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BACKGROUND: Osteoporotic vertebral compression fracture is the most common complication of osteoporosis. Percutaneous kyphoplasty is an effective treatment for osteoporotic vertebral compression fractures. Its operative approaches include unilateral and bilateral pedicle approaches. The two approaches have their advantages and disadvantages. OBJECTIVE: To explore the clinical effect and value of the unipedicular and bipedicular approaches to percutaneous kyphoplasty in the treatment of osteoporotic vertebral compression fracture. METHODS: 383 patients with osteoporotic vertebral compression fractures of the thoracic and lumbar spine were operated on from March 2014 to April 2020 via bipedicular approach (bipedicular group, 208 cases) and unipedicular approach (unipedicular group, 175 cases) percutaneous kyphoplasty. All patients were followed-up using the Oswestry dysfunction index, visual analog scale score and X-ray inspection preoperatively and postoperatively. The operation time, blood loss, amount of bone cement injected, frequency of X-ray exposure, Cobb angle of vertebral kyphosis, vertebral body leading edge height, intermediate height, cement leakage rate, and incidence of adjacent vertebral body re-fracture were measured and compared between the two groups. [ABSTRACT FROM AUTHOR]

ObjectiveTo examine the participation in on-the-spot first aid among inpatients in Hunan province and the outcome and influencing factors of the participation for providing a reference to improve pre-hospital emergency and field rescue.MethodsUsing stratified random sampling and a self-designed questionnaire, an online survey was conducted among 6 004 inpatients in 109 medical institutions in Hunan province during January – February 2022. The information on the inpatients′ participation in on-the-spot first aid, the outcomes and influencing factors of their participations were collected and analyzed. Unconditional multivariate logistic regression model was used to explore influencing factors for outcomes of the on-the-spot first aid actions.ResultsFor the 5 964 inpatients finally included in the analysis, 1136 (19.05%) reported ever encountering on-site rescue events. Among the 1136 inpatients ever encountering on-site rescue events, 440 (38.73%) had participated in on-site rescue. Of the 440 participants taking on-site rescue, 71.86% called emergency services; 24.42% sent the first aid recipients to hospital; 12.79% performed cardiopulmonary resuscitation; and 2.56% conducted electric defibrillation. For all the first aid recipients in the on-the-spot first aids being involved by the inpatient participants, 213 (48.41%) were cured, 127 (28.86%) were improved, 75 (17.05%) died, and 25 (5.68%) had an unknown outcome. The results of unconditional multivariate logistic regression analysis showed that emergency personnel not arriving at the first aid site within 10 minutes was a hindering factor for the outcomes of the latest on-the-spot first aid; ever participating in on-the-spot first aid more than 3 times and emergency personnel arriving at the first aid site within 30 minutes were promoting factors for the outcomes of the latest on-the-spot first aid.ConclusionThe participation of on-the-spot first aid was low among inpatients in Hunan province. The outcome of the resued persons for the latest on-the-spot first aid being involved by the inpatient participants was mainly influenced by the time of emergency personnel arriving at the first aid site and the frequency of inpatients′ ever participating in on-the-spot first aid.

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To report the diagnosis and treatment of Mucor infection in two cases of renal transplantation, and to provide reference for diagnosis and treatment of Mucor infection. Case 1, a male patient, who underwent allogeneic kidney transplantation due to increased creatinine for more than 8 years. The renal function had partially recovered 25 days after the operation, but then the patient suddenly got worse epigastric pain. Pathogen culture, smear microscopy, mass spectrometry identification and next-generation metagenomic sequencing (mNGS) were performed on the peritoneal drainage, with the result pointing to Rhizopus microsporus. The patient's condition improved after antifungal treatment using amphotericin B lipid complex (ABLC) and was discharged. Case 2, a male patient with hypertension and increased creatinine for more than 7 years was admitted to the hospital. After allograft kidney transplantation, tissue culture smear and histopathological examination suggested Mucor infection. The patient then underwent a "hand muscle debridement surgery + closed negative pressure drainage (VSD)" procedure, and amphotericin B was given postoperative treatment against Mucor infection and debridement. Subsequent retesting with mNGS showed no signs of Mucor infection. In the course of treatment, two patients developed abdominal pain after treatment with tegacycline, which was immediately diagnosed as pancreatitis and recovered after withdrawal. Both patients being male, with one case associated with hypertension. After initially guiding the diagnosis with traditional smear tests, final confirmation was done using histopathological examination, mNGS and mass spectrometry. One case was infected by Rhizopus microspora, and the other was infected by Rhizopus oryzae and Cunninghamia microbicans. The causes leading to Mucor infection in patients post renal transplantation varied greatly. Early diagnosis is the key to treatment of patients with Mucor infection after renal transplantation. Treatment with amphoteric B and its liposome is an effective means to improve mucormycosis patients after renal transplantation. The use of amphotericin B lipid complex treatment proved to be an effective treatment method for patients with Mucor infection after renal transplantation. [ABSTRACT FROM AUTHOR]

Objective To explore the effect of autologous blood transfusion on coagulation functions and prognoses in children after a removal of cerebral hematoma. Methods For this retrospective study, 132 children undergoing cerebral hematoma removal from February 2016 to April 2022 were selected as study subjects.They were assigned into three groups of A(n=16, autologous blood intra-operation), B(n=88, allogenic blood intra-operation)and C(n=28, both autologous and allogenic blood intra-operation). Coagulation functions and blood routines post-operation were compared among three groups.Hospitalization expense, length of hospitalization stay, postoperative complications and prognoses as valued by Glasgow outcome scale(GOS)were recorded. Results In three groups, partial thrombin activation time was[33.0(29.0, 38.6)], [33.2(30.3, 37.9)]and[33.8(30.7, 44.3)]s; Prothrombin time(13.5±1.2), (13.8±1.5), (14.2±2.2)s; International standardized ratio(1.1±0.1), (1.2±0.1), (1.2±0.1); Postoperative fibrinogen concentration(2.4±0.8), (2.0±0.6), (2.0±0.9)g/L.There were no statistical differences(P>0.05). No postoperative complications were caused by blood transfusion.Postoperative hemoglobin was(111.0±13.4), (112.4±20.0), (121.7±19.9)g/L; Postoperative hematocrit(32.1±3.8)%, (32.2±5.6)%, (34.7±5.4)%.There were no statistical differences(P>0.05). Postoperative platelet of three groups was[265.0(214.5, 318.5)]×109, [217.0(165.0, 267.5)]×109, [179.5(106.2, 237.5)]×109.There were no statistical differences(P<0.05). The count of platelet was significantly lower in group C than that in group A. There was statistical difference(P<0.017). Hospitalization time of three groups was[9(5, 14)], [8(5, 11)], [12(5, 21)]day; Hospitalization expense[57 260(39 165, 72 648)], [48 998(38 880, 64 447)], [63 130(42 181, 83 260)]yuan; Infection complications 4, 12, 5 cases; Complication of cerebral hernia 0, 2, 0 case; Complications of epilepsy 1, 8, 3 cases; Thrombotic complications 0, 3, 0 case.There were no statistical differences(P>0.05). GOS was 5(n=0), 4(n=16), 3(n=0), 2(n=0), 1(n=0)in group A, 5(n=1), 4(n=66), 3(n=9), 2(n=12), 1(n=1)in group B and 5(n=3), 4(n=15), 3(n=7), 2(n=3), 1(n=3)in group C. The differences were statistically significant(P<0.05). GOS of group A was significantly better than that of group C and the difference was statistically significant(P<0.017). No significant changes existed in duration of hospitalization, expense of hospital or rate of complication among three groups(P>0.05). GCS, ASA and GOS grading of group A was significantly better than that(P<0.05). Conclusion Autologous blood transfusion does not impair blood coagulations significantly and the outcome is excellent in children after a removal of cerebral hematoma. [ABSTRACT FROM AUTHOR]

Background Chinese medicine and acupuncture are widely used in the treatment of myasthenia gravis (MG), but there is a lack of high-quality evidence to verify their effectiveness and safety. One of the reasons is the lack of recognized and unified outcomes in the randomized controlled trial (RCT) design, which leads to the inability to combine data in secondary studies such as meta-analysis. The construction of the core outcome set (COS) of traditional Chinese medicine (TCM) for MG is conducive to the design of clinical research and the accumulation of high-quality evidence. Objective To describe the current situation of outcome selection in RCTs of MG treated with TCM, and analyze the existing problems, then put forward suggestions, promoting the construction of a COS of TCM. Methods Electronic databases of CNKI, Wanfang Data, VIP, SinoMed, Medline, PubMed, Cochrane Library, and Web of Science were systematically searched for RCTs of MG treated with TCM from inception to April 1, 2022. Two researchers independently screened the literature, extracted data, classified the outcomes and counted their frequency of use, and divided the outcomes into different outcome domains according to the functional attributes. Then, we analyzed the current status and existing problems in the selection of outcomes, and put forward corresponding suggestions. Results A total of 186 RCTs were included, involving 71 outcomes, with a frequency of use of 724 times in total. The roughly classified seven categories of all outcomes with frequency of use are as follows: MG severity scale (133 times), MG quality of life scale (20 times), TCM syndrome score (70 times), safety outcomes (66 times), blood biochemical outcomes (224 times), muscle strength changes (three times), and others (208 times). According to the functional attributes, the outcomes can be classified into seven outcome domains. A single study selected at least one and at most 12 outcomes. The most frequently used outcomes include effective rate, MG absolute and relative score, and TCM syndrome score. Among the included RCTs, only two reported the primary and secondary outcomes explicitly. The number of follow-up time point ranged from two to seven, and most RCTs chose three evaluation time points. Most RCTs did not report the use of blinding in the process of outcome evaluation. Conclusion At present, there are many problems in the selection of outcomes in RCTs of MG treated with TCM, including unclear distinction between primary and secondary outcomes, lack of internationally recognized outcomes, insufficient attention given to safety, large inter-study differences in the number of outcomes and evaluation time points, evaluation bias, and failure to include health economic outcomes, and non-standardized TCM curative effect evaluation. According to the existing problems, we proposed the following specific recommendations: promoting the establishment of a COS for TCM clinical research, selecting internationally recognized outcomes (including safety outcomes) with clear defining of the primary and secondary ones, selecting the appropriate treatment cycle and evaluation time point, completing clinical research registration, using blinding method, and standardizing the report of study.

Objective The role of activin A receptor type 1C(ACVR1C) in white matter remyelination and neurological outcome of mice with ischemic stroke were investigated. Methods Mice were randomly divided into empty virus vector sham operation group, adeno-associated virus(AAV) sham operation group, empty virus vector model group, AAV model group, empty virus vector activin group A and AAV activin group A.Acvr1cflox/flox mice with middle cerebral artery oclusion-reperfusion (MCAO/R) for 1 to 10 days were established. Adeno-associated virus AAV-PDGFRα-cre and AAV-PLP-cre with cre recombinase were injected into the lateral ventricles of the mice. Conditional knockout of Acvr1c on oligodendrocytes and oligodendrocytes. Neurological function score was used to observe the prognosis of neurological function. The expressions of ACVR1C protein and myelin basic protein (MBP) were detected by Western blot. Results With the extension of reperfusion time, activin A improved the behavioral outcome of mice by ACVR1C on oligodendrocytes at day 7 (P＜0.05), and significantly increased the expression of MBP protein in corpus callosum at day 10 (P＜0.05). Conclusions Activin A promotes white matter remyelination and improves outcomes of neurological function of ischemic stroke mice by acting on ACVR1C on oligodendrocytes.

Objective To assess the efficiency and safety of simultaneous coiling and clipping of multiple intracranial aneurysms in elderly patients. Methods The clinical data of 189 elderly patients with multiple intracranial aneurysms admitted to Department of Neurosurgery, the First Affiliated Hospital, Chongqing Medical University from May 2011 to May 2020 were analyzed retrospectively, including age, gender, smoking history, hypertension history, clinical classification, aneurysm characteristics, treatment methods, clinical complications and prognosis. Results Compared with the clipping group, elderly patients with simultaneous occlusion of all aneurysms were obviously more in the coiling group (82.2% vs. 31.0%, P<0.05). The incidence of hemorrhagic and ischemic complications ensuing the simultaneous occlusion of all aneurysms was markedly higher than that ensuing the only occlusion of a ruptured aneurysm (16.8% vs. 5.7%, 37.0% vs. 21.4%, P<0.05). The morbidity associated with simultaneous occlusion of all aneurysms was significantly higher than that of occlusion the ruptured aneurysm only (20.2% vs. 5.7%,P<0.05). Conclusion Simultaneous treatment of all aneurysms is associated with a higher risk of encountering complications in elderly patients which increases morbidity. [ABSTRACT FROM AUTHOR]

Copyright of China Tropical Medicine is the property of China Tropical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

With the application of ultrasound and magnetic resonance imaging in prenatal diagnosis, the clinically detected cases of fetal intracranial hemorrhage (FICH) are increasing year by year, and FICH is usually associated with adverse fetal outcomes and prognosis. This not only brings losses to pregnant women and their families, but also inevitably brings more medical disputes to clinicians and hospitals. However, so far, there is a lack of unified diagnostic criteria at home and abroad, and the etiology is still unclear. Therefore, understanding the underlying etiology of FICH is essential for formulating unified diagnostic criteria, prenatal consultation and management of FICH, as well as early intervention and prognosis improvement of FICH. [ABSTRACT FROM AUTHOR]

目的 探究脑机接口训练对存在感觉障碍的卒中患者运动功能恢复的影响。 方法 前瞻性招募同时存在上肢感觉和运动功能障碍的卒中受试者，随机分为试验组与对照组。试验组接受每周5 d，每日1次，每次30 min，共4周的基于运动尝试的机器人辅助下的抓握张开脑机接口训练，对照组则进行每周5 d，每日1次，每次30 min，共4周的抓握张开相关任务导向性训练。在干预前后采用Fugl-Meyer上肢运动功能评定量表（Fugl-Meyer assessment upper extremity scale，FMA-UE）、上肢动作研究量表（action research arm test，ARAT）评估患者的上肢运动功能；Fugl-Meyer量表上肢感觉评分评价感觉功能；改良的Ashworth量表（modified Ashworth scale，MAS）评估肌张力；改良Barthel指数（modified Barthel index，MBI）评估日常生活能力。比较2组治疗后较本组治疗前上述指标的改善情况，治疗后2组上述指标的差异以及各指标干预后较干预前的进步情况（干预后分值-干预前分值）。 结果 共纳入12例存在上肢感觉和运动功能障碍的卒中患者，试验组与对照组各6例。试验组[19.00（16.50～42.25）分 vs. 10.00（7.75～23.25）分，P=0.028]、对照组[13.00（10.50～27.50）分 vs. 9.00（8.50～21.00）分，P=0.042]干预后FMA-UE评分均较本组干预前显著改善，此外，试验组患者干预后在ARAT[4.00（3.50～10.50）分 vs. 2.00（1.00～14.00）分，P=0.042]、MBI评分[75.00（58.75～87.50）分 vs. 57.50（50.00～67.50）分，P=0.041]方面也较本组干预前显著改善。干预后2组的比较显示，试验组MBI较对照组提高[75.00（58.75～87.50）分 vs. 45.00（45.00～55.00）分，P=0.023]，余指标差异无统计学意义。另外，比较2组干预后各指标的进步情况，试验组FMA-UE[9.50（6.75～15.25）分 vs. 4.50（3.00～8.25）分，P=0.030]及屈指MAS[-0.50（-1.00～0.00）分 vs. 0.00（0.00～0.50）分，P=0.020]的进步较对照组明显。 结论 对于存在感觉障碍的患者，进行脑机接口干预可促进其运动功能恢复及日常生活能力的提升。 Abstract: Objective To investigate the effects of brain-computer interface (BCI) training on motor function recovery in stroke patients with sensory impairment. Methods The stroke subjects with upper limb sensory and motor function impairment were prospectively enrolled in this study, and all the subjects were randomly divided into experimental group and control group. The experimental group received the robot-assisted graspping and opening brain-computer interface training based on motor attempt, 5 days a week, once a day, 30 minutes each time, for 4 weeks, while the control group received the graspping and opening task-oriented training, 5 days a week, once a day, 30 minutes each time, for 4 weeks. Fugl-Meyer assessment upper extremity scale (FMA-UE) and action research arm test (ARAT) were used to evaluate the upper limb motor function of patients before and after the intervention, and Fugl-Meyer Scale upper limb sensory score was used to evaluate sensory function. The modified Ashworth scale (MAS) was used to evaluate muscle tone. The modified Barthel index (MBI) to evaluate the activity of daily living. The improvement of the above indexes after treatment were compared between the two groups, and the difference of the above indexes after treatment were compared between the two groups. Results A total of 12 eligible stroke patients were included, with 6 cases in each group. The FMA-UE score improved in the experimental group [19.00 (16.50-42.25) vs. 10.00 (7.75-23.25), P=0.028] and the control group [13.00 (10.50-27.50) vs. 9.00 (8.50-21.00), P=0.042] after intervention compared with that before intervention. The ARAT [4.00 (3.50-10.50) vs. 2.00 (1.00-14.00), P=0.042] and MBI scores [75.00 (58.75-87.5) vs. 57.50 (50.00-67.50), P=0.041] in experimental group after intervention also improved compared with those before intervention. The MBI score after intervention in experimental group was higher than that in the control group [75.00 (58.75-87.5) vs. 45.00 (45.00-55.00), P=0.023], and there were no satistical differences in other indexes. The improvements of FMA-UE [9.50 (6.75-15.25) vs. 4.50 (3.00-8.25), P=0.030] and flexion MAS scores [-0.50 (-1.00-0.00) vs. 0.00 (0.00-0.50), P=0.020] in the experimental group were better than those in the control group. Conclusions For patients with impaired sensory function, brain-computer interface intervention can promote the recovery of motor function and activity of daily living.

Objective To investigate the impact of hemodialysis blood flow rate（BFR）on outcome in elderly maintenance haemodialysis（MHD）patients. Methods Retrospective analysis was carried out focusing on the general clinical data of 221 elderly MHD patients with in-center hemodialysis from December 2012 to December 2020. Elderly MHD patients was subgrouped into high-BFR（BFR > 211 mL/min）and low-BFR（BFR ≤ 211 mL/min） groups based on the median hemodialysis BFR level. Results Compared with the low BFR group, high BFR patients were younger, longer durations on dialysis, had higher proportion of males, high-flux dialyzer, BMI and systolic blood pressure. The hemoglobin level in high BFR was higher than that in low BFR group. Compared with the low BFR group, high BFR patients were younger, longer durations on dialysis, had higher proportion of males, high-flux dialyzer, BMI and systolic blood pressure. The hemoglobin level in high BFR was higher than that in low BFR group. Cardiovascular diseases is the leading cause of mortality. There were no statistically significant differences in the survival-time and mortality between the two groups. Multivariable Cox regression analysis showed that each 10ml/min BFR increase was associated with a 28.5%（HR：1.285, CI：1.011 ~ 1.635, P = 0.040）increase in the relative risk of death, which is more pronounced in patients with shorter durations on dialysis, dialysis access was central venous catheterization, low hemoglobin, hyperphosphatemic, and a history of coronary artery disease. Conclusion BFR was an independent risk factor of mortality in MHD patients. [ABSTRACT FROM AUTHOR]

Objective The role of activin A receptor type 1C (ACVR1C) in white matter remyelination and neurological outcome of mice with ischemic stroke were investigated. Methods Mice were randomly divided into empty virus vector sham operation group, adeno-associated virus (AAV) sham operation group, empty virus vector model group, AAV model group, empty virus vector activin group A and AAV activin group A.Acvr1cflox/flox mice with middle cerebral artery conclusion-reperfusion (MCAO/R) for 1 to 10 days were established. Adeno-associated virus AAV-PDGFRα-cre and AAV-PLP-cre with cre recombinase were injected into the lateral ventricles of the mice. Conditional knockout of Acvr1c on oligodendrocytes and oligodendrocytes. Neurological function score was used to observe the prognosis of neurological function. The expressions of ACVR1C protein and myelin basic protein (MBP) were detected by Western blot. Results With the extension of reperfusion time, activin A improved the behavioral outcome of mice by ACVR1C on oligodendrocytes at day 7 (P＜0.05), and significantly increased the expression of MBP protein in corpus callosum at day 10 (P＜0.05). Conclusions Activin A promotes white matter remyelination and improves outcomes of neurological function of ischemic stroke mice by acting on ACVR1C on oligodendrocytes. [ABSTRACT FROM AUTHOR]

目的 通过中国国家卒中登记Ⅱ（China national stroke registry Ⅱ，CNSRⅡ）的数据，分析入院收缩压（systolic blood pressure，SBP）、舒张压（diastolic blood pressure，DBP）及平均动脉压（mean arterial pressure，MAP）与脑出血患者死亡和功能结局的关系。 方法 收集CNSRⅡ数据库中自发性脑出血患者的人口学信息和临床数据，应用logistic回归分析患者入院时不同SBP分层、SBP、DBP和MAP对患者短期和长期预后（包括院内死亡、3个月死亡及预后不良和1年预后不良）的影响。 结果 共有1048例脑出血患者的资料纳入统计分析，平均年龄62.1±12.5岁，男性666例（63.5%）。入院时平均SBP为162.1±28.9 mmHg，平均DBP为95.1±17.6 mmHg，平均MAP为117.4±20.1 mmHg。与入院SBP 120～139 mmHg的患者相比，入院SBP 180～199 mmHg（OR 17.53，95%CI 2.25～136.66，P=0.0063）和SBP≥200 mmHg的患者（OR 21.74，95%CI 2.74～172.55，P=0.0036）的在院死亡风险均增加。入院SBP每升高10 mmHg，患者在院死亡风险（OR 1.25，95%CI 1.14～1.37，P

Hydrosalpinx is one of the causes of repeated embryo implantation failures in assisted reproductive technology. It is generally considered that mechanical washout, reduced endometrial receptivity, and toxic effects of hydrosalpinx on the embryos are the major pathogenic mechanisms underlying the effect of hydrosalpinx upon pregnancy outcomes. In recent years, research progress has been achieved in the pathogenic mechanism of hydrosalpinx affecting pregnancy outcomes. For the selection of treatment strategies of hydrosalpinx, clinicians should choose individualized treatment according to the severity of hydrosalpinx of each patient. This article reviews the research progress on the impact of hydrosalpinx on pregnancy outcomes and the selection of treatment strategies, aiming to improve the pregnancy outcomes of patients with hydrosalpinx.

Objective To evaluate the safety and effectiveness of endovascular treatment of intracranial arteriosclerotic disease-related acute basilar artery occlusion (ICAD-related ABAO). Methods The clinical data of patients with ABAO who underwent endovascular treatment in Pudong New Area People's Hospital and Renji Hospital Affiliated to Shanghai Jiaotong University from October 2016 to November 2020 were analyzed retrospectively. According to the etiology of vascular occlusion, the patients were divided into the ICAD-related ABAO group and the embolic ABAO group. Baseline characteristics, surgical details and clinical prognostic indicators were compared between the two groups. Results A total of 72 patients included 31 cases of ICAD-related ABAO occlusion and 41 cases of embolic ABAO occlusion. There were significant differences in baseline characteristics between the two groups. ICAD-related ABAO was most common in the middle and proximal basilar arteries, but the distal portion in Embolic ABAO. The interval from onset to artery puncture and procedure time in the ICAD-related ABAO group were longer significantly than those in the embolic ABAO group (409.0 min vs 272.0 min, P=0.015, 60.0 min vs 43.0 min, P=0.010). The ratio of successful recanalization (mTICI ≥2b) in the ICAD-related ABAO group was consistent with that in the embolic ABAO group (100.0% vs 100.0%). The prognosis ratio of 90-day mRS 0-2 and mRS 0-3 in ICAD-related ABAO group was similar to that in Embolic ABAO group (51.6% vs 63.4%, adjusted OR 1. 273, 95% CI 0. 259-6. 252, P = 0. 766; 54. 8% vs 68. 3%, adjusted OR 0. 898, 95% CI 0. 173-4. 650, P =0. 898). The 90-day mortality rate was similar in both groups (32. 3% vs 14. 6%, adjusted OR 3. 802, 95%CI 0. 519-27. 857, P = 0. 189). There was no significant difference in symptomatic bleeding (3. 2% vs 4. 9%, P =0. 683). Conclusions The efficacy and safety of endovascular treatment on ICAD-related ABAO and Embolic ABAO are similar. Mechanical thrombectomy combined with salvage therapy is an effective strategy for the treatment of ICAD-related ABAO. [ABSTRACT FROM AUTHOR]

BACKGROUND: Severe aplastic anemia has severe illness and high mortality, which requires rapid recovery of hematopoietic function. At present, hematopoietic stem cell transplantation is the first-line treatment, human leucocyte antigen-matched sibling donor hematopoietic stem cell transplantation is the first choice, and haploidentical hematopoietic stem cell transplantation has also achieved good results as an alternative treatment. OBJECTIVE: To investigate the efficacy of allogeneic hematopoietic stem cell transplantation (including matched sibling donor hematopoietic stem cell transplantation and haploidentical hematopoietic stem cell transplantation) in the treatment of severe aplastic anemia. METHODS: The clinical data of 24 patients with severe aplastic anemia diagnosed from April 2015 to July 2021 undergoing allogeneic hematopoietic stem cell transplantation in Xuzhou Center Hospital were retrospectively analyzed. Among them, 8 patients received matched sibling donor hematopoietic stem cell transplantation and 16 patients received haploidentical hematopoietic stem cell transplantation. The pretreatment regimen of 24 patients with severe aplastic anemia was fludarabine, cyclophosphamide and anti-lymphocytic globulin. The prevention of graft versus host disease was cyclosporine combined with shortrange methotrexate in matched sibling donor hematopoietic stem cell transplantation, and in haploid matched hematopoietic stem cell transplantation on the basis of this addition of mycophenolate mofetil. RESULTS AND CONCLUSION: (1) Among the 24 patients, 2 severe aplastic anemia patients died of severe infection during pretreatment, and the other 22 patients reached hematopoietic reconstitution. The median time of neutrophil implantation was 12.5 (10-18) days, and the median time of platelet implantation was 14.5 (10-26) days. (2) Totally 22 patients with successful implantation developed acute graft versus host disease in 8 patients (36%), grade III/IV acute graft versus host disease in 2 patients, chronic graft versus host disease in 4 patients (18%), and grade III/IV chronic graft versus host disease in 1 patient. (3) Totally 18 patients survived and 6 patients died. The 5-year estimated overall survival rate was 74%. (4) These results indicate that allogeneic hematopoietic stem cell transplantation is an effective treatment for severe aplastic anemia. Human leucocyte antigen-matched sibling donor is the first choice. When human leucocyte antigen-matched sibling donor is not available, related human leucocyte antigen-haplo identical donor will be an alternative method. [ABSTRACT FROM AUTHOR]

BackgroundMild cognitive impairment (MCI) has highly variable cognitive trajectories. Approximately 10% to 15% of MCI patients progress to dementia, and nearly 24% revert to normal cognition each year. There are few studies on the progression and reversion of MCI, especially there version of MCI to normal cognition.ObjectiveTo construct a multi-class classification model of MCI outcomes (reversion, stabilization and progression) and to explore the possible associated factors of these outcomes.MethodsData were collected from the National Alzheimer's Disease Coordinating Center Unified Data Set, involving 397 patients who were initially diagnosed with MCI during 2005—2019 with at least two follow-ups and complete clinical and follow-up data. Patients' demographic information, physical examination, disease history, and measurement results by assessment scales in MCI were selected for analysis. Boruta was used for feature selection. Random forest was used for supporting the classification of MCI outcomes. A stepwise multinomial logistic regression was used to explore the associated factors of different MCI outcomes.ResultsOf the 397 cases, 124 (31.23%) reverted to normal cognition, 77 (44.58%) were in stable condition, and 96 (24.18%) progressed to dementia. In the multi-classification task, the accuracy of direct three-class classification was 67.58%. In multiple binary classifications, the accuracies of reversion and stabilization, and reversion and progression were above 90%. Among the hierarchical three-class classification, the accuracy based on stabilization→ reversion → progression was 84.38%. Stepwise multinomial Logistic regression analysis showed that age ≥80 years 〔OR=0.260, 95%CI (0.117, 0.574) 〕, self-reported cognitive impairment 〔OR=0.295, 95%CI (0.139, 0.623) 〕, and decreased Clinical Dementia Rating (CDR) scores〔OR=0.220, 95%CI (0.092, 0.525) 〕 were associated with decreased risk of MCI progressing to dementia, while history of stroke 〔OR=2.896, 95%CI (1.370, 6.122) 〕, fecal incontinence 〔OR=6.556, 95%CI (1.787, 24.047) 〕, and higher Functional Activities Questionnaire score〔OR=1.048, 95%CI (1.003, 1.095) 〕were associated with increased risk of MCI progressing to dementia. Decreased probability of reversion from MCI to normal cognition was related to age ≥80 years 〔OR=0.289, 95%CI (0.091, 0.914) 〕, obesity 〔OR=0.236, 95%CI (0.075, 0.740) 〕, self-reported cognitive impairment 〔OR=0.289, 95%CI (0.111, 0.757) 〕, and higher CDR scores 〔OR=0.015, 95%CI (0.003, 0.089) 〕, while increased probability of reversion from MCI to normal cognition was related to higher MMSE score 〔OR=1.708, 95%CI (1.428, 2.043) 〕 and higher numbers of correct naming of animals 〔OR=1.139, 95%CI (1.046, 1.240) 〕.ConclusionThe outcome of MCI patients is affected by multiple factors. Advanced age, obesity, history of stroke, fecal incontinence, self-reported cognitive impairment and reduced functional activity were important factors influencing MCI progression and reversion.

Objective To analyze the clinical features of HBeAg and HBeAb double-positive patients with chronic hepatitis B, and explore the efficacy and outcomes of different antiviral regimens. Methods A total of 158 HBeAg and HBeAb double-positive patients with chronic hepatitis B who met the antiviral treatment criteria were selected from Chongqing Three Gorges Hospital from 2014 to 2018. They were divided into entecavir treatment group (n=52), interferon treatment group (n=49), and control group (without antiviral treatment, n=57) according to the actual treatment regimen, and were followed up for 48 weeks. The efficacy and outcomes of patients were observed and compared among different groups. Results Baseline distribution of HBeAg and HBeAb: among 158 HBeAg/HBeAb double positive chronic hepatitrs B patients, 79 patients had HBeAg≥10, and 79 patieats had HBeAg < 10, each accounting for 50%; HBV DNA level was 4.77±1.23 Lg. Antiviral efficacy: the decrease of HBV DNA level, the HBV DNA negative conversion rate, and the normalization rate of ALT were all better in the entecavir group than the interferon group (P < 0.05), while the decline of HBeAg and HBeAb levels, as well as the HBeAg negative conversion rate were greater in the interferon group (P < 0.05). Clinical outcomes: the proportion of patients who became HBeAg negative or only presented HBsAg and HBcAb positive was significantly larger in the antiviral groups as compared with the control group (P < 0.05), while the control group showed higher proportion of continuous "double-positive" (P < 0.05). In addition, the decrease range of HBeAg-Lg/HBeAb ratio before and after treatment had the greatest value in predicting HBeAg negative conversion. Conclusion For HBeAg and HBeAb double-positive patients with chronic hepatitis B, interferon treatment shows greater advantage in HBeAg negative conversion. Monitoring the decline of HBeAg-Lg/HBeAb is helpful to predict clinical outcome in the double-positive patients.

Objective To analyze the effect of the first metatarsophalangeal joint fusion combined with 2-5 metatarsophalangeal arthroplasty in the treatment of rheumatoid foot deformity. Methods From January 2015 to December 2019, 21 patients (36 feet) who have rheumatoid anterior foot deformity, with an average age of 63.6±6.0 years, were performed first metatarsophalangeal joint fusion and 2-5 metatarsophalangeal arthroplasty. The results of the operation were evaluated by the American Orthopaedic Foot and Ankle Society (AOFAS) scores and visual analog scale (VAS). The hallux valgus angle (HVA) and the intermetatarsal angle (IMA) were measured on the X-ray pre-operative and post-operative films. Results The follow-up period of 21 cases (36 feet) was 39.2±5.1 months, without any complication. The preoperative and postoperative scores of AOFAS, VAS, HVA and IMA were 81.6±9.1, 8.4±1.1, 37.2 °±7.5 °, 16.9 °±2.7 °,and 84.25±2.87, 1.9±0.9, 14.4 °±2.0 °, 11.1 °±1.7 ° respectively. The improvement was statistically significant (P＜0.05). Conclusions The first metatarsophalangeal joint fusion combined with 2-5 metatarsophalangeal arthroplasty was effective on rheumatoid forefoot deformity, which can correct the deformity, relieve pain and improve the function.

Objective: To establish and validate a prediction model combined machine learning with radiomics features in predicting outcome after mechanical thrombectomy in acute stroke. Methods: Imaging data of acute stroke patients in Nanjing First Hospital were retrospectively collected. These patients were divided into a training set(n=105)and a test set(n=50)according to random number table method. Acute stroke(n=45)in the Second People’s Hospital of Changzhou were collected as the validation set. A.K. software was used to extract radiomics features on diffusion weighted imaging(DWI)and perfusion weighted imaging(PWI). Least absolute shrinkage and selection operator(LASSO)regression model was used to screen the features, and then, the selected features were used to establish the prediction model by support vector machine(SVM)classifier. Receiver operating characteristic(ROC)curve was used to evaluate the predictive efficacy of the model, and the validation set was used to verify the generalization ability of the model. Results： One thousand three hundred and sixteen radiomics features of each patient were extracted from DWI and PWI, and 40 features highly related to outcome after mechanical thrombectomy in acute stroke were screened after dimension reduction. ROC analysis showed that the area under curve(AUC)of DWI+PWI model(training set：0.981；test set：0.891)was higher than those of DWI or PWI model, and the accuracy were 0.943 and 0.900, respectively. The results of validation of the model showed that the prediction model based onDWI + PWI was also better than that of single sequence(DWI or PWI), the sensitivity and specificity were 0.864 and 0.783 respectively, and the accuracy was 0.822. Conclusion: The prediction model combined machine learning and radiomics can effectively predict outcome after mechanical thrombectomy in acute stroke, and has good generalization ability. [ABSTRACT FROM AUTHOR]

Objective To investigate the characteristics of disturbance of electrolyte balance after primary brainstem hemorrhage (PBH) and their correlation with the outcome of patients with disorders of consciousness (DOC). Methods A retrospective survey was used to statistically analyze the clinical data of 350 patients with brainstem hemorrhage admitted to the Second Affiliated Hospital of Army Military Medical University from January 1, 2010 to September 1, 2020. With our strict inclusion and exclusion criteria, 47 PBH cases undergoing standardized fluid replacement were screened out. Then they were divided into the non-DOC group (n=21), DOC group (n=21) and DOC translating to non-DOC group (n=5) according to their state of consciousness. The quantities of venous blood electrolyte and carbon dioxide during the whole duration of hospital stay were collected, and then analyzed for the changes of sodium, potassium, chloride, anion gap (AG) and CO2. Next, we analyzed the rule and characteristics of the changes of mean value, maximum value, minimum value, abnormal rate, average fluctuation range and other indicators, and explored their relationship with PBH. Results One-way analysis of variance (ANOVA) showed that there were significant differences in the mean value, maximum value, minimum value, abnormal rate and average fluctuation range of chloride ion and AG among the 3 groups (P < 0.05). But in addition to the abnormal rate and average fluctuation range of CO2 content, there were no statistical differences in the contents of sodium ion, potassium ion and CO2 among the 3 groups. Further multiple intra-group comparative analysis indicated that the mean value, maximum value, abnormal rate and average fluctuation range of chloride ion and AG were significantly increased, while the minimum value was decreased in the DOC group than the non-DOC group (P < 0.01). The abnormal rate and average fluctuation range of potassium ion, AG and CO2 content were significantly increased (P < 0.01), but no statistical significance was seen in sodium and chloride in the DOC translating to non-DOC group than the non-DOC group. Conclusion The disturbance of electrolyte balance is closely associated with the DOC severity in PBH patients. The higher the abnormal rate of chloride ion and AG and the average fluctuation range are, the more severe DOC is.

Objective To investigate the effect of the normal sperm morphology rate on the outcome of rescue ICSI and the clinical value of rescue ICSI. Methods This retrospective analysis was conducted among 137 infertile couples receiving rescue ICSI in our hospital from January 2014 to December 2019.According to the IVF fertilization（including total fertilization failure or partial fertilization failure） and different normal sperm morphology rate, it is divided into rescue ICSI cycle of TFF:NSMR < 4% group（n=41） and NSMR ≥ 4% group（n=34）;The rescue ICSI cycle of PFF: NSMR < 4% group（n=37） and NSMR ≥ 4% group（n=25）, all transferred embryos were come from rescue ICSI. To observe and compare the general clinical data, embryonic development and clinical outcome of patients with different normal sperm morphology rate under two situation of IVF fertilization failure. Meanwhile, to explore the effect of rescue ICSI on the fertilization outcome of conventional IVF total fertilization failure and partial fertilization failure. Results（1） The rescue ICSI cycle of TFF: There was no significant difference in the general clinical data, embryonic development and clinical outcome between the two groups（P>0.05）.（2） The rescue ICSI cycle of PFF: There was no significant difference in the general clinical data between the two groups（P>0.05）.The fertilization rate of NSMR ≥4% group was higher than that of NSMR<4% group, and there was significant difference between the two groups（89.77% vs 82.04%, P<0.05）.However, there was no significant difference in the normal fertilization rate, cleavage rate, good embryo rate, implantation rate, clinical pregnancy rate, live birth rate and abortion rate between the two groups（P> 0.05）.（3） The rescue ICSI cycle of TFF: a total of 75 fresh cycles, a total of 722 unfertilized oocytes, 545 MII oocytes were treated with rescue ICSI, the fertilization rate was 82.39%, the normal fertilization rate was74.50%, the cleavage rate was 98.00%, the good embryo rate was 40.81%, and the clinical pregnancy rate was 45.28%. 29 live births were obtained.（4） The rescue ICSI cycle of PFF: a total of 62 fresh cycles, a total of 709 unfertilized oocytes, 549 MII oocytes were treated with rescue ICSI, the fertilization rate was 85.06%, the normal fertilization rate was 70.86%, the cleavage rate was 97.64%, the good embryo rate was 43.46%, and the clinical pregnancy rate was 46.88%. 12 live births were obtained.Conclusion In the case of partial fertilization failure of IVF, the normal sperm morphology rate affects the fertilization rate of R-ICSI; whether it is a total fertilization failure of conventional IVF or partial fertilization failure, ICSI can be used as an effective remedy way. [ABSTRACT FROM AUTHOR]

Objective To explore the law of natural outcome of high-risk human papillomavirus (HR-HPV) infection and determine the optimal cutoff for prediction of the infection natural outcome based on the synchronous HPV genotyping and quantification. Methods A total of 2 784 women who underwent primary cervical screening with single type HPV infection for the first time by the synchronous HPV genotyping and quantification assay were enrolled and followed up for 2 years in this study. The correlation between standardized quantification and HR-HPV infection natural outcome was analyzed. Receiver operating characteristic (ROC) curve was plotted to determine the optimal cutoffs of individual HR-HPV standardized quantification in prediction of persistent infection. Results Among all the subjects, the natural clearance rate of HR-HPV infection was 73.71%, the persistent infection rate was 20.26% and the progression rate was 6.03%. Statistical differences were observed in the 13 HR-HPVs standardized quantifications among the natural clearance group, persistent infection group, and progression group (H=673.943, P < 0.001). The best threshold of the synchronous HPV genotyping and quantification assay to predict the outcome of HR-HPV infection was established according to ROC curve, and the optimal cutoffs of the log10-transformed quantification for HPV16, 18, 33, 52, 58, 59 and 68 in prediction of persistent infection were 3.00 copies per 10 000 cells, those for HPV31, 39, 51 and 56 were 4.00 copies per 10 000 cells. The optimal cutoff of the log10-transformed quantification for 13 HR-HPVs in prediction persistent infection was 3.00 copies per 10 000 cells, and the sensitivity was 88.66% and the specificity was 59.36% (P < 0.001). Conclusion HR-HPV standardized quantification can be used as a biological maker to predict the outcome of HR-HPV infection in the genital tract of female.

Objective: To summarize the procedures and efficacy of surgical treatment for Andrew stage Ⅰ-Ⅲ juvenile nasopharyngeal angiofibroma（JNA）. Methods: A total of 12 patients with JNA who underwent surgery from 2016 to 2021 were enrolled, including 1 case in stage Ⅰ, 3 cases in stage Ⅱ, and 8 cases in stage Ⅲ. JNA was resected by transnasal endoscopic approach alone, or combined with transoral approach or Caldwell-Luc approach was performed. Results: Eleven cases underwent complete resection without recurrence and 1 case had residual tumor. There were no serious complications. The median intraoperative blood loss was 200 mL, and 1 patient received blood transfusion. The median operative time was 110 minutes. Conclusion: JNA in Andrew stage Ⅰ-Ⅲ can be quickly and completely resected by standardized surgical procedures using endoscopy and coblation technology., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of West China Journal of Stomatology is the property of Sichuan University, West China College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective Delphi method was used to screen the evaluation tools and indicators for people at high risk of osteoporosis, so as to provide reference for the clinic. Methods Questionnaires were designed based on literature research and expert opinions. Two rounds of surveys were conducted among experts in the field of osteoporosis. The positive coefficient, concentration degree, and coordination degree of experts were statistically analyzed. Results In the first round, 20 questionnaires were sent out and 20 were returned. Thirty questionnaires were sent out and 28 were returned in the second round. The positive coefficient of experts was 100% and 93. 33%, respectively. The result show that the IOF One-minute osteoporosis risk test, traditional Chinese medicine assessment scale, and osteoporosis self-assessment tool for Asians could be used as risk assessment tools for people at high risk of osteoporosis. Dual energy X-ray absorptiometry, bone conversion index, blood calcium, and blood phosphorus should be taken as the main auxiliary examination contents. Bone mineral density, traditional Chinese medicine syndrome score, blood calcium and phosphorus, balance ability, quality of life score, bone turnover index, pain visual analogue scale, fall times, and fracture occurrence times could be used as key outcome indicators. Conclusion Based on the Delphi method, this study determines the evaluation tools and indicators for people at high-risk of osteoporosis, providing a reference for the screening and evaluation of high-risk population of osteoporosis. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

【摘要】 目的 探讨基于SWI的后循环Alberta卒中项目早期CT评分（posterior circulation Alberta stroke program early CT score，pc-ASPECTS）对后循环急性缺血性卒中（acute ischemic stroke，AIS）患者临床3个月预后的预测价值。 方法 回顾性连续收集来自河南省濮阳市人民医院神经内科2014年12月-2016年12月期间未接受静脉或动脉溶栓及血管内再通治疗的后循环AIS患者的临床及影像学数据。采用mRS评分评估发病后3个月预后，mRS评分0～2分定义为预后良好，3～6分定义为预后不良。使用多因素Logistic回归分析确定良好临床预后的独立预测因素。采用受试者工作特征（receiver operating characteristic，ROC）曲线分析来评估基于SWI的pc-ASPECTS评分对后循环AIS患者3个月预后的预测诊断价值。 结果 研究共收录63例后循环AIS患者，预后良好组42例（66.7%），预后不良组21例（33.3%）。单因素分析显示，入院时基线NIHSS评分（P＜0.001）、pc-ASPECTS评分（P＜0.001）在预后良好和预后不良组差异具有统计学意义。多因素Logistic回归分析提示，pc-ASPECTS≥6分是后循环AIS患者3个月预后良好的独立预测因素（OR 2.03，95%CI 1.04～3.95，P=0.039）；ROC曲线分析显示，基于SWI的pcASPECTS曲线下面积为0.80（95%CI 0.69～0.91）。 结论 在后循环AIS患者中，基于SWI影像的pc-ASPECTS评分可独立预测患者的3个月临床预后。 【Abstract】 Objective To assess the value of posterior circulation ASPECTS (pc-ASPECTS) based on SWI in predicting the clinical outcome of patients with posterior circulation acute ischemic stroke (AIS). Methods The clinical and imaging data of posterior circulation AIS patients who were not treated with endovascular recanalization and intravenous or intra-arterial alteplase were analyzed. The prognosis at 3 months after symptom onset was assessed by mRS, good prognosis was defined as mRS 0-2, and poor prognosis was defined as mRS 3-6. Multivariate logistic regression analysis was used to determine the independent predictors of clinical outcome. The area under the receiver operating characteristic (ROC) curve was used to evaluate the predictive value of the pc-ASPECTS based on SWI for the prognosis of patients with posterior circulation AIS. Results A total of 63 patients with posterior circulation AIS were included in the study, 42 (66.7%) patients had a good prognosis, and 21 (66.7%) patients had a poor prognosis. The univariate analysis showed that there was significant difference in the NIHSS on admission (P

目的 探讨胰岛素样生长因子-1（insulin like growth factor-1，IGF-1）水平对动脉瘤性蛛网膜下腔出血（aneurysmal subarachnoid hemorrhage，aSAH）患者院内并发症及出院时临床预后的预测价值。 方法 连续入组发病72 h内的aSAH患者及健康对照。在动脉瘤闭塞术前采集血样，测定血浆IGF-1水 平。对患者基本信息，神经内分泌因子、院内并发症及结局进行分析，用Logistic回归确定院内并发症 及出院时预后不良（mRS评分＞2分）的预测因素，计算预测因素的受试者工作特征曲线下面积。 结果 共入组118例aSAH患者和122例健康对照者。aSAH患者血浆IGF-1水平较健康对照低[69.00 （50.98，93.85）ng/mL vs 81.05（69.40，102.78）ng/mL，P 0.05）。71例（60.2%）患者 住院期间发生至少1种并发症。仅有入院时I GF-1浓度（OR 0.984，95%CI 0.973～0.996，P =0.0082）对 院内并发症有预测价值。 结论 aSAH急性期患者血浆IGF-1浓度越低，住院期间并发症发生率越高，出院时功能预后越差。 Objective To investigate the predictive value of insulin like growth factor-1 (IGF-1) for inhospital complications and short-term clinical outcomes after aneurysmal subarachnoid hemorrhage (aSAH). Methods Patients who were diagnosed as aSAH and within 72 h after symptom onset were selected. Upon admission and before aneurysm occlusion, plasma IGF-1 levels were measured. Patients with aneurysmal subarachnoid hemorrhage characteristics, perioperative complications and outcomes at discharge were analyzed. Logistic regression analyse was performed to identify independent factors associated with the poor clinical outcomes (mRS>2) and complications in hospital. Results 118 consecutive aSAH patients and 122 health controls were evaluated. The IGF-1 levels of aSAH patients were lower than that of health controls [69.00 (50.98, 93.85) ng/mL vs 81.05 (69.40, 102.78) ng/mL, P0.05). A total of 71 aSAH patients (60.2%) had at least one complication. Only the IGF-1 level on admission (OR 0.984, 95%CI 0.973-0.996, P=0.0082) can predict complications in hospital. Conclusions Lower IGF-1 levels at acute phase is the predictive factor for inhospital complications and short-term poor outcome in patients with acute aSAH.

Objective To explore the predictive value of neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio (PLR) in the prognosis and curative effect of locally advanced nasopharyngeal carcinoma(NPC) patients. Methods We collected the clinical information of locally advanced NPC patients from a randomized prospective clinical trial in Guizhou cancer hospital from July 2015 to December 2016. The patients were treated with two cycles of TPF induction chemotherapy and cisplatin-based concurrent chemoradiotherapy. The relationship between NLR, PLR before treatment and the therapeutic effect of patients was analyzed. We compared the curative effect between chrono-chemotherapy group and routine group. Results The mean values of NLR and PLR in stage Ⅳa/b patients were higher than those in stage Ⅲ patients (P=0.010); the immediate effect of metastatic lymph nodes in low PLR group was better than that in high PLR group (P=0.029), and the curative effect of primary lesion and overall curative effect three months after radiotherapy were better in low PLR group (P=0.012, P=0.027); there was no significant difference in immediate effect or overall curative effect three months after radiotherapy between conventional group and chronological group (P > 0.05). Conclusion NLR and PLR are related to the clinical staging of nasopharyngeal carcinoma. The later tumor stage is, the higher NLR and PLR values are. The predictive value of NLR for the patients' short-term efficacy is not well. PLR may be a predictor for recent outcomes of patients with locally advanced nasopharyngeal carcinoma, and high PLR may predict poor short-term efficacy.

Objective To explore the etiology and coping strategies for intracranial hemorrhage after microvascular decompression ( MVD ) . Methods The clinical data of 12 patients with intracranial hemorrhage after MVD for hemifacial spasm and trigeminal neuralgia were analyzed retrospectively, and the relevant literatures were reviewed. Results In this group of patients, there were 3 intracerebral hematoma, 3 cerebellar hemorrhage extended into ventricle, 2 subarachnoid hemorrhage, 2 intraventricular hemorrhage, 1 posterior fossa epidural hematoma and 1 supratentorial subdural hematoma. One patient with intraventricular hemorrhage was abandoned treatment and died within 48 hours after hemorrhage. Four patients were treated with craniotomy, evacuation of intracranial hematoma and posterior fossa decompression. One case of intracerebral hematoma was treated with stereotactic puncture and drainage. Two cases were treated with lateral ventricle puncture and drainage. One case of chronic supratentorial subdural hematoma underwent drilling and drainage. 3 cases were treated with conservative medicine and lumbar puncture. The prognosis showed 5 cases were cured. 1 was severely disabled, 3 were complicated with cranial nerve damage and 3 died ( 2 died during hospitalization, 1 died within half a year after discharge ) . Conclusions lntracranial hemorrhage following MVD has a high mortality and disability rate, and it is one of the most serious complications after MVD. Poor blood pressure control during the perioperative period, the pe1forating blood vessels from the responsible blood vessels that surround the nerve root exit zone ( REZ) and severe cerebellar hemisphere traction are the independent risk factors for intracranial hemorrhage after MVD. Bedside mobile CT for head CT examination can find early intracranial hemorrhage in time, which can effectively reduce the mortality and disability rate after bleeding and improve the prognosis. [ABSTRACT FROM AUTHOR]

Objective To analyse the treatment outcomes of isoniazid-resistant tuberculosis (Hr-TB) in Shenzhen, and we provide scientific evidences for the optimization of therapeutic regimen and control measure of Hr-TB in the future. Methods Data of registration records of Hr-TB patients which were enrolled in Shenzhen's drug-resistant TB project for treatment from January 2016 to January 2019, and the treatment outcome of patients with completed treatment course of Hr-TB patients and the reasons for unsuccessful treatment before February 2020 were analyzed. Results In 144 Hr-TB patients treated with the project, 102 cases were successful treatment (70.83%), 42 cases without successful treatment (29.17%). There were no significant difference in different gender, household registration and the successful treatment rate between the treatment regimen containing Levofloxacin (Lfx) and without Lfx (P>0.05). 37 cases with treatment unsuccessfully (88.10%) were due to the subjective factors (loss of follow-up/self discontinuation/return home/drop out), and 5 cases with treatment unsuccessfully (11.90%) were due to non-subjective factors (death/withdrawal for the adverse reactions/convert to multidrug resistance). In terms of non-subjective factors or subjective factors leading to unsuccessful treatment, there were no statistically significant differences between patients of different genders, household registration and treatment regimen (including Lfx and without Lfx) (P>0.05). Conclusion Lfx in the therapeutic regimen of Hr-TB patients had no difference in the rate of successful treatment in Shenzhen, loss of follow-up, self-discontinuation and drop out were the main reasons of treatment unsuccessfully in patients with Hr-TB in Shenzhen. To optimize the appropriate control measures for them could achieve better therapeutic effect. [ABSTRACT FROM AUTHOR]

目的 探讨幕上高血压性脑出血（intracerebral h emorrhage，ICH）微创颅内血肿抽吸引流术1年预后及 其相关因素。 方法 收集2014年1月-2016年8月就诊的进行微创颅内血肿抽吸引流术的幕上高血压性ICH患者。记 录患者人口学特征等基本信息、临床信息、手术治疗信息及1年改良Rankin量表（modified Rankin scale， mRS）评分。主要临床结局为1年预后不良，定义为1年mRS>3分。用多因素Logistic回归分析1年预后不 良的相关因素。 结果 研究共纳入117例完成微创颅内血肿抽吸引流术的幕上高血压性I C H患者。平均年龄 （56.5±12.5）岁，基线血肿体积（59.0±28.5）ml。59例（50.4%）ICH患者1年预后不良。多因素Logistic 回归分析显示，基线血肿体积20～50 ml[比值比（odds ratio，OR）0.161，95%置信区间（confidence interval，CI）0.034～0.748，P =0.020]、年龄≤60岁（OR 0.169，95%CI 0.055～0.515，P =0.002）是1年预 后不良的保护性因素。 结论 基线血肿体积和年龄是幕上高血压性ICH微创颅内血肿抽吸引流术1年预后的独立影响因素， 该结论为选择微创颅内血肿抽吸引流术适宜人群提供依据。 Abstract: Objective To study 1-year clinical outcomes after minimally invasive catheter evacuation followed by urokinase for clot removal in patients with acute supratentorial spontaneous intracerebral hemorrhage (ICH) and determine the factors associated with the 1-year outcome. Methods Supratentorial spontaneous ICH patients who had undergone minimally invasive catheter evacuation followed by urokinase for clot removal during January 2014 and September 2016 were collected . Patients' demographic and clinical information, surgery information and one-year modified Rankin scale (mRS) were recorded. The main clinical outcome was poor outcome, defined as mRS score >3 at 1 year. The multi-factor logistic regression analysis was used to determine factors associated with 1-year clinical outcome after ICH. Results A total of 117 patients with supratentorial spontaneous ICH and having undergone minimally invasive surgery were enrolled in the study. The mean age was (56.5±12.5) years and the mean baseline hematoma volume was (59.0±28.5) ml. 59 (50.4%) ICH patients had 1-year poor outcome after surgery. Multi-factor Logistic regression analysis revealed that baseline hematoma volume 20-50 ml [odds ratio (OR) 0.161, 95% confidence interval (CI) 0.034-0.748, P =0.020] and age≤60 years (OR 0.169, 95%CI 0.055-0.515, P =0.002) were independent protective factors of 1-year poor outcome. Conclusion Baseline hematoma volume and age were independent predictors of 1-year outcome in acute ICH patients who had undergone minimally invasive surgery, which could allow better selection of ICH patients appropriate for minimally invasive surgery.

目的 探讨超急性期血肿增长速度（ultraearly hematoma growth，UHG）与急性原发性脑出血 （intracerebral hemorrhage，ICH）血肿扩大及临床预后的关系。 方法 连续收集发病6 h内就诊的ICH患者。患者完成基线及（24±2）h颅脑计算机断层扫描（computed tomography，CT），记录临床信息及结局信息。UHG定义为基线血肿体积除以发病至头CT扫描时间。血 肿扩大定义为发病24 h血肿体积较基线血肿体积增加>33%或者>6 ml。90 d及1年预后不良定义为改 良Rankin量表评分>2分。多元Logistic回归分析UHG与血肿扩大及ICH临床预后的关系。 结果 研究共纳入148例发病6h内到院的ICH患者。所有ICH患者的UHG为5.3（2.3，12.9）ml/h。UHG在 完成头CT较早（P 4.7 ml/h是1年不良预后的独立危险因素，比值比为17.5，95%可信区间 为1.44～21.23（P =0.025）。其预测1年不良预后的灵敏度为61.5%，特异度为65.1%，阳性预测率为 68.4%，阴性预测率为58%。结论 UHG是ICH患者1年不良预后的独立危险因素。 Abstract: Objective To investigate the association of ultraearly hematoma growth (UHG) with the hematoma growth (HG) and clinical outcomes in patients with acute spontaneous intracerebral hemorrhage (ICH). Methods Acute ICH patients who went for consultation within 6 hours after onset were enrolled into study consecutively. Patients underwent baseline and 24-hour computed tomography (CT) scans. The clinical data and outcome were recorded. UHG was defined as the relation between baseline ICH volume/onset-to-imaging time (OIT). Hematoma enlargement was defined as HG volume >33% or >6 ml at 24 hours after onset. And poor outcome was defined as modified Rankin Scale score >2 at 90 days and 1 year after onset. The multivariable logistic regression analysis was used to investigate the association of UHG with HG and clinical outcomes after ICH. Results A total of 148 patients with acute (4.7 ml/h was an independent risk factor for 1-year poor outcome (odds ratio 17.5; 95% confidence interval 1.44-21.23, P =0.025). For UHG to predict 1-year poor outcome, the sensitivity, specificity, positive predictive value and negative predictive value were 61.5%, 65.1%, 68.4% and 58%, respectively. Conclusion UHG was an independent risk factor for 1-year poor outcome after acute ICH.

目的 探讨院前通知对取栓患者入院-再灌注时间（door-to-reperfusion time，DRT）和临床预后的影响。 方法 回顾性分析2015年1月-2016年12月在浙江省人民医院神经内科接受取栓患者的临床和影像 学资料。将院前通知定义为当地医院在患者转运之前向本中心卒中小组进行短信告知。对院前通知 和非院前通知组的基线特点，以及两组DRT和预后进行比较。预后良好定义为3个月改良Rankin量表 评分≤3分。 结果 共纳入123例接受取栓治疗的缺血性卒中患者，57例（46.3%）患者在转运到达前进行了院前 通知。在术后达到再灌注的人群中（100例），与非院前通知组患者相比，院前通知组患者的DRT明显 较短（P＜0.001）。术前静脉溶栓[优势比（odds ratio，OR）=2.774，P =0.023]是预后良好的独立影响因 素，院前通知不是影响预后的独立因素（OR =2.586，P =0.058）。但院前通知联合术前静脉溶栓是预 后良好的独立影响因素（OR =7.662，P =0.006）。 结论 院前通知可以缩短DRT。在取栓后达到再灌注的人群中，术前进行静脉溶栓能够使患者获益， 而术前静脉溶栓联合院前通知将使获益概率增加2.7倍。 Abstract: Objective To investigate the impact of prehospital notification (PN) on the door-to-reperfusion time (DRT) and outcome of patients who underwent thrombectomy. Methods A retrospective analysis was made upon clinical and imaging data of patients who underwent thrombectomy in Zhejiang Provincial People's Hospital from January 2015 to December 2016. PN was defined as a local hospital informing our stroke team prior to the transfer of thrombectomy candidates. The baseline characteristics, DRT and outcome between patients with and without PN were compared. Good outcome was defined as modified Rankin Scale score ≤3 at 3 months. Results A total of 123 patients underwent thrombectomy were enrolled, including 57 (46.3%) patients that was identified as PN group. Among patients who achieved reperfusion after thrombectomy (n =100), the DRT of PN group was significantly shorter than that of non-PN group (P

Objective To investigate the correlation between serum hydroxyl vitamin D level and fragile hip fractures. Methods The clinical data of 181 female fragile hip fracture patients (age ≥50 years), who were admitted to our hospital from January 2013 to December 2015 and undergone serum 25-hydroxyl vitamin D (25OHD) test, were analyzed retrospectively. The age, fracture site, serum 25OHD level and bone mineral density (BMD) of the patients, as well as the outcome of 67 patients followed up for at least one year, were recorded. The correlation between serum 25OHD level and these indices was observed. Results In 181 over 50 years old female patients with fragile hip fractures, there were 127 cases (70.2%) with vitamin D deficiency, 42 cases (23.2%) with vitamin D insufficiency, and 12 cases (6.6%) sufficient vitamin D. The serum 25OHD level in patients who were less than 75 years was markedly higher than that in patients over 75 years old. BMD level in patients with 25OHD over 20ng/mL was higher than in patients with 25OHD less than 20ng/mL. The serum 25OHD level in patients with femoral neck fractures was higher than in patients with inter-trochanter fractures, but the difference was not statistically significant. Among patients followed up within one year, the patients with 25OHD over 20ng/mL had lower fall rate, fracture rate, and all-cause mortality than those with 25OHD less than 20ng/mL, but the difference was not statistically significant. The outdoor action ability in patients with 25OHD over 20ng/mL was markedly higher than that in patients with 25OHD less than 20ng/mL. Conclusion Vitamin D deficiency and insufficiency are prevalent in elderly female patients with fragile hip fractures. Serum 25OHD level is correlated with age, BMD, and the outcome of the patients. [ABSTRACT FROM AUTHOR]

Acute - on - chronic liver failure (ACLF) is a complex clinical syndrome characterized by acute liver function decompensation on the basis of chronic liver diseases, with organ failure and a high short - term mortality rate. The course of ACLF varies across patients, and the disease is reversible. Patients tend to have diverse long - term outcomes, and clinicians should evaluate the prognosis of patients as early as possible to optimize treatment regimen and improve survival rate. This article describes the following five grades of the long - term prognosis of patients with ACLF for the first time: grade I is the ideal outcome of no cirrhosis; grade II is the satisfactory outcome of compensated liver cirrhosis manifesting as reversible liver cirrhosis or persistent compensated liver cirrhosis ; grade III is the acceptable outcome of decompensated liver cirrhosis manifesting as decompensated liver cirrhosis or chronic liver failure; grade IV is the outcome of survival after transplantation; grade V is the outcome of death. This article aims to provide a reference for judging long - term clinical prognosis. [ABSTRACT FROM AUTHOR]

Lung cancer is the leading cause of cancer death in China. Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancer cases, with the majority of the cases diagnosed at the advanced stage. Molecular targeted therapy is becoming the focus attention for advanced NSCLC. Echinoderm microtubule-associated protein-like 4 gene and the anaplastic lymphoma kinase gene (EML4-ALK) is among the most common molecular targets of NSCLC; its specific small-molecule tyrosine kinase inhibitors (TKIs) are approved for use in advanced NSCLC cases of ALK-positive. However, the influence of EML4-ALK fusion gene on the outcome of early-stage NSCLC cases and the necessity of application of TKIs for early-stage ALK-positive NSCLC patients are still uncertain. In this paper, we summarized the progression of testing methods for ALK-positive NSCLC patients as well as clinicopathological implication, outcome, and necessity of application of TKIs for early-stage ALK-positive NSCLC patients.

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Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective:To explore the feasibility, safety of laparoscopic treatment of hetertopic pregnancy (HP) and the effect on the outcome of pregnancy. Methods:34 HP patients with tubal pregnancy admitted to our hospital from January 2011 to January 2018 were selected for retrospective analysis, to explore the high-risk factors of hetertopic pregnancy, the feasibility of laparoscopic surgery and the pregnancy outcome. Results:There were 34 cases. Special cases included: 1 case of intrauterine twin pregnancy with right tubal pregnancy, 1 case of intrauterine pregnancy with right tubal interstitial pregnancy, and 1 case of intrauterine twin right uterine pregnancy with left tubal pregnancy. All the patients were treated with laparoscopic surgery and recovered well after surgery, operation time was 15-110 minutes, (45.21±8.33) min on average. Intraoperative hemorrhage was 5-200 mL, with an average was (33.04±10.12) mL. 3 cases with preoperative intraperitoneal hemorrhage more than 800 mL were treated with blood transfusion therapy in the operations. No fever, incision infection or complications were observed. Ultrasound suggest intrauterine pregnancy is normal after the operation for each patient and all patient recovered well. Only one case of artificial abortion was performed with missed abortion. All the rest has live births without birth defects. Conclusions:For patients with intrauterine pregnancy with unilateral tubal pregnancy during first trimester, laparoscopic surgery can safely remove ectopic pregnancy in the fallopian tube, and the operation is safe and effective, without increasing the incidence of iatrogenic abortion and birth defects. [ABSTRACT FROM AUTHOR]

With the increase in the survival rate of very preterm infants, the long-term neurodevelopmental outcomes of such infants have attracted more and more attention. Very preterm infants tend to develop movement disorders and psychological and behavioral problems, including cerebral palsy, developmental coordination disorders, autism spectrum disorders, attention deficit hyperactivity disorders, specific learning disorders, and intellectual developmental disorders. It is of vital importance to improve the long-term prognosis of very preterm infants, and early comprehensive intervention measures can minimize disability and achieve optimal parenting outcomes. This article provides a review of the research progress on the long-term neurodevelopmental outcomes in extremely preterm infants.

Ｏｂｊｅｃｔｉｖｅ　Ｔｏ ｉｎｖｅｓｔｉｇａｔｅ ｔｈｅ ｖａｌｕｅ ｏｆ ｔｕｍｏｒ ｐｅｒｆｕｓｉｏｎ ｐａｒａｍｅｔｅｒ ｍｅａｓｕｒｅｄ ｂｙ ｕｓｉｎｇ ｄｏｕｂｌｅ ｃｏｎｔｒａｓｔ⁃ｅｎｈａｎｃｅｄ ｕｌｔｒａｓｏｕｎｄ （ＤＣＥＵＳ） ＱｏｎｔｒａＸｔ ｔｈｒｅｅ⁃ｄｉｍｅｎｓｉｏｎａｌ ｐｓｅｕｄｏｃｏｌｏｒ ｑｕａｎｔｉｔａｔｉｖｅ ａｎａｌｙｓｉｓ ｔｏ ｔｈｅ ｔｈｅｒａｐｅｕｔｉｃ ｅｆｆｅｃｔ ｅｖａｌｕａｔｉｏｎ ｏｆ ｐｒｅｏｐｅｒａｔｉｖｅ ｎｅｏａｄｊｕｖａｎｔ ｃｈｅｍｏｔｈｅｒａｐｙ （ＮＡＣ） ｉｎ ａｄｖａｎｃｅｄ ｇａｓｔｒｉｃ ｃａｎｃｅｒ （ＡＧＣ） ｐａｔｉｅｎｔｓ． Ｍｅｔｈｏｄｓ 　Ｅｉｇｈｔｙ⁃ｎｉｎｅ ＡＧＣ ｐａｔｉｅｎｔｓ ｕｎｄｅｒｗｅｎｔ ３ ｃｙｃｌｅｓ ｏｆ ｐｒｅｏｐｅｒａｔｉｖｅ ＮＡＣ （ＸＥＬＯＸ） ｆｏｌｌｏｗｅｄ ｂｙ ｃｏｍｐｌｅｔｅ ｒｅｓｅｃｔｉｏｎ ｏｆ ｌｅｓｉｏｎ． Ｔｈｅ ＤＣＥＵＳ ＱｏｎｔｒａＸｔ ｔｈｒｅｅ⁃ｄｉｍｅｎｓｉｏｎａｌ ｐｓｅｕｄｏｃｏｌｏｒ ｗａｓ ｐｅｒｆｏｒｍｅｄ ｏｎｅ ｏｒ ｔｗｏ ｗｅｅｋｓ ｂｅｆｏｒｅ ｔｈｅ ＮＡＣ ａｎｄ ｏｐｅｒａｔｉｏｎ ｗｅｒｅ ａｐｐｌｉｅｄ， ｒｅｓｐｅｃｔｉｖｅｌｙ． Ｔｈｅ ｐｅａｋ ｅｎｈａｎｃｅｍｅｎｔ （ＰＥ）， ｔｉｍｅ ｔｏ ｐｅａｋ （ＴＰ）， ｓｈａｒｐｎｅｓｓ ｏｆ ｔｈｅ ｂｏｌｕｓ （β） ａｎｄ ａｒｅａ ｕｎｄｅｒ ｔｈｅ ｅｎｈａｎｃｅｍｅｎｔ ｃｕｒｖｅ （ＡＵＣ） ｏｆ ｐｒｉｍａｒｙ ｇａｓｔｒｉｃ ｔｕｍｏｒ ｗｅｒｅ ｍｅａｓｕｒｅｄ ｂｙ ＱｏｎｔｒａＸｔ ｔｈｒｅｅ⁃ｄｉｍｅｎｓｉｏｎａｌ ｐｓｅｕｄｏｃｏｌｏｒ ｑｕａｎｔｉｔａｔｉｖｅ ａｎａｌｙｓｉｓ． ＴｈｅｓｅＤＣＥＵＳ ｐａｒａｍｅｔｅｒｓ ｂｅｔｗｅｅｎ ｒｅｓｐｏｎｄ ａｎｄ ｎｏｎ⁃ｒｅｓｐｏｎｄ ｇｒｏｕｐｓ ｂｅｆｏｒｅ ａｎｄ ａｆｔｅｒ ＮＡＣ ｔｈｅｒａｐｙ ｗｅｒｅ ｃｏｍｐａｒｅｄ． Ｔｈｅ ｐｒｅｄｉｃｔｉｏｎ ａｃｃｕｒａｃｙ ｏｆ ＤＣＥＵＳ ｔｏ ｔｈｅ ｔｈｅｒａｐｅｕｔｉｃ ｅｆｆｅｃｔ ｅｖａｌｕａｔｉｏｎ ｏｆ ｐｒｅｏｐｅｒａｔｉｖｅ ＮＡＣ ｗａｓ ｄｅｔｅｒｍｉｎｅｄ ｂｙ ｔｈｅ ｒｅｃｅｉｖｅ ｏｐｅｒａｔｉｎｇ ｃｈａｒａｃｔｅｒｉｓｔｉｃ （ＲＯＣ） ｃｕｒｖｅｓ． Ｒｅｓｕｌｔｓ 　Ａｍｏｎｇ ８９ ＡＧＣ ｐａｔｉｅｎｔｓ， ５２ ｐａｔｉｅｎｔｓ ｒｅｓｐｏｎｄｅｄ ｔｏ ＮＡＣ ｔｈｅｒａｐｙ， ｗｈｉｌｅ ３７ ｐａｔｉｅｎｔｓ ｒｅｓｉｓｔｅｄ ｔｏ ＮＡＣ ｔｈｅｒａｐｙ． Ｔｗｅｌｖｅ ｃａｓｅｓ ｉｎ ｒｅｓｐｏｎｄ ｇｒｏｕｐ ａｎｄ ２６ ｃａｓｅｓ ｉｎ ｎｏｎ⁃ｒｅｓｐｏｎｄ ｇｒｏｕｐ ｗｅｒｅ ｍｕｃｉｎｏｕｓ ｃａｒｃｉｎｏｍａ． Ｆｏｒｔｙ ｃａｓｅｓ ｉｎ ｒｅｓｐｏｎｄ ｇｒｏｕｐ ａｎｄ １１ ｃａｓｅｓ ｉｎ ｎｏｎ⁃ ｒｅｓｐｏｎｄ ｇｒｏｕｐ ｗｅｒｅ ｎｏｎ⁃ｍｕｃｉｎｏｕｓ ｃａｒｃｉｎｏｍａ （Ｐ＜０．０５）． Ｉｎ ｒｅｓｐｏｎｄｅｒ ｇｒｏｕｐ， ｔｈｅ ＰＥ ａｎｄ ＴＰ ｂｅｆｏｒｅ ＮＡＣ ｗｅｒｅ （５３．７±９．３）％ ａｎｄ （１４ ５２１±２ ６６７） ｍｓ， ａｎｄ （３２．２±５．５）％ ａｎｄ （１７ ２３５±１ ８９８） ｍｓ ａｆｔｅｒ ＮＡＣ． Ｔｈｅ ｒａｔｉｏ ｏｆ ｃｈａｎｇｅｓ ｏｆ ＰＥ （ΔＰＥ） ａｎｄ ＴＰ （ΔＴＰ） ｗｅｒｅ ０．４３±０．１７ ａｎｄ ０．３６±０．１４， ｒｅｓｐｅｃｔｉｖｅｌｙ． Ｉｎ ｎｏｎ⁃ｒｅｓｐｏｎｄ ｇｒｏｕｐ， ｔｈｅ ＰＥ ａｎｄ ＴＰ ｂｅｆｏｒｅ ＮＡＣ ｗｅｒｅ （５４．４±７．２）％ ａｎｄ （１３ ８６９±３ ２４７） ｍｓ， ａｎｄ （４５．３±６．１）％ ａｎｄ （１５ １２７±１ ４２３） ｍｓ ａｆｔｅｒ ＮＡＣ ｔｈｅｒａｐｙ． Ｔｈｅ ｒａｔｉｏ ｏｆ ΔＰＥ ａｎｄ ΔＴＰ ｗｅｒｅ ０．２４±０．２０ ａｎｄ ０．２２±０．１２． Ｔｈｅ ＰＥ ａｎｄ ＴＰ ａｆｔｅｒ ＮＡＣ， ｔｈｅ ｒａｔｉｏ ｏｆ ΔＰＥ ａｎｄ ΔＴＰ ｗｅｒｅ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｔ ａｍｏｎｇ ｔｈｅｓｅ ｔｗｏ ｇｒｏｕｐｓ （ａｌｌ ｏｆ Ｐ＜ ０．０５）． Ｔｈｅ ＲＯＣ ｃｕｒｖｅｓ ｓｈｏｗｅｄ ｔｈａｔ ｔｈｅ ｒａｔｉｏ ｏｆ ΔＰＥ ｉｎ ａｓｓｅｓｓｉｎｇ ｔｈｅ ｒｅｓｐｏｎｄ ｏｆ ｇａｓｔｒｉｃ ｃａｎｃｅｒ ｐａｔｉｅｎｔｓ ｔｏ ＮＡＣ ｗａｓ ｓｕｐｅｒｉｏｒ ｃｏｍｐａｒｅｄ ｔｏ ｏｔｈｅｒ ｐａｒａｍｅｔｅｒｓ （ＡＵＣ＝０．７８４， Ｐ ＝０．００４）． Ｔｈｅ ｏｐｔｉｍａｌ ｃｕｔ⁃ｏｆｆ ｖａｌｕｅ ｏｆ ｔｈｅ ｒａｔｉｏ ｏｆ ΔＰＥ ｗａｓ ２４％ ａｎｄ ｉｔｓ ｓｅｎｓｉｔｉｖｉｔｙ ａｎｄ ｓｐｅｃｉｆｉｃｉｔｙ ｔｏ ｔｈｅ ｔｈｅｒａｐｅｕｔｉｃ ｅｆｆｅｃｔ ｅｖａｌｕａｔｉｏｎ ｏｆ ＮＡＣ ｉｎ ｇａｓｔｒｉｃ ｃａｎｃｅｒ ｗｅｒｅ ８２．７％ ａｎｄ ６４．９％． Ｃｏｎｃｌｕｓｉｏｎ　ＤＣＥＵＳ ＱｏｎｔｒａＸｔ ｔｈｒｅｅ⁃ｄｉｍｅｎｓｉｏｎａｌ ｐｓｅｕｄｏｃｏｌｏｒ ｑｕａｎｔｉｔａｔｉｖｅ ａｎａｌｙｓｉｓ ｍｉｇｈｔ ｂｅ ａ ｎｏｖｅｌ， ｎｏｎｉｎｖａｓｉｖｅ ａｎｄ ｒｅｌｉａｂｌｅ ｍｅｔｈｏｄ ｔｏ ｅｖａｌｕａｔｅ ｔｈｅ ｔｈｅｒａｐｅｕｔｉｃ ｅｆｆｅｃｔ ｏｆ ｐｒｅｏｐｅｒａｔｉｖｅ ＮＡＣ ｉｎ ＡＧＣ ｐａｔｉｅｎｔｓ. [ABSTRACT FROM AUTHOR]

Objective: To explore the expression of cervical P16/Ki67 in patients with cervical human papillomavirus 16(HPV16)persistent infection and its correlation with the incidence of cervical cancer. Methods: P16/Ki-67 dual immunostaining was performed to detect the expression of P16/Ki67 in 102 cases of patients with cervical HPV16 persistent infection,136 patients with cervical HPV16non-persistent infection, all the patients were divided into dual stain positive group and dual stain negative group according to the immunohistochemical results. All the patients were followed up for 2 years, the difference in the outcome and early-stage cervical cancer and incidence of cervical cancer were compared between the two groups. Results: The positive rate of P16, Ki67 and P16/Ki67 dual stain were 40.3%, 44.5% and 34.0% respectively. The positive rate of P16, Ki67 and P16/Ki67 dual stain in HPV16 persistent infection patients was significantly higher than that in non-persistent infection patients(P<0.05). P16, Ki67 were significantly and positively correlated in persistent infection patients(P<0.05). The outcome in dual stain negative group was superior to that in dual stain positive group(P<0.05). In HPV16 persistent infection patients, the outcome in dual stain positive group was inferior to that in dual stain negative group, and inferior to that in dual stain negative and positive group of persistent infection patients, the proportion of advance patients increased significantly(P<0.05). In HPV16 persistent infection patients, the progression e towards cervical HSIL in dual stain positive group was 32.5%, which was significantly higher than that in dual stain negative group that was 6.5%(P<0.05). Conclusions: P16 and Ki67 dual-stain positive were correlated with the progression of cervical intraepithelial neoplasia in the stage of HPV16 persistent infection. It has an early warning value for the progression of HPV16 persistent infection to cervical high-grade lesions. It can be used as a sensitive indicator of HPV16 positive early treatment. [ABSTRACT FROM AUTHOR]

Objective To evaluate the reliability of EOR （estradiol: oocyte ratio） in predicting the outcome of assisted reproduction. Methods From 2010 to 2014，12564 cases of infertility in the Reproductive Center of the First People's Hospital of Yunnan Province were selected and divided into three groups according to their age（< 35，35 - 39，and ≥ 40 years old） . On the day of hCG trigger，the concentration of estradiol in serum were measured. The ratio of estradiol to the number of oocytes was calculated，and the samples were divided into 12 groups according to the EOR value. The relationship between EOR and the following parameters: oocyte retrieval number，oocyte MII rate，normal fertilization rate，cleavage rate，sustained development rate，high qualified embryo rate and outcome of pregnancy were statistically analyzed. Results （1） On the day of hCG trigger，the serum estradiol （E2） levels showed a downward trend with the increase of age，while EOR showed an upward trend. With the increasing of EOR，the pregnancy rate was significantly decreased （ ＜0.05）. Clinical pregnancy rate（CPR） between the three age groups had no significant difference，but older women showed a lower pregnancy rate trend. （2） The highest biochemical pregnancy rate and clinical pregnancy rate was in the group of 500-550 （pg/mL），respectively，72.25% and 64.32%. （3） The number of oocytes retrieved and oocyte retrieved rate were significantly decreased with the increasing of EOR （ < 0.05） . The group of highest oocyte MII rate was ≥650 （pg/mL） . （4） In conventional IVF and ICSI，with increasing EOR，the normal fertilization rate deavage rate， sustained development rate and high qualified embryo rate had no significant difference. （5） There were no significant differences in the number of blastocyst formation，the rate of blastocyst formation， the number of high-quality blastocyst and the rate of high quality blastocyst in each EOR group. Conclusions EOR plays an important role in predicting the outcome of ART and there will be a better prospect in future clinical applications [ABSTRACT FROM AUTHOR]