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Objective To explore the effect of traditional Chinese medicine nursing intervention guided by problem solving (ADOPT) model on the quality of life of patients with early Parkinson's disease. Methods A total of 86 patients with early Parkinson's disease who met the inclusion and exclusion criteria in the Department of Geriatrics of Kunming Hospital of Traditional Chinese Medicine from March to November 2023 were selected and divided into the control group and the observation group by random number table method. The first ward was the control group (43 cases), and the second ward was the observation group (43 cases). The control group was given routine TCM nursing intervention, and the observation group was given TCM nursing intervention plan based on ADOPT model. Results There was no significant difference in self- management ability score, modified Hoehn-Yahr (H-Y) grade and quality of life score between the two groups before intervention (P>0.05). After intervention, the self-management ability score, Hoehn-Yahr (H-Y) grade and quality of life score of patients in the observation group were better than those in the control group, and the difference were statistically significant (P<0.05). Conclusion The traditional Chinese medicine nursing intervention program under the guidance of problem solving model can improve patients' self-management ability, delay disease progression, and improve patients' quality of life. [ABSTRACT FROM AUTHOR]

Objective: To explore the diagnostic value of diffusion kurtosis imaging (DKI) the microstructure changes of substantianigra in patients with early Parkinson's disease (PD). Methods: 30 patients with early PD were collected as the PD group while 20 healthy volunteers as the control group. All the subjects underwent brain routine magnetic resonance imaging (MRI) and DKI examination. The DKI scan data were processed to obtain quantitative parameter maps, with the three paramrters as fractional anisotropy (FA), mean diffusivity (MD) and mean kurtosis (MK). The DKI parameters of substantianigra (SN) were measured respectively and the differences between the two groups were statistically analyzed. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of DKI parameters in patients with early PD. Results: The FA value of the substantianigra of the PD group was lower than that of the healthy control group, and the difference between the two groups was statistically significant. Compared with the healthy control group, the MD value of the substantianigra in the PD group was slightly higher, and the difference between the two groups was not statistically significant. The MK value of the substantianigra in the PD group was significantly higher than that in the healthy control group, and the difference between the two groups was statistically significant. The ROC curve showed the AUC of FA value, MD value and MK value in the substantianigra in the diagnosis of early PD were 0.716, 0.613 and 0.820, respectively. The substantianigra MK value showed certain accuracy in the diagnosis of early PD patients, and the diagnostic sensitivity and specificity were higher than the FA value and MD value. Conclusions: DKI can be used to analyze the changes of the microstructure of substantianigra in early PD patients, and the MK value can better reflect the changes of the microstructure of substantianigra in early PD patients.

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