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Objective: This study was to investigate the correlation between airway inflammation and lung function impairment in patients with bronchiectasis with different FEV, and to analyze the influencing factors of lung function impairment. Methods: 80 patients with bronchiectasis admitted to the respiratory department of our hospital from May 2022 to January 2024 were selected as research objects. General data of each group were analyzed, and lung function and airway inflammatory cytokine levels were compared in each group. Pearson linear analysis was used to analyze the relationship between lung function and airway inflammation in patients with bronchiectasis, and multi-factor Logisitic regression was used to analyze the influencing factors of lung function impairment in patients with bronchiectasis. Results: The FVC, FEV1/FVC and DLCO evaluation of the three groups were included in the study and the difference among the groups was compared. The results showed that the FVC, FEV1/FVC and FVC of the high FEV, group and the medium FEV, group were higher than those of the low FEV, group. FVC, FEV1/FVC and FVC in high FEV, group were higher than those in medium FEV, group (P<0.05). The levels of ESR, CRP, WBC, NEUT, PCT, IL-4, IL-6, IL-10 and TNF-a in the three groups were included in the study and the differences between the groups were compared. The levels of ESR, CRP, WBC, NEUT, PCT, IL-4, IL-6 and TNF-a in high and medium FEV, groups were lower than those in low FEV, group, and the levels of IL-10 were higher than those in low FEV₁ group (P<0.05). The levels of ESR, CRP, WBC, NEUT, PCT, IL-4, IL-6 and TNF-a in high FEV₁ group were lower than those in medium FEV₁ group, and the levels of IL-10 were higher than those in medium FEV, group(P<0.05). The results of Pearson linear analysis showed that FEV₁, FVC, FEV1/FVC and DLCO were positively correlated with airway inflammatory factors ESR, CRP, WBC, NEUT, PCT, IL-4, IL-6 and TNF-a, and negatively correlated with IL-10 in patients with bronchiectasis (P<0.05). Independent variables were set as the indicators with differences in comparison in the above data, including FVC, FEV1/FVC, DLCO, ESR, CRP, WBC, NEUT, PCT, IL-4, IL-6, IL-10, and TNF-a. The dependent variable was impaired lung function in patients with bronchiectasis. Multivariate Logisitic regression analysis was performed, and the results showed that The influential factors of impaired lung function in patients with bronchiectasis are FVC, FEV1/FVC, DLCO, ESR, CRP, WBC, NEUT, PCT, IL-4, IL-6, IL-10, TNF-α. Conclusion: Airway inflammation increases with the increase of FEV, level in patients with bronchiectasis, which is closely related to lung function and is an influential factor of lung function impairment. [ABSTRACT FROM AUTHOR]

This case report describes the experience of caring for a 28-year-old man with diffuse axonal injury (DAI). During hospitalization, the patient experienced sudden altered consciousness and sensory disturbance, which resulted in caregiver role strain. Problems during the nursing period included disturbed sensory perception, impaired swallowing, and caregiver role strain. To promote the patient's recovery of daily activity, interventions for the patient and caregiver were planned separately. The intervention for the patient included multisensory stimulation and swallowing training. To promote the caregiver's knowledge of the disease course and improve the caregiver's daily nursing skill, we employed a humanoid diagram and clock drawing exercise. Our experience described herein can help promote recovery in patients with DAI and assist overwhelmed caregivers. [ABSTRACT FROM AUTHOR]