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Objective: To evaluate the clinical efficacy of locking compression plate (LCP) with minimally invasive plate osteosynthesis (MIPO) on the elderly patients with distal femur fracture. Methods: From January 2012 to June 2015, 27 cases over 60 years distal femoral fracture patients were cured with LCP with MIPO in our hospital. We evaluate the clinical efficacy by observing incision healing, fracture healing and related complications and analyzing Kolmert knee score. Results: 27 patients were followed up for 6-30 months, average of 14.7 months, one patient (unilateral) died in the 25 d after operation. 26 cases' incision recoverd and one case' was delayed healing after operation. After LCP plate treatment, fractures were healed in all cases at the end of follow-up.All cases were no fracture displacement, internal fixation failure, malunion, nonunion and other undesirable complications. According to Kolmert knee score, the postoperative outcomes showed 10 cases were excellent, 13 cases were good, 3 cases and 1 case was poor, total good rate was 85 %. Conclusions: Using LCP plate with MIPO method is effective in senile distal femoral fracture for old patients. Fixation can be achieved, lead to early functional exercise, fewer complications and postoperative satisfactory results. [ABSTRACT FROM AUTHOR]