness significantly decreased in the macular region of chronic CSC patients, and the FAZ area, FAZ circumference, AI and SFCT increased considerably. Compared with non-neovascular CSC patients, the outer nuclear layer thickness significantly decreased in neovascular CSC patients, and the incidence of the double-layer sign significantly increased. There were correlations between macular choroidal indexes and macular retinal indexes in patients with chronic CSC. [ABSTRACT FROM AUTHOR]

Objective To compare the macular structure and microcirculation in both eyes of the patients with myopic anisometropia.Methods Optical coherence tomography angiography(OCTA)was employed to scan the macular areas in both eyes of 44 patients with myopic anisometropia.The patients were assigned into high and low groups based on the refractive diopter,and the parameters such as retinal thickness,choroidal thickness,vascular density,and perfusion density in the macular areas of both eyes were compared between the two groups.Results Other macular areas except the central and external nasal areas and the choroid of the fovea in the high group were thinner than those in the low group(all P <0.05).There was no statistically significant difference in retinal vascular density or perfusion density in different areas between the two groups(all P >0.05).Conclusion In the patients with myopic anisometropia,most areas of the retina in the case of high myopia is thinner than that in the case of low myopia,while there is no difference in retinal vascular density or perfusion density in both eyes.