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Objective To explore the correlation between the prolongating PR interval of electrocardiogram and the general information and biochemical indicators of diabetes patients with microvascular complications, and the predictive value of diabetes microvascular complications. Methods A total of 217 patients with diabetes who hospitalized in Department of Endocrinology, Xi'an Third Hospital from August 2020 to November 2022 were selected retrospectively. Among them, 149 patients only with diabetes were divided into control group, while 68 diabetes patients with microvascular complications were divided into observation group. The general data and biochemical indexes of all diabetes patients were collected, and the PR interval was measured by standard 12 lead synchronous electrocardiograph. The correlation between PR interval and general data and biochemical indicators in patients with microvascular complications of diabetes were analyzed. The predictive value of PR interval on microvascular complications in diabetes was analyzed by receiver operating characteristic (ROC) curve. Results Age, duration of diabetes, body mass index (BMI), hemoglobin A1c (HbA1c), PR interval in the observation group were higher than those in the control group (P＜0.01). PR interval of diabetes patients with microvascular complications was positively correlated with age, diabetes duration, BMI, HbA1c (P＜0.01). The AUC of PR interval for predicting microvascular complications in diabetes was 0.812 (95%CI:0.752-0.872), the sensitivity was 70.6%, the specificity was 78.5%, and the cut-off value was 212.61 ms. Prolonged PR interval was an independent risk factor for microvascular complications in diabetes (OR=2.475, 95%CI: 1.472-5.120, P＜0.01). Conclusion In patients with microvascular complications of diabetes, the PR interval in electrocardiogrom is significantly prolonged. Prolonged PR interval is an independent risk factor for microvascular complications in diabetes, which is helpful to predict the occurance of diatetic microvascular complications.

Objective To explore the correlation between the prolongating PR interval of electrocardiogram and the general information and biochemical indicators of diabetes patients with microvascular complications, and the predictive value of diabetes microvascular complications. Methods A total of 217 patients with diabetes who hospitalized in Department of Endocrinology, Xi'an Third Hospital from August 2020 to November 2022 were selected retrospectively. Among them, 149 patients only with diabetes were divided into control group, while 68 diabetes patients with microvascular complications were divided into observation group. The general data and biochemical indexes of all diabetes patients were collected, and the PR interval was measured by standard 12 lead synchronous electrocardiograph. The correlation between PR interval and general data and biochemical indicators in patients with microvascular complications of diabetes were analyzed. The predictive value of PR interval on microvascular complications in diabetes was analyzed by receiver operating characteristic (ROC) curve. Results Age, duration of diabetes, body mass index (BMI), hemoglobin A1c (HbA1c), PR interval in the observation group were higher than those in the control group (P＜0.01). PR interval of diabetes patients with microvascular complications was positively correlated with age, diabetes duration, BMI, HbA1c (P＜0.01). The AUC of PR interval for predicting microvascular complications in diabetes was 0.812 (95%CI:0.752-0.872), the sensitivity was 70.6%, the specificity was 78.5%, and the cut-off value was 212.61 ms. Prolonged PR interval was an independent risk factor for microvascular complications in diabetes (OR=2.475, 95%CI: 1.472-5.120, P＜0.01). Conclusion In patients with microvascular complications of diabetes, the PR interval in electrocardiogrom is significantly prolonged. Prolonged PR interval is an independent risk factor for microvascular complications in diabetes, which is helpful to predict the occurance of diatetic microvascular complications.

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Objective: To study the serum hypersensitive c-reactive protein(hs-CRP) and glycosylated hemoglobin(HbA1 c) levels in the ischemic stroke patients and their correlation with the neurological deficits. Methods: 123 cases of patients with ischemic stroke admitted in our hospital from October 2016 to September 2017 were selected as the observation group and 123 healthy people who underwent physical examination in our hospital during the same period were selected as the control group, the serum hs-CRP and Hb A1 c levels were detected and compared between the two groups, and the relationship between serum hs-CRP and HbA1 c levels in patients with ischemic stroke and their scores on the national institutes of health stroke scale(NIHSS) was analyzed. Results: The serum hs-CRP and HbA1 c levels in the observation group were significantly higher than those in the control group [(6.23±1.97)mg/L,(7.96±0.65)%vs.(2.54±0.85)mg/L,(5.21±0.30)%], and the NIHSS scores were significantly higher than those in the control group [(4.08±3.12)points vs. 8.62±3.25) points](P<0.05). The serum hs-CRP and Hb A1 c levels were significantly negatively correlated with NIHSS scores in patients with ischemic stroke(r=-0.465,-0.564, P <0.05). Conclusion: The serum hs-CRP and Hb A1 c levels were significantly up-regulated in the patients with ischemic stroke, which were related to the severity of neurological impairment in patients with ischemic stroke to some extent. [ABSTRACT FROM AUTHOR]

Objective: To observe the relationship between carotid intima-media thickness(CIMT) and hemoglobin A1c(Hb A1c)control in type 2 diabetes mellitus(T2DM) patients. Methods: 328 cases with T2 DM were selected from the endocrinology department of our hospital. All patients underwent assessment, biochemical test and CIMT measurement. According to the value of CIMT, patients were divided into normal CIMT group(<0.9 mm) and abnormal CIMT group(>0.9 mm). A multi-factor Logistic regression was performed to analyze the risk factors associated with the abnormal CIMT. Results:(1) Among the 328 T2 DM patients, 154 cases had normal CIMT and 174 cases had abnormal CIMT.(2) Pearson correlation analysis indicated that the cholesterol and HbA1c levels were positively correlated with CIMT(P<0.05).(3) Univariate analysis showed that the incidence of CIMT was associated with age(t=4.132, P=0.041), systolic blood pressure(t=8.456, P<0.01), Hb A1c≥9.0%(x2=9.912, P<0.01), cholesterol(t=5.549, P=0.018), triglyceride(t=6.592, P=0.008), UA(t=9.618, P<0.01), fasting plasma glucose(t=4.592, P=0.037).(4) Multi-factor Logistic regression indicated that age, systolic blood pressure, cholesterol and HbA1c ≥9.0% were the independent risk factors for the onset of CIMT(P <0.05). Conclusions: The level of HbA1c in T2 DM patients was associated with CIMT; And HbA1c ≥9% was the independent risk factors for the increase of CIMT. [ABSTRACT FROM AUTHOR]

Objective: To understand the status quo of sleep and its associations with serum hemoglobin A1c (HbA1c) among nondiabetic people of 18-79 years old in Beijing. Methods: Data was gathered from the 2017 Beijing Non-communicable and Chronic Disease Surveillance Program. Multiple classified clusters sampling method was used while the 18-79 years old were sampled from the 16 districts of Beijing. Questionnaires would include information on demographic characteristics, chronic diseases and related risk factors, sleep duration and related problems (snore/asphyxia, difficult to get to sleep, waking often during the night, waking up early or taking sleeping pills) within the last 30 days. Complex sampling logistic regression models were established to analyze the association between sleep-related problems and serum HbA1c. Results: A total of 11 608 non-diabetic participants were involved in this study, with average age, reported sleep duration and median of serum HbA1c level as (43.36±15.27) years old, (7.49±1.29) h/d and 5.30%, respectively. 47.38% of them reported having sleep problems within the last 30 days. With the increasing time of sleep, serum HbA1c level was fluctuating significantly ( F =413.06, P <0.01). Significant differences appeared in serum HbA1c levels among different age groups ( t =358.3, P <0.01). Among participants with several kinds of sleep problems, the serum HbA1c levels were significantly higher than those without, through the single factor analysis ( U =15.11, P <0.01). After adjusting for potential confounding factors, the combination of one sleep-related problem ( OR =1.21, 95% CI : 1.03-1.41) and snore/asphyxia were associated with higher serum HbA1c levels (HbA1c≥5.7%) ( OR =1.37, 95% CI : 1.16-1.61). People under 60 years of age were with higher risk of having higher serum HbA1c levels. Conclusion: Duration and sleep-related problems might affect the serum HbA1c levels, especially among those younger than 60 years of age.

Objective: To evaluate the effect of health literacy and exercise-focused interventions on glycemic control in patients with type 2 diabetes (T2DM) in China. Methods: In this cluster randomized controlled trial, a total of 799 T2DM patients with most recent hemoglobin A1c (HbA1c) ≥ 7.5% (or fasting plasma glucose level ≥10 mmol/L) were recruited from 8 communities in Minhang and Changning districts of Shanghai, and randomized into a health literacy intervention group, an exercise intervention group, a comprehensive intervention group and a control group. After baseline survey and examination, a one-year intervention and 3 times (at 3(rd), 6(th), and 12(th) month) follow-up surveys were conducted. Results: The follow-up rates for all the subjects were 99.4%, 98.4% and 95.2%, respectively, at 3(rd), 6(th) and 12(th) month. Patients in intervention groups were more likely to achieve a goal HbA1c level (HbA1c <7.0%) than those in control group, with the highest glycemic control rate (25.3%) observed in comprehensive intervention group at 3(rd) month and then in exercise intervention group (25.3% and 34.6%) respectively, at 6(th) month and 12(th) month. The average levels of HbA1c in three intervention groups were lower at each follow-up time point than those at baseline survey. However, the decreases in HbA1c were obvious only at 6(th) month ( P <0.001), with ls-mean (95 %CI ) of -0.48% (-0.71%, -0.25%), -0.33% (-0.55%, -0.11%) and -0.70% (-0.92%, -0.48%), respectively, in comprehensive, health literacy and exercise intervention groups, but it increased slightly by 0.03% (-0.19%, 0.25%) in control group. Compared with control group, the interventions were significantly associated with the decrease of HbA1c level, with the most improvement observed in comprehensive group ( β =-0.47, 95 % CI : -0.73, -0.20) at 3(rd) month, and in exercise intervention group at 6(th) month ( β =-0.73, 95 %CI : -0.98, -0.47) and at 12(th) month ( β =-0.75, 95 %CI : -1.05, -0.45) of follow-up. Stratified analyses showed that patients with lower health literacy level could benefit from any intervention, while those with higher numeracy skill benefited more from exercise intervention. Conclusion: Both health literacy and exercise-focused interventions may decrease HbA1c level in patients with T2DM, which would be helpful in reducing the risks of complications and deaths in diabetes patients.