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Objective: To investigate the correlation between Th17 and related cytokines with liver stiffness measurement (LSM), liver function and adiponectin (APN) levels in alcoholic cirrhosis patients. Methods: 72 cases of alcoholic cirrhosis patients admitted to our hospital from January 2018 to January 2020 were treated as alcoholic cirrhosis group, 100 healthy volunteers who underwent physical examination in our hospital during the same period were treated as healthy control group. Differences of Th17, interleukin-17 (IL-17), LSM, liver function indicators, APN levels between two groups were compared. Pearson test was used to evaluate the correlation between Th17 and IL-17 with disease related indicators in alcoholic cirrhosis patients. Results: Distribution ratio of Th17, IL-17 levels, LSM in alcoholic cirrhosis group were higher than those in healthy control group (P<0.05). The levels of alanine aminotransferase (ALT), aspartate transaminase (AST) and serum total bilirubin (STB) in peripheral blood in alcoholic cirrhosis group were higher than those in healthy control group, albumin (ALB) was lower than that in healthy control group, the level of APN in serum was lower than that in healthy control group (P<0.05). The correlation analysis showed that the Th17 distribution ratio and IL-17 level in alcoholic cirrhosis patients were positively correlated with the levels of LSM, ALT, AST and STB, and negatively correlated with the levels of ALB and APN (P<0.05). Conclusion: The expression levels of Th17 and IL-17 increase abnormally in alcoholic cirrhosis patients, it may be a good indicator that reflects the degree of abnormal changes in disease. [ABSTRACT FROM AUTHOR]

Objective: To explore the current status of alcoholic hepatitis diagnosis by clinicians' in China. Methods: Clinical data of inpatients confirmed with alcohol-associated liver disease diagnosed at Tongliao Infectious Disease Hospital of Inner Mongolia from June 1, 2018 to May 31, 2019 were retrospectively analyzed. The consistency of clinical diagnosis of alcoholic hepatitis was judged according to the diagnostic criteria recommended by the National Institute of Alcohol Abuse and Alcoholism (USA), and then the alcoholic hepatitis severity assessment model recommended by international guidelines, including Maddrey discriminant function, Model for end-stage liver disease, and Glasgow alcoholic hepatitis score and ABIC scores (age, total bilirubin, international normalized ratio and creatinine) were applied to evaluate this group of cases. Results: Among 79 cases with alcohol-associated liver disease, 75 were males and 4 were females, age ranged between 27~75 (51.1±8.8) years. Alcohol consumption varied from 60 g/d to 600g/d, with an average consumption of 148.8 ± 76.6 g/d. The alcohol consumption duration ranged from 4 to 50 [average (23.9 ± 9.6)] years. According to the initial discharge diagnosis, there were 47 and 32 cases in alcoholic hepatitis and alcoholic liver cirrhosis group, respectively. The mean erythrocyte volume, serum alanine aminotransferase, aspartate aminotransferase and total bilirubin were increased in alcoholic liver cirrhosis than alcoholic hepatitis group, while albumin and total cholesterol were lowered in alcoholic liver cirrhosis than alcoholic hepatitis group, and coagulation indexes were significantly extended. Alpha-fetoprotein of both groups were in the normal range; however, it was significantly higher in the alcoholic hepatitis group than the alcoholic cirrhosis group. The 10 cases in the alcoholic cirrhosis group met the definition and diagnosis of alcoholic hepatitis defined by the National Institute of Alcohol Abuse and Alcoholism (USA), but there was no case in the alcoholic hepatitis group. Among the 10 diagnosed cases of alcoholic hepatitis, 5, 6, 1 and 3 cases met the diagnostic criteria of Maddrey discriminant function, Model for end-stage liver disease, Glasgow alcoholic hepatitis score, and ABIC score for severe alcoholic hepatitis, respectively. The Maddrey discriminant function, ABIC score, and Glasgow alcoholic hepatitis score within the Model for end-stage liver disease scores> 20 points had 5, 1, and 3 cases, respectively. Conclusion: Alcoholic hepatitis is over-diagnosed by clinicians. Alcoholic hepatitis patients have the base of liver cirrhosis who meet the diagnostic criteria of National Institute of Alcohol Abuse and Alcoholism (USA). Patients with Model for end-stage liver disease score > 20 points have good consistency with Maddrey discriminant function score ≥ 32 points, and both can be used to evaluate the alcoholic hepatitis patient clinical severity.