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Objective: To explore the clinical effect of gliquidone combined with compound anisodine in the treatment of diabetic papillitis. Methods: A total of 100 patients with diabetic papillitis,who were treated in People's Hospital of Xinjiang Uygur Autonomous Region from June 2019 to January 2020, were divided into experimental group and control group (50 cases in each group). The patients in the control group were given compound anisodine only, and the patients in the experimental group were treated with gliquidone on the basis of the control group's therapy. The treatment effect, vision level, average visual field defect degree, adiponectin level, hs-CRP level, vascular endothelial growth factor (VEGF) level, adverse mood and quality of life of the two groups were compared before and after treatment, and the incidence of adverse reactions during treatment was compared. Results: (1) The total effective rate was 98.00 % in the experimental group and 86.00 % in the control group, with significant difference between the two groups (P<0.05). (2) Before treatment, there was no significant difference in visual acuity and visual field average defect degree between the two groups, but after treatment, the visual acuity of the two groups was significantly improved, while the visual field average defect degree of the experimental group was higher than that of the control group (P<0.05). (3) Before treatment, the levels of adiponectin, hs-CRP and VEGF in the two groups were not significantly different (P>0.05), but after treatment, the levels of adiponectin in the experimental group were higher than those in the control group,but hs-CRP and VEGF in the experimental group were lower than those in the control group (P<0.05). (4) Before treatment, the scores of HAMA, HAMD and SF-36 in the two groups were not significantly different (P>0.05), while the scores of HAMA and HAMD in the experimental group were lower than those in the control group (P<0.05), and SF-36 was higher than that in the control group (P<0.05). (5) The total incidence of adverse reactions was 12.00 % in the experimental group and 10.00% in the control group, with little difference between the two groups (P>0.05). Conclusion: Gliquidone combined with compound anisodine has a good therapeutic effect on diabetic papillitis. It can significantly reduce the degree of visual field defect, improve patients' visual acuity, reduce the levels of inflammatory mediators and vascular growth factors, relieve patients' anxiety and depression, and improve patients' quality of life. At the same time, the treatment is safe and worthy of clinical application. [ABSTRACT FROM AUTHOR]

OBJECTIVE:To observe the clinical effects of compound anisodine injections combined with vitamin B12 injections in treatment of primary and secondary ischemic optic neuropathy. METHODS： 141 cases (group A) of primary ischemic optic neuropathy and 108 cases ( group B ) of secondary ischemic optic neuropathy admitted into Zhengzhou the Second People’s Hospital from Jan. 2013 to Oct，in order to facilitate，for binocular ION patients，chose one eye with worse vision into the study. 2015 were extracted. Group A were divided into control group A，observation group A1，observation group A2 via the random number table，with 47 cases. Group B were divided into control group B， observation group B1，observation group B2 via the random number table， with 36 cases. Based on the conventional treatment，control group A and observation group B were treated with compound anisodine injections in compound anisodine 2ml subcutaneous injection beside the affected side arteriae temporalis superficial; observation group A1，observation group B1 were given were treated with compound anisodine subcutaneous injection beside the affected side arteriae temporalis superficialis with vitamin B。intramuscular injection，once a day. Observation group A2，observation group B2 were given mixture of the compound anisodine and vitamin B12 subcutaneous injection beside the affected side arteriae temporalis superficialis，once a day. The period of treatment of the both groups was three courses (two weeks as one course). Visual acuity changes and visual field defect of each group were compared before and after treatment，changes of eyesight and vision were set as the efficacy indicators. RESULTS： After treatment，the recovery of eyesight and vision and total effective rate were significantly higher than those of control group % and observation group A2 % observation group B2 were respectively higher than those of observation group A1 and observation group B1 % with statistical significance ( P < 0. 05 )； There were no sever adverse drug reactions in all patients during treatment. CONCLUSIONS： The efficacy of compound anisodine injections combined with vitamin B12 injections in treatment of primary and secondary ischemic optic neuropathy is remarkable，with high safety. [ABSTRACT FROM AUTHOR]