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Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To compare and analyze the clinical efficacy, recurrence rate, and breast appearance evaluation of simple surgery and surgery combined with glucocorticoids in the treatment of mass type granulomatous mastitis. Methods This study retrospectively analyzed 106 patients with nodular granulomatous mastitis who visited the Department of Breast Surgery at Yichang Central People's Hospital from January 2017 to January 2022 as the study subjects. According to the different treatment methods during the visit, patients were divided into Group A with simple surgical treatment （n = 67） and Group B with surgery combined with glucocorticoid treatment （n = 39）. The general information and clinical indicators of the two groups of patients were observed and compared. Obtain patient clinical efficacy, time to clinical cure （TTCR), recurrence rate within one year, and breast appearance evaluation through follow⁃up. Results The prognosis of the follow⁃up patients after treatment showed that Group B patients had better clinical cure rate and one⁃year recurrence rate than the simple surgery group （P < 0.05）. More⁃over， the difference in breast appearance evaluation between the two groups was statistically significant, with Group B patients having a significantly higher rate of excellent appearance （88.06%） than Group A （92.31%）. According to statistics, only 5.13% of patients in Group B experienced gastrointestinal reactions within one year after taking hormone therapy. Conclusions The combination of surgery and glucocorticoids in the treatment of mass type GM can effectively improve the overall clinical treatment effect of patients， reduce the short⁃term recurrence rate, and have a significant effect on ensuring the integrity of breast appearance. At the same time, low⁃dose oral steroid drugs have fewer adverse reactions and high safety. [ABSTRACT FROM AUTHOR]

Objective To analyze the efficacy and safety of intralesional triamcinolone acetonide in the treatment of mass granulomatous mastitis (GLM). Methods Retrospective analysis was made on 67 patients with GLM who were treated in Xijing Hospital from July 2021 to May 2022 and met the inclusion criteria. Among them, 31 patients were treated with local injection of triamcinolone acetonide, while 36 ones were treated with oral methylprednisolone. All the included patients underwent surgical treatment after their condition met the surgical criteria, and the follow-up period lasted for up to six months after surgery. The two groups were compared in improvement of symptoms and signs, treatment time, clinical effectiveness and safety, and recurrence rate. Results The effective rate of triamcinolone acetonide group and methylprednisolone group was 100%, but the clinical cure rate was significantly higher in triamcinolone acetonide group than in methylprednisolone group in stratified analysis (P<0.05). The improvement time of symptoms and signs in triamcinolone acetonide group was significantly shorter than that in methylprednisolone group (P<0.05). The incidence of side effects in triamcinolone acetonide group was also significantly reduced compared to methylprednisolone group (P<0.05). Follow-up for half a year showed no recurrence in both groups. Conclusion Compared with the traditional oral methylprednisolone group, local injection of triamcinolone acetonide in the treatment of mass granulomatous mastitis can rapidly relieve clinical symptoms and signs, shorten treatment time, and has higher efficiency and fewer side effects. Local injection of hormone combined with surgery is effective in treating mass granulomatous mastitis with low recurrence rate. [ABSTRACT FROM AUTHOR]

Granulomatous mastitis (GM) is a rare benign mastitis disease in clinical practice. In recent years, the incidence has been increasing year by year, but so far, its etiology and pathogenesis are still unclear. This disease mainly occurs in women of childbearing age who have a history of breastfeeding, with prevalence old is 30-42 years. The main clinical manifestations are often affected breast redness, swelling, and pain, with local palpable masses and a longer course of disease. Using histopathological diagnosis as the “gold standard”, the biopsy results showed granuloma formation accompanied by multinucleated giant cells, epithelioid tissue cells, and plasma cell infiltration. At present, the treatment plans for GM include drug therapy (antibiotics, steroids, immunosuppressants), surgical treatment, traditional Chinese medicine treatment, and the combination of multiple treatment methods, but a unified diagnosis and treatment standard has not yet been formed. This article mainly provides a brief review of the common causes and pathogenesis of GM, as well as the latest progress in clinical diagnosis and treatment. [ABSTRACT FROM AUTHOR]

This paper summarized the effect observation and nursing measures for a patient with patient with postoperative pain after granulomatous mastitis surgery under local anesthesia. On the basis of improving the routine postoperative nursing, auricular acupoint sticking and pressing therapy was carried out to relieve the postoperative pain of the patients. It has the advantages of low adverse reactions, high safety and easy acceptance by patients. (本文总结1例乳腺炎局部麻醉术后疼痛患者给予耳穴贴压治疗的效果及护理措施。在完善术后常规护理的基础上, 耳穴贴压治疗能够有效缓解患者术后疼痛, 且该方法具有不良反应小、安全性高等优势, 患者易于接受。)

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To examine the effect of"lesion removal plus whole breast exploration and washing plus micro-plastic surgery"in granulomatous lobular mastitis. Methods: A single-center prospective randomized controlled study method was used to enroll patients diagnosed with granulomatous lobular mastitis for whom surgical procedures were projected from March 2017 to September 2019 at Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University. The sample size is determined by the superiority test. Based on the literatures and the previous work, the two groups require 97 cases. Fifty-two patients underwent"lesion removal+whole breast exploration and washing plus micro-plastic surgery"(observation group). Forty-five cases underwent"empirical breast lesion resection plus fascia tissue flap plasty plus nipple and areola correction"(control group). The primary study endpoint is the recurrence rate, and the secondary study endpoints include surgical complications, incision healing time, and postoperative patient satisfaction. Independent sample t test, Wilcoxon rank-sum test, χ² test and Fisher exact test were used for comparison between groups. Results: All procedures were completed successful, with no severe complications. All patients were followed up for (15.2±1.9) months (range: 12 to 24 months). There were no significant differences in incidence of postoperative complications (7.7% (4/52) vs. 6.7%(3/45), P= 1), drainage time ((8.6±0.6) days vs. (8.4±0.8) days, t= 1.921, P= 0.053) and hospital stay ((7.7±0.6) days vs. (7.6±0.5) days, t= 1.633, P= 0.102) between the two groups. The recurrence rate of the observation group was lower significantly than that of the control group (3.8% (2/52) vs. 24.4%(11/45), χ²=8.819, P= 0.003). The observation group had better cosmetic effects ( Z= -2.657, P= 0.008) and patient satisfaction than control group ( Z= -5.730, P= 0.000). Conclusion: The "lesion removal plus whole breast exploration and flushing plus micro-plastic surgery" has a good therapeutic effect and cosmetic value for patients with refractory granulomatous lobular mastitis.

Objective: To investigate the clinicopathologic features and possible causes of granulomatous lobular mastitis(GLM). Methods: Three hundred cases of GLM were collected from surgical specimens diagnosed at Longhua Hospital, Shanghai University of Traditional Chinese Medicine from January 2015 to November 2017. Morphologic features were reviewed using HE staining. A total of 116 cases were investigated by Gram staining. The expression of CD3, CD20, CD68, IgG, IgG4, CD38 and CD138 was detected by immunohistochemical staining. Results: The age of the patients was 23 to 47 years and the median age was 32 years. All patients were female, 96.7% (290/300) had a history of lactation.There were 143 cases of left breasts, 138 cases of right breast and 19 cases of bilateral breasts. Serum prolactin increased in 39.7%(119/300) patients. Within 15.7%(47/300) of patients were associated with nodular erythema or joint swelling and pain of the lower extremities. Pathological observation showed that lobular-centric suppurative granulomatous inflammation, accompanied by dilatation of intralobular and interlobular ducts. There were 16 cases accompanied with duct ectasia. Immunohistochemistry showed CD3-positive lymphocytes were more than CD20-positive lymphocytes in the peripheral aggregation zone of neutrophils within granulomatous lesions. Gram positive bacteria were found in the lipid vacuoles of the 51.7%(60/116) patients. Conclusions: GLM has distinctive histologic features. It may be related to corynebacterium infection, or accompanied by the increase of serum prolactin and erythrocyte sedimentation rate. The age, location and history of the disease are importance in the diagnosis and differential diagnosis.