Search

Objective To assess the value of transabdominal real-time 2-D ultrasound and spatio-temporal image correlation (STIC) combined with high-definition flow imaging (HDFI) for detecting fetal aberrant right subclavian artery (RSA) in unselected population during early pregnancy. Methods From November 2018 to September 2019, routine ultrasound was performed on 801 fetuses at 11 to 13 6 gestational weeks. The fetal RSA was observed using both transabdominal 2-D HDFI and STIC-HDFI. The sensitivities, specificities, positive predictive value (PPV) and negative predictive value (NPV) of screening tests were compared between the two methods. Results According to the inclusion criteria and follow-up results, a total of 305 fetuses including 283 singletons and 11 twins were included in this study. Of 14 confirmed aberrant RSA including 12 isolated aberrant RSA and 2 cases with multiple severe malformations, 7 isolated aberrant RSA were detected by both two methods, 11 by 2-D HDFI, and 8 by STIC HDFL The diagnostic sensitivity of 2-D HDFI (78.6%) was significantly higher (P=0.001) than that of STIC-HDFI (57.1%). Combined both methods, the sensitivity (85.7%) was significantly higher than that of STIC-HDFI (P<0.001) without significant difference from that of 2-D HDFI (P=0.193). There was no significant difference in specificity (all 100%), accuracy (98%-99.3%), PPV (all 100%) or NPV (98%-99.3%) between the combined and single methods (P>0.05). Conclusion Real-time transabdominal 2-D ultrasound combined with HDFI and STIC can improve detection of fetal aberrant RSA in the first-trimester pregnancy. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical significance of aberrant right subclavian artery(ARSA) in the screening of fetal chromosome abnormalities. Methods From January 2017 to May 2018, 4 862 pregnant women were examined by ultrasound before delivery in Xinxiang Central Hospital. A total of 36 fetuses with aberrant right subclavian artery were detected. All fetuses were followed up. The ultrasound images, karyotype results and clinical outcome were summarized. Results All 36 cases of ARSA were detected by three vessels and trachea view. of which 25 cases of simple ARSA fetuses had normal karyotype, all of them were alive and term delivery. The body developed well for 12 months, and no symptoms of respiratory tract and esophageal compression occurred. 11 cases of complex ARSA fetuses were abnormal in cardiac structure and ultrasonic soft index, 9 cases of 21 trisomy, 1 case of 18 trisomy and 1 case of 22qll microdeletion were confirmed by chromosome examination, and 11 cases were terminated pregnancy bb y antenatal consultation. Conclusion ARSA alone has a good prognosiis and do es not increase the risk of aneuploidy. If there are cardiac defects, extracardiacanomalies or multiple abnormal ultrasonic soft indexes, the risk of chromosome abnormalities 1s high. Aberrant right subclavian artery with additional ultrasound findings constitute a strong predictor for fetal chromosome abnormalities. [ABSTRACT FROM AUTHOR]