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Using 304 stainless steel mesh as the outer support bed and serrated stainless steel mesh as the inner support structure，and filling coke in the serrated voids of the composite serrated mesh，a filled-bed electrode coupled with two materials of coke and stainless steel was prepared for solving the problem that the cathode for electrochemical water softening could not be operated efficiently in the long term. The optimal electrode structural parameters were explored，and the results showed that the electrode achieved the optimal softening rate of 46.873 g/（m2·h） for simulated circulating cooling water with a total hardness of 700 mg/L when the cathode-anode spacing，the number of mesh of the outer flat mesh，and the apparent current density were 1.5 cm，20 mesh，and 80 A/m2，respectively. When the surface of the electrode was covered by a scale layer resulting in a significant decrease in the softening rate，the electrode was regenerated by vibration，and the service life of the electrode was investigated，and the results showed that maintaining the electrode in continuous operation for 37 d，the electrode still maintained a high softening rate for the circulating cooling water，which could maintain the long-term efficient operation of the electrochemical water softening system. This study can provide a reference for solving the performance degradation problem of electrochemical water softening system caused by ineffective regeneration of electrochemical water softening cathode.

Objective To investigate the potential caries prevention mechanism of the Xinjiang Mori cortex and to analyze its effect on the main cariogenic bacteria. Methods The active components of the Xinjiang Mori cortex and the main targets were predicted and screened using the TCMSP database. The GeneCards, DisGENET and TTD databases were used to obtain caries-related targets. The common targets were derived, and core genes were screened. The enrichment analysis was performed using the DAVID data platform. Molecular docking was performed using AutoDock software. In in vitro antibacterial experiments, first, the 50% minimum inhibitory concentration (MIC50) and the minimum bactericidal concentration (MBC) of the Xinjiang Mori Cortex extract against Streptococcus mutans, Streptococcus sanguis and Actinomyces viscosus were determined and the growth curves were measured. The effects of the Xinjiang Mori Cortex extract on acid production, polysaccharide production and adhesion ability of Streptococcus mutans, Streptococcus sanguis and Actinomyces viscosus in the planktonic state were determined. The 50% minimum biofilm inhibition concentration (MBIC50) and 50% minimum biofilm reduction concentration (MBRC50) were determined by crystal violet staining, and biofilm morphology was visualized using scanning electron microscopy (SEM). Results The main active components of the Xinjiang Mori cortex included quercetin, kaempferol, and β-sitosterol. Tumor necrosis factor (TNF), interleukin-6 (IL-6), and interleukin-1beta (IL-1β) could be the most important targets of the Xinjiang Mori cortex for the prevention of dental caries. The enrichment analysis results showed that Mori cortex extract may have effects on the AGE-RAGE signaling pathway, IL-17 signaling pathway, and TNF signaling pathway. The antibacterial experiment results showed that the MIC50 values of Xinjiang Mori Cortex extract against Streptococcus mutans, Streptococcus sanguis and Actinomyces viscosus were 0.5, 0.5 and 0.25 mg/mL, respectively, and the MBCs were 4.0, 2.0 and 1.0 mg/mL, respectively. The inhibitory effect of Xinjiang Mori Cortex extract on the acid production, polysaccharide production and adhesion ability of three major cariogenic bacteria in the planktonic state was stronger than that of the control group, and the differences were statistically significant (P

In this study, zein-based gluten-free model dough (Z dough) was prepared with zein, corn starch, and wormwood gum. Based on the flour quality test, the kneading torque, water composition and protein distribution of the zein simulated dough with different lactic acid content were compared when finish dough (torque up to 1.1 Nm; set as ZS dough) and kneading for 12 minutes (set as ZL dough) conditions. The optimal amount of lactic acid added to kneadable dough was explored, and the physical and chemical properties of zein in dough with different lactic acid content were discussed under the action of kneading for a certain period of time, which could and provide reference for the preparation of related cereal products. Studies have shown that adding a small amount of lactic acid could promote zein to build a protein network in the dough, but long-term kneading would lead to decreasing the strength of the acidified dough, destroying the continuity of the zein network in the dough, reducing the level of zein wrapping on starch granules and weak bonding in the dough. The proportion of water decreased and the proportion of free water increased. The surface hydrophobicity increased and the relative molecular weight decreased, when the deamidation reaction of zein occurred. The analysis showed that the dough gradually weakened after a long time of kneading, because the kneading effect would expand the effect of lactic acid on zein in the dough, which would increase the hydrophobicity of the protein surface and fragment the protein, and lead to a decrease in the coherence of the zein network.

Objective To explore dental caries-related factors among children aged 3-5 years in Urumqi City and to provide evidence for the etiological study and primary prevention of caries among local children. Methods A multistage stratified cluster sampling method was used to randomly select children aged 3-5 years in Urumqi City for oral examination, physical examination and questionnaire survey. Data were collected and analyzed by principal component logistic regression using SPSS 23.0 software. Results Principal component analysis showed that there were seven risk factors whose characteristic root value was greater than 1: oral hygiene habits, family education level, sugar intake, bedtime eating habits, age, gestational age, feeding mode, and cumulative contribution were 66.486% of the total variance. Principal component logistic regression analysis indicated that five factors, namely, oral hygiene habits (OR = 0.795, P = 0.044), family education level (OR = 0.667, P = 0.019), sugar intake (OR = 1.260, P = 0.006), bedtime eating habits (OR = 5.432, P

Objective To explore the medication law and mechanism of traditional Chinese medicine compounds in the treatment of periodontal disease through data mining, network pharmacology, and molecular docking. Methods First, data mining was used to search single medicinal materials for the treatment of periodontal disease, and the active components and their action targets were screened. Second, the disease target database was employed to download the targets related to the pathogenesis of periodontal disease, map them with the action targets of traditional Chinese medicine, and obtain the targets that are considered potential targets of traditional Chinese medicine in the treatment of periodontal disease. Potential targets were analyzed for gene ontology function and signaling pathway. They were then screened to obtain the key targets for the treatment of periodontal disease. Finally, the active components were docked with key targets. Results Among the traditional Chinese medicine prescriptions for the treatment of periodontal disease, Shudihuang, Mudanpi, Danggui, Fuling, Jinyinhua, Shanyao and Zhimu had the highest frequencies. Forty-three active components and 118 action targets were screened, and 52 potential targets were obtained by intersection with 856 disease targets. The molecular functions and biological processes in which potential targets may participate mainly focus on vitamin D biosynthesis and RNA polymerase Ⅱ regulation and involve 96 signaling pathways. Through the analysis of network topology parameters, 11 key targets were obtained. The results of molecular docking showed that the active components and RAC-alpha serine/threonine-protein kinase (AKT1), cellular tumor antigen p53 (TP53), and mitogen-activated protein kinase-1 (MAPK-1) have good binding activity. Conclusion Traditional Chinese medicine compounds may play a role in the treatment of periodontal disease by inhibiting alveolar bone absorption, have antibacterial and anti-inflammatory properties, and promote tissue repair. The effective treatment of periodontal disease by traditional Chinese medicine compounds provides a more scientific reference to the sustainable development of traditional Chinese medicine.

Objective To compare the effects and characteristics of cigarette smoke exposure (CSE) alone and CSE combined with airway instillation of bacterial lipopolysaccharide (LPS) in chronic obstructive pulmonary disease (COPD).Methods Male SD rats were randomly divided into control, CSE, and CSE+LPS groups, with 10 rats in each group. After 24 weeks, the models were established and the lung function of the rats was measured. Hematoxylin-eosin (HE) staining was performed to observe the pathological changes in the airway and lung tissue. The ELISA method was used to detect the level of serum interleukin-8 (IL-8) and tumor necrosis factor α (TNF-α) in peripheral blood.Results Airway resistance (RI), functional residual capacity (FRC), and chord compliance (Cchord) of the CSE and LPS+CSE groups were higher than those of the control group (all P < 0.05), while the tidal volume (TV), minute volume (MV), and forced expiratory volume in 50 ms (FEV50) / forced vital capacity (FVC) of the CSE and LPS+CSE groups were lower than those of the control group (all P < 0.05). HE staining of lung tissue showed that the average alveolar intercept and thickness of the small airway walls were higher in the CSE and LPS+CSE groups than those in the control group. Compensatory enlargement was evident in the alveolar cavity of the CSE and CSE+LPS groups, and the alveolar septum widened, with a fusion of pulmonary alveoli in the CSE+LPS group. The levels of IL-8 and TNF-α in serum of the CSE and CSE+LPS groups were higher than those of the control group (all P < 0.05). The level of TNF-α in serum of the CSE+LPS group was higher than that of the CSE group (P < 0.05).Conclusion The CSE combined with LPS method is superior to CSE alone for establishing the COPD rat model, and the combined model is closer to clinical manifestations.

Adding particles to the Ni - P coating for forming a composite coating could further improve the mechanical properties, corrosion resistance and lubricating properties of the coating. Hence, Ni - P/WS2 composite coatings were prepared by chemical coprecipitation on the surface of Q235 steel, and the coatings were post - treated by heating. Subsequently, the influence mechanism of WS2 content in plating solution and heat treatment after precipitation on the hardness and self - lubrocating performance of Ni - P/WS2 composite coating was studied by electron microprobe (EPMA), X - ray diffractometer (XRD), scanning electron microscope (SEM) and hardness tester. Results showed that the content of P in the plating solution was stable, which was not affected by the concentration of WS2 particles in plating solution, and it was beneficial to precipitation of a proper amount of body centered cubic Ni3P hardening phase in the subsequent heat treatment, causing that the surface hardness of the composite coating was effectively improved. Moreover, WS2 particles in the coating played a lubricating role on the surface of the coating, which could effectively reduce the friction coefficient of the coating surface, and the heat treatment enabled the precipitation of body centered cubic Ni3P phase in the coating. Thus, the surface support for WS2 particles was enhanced, which was conducive to increase the self - lubrication of the coating surface and effectively reduce the friction coefficient.

This study focused on the radioprotective effects of Lanzhou lily polysaccharide fragment (LLP) on murine bone marrow nucleated cells (BMNCs) subjected to X-ray-induced injury. The lily polysaccharide extract was prepared using the ultrasonic auxiliary hot water method, followed by purification using ultrafiltration and Sephadex G-150 chromatography. The average molecular weight of the extract was 8 629.8 Da. Unlike the control and simple irradiation groups, the murine model of acute radioactive injury model was treated with different amounts of LLPs. Each group was evaluated for the number of BMNCs, micronucleus ratio, DNA injury, and cyclical changes. The results revealed increased injury in the simple irradiation group than in the LLP-treated group. The number of BMNCs increased by 45.5% (p

Objective To explore the potential mechanism of the main active component Tripterygium wilfordii in the treatment of oral lichen planus based on network pharmacology. Methods The components of Tripterygium wilfordii and targets were searched through the Traditional Chinese Medicine system pharmacology database and analysis platform (TCMSP) and the Traditional Chinese Medicine integrated database (TCMID) databases. The related targets of oral lichen planus (OLP) were obtained through databases such as Gene Cards. The OLP targets were mapped by Venn analysis to the targets of Tripterygium wilfordii to screen out the common targets as the treatment of OLP targets of Tripterygium wilfordii. The Cytoscape software and STRING were used to construct a chemical component-target network and protein-protein interaction network, a network analyzer was used to compute the network topology properties, a cluster profiler software was used to analyze the GO classification enrichment analysis and KEGG signal path analysis, and a Tripterygium wilfordii chemical components-targets-pathway network diagram was constructed. Results Twenty-three components and 44 OLP treatmenttargets of Tripterygium wilfordii were obtained. The key active ingredients of Tripterygium wilfordii in the treatment of OLP are triptolide, kaempferol, and tangerine peel. The key targets include TNF and AKT1. The GO classification enrichment analysis obtained 63 GO terms, which are mainly involved in the leukocyte differentiation and reaction to lipopolysaccharides. The KEGG analysis identified 111 signaling pathways, which are mainly related to the TNF signaling pathway and IL17 signaling pathway. Conclusion Based on the network pharmacology, this study preliminarily revealed themain components, targets and pathways of Tripterygium wilfordii in the treatment of OLP. This study can provide a theoretical basis for further research to explore drugs with high activity and low toxicity to treat OLP from Tripterygium wilfordii.

Recommendation system,as a very effective technique to solve the information overload,has received a great deal of attention from researchers.However,the real application of recommending systems can be modeled as heterogeneous networks with multi-typed nodes and relations.Thus,heterogeneous network embedding based recommendation becomes a very hot research topic in recent years.However,most of the existing studies do not fully explore the auxiliary information and complex relations which are valuable for enhancing recommending performance.To address the above problems,a recommendation algorithm based on heterogeneous information network embedding and attention neural network is proposed.First,this paper proposes a heterogeneous information network embedding method that maintains semantic relationship and topological structure simultaneously.Then,it designs a meta-path based random walk strategy to extract node sequences from heterogeneous information networks.All the sequences are filtered and then employed to learn the embeddings for each user and item in different meta-paths.At last,this paper presents a recommendation algorithm based on attention neural network with the above embeddings as input.The attention network composed of attention layers and hidden layers is able to explore the complex relationships and hence enhance the performance of recommendation.To verify the effectiveness of the proposed method,this paper conducts experiments on two kinds of real-world datasets and makes a comparison with three competitive algorithms.The results show that the proposed algorithm improves the recommending performance in terms of MAE and RMSE,with a maximum increase of 8.9%.

To meet the development needs of advanced aeroengines,the structure of aeroengine turbine blades is becoming increasingly complex, and the content of refractory elements is increasing in single crystal superalloys, which are the preferred materials for turbine blades. As a result, the tendency to form the grain defects increases during the preparation of single crystal turbine blades, which directly affects the quality of single crystal turbine blades. In this paper, a kind of grain defect that appears in the directional solidification process of single crystal superalloys—freckle was discussed. The research works on the formation mechanism, the criterion model and the control method of freckles formation during the directional solidification of single crystal superalloys in recent years was reviewed. The influence of the alloy composition, blade structure, directional solidification process and crystal orientation of single crystal castings on the formation of freckles was analyzed. Considering the influence of the alloying elements in different alloy systems and the parameters of the directional solidification process on the freckle formation, further studying the freckle formation mechanism of the single crystal turbine blade with complex structures, establishing an effective method for prediction and control of freckles are the future research directions.

Chronic periodontitis is an infectious disease caused by plaque as the initiating factor. Clinically, it manifests as irreversible loss of hard tissue, leading to the destruction of surrounding periodontal tissue, including the deep periodontal pocket, loss of attachment, and finally, tooth loss. Interleukin-18 (IL-18) can promote inflammation and regulate immune function and plays an important role in mediating the host immune response and inflammatory response. An increase in IL-18 in vivo can induce the production of interferon and inflammatory factors, such as interleukin, tumor necrosis factor and matrix metalloproteinase, thus mediating the dual reaction of immunity and inflammation. These inflammatory factors are involved in the occurrence and development of chronic periodontitis. Many clinical studies have shown that the levels of IL-18 in serum, saliva, gingival crevicular fluid and gingival tissue samples of patients with chronic periodontitis may be positively correlated with the severity of periodontitis; however, as a candidate gene, IL-18 is involved in the susceptibility polymorphism of periodontitis. Understanding how to quantify the level of IL-18 in clinical studies and apply it to diagnostic tools and new sites identified by new methods (genome-wide association studies and omics research) will also deepen our understanding of the pathogenesis of IL-18 in chronic periodontitis and provide new ideas for future precision medicine and the formulation of personalized programs. In this paper, the structure, biological function and association between IL-18 and periodontitis are reviewed.

This paper reviewed the clinical data of a patient with sleep disorder caused by insomnia. Based on the psychological, physical and social assessment, the Traditional Chinese Medicine techniques acupoint massage combined with ginger-partitioned moxibustion were conducted to improve the sleep quality of the patient. Comprehensive nursing interventions such as basic nursing, dietary management, emotional care were carried out during the treatment. (本文回顾1例因失眠导致睡眠紊乱患者的临床资料, 总结穴位按摩联合隔姜灸的干预效果和相关护理经验。在心理、生理、社会评估的基础上, 医护人员采用中医特色护理技术穴位按摩联合隔物灸进行干预, 同时配合实施常规护理、饮食护理、情志护理等综合干预措施, 有效改善患者失眠症状。)

Fiber Bragg Grating (FBG) has the advantages of anti-electromagnetic interference, corrosion resistance, small size and low cost. Moreover, the FBG fabricated by femtosecond laser has the unique advantages of high temperature resistance. Firstly, three mainstream methods for writing FBG with femtosecond laser are introduced, including femtosecond laser phase mask method, femtosecond laser direct writing method, and femtosecond laser holographic interferometry. The advantages and disadvantages are compared and analyzed. Secondly, the principle and application on temperature, pressure (strain) and refractive index sensing of FBG prepared by femtosecond laser are reviewed. Finally, the future development of FBG fabricated by femtosecond laser in lakes, oceans and other fields is prospected.

Magnesium batteries with the advantages of low cost, high energy density and high safety are expected to be applied in large-scale energy storage and power vehicles in the future. However, magnesium batteries are still in the early development, and cathode is the key reason that limits the battery performance. The high charge density of Mg2+ results in slow diffusion of Mg2+ in cathode materials. Therefore, how to improve the electrochemical performance of cathode materials is the focus and difficulty in the field of magnesium batteries. By analysing the related researches, six strategies for improving the electrochemical performance of cathode materials were summarized in this paper, namely, reducing the particle size, using the shielding effect of the solvent, increasing the interlayer distance, regulating anions, exploring new structures and developing double ion batteries. By clarifying the root cause that makes the strategies effective and pointing out the advantages and limitations of the strategies, this paper provides valuable guidance for the development of high-performance cathode materials for magnesium batteries. Finally, the development status of magnesium battery cathode materials was summarized, and the future development trend of cathode and the whole battery system was prospected.

At the conditions of 760℃/800 MPa, 980℃/250 MPa and 1100℃/137 MPa, the transv-erse stress rupture properties of a nickel-based third generation single crystal superalloy were investigated. The results show that the stress rupture life and elongation of the transverse specimens are lower than those of the longitudinal specimens at 760℃/800 MPa, 980℃/250 MPa and 1100℃/137 MPa. The dislocation configurations of the stress ruptured transverse and longitudinal specimens are the same. There are intersecting stacking faults in the γ' phases after stress ruptured at 760℃/800 MPa, and the dislocations are tangled and high densities of dislocation networks have formed at the γ/γ' interface after stress ruptured at 1100℃/137 MPa. The transverse and longitudinal specimens show quasi-cleavage and dimple mixture mode at 760℃/800 MPa, while they both show dimple mode at 980℃/250 MPa and 1100℃/137 MPa. The fracture mechanisms of transverse specimens of the first generation single crystal superalloy DD3, the second generation single crystal superalloy DD6 and the third generation single crystal superalloy in our study at medium and elevated temperatures are basically the same. The main reason for the transverse specimens have a lower stress rupture properties than the longitudinal specimens is that the external applied stress is perpendicular to the primary interdendritic interface formed during the directional solidification process.

To understand the trends of nutrients and harmful substances in the processing of rice bran oil(RBO).Three batches of RBO samples from three RBO factories, including crude oil, degum ming,dewaxing, deacidification, decolorization and degreasing were collected, Measurement of its vita min E,oryzanol and sterol and two harmful substances.Study its trends.Two harmful matters including benzopyrene (BaP), 3-chloro-1,2-propanediol (3-MCPD) and three nutritional contents including vita min E,oryzanol, sterol were determined.The trends of these substances change were studied.The vita min E decreased by 37.92%, oryzanol decreased by 23.05%, sterol decreased by 22.69%, BaP content of RBO decreased by 97.61%, 3-MCPD decreased by 80.47%, when compared with crude oil.BaP and 3-MCPD are produced, 3-MCPD shows a decreasing trend, and vita min E, oryzanol, sterol are decrease with different degrees during the processing of RBO.

A series of copolymers (P(AA-co-MPC)) with acrylic acid (AA) and 2-methacryloy-loxyethyl phosphorylcholine (MPC) monomers were synthesized via RAFT polymerization. Then the magnetic iron oxide nanoparticles were modified by these synthesized copolymers through chemical coprecipitation method. Copolymers and the nanoparticles were characterized by 1H NMR, FTIR, GPC, TG, TEM, XRD, Zeta potential and particle size analyser, and Squid-VSM magnetic measure system. The results show that the P(AA-co-MPC) with narrow molecular mass distribution is successfully synthesized by RAFT polymerization and the surface of the magnetic iron oxide nanoparticles is modified by these copolymers. The modified magnetic iron oxide nanoparticles by copolymer synthesized with the monomer molar ratio of AA:MPC of 1:1 exhibit the best dispersion, the smallest hydrodynamic particle size (36.54±4.00) nm, the narrowest particle size distribution and the highest Zeta potential (-30.98±1.25) mV. The saturation magnetization is 65.57A·m2·kg-1. The nanoparticles show superparamagnetism, with no residual magnetism and zero coercive force.

Objective To compare the apical sealing effects of two root canal fillers, GuttaFlow and AH Plus, for clinical reference. Methods The Cochrane system evaluation method was used to search the Cochrane Library, Em⁃ base, CBM, PubMed, CNKI, Weipu, and Wanfang databases. Additionally, relevant journals and conference papers were manually retrieved, and relevant randomized controlled trials were collected. Two reviewers independently evaluated the quality of each study and extracted the data. A meta⁃analysis was performed using the RevMan5.3 software for homoge⁃ nous studies, and a descriptive analysis was performed for studies with poor homogeneity. Results In total, 10 random⁃ ized controlled trials containing 398 isolated teeth were included. The meta⁃analysis results showed that the difference in apical microleakage was statistically significant at 1 week and 3 months [1 week: MD＝⁃0.13, 95% CI (⁃0.22,⁃0.04), P＝0.007; 3 months: MD＝⁃1.27, 95% CI (⁃1.94,⁃0.60), P＝0.000 2] but not at 6 months [MD＝⁃0.10, 95% CI (⁃0.26, 0.06), P＝0.23]. Conclusion Based on existing research results, GuttaFlow may achieve better results than AH Plus in the short term (≤ 1 week). Because it is subject to limitations of time, quality, and research methods, this conclusion re⁃quires more long⁃term, high⁃quality, large⁃sample, multimeasurement randomized controlled trials for further validation.

The specimens of the fourth generation single crystal superalloy after heat treatment and at as-cast state were indented and annealed in vacuum at 1100, 1150, 1200, 1250, 1300℃ and 1340℃, respectively. The recrystallized microstructures of the alloy were examined by optical microscopy (OM), scanning electron microscopy (SEM) and electron back scattering diffraction (EBSD). The results show that cellular recrystallization (CRX) occurs in the standard heat treatment samples and as-cast samples after annealing treatment at 1100, 1150℃ and 1200℃. Mixed recrystallization occurs in standard heat treatment samples and as-cast samples after annealing treatment at 1250℃. Equiaxed recrystallization (ERX) develops when the standard heat treatment samples are annealed treatment at 1300℃, while mixed recrystallization occurs in as-cast samples at same condition. ERX develops when these two samples are annealed at 1340℃. The recrystallized layer depth of these two samples increases with the increase of annealing treatment temperature and the depth of standard heat treatment samples is obviously larger than that of as-cast samples.The recrystallized grain of standard heat treatment samples easily grows up at same condition. The interface between the recrystallization grain and original grain is low angle boundary and high angle boundary, while the interface between adjacent recrystallization grains is low angle boundary, high angle boundary, and twinning boundary. It can be inferred that the formation of twins can play an important role in the process of recrystallization.

Objective To study the detection rate of Streptococcus mutans in oral cavities of 3⁃5⁃year⁃old Han, Uygur and Mongolian children in Bortala Mongolian Autonomous Prefecture, and the correlation between genotype and dental caries of preschool children. Methods Ninety children were randomly selected from the sample bank of chil⁃ dren′s oral epidemiological survey data in the Bozhou area of Xinjiang. Forty⁃five children were included in the high caries group (more than 5 missing teeth), and 45 children were included in the noncaries group (0 missing teeth); each group comprised 15 children of each of the Han, Uygur and Mongolian nationalities. Plaque samples were collected and cultured with light saliva⁃bacillin agar medium and brain⁃heart infusion medium. Streptococcus mutans were cultured, and clinical isolates were further isolated and identified by Gram staining, biochemical identification and polymerase chain reaction. Genotype distribution was detected by random primer polymerase chain reaction. Results The detec⁃ tion rate of Streptococcus mutans in the 90 included children was 75.5%. The detection rate of Streptococcus mutans in the high caries group was 86.7%, which was significantly higher than that in the caries⁃free group (64.4%) (P＝0.014). There was no significant difference in the distribution of Streptococcus mutans among Han, Uygur and Mongolian nation⁃ alities (P＝0.457). A total of 549 clinical strains of Streptococcus mutans were obtained, and 113 different genotypes were found. In the high caries group, 61.5% carried more than one genotype of Streptococcus mutans, and 37.9% of the caries ⁃ free group had more than one genotype. The genetic polymorphism of Streptococcus mutans in the high caries group was significantly higher than that in the caries⁃free group (P＝0.035). Spearman correlation analysis showed that there was a positive correlation between oral Streptococcus mutans gene polymorphism and caries sensitivity (r＝0.258, P＝0.034). Conclusion The distribution of Streptococcus mutans in children′s oral cavity in the Bozhou area was dif⁃ ferent between the high caries group and the caries⁃free group, but there was no difference among nationalities. Strepto⁃ coccus mutans in the high caries group had more genotypes than those in the caries⁃free group. The genetic polymor⁃ phism of Streptococcus mutans might be related to the caries⁃causing ability of Streptococcus mutans.

To improve flame retardant properties of polypropylene,the brominated epoxy resin (BEO) and nano-Sb2O3 were added into polypropylene by using a high energy ball milling technique. Flame retardant properties of polypropylene composites were evaluated by UL94 vertical combustion tests and limit oxygen index (LOI). The surface morphology of combustion products of composites was characterized by scanning electron microscopy(SEM) and the flame-retardant mechanism of flame retardant additives acting on the polymer matrix was studied by using thermo gravimetric analysis(TGA) and Fourier transform infrared (FT-IR) spectroscopy. The results show that the reaction between modified nano-Sb2O3 and BEO can prolong residence of the halogens in the combustion area, resulting in more hydroxyl and hydrogen radicals are replaced by the bromine radicals. When the content of modified nano-Sb2O3 is 7% (mass fraction, the same below) and that of BEO is 21%, the nano-Sb2O3/BEO/PP composite has excellent flame retardant performance with 28.6% of LOI value and V-0 of UL94 grade of vertical combustion.

It is difficult for a single robot to perform tasks in a complex environment, so Unmanned Air/Ground Vehicle(UAV/UGV) cooperative systems have been widely concerned. In order to improve the efficiency of UAV/UGV cooperative systems, a global path planning for UGV under the target recognized by UAV was proposed. Firstly, SURF algorithm was studied in identify targets and image segmentation was applied to build a map. Then, the optimized A* algorithm was proposed in global path planning for UGV based on the information acquired by UAV. Finally, simulations were performed in a typical rescue scenario. Experiments show that SURF algorithm can achieve the accuracy, real-time and robustness of target recognition. The optimized A* algorithm can achieve the feasibility and real-time of global path planning.

Objective To investigate the effect of different concentrations of MTA on the proliferation and differen⁃ tiation of stem cells from the apical papilla (SCAP) and the potential of the SCAP to differentiate into odontoblasts. Methods SCAP were cultured in different concentrations of mineral trioxide aggregate（MTA） . MTA experimental group with concentration of 0.01 mg/mL, 0.02 mg/mL, 0.1 mg/mL, 0.2 mg/mL, 1 mg/mL, 2 mg/mL, 10 mg/mL and 20 mg/mL were prepared. The number of cells at 1 day, 3 days, 5 days and 7 days were measured via a CCK⁃8 assay to ob⁃ serve the effect of MTA on SCAP proliferation. Real⁃time PCR was used to detect the gene expression changes. Cells cultured in alpha MEM culture containing 15% FBS without MTA were set as the control group. Results When cul⁃ tured for 1 d, statistically significant differences in the promotion of in vitro proliferation of SCAP were not observed be⁃ tween each MTA experimental group and the control group (P＞0.05). When cultured for 3 d, 5 d and 7 d, the 0.01 mg/ mL MTA group presented obvious promotion of SCAP proliferation compared with the control group (P＜0.05), whereas the 0.02 mg/mL, 0.1 mg/mL, 0.2 mg/mL, 1 mg/mL groups did not presented differences with the control group (P＞ 0.05). The in vitro proliferation of the 2 mg/mL, 10 mg/mL and 20 mg/mL groups was lower than that of the control group (P＜0.05). Real⁃time PCR detection showed that the expression levels of DSPP (t＝⁃11.12, P < 0.05) and Runx2 (t＝⁃10.62, P < 0.05) in the experimental group treated with 0.01 mg/mL MTA for 7 days were higher than those in the control group. Conclusion The 0.01 mg/mL concentration of MTA significantly promotes the proliferation of SCAP and shows the best ability to induce osteogenic and odontoblast differentiation in the SCAP, whereas high concentrations of MTA inhibited the proliferation of SCAP.

Sandwich structural composites were prepared by aluminum foam as core materials with basalt fiber(BF) and ultra-high molecular weight polyethylene(UHMWPE) fiber composite as faceplate. The effect of factors of different fiber type faceplates, fabric layer design and the thickness of the corematerials on the impact properties and damage mode of aluminum foam sandwich structure was studied. The impact properties were also analyzed to compare with aluminum honeycomb sandwich structure. The results show that BF/aluminum foam sandwich structural composites has bigger impact damage load than UHMWPE/aluminum foam sandwich structure, but less impact displacement and energy absorption. The inter-layer hybrid fabric design of BF and UHMWPE has higher impact load and energy absorption than the overlay hybrid fabric design faceplate sandwich structure. With the increase of the thickness of aluminum foam,the impact load of the sandwich structure decreases, but the energy absorption increases. Aluminum foam sandwich structure has higher impact load than the aluminum honeycomb sandwich structure, but smaller damage energy absorption; the damage mode of aluminum foam core material is mainly the fracture at the impact area, while aluminum honeycomb core has obvious overall compression failure.

The low-velocity impact and compression after impact (CAI) properties of three-dimensional (3D) five-directional carbon fiber/epoxy resin braided composites were experimentally investigated. Specimens prepared with different braiding angles were tested at the same impact energy level. Residual post-impact mechanical properties of the different configurations were characterized by compression after impact tests. Results show that the specimens with bigger braiding angle sustain higher peak loads, and smaller impact damage area, mainly attributes to a more compact space construction. The CAI strength and damage mechanism are found to be mainly dependent on the axial support of the braiding fiber tows. With the increase of braiding angle, the CAI strength decreases, and the damage mode of the composites is changed from transverse fracture to shear failure.

In view of problems of poor accuracy and weak maneuverability existed in roof stability evaluation methods, the extension theory was applied to stability analysis of coal seam roof. For problem of roof stability of No.3 coal seam of Panxie peripheral, fault fractal value, hard-rock ratio, strength coefficient of immediate roof and number of layers in the statistical thickness were used as evaluation factors. And classification standard of each factor was determined by quartering and mathematical statistics analysis. Finally, the grey relation method and the extension matter-element model were used to evaluate roof stability. The evaluation results show that stable region has a large area in Panxie peripheral, mid-stable zone is scattered, unstable and extreme unstable areas are located in the central of peripheral and the vicinity of F66 fault and magmatic intrusive area; the overall roof stability in the south is better, while roof stability in the northern and southern parts is poor, which mainly related to magmatic erosion; from northwest to southeast, the influence of F66 fault on roof stability of nearby coal seam decreases gradually.

Objective Meta analysis was used to evaluate and compare the efficacy of treatment of dentin hypersen⁃ sitivity with arginine desensitization toothpaste and commonly used desensitization toothpaste. Methods A computer⁃ ized search of Wanfang, PubMed, web of science, and Cochrane library databases was performed, and a manual retrieval was supplemented. Randomized control trials (RCT) about arginine⁃containing desensitization toothpaste for dentine hy⁃ persensitivity were collected, then data extraction and quality assessment were performed by 2 raters independently. Meta ⁃analysis was carried out by RevMan 5.3 software. Results A total of 7 RCTs were included. All the results were eval⁃ uated by the tactile sensitivity test and the air blast test. The mean and standard deviation of each treatment group were analyzed by the random effects model. Meta⁃analysis results showed there was statistical significance in the therapeutic effects between arginine⁃containing desensitization toothpaste and potassium⁃containing desensitization toothpaste(tac⁃ tile sensitivity test to evaluate: SMD = 1.83, 95% CI BP, 2.58], P < 0.05; cold air assessment: SMD = ⁃1.19, 95% CI [ ⁃ 1.69, ⁃ 0.69], P < 0.05); However, there was no statistical significance between arginine ⁃ containing desensitization toothpaste and strontium⁃containing desensitization toothpaste (tactile sensitivity test to evaluate: SMD = 0.68, 95% CI [⁃1.59, 2.96], P > 0.05; cold air assessment: SMD = ⁃0.94, 95% CI [⁃2.28, 0.40], P > 0.05). Conclusion It shows that arginine⁃containing desensitization toothpaste has greater effects than potassium⁃containing desensitization toothpaste for dentin hypersensitivity, but no better effects than strontium⁃containing desensitization toothpaste.

When a pulse power supply is used for sewage treatment, parameters of AC-DC coupling circuit must be repeatedly regulated to make the reactor work in streamer discharge mode, and there are problems of no effective controllable and quantifiable index and imprecise regulation. So the paper proposed a fuzzy control scheme for the reactor which takes streamer discharge coefficient as a controllable and quantifiable parameter to get required superposition signal of AC and DC on the basis of research of voltage amplitude-frequency characteristics of the reactor and the basic condition of streamer discharge. The simulation and experiment results showed the scheme is feasible and effective.

The relation of BGP convergence and the characteristics of the inter-domain system was analyzed.The in-ter-domain routing system is classified into three hierarchies—core layer,transmit layer and stub layer based on the power law and commercial relations of autonomous systems.The relation of network topology and convergence parame-ters were presented of all sorts of convergence events in different layers.And a new proposal has been presented to im-prove BGP convergence based on the above analysis,called Best Up,which behaved better than normal convergence mode in the experiments.

The optical network unit management and control interface (OMCI) is a crucial protocol for interconnectivity between the optical line terminal (OLT) and optical network unit (ONU) in Gigabit- capable passive optical networks (GPON) systems. When addressing OMCI interoperability issues, developers often need to conduct exception analysis on OMCI service models. However, due to the complexity of OMCI domain knowledge, directly analyzing OMCI service models can be extremely challenging, time-consuming, and laborious for inexperienced developers. To address these challenges, the OMCI model exception analysis method based on graph neural networks (GNNs) is proposed. This method leverages graph similarity computation algorithms to search for similar OMCI models from a database as references, compares the differences, and identifies anomalies. Firstly, real OMCI data is structured into graph data. Subsequently, the similarity graph neural network (SimGNN) is improved by integrating graph isomorphism networks and self-attention pooling for fast graph similarity computation. Finally, the similarity scores between each graph in the OMCI graph database and the anomalous graph data are calculated, and the most similar OMCI service model graphs are recommended based on the score ranking. Experimental results show that the improved graph similarity computation model outperforms the baseline model on the OMCI dataset used in this study. Moreover, it proves effective in practical applications, offering valuable assistance in analyzing OMCI interoperability issues. [ABSTRACT FROM AUTHOR]

Purpose: To effectively address the disposal issues of gold tailings and alleviate the shortage of sandstone resources,this study investigated the potential of utilizing gold tailings as a partial replacement for natural sand in the production of gold tailings concrete. Method: Through a series of cube compressive strength tests and orthogonal experimental methods,this research conducted a comprehensive analysis of the impacts of four factors: water-binder ratio, go Id tailings substitution rate, sand ratio, and fly ash content, on the 28-day compressive strength of gold tailings concrete. The systematic analysis was performed using range and variance analysis methods, which determined the relative importance of each factor in influencing the 28-day compressive strength of the concrete. Furthermore,a multiple regression equation was established for predicting the compressive strength of gold tailings concrete based on the orthogonal experimental data. Conclusion: The results indicated that the water-binder ratio had the most significant effect on the compressive strength, followed by the gold tailings substitution rate, fly ash content,and sand ratio. The regression equation,with an R2 value of 0. 872,can predict the compressive strength to a considerable degree. Significance: The research results can provide some reference value for the comprehensive utilization of gold tailings resources. [ABSTRACT FROM AUTHOR]

Objective To analyze the incidence trends and spatiotemporal distribution characteristics of dengue fever in China based on the data from the China Disease Control Information System and the "National Statutory Infectious Disease Epidemic Overview" published by the National Health Commission of the People's Republic of China, and to provide a scientific basis for the prevention and control of dengue fever epidemics. Methods The incidence rates and monthly case numbers of dengue fever in China from 2015 to 2023 were collected. Provinces were classified according to the severity of the epidemic and the distribution status of the Aedes vector. The incidence trends, seasonal distribution, and spatial aggregation of dengue fever in China were statistically analyzed. Results The top five provinces with the highest average annual incidence rates from 2015 to 2023 were Yunnan (6.16/100 000), Guangdong (1.70/100 000), Hainan (1.13/100 000), Fujian (1.13/100 000), and Chongqing (0.74/100 000). The average annual incidence rate of dengue fever in China increased by 70.79% from 2015 to 2019 (AAPC=70.79, P=0.045). In Class I regions, the incidence of Guangxi and Hainan showed a linear regression trend, with average annual increases of 844.73% (AAPC=844.73, P=0.021) and 516.51% (AAPC=516.51, P=0.013), respectively. In Class II regions, except for Shanghai, the incidence of other provinces showed a linear regression trend, with Jiangxi having the highest average annual increase of 610.16% (AAPC=610.16, P=0.021), followed by Chongqing at 345.12% (AAPC=345.12, P=0.038). In Class III regions, the incidence of Hebei, Shanxi, and Liaoning had a linear regression trend, with average annual increases of 80.67% (AAPC=80.67, P=0.028), 202.31% (AAPC=202.31, P=0.001), and 70.19% (AAPC=70.19, P=0.031), respectively. The epidemic of dengue fever showed no obvious seasonality in 2021, strict seasonality in 2022, and strong seasonality in the rest of the years. The epidemic peak days were mostly concentrated in the middle and late September to early October of each year, and the epidemic peak periods were mainly concentrated in August-early November. From 2015 to 2018, the incidence rate had no spatial aggregation nationwide, and the incidence rate in 2019 had spatial aggregation nationwide. In 2015-2019 and 2023, there were no high-low gathering areas in the country, and high-high gathering areas appeared in 2018 (Fujian, Hainan) and 2019 (Guangxi). Conclusions The situation of dengue fever prevention and control in China is grim. High-risk epidemic areas of dengue fever will no longer be limited to Class I provinces, and the risk of expansion to Class II provinces is increasing. [ABSTRACT FROM AUTHOR]

Using red mud from alumina industry waste and edible fungus industry waste fungus rod as raw materials, red mud/waste fungus magnetic biochar (RMMBC) was prepared by co-pyrolysis method, and its morphological characteristics, pore structure and surface functional group changes were analyzed, its adsorption effect on norfloxacin(NOR) in water was explored, and its adsorption mechanism was explored by adsorption kinetics and isothermal adsorption characteristics, and tested in actual wastewater. The results showed that the optimal preparation conditions were raw material ratio (red mud, waste bacterial residue, urea) 1: 2.5: 0.5, calcination time 1 h, calcination temperature 700 °C. The maximum removal rate of NOR was 96.3% when a NOR concentration was 10 mg/L and 0.25 g RMMBC was added. The results showed that RMMBC had a large specific surface area(59.295 m²/g), pore volume (20.157 cm³/g) and saturation magnetic susceptibility(16.735 emu/g). The quasi-secondary kinetics of RMMBC and the Fre- undlich isothermal model can accurately describe the adsorption process of NOR on RMMBC, indicating that chemisorption may be the main mechanism of NOR adsorption on RMMBC, mainly including IT-IT interaction, surface complexation, hydrophobicity, hydrogen bonding and electrostatic interaction. The use of red mud and waste bacterial residue to prepare magnetic biochar adsorption effect is remarkable, which has the advantage of easy separation from the water body to avoid secondary pollution to the environment, which not only provides new ideas for low-cost treatment of antibiotic wastewater, but also helps to realize the stability, harmlessness and resource utilization of red mud and waste bacterial residue, and achieves the environmental protection goal of "waste treatment". [ABSTRACT FROM AUTHOR]

Since the multi-person pose estimation in crowded scenes is still affected by the problems of small detection objects, resulting in low accuracy of pose estimation, this paper proposes a multiperson pose estimation correction algorithm based on improved YOLOv5. Firstly, in the backbone network of YOLOv5, a jump attention module is integrated to help the network find the region of interest in the image. Secondly, in the neck network, the weighted bidirectional feature pyramid is used to improve the feature fusion ability between feature maps of different scales, and the jump attention module and Transformer encoder are used jointly to enable the network to obtain global information and rich context information. Thirdly, a detection head is added to the detection part to make the network more sensitive to tiny objects. Finally, the key point object information obtained by network prediction is used to modify the attitude object information to obtain the final multi-person pose estimation result. Experimental results show that the proposed algorithm improves YOLOv5's AP50 by 2.2% and AP75 by 3.3% on the COCO dataset, validating the accuracy and robustness of this algorithm. [ABSTRACT FROM AUTHOR]

Using the daily temperature data from the Dongying national meteorological observatory from 1981-2021, the daily temperature and water temperature data of the agricultural waters of the Yellow River Estuary from 2019-2021, and the hairy crab yield data of the Yellow River Estuary in Dongying from 2004-2021, the meteorological yield reduction rate was calculated after the meteorological yield was separated by moving-average model, and the relationship between temperature factors and yield reduction rate during the growth cycle of hairy crabs was analyzed by correlation analysis, the high temperature index (HTI) was selected as the key factor, and the HTI-damage model was constructed by stepwise regression method, then the damage threshold and compensation rate were determined, and the high temperature index insurance product of hairy crab in the Yellow River Estuary was designed. With the improvement of production technology in recent years, the yield of hairy crabs increased in most years, but the yield reduction rate fluctuated obviously under the influence of meteorological conditions in different years, for example, in 2008 and 2019, high temperatures and typhoons and torrential rains caused a relative increase in yield loss, and the growth and development of hairy crabs were closely related to temperature, the daily mean effective accumulated temperature above 35°C was significantly correlated with the yield reduction rate, which passed the 0.01 level test, the daily mean of effective accumulated temperature above 35°C, that is, the maximum of high temperature index reached 1.893°C·d, and the maximum of high temperature lead a 12.4% reduction of hairy crab yield. According to the calculation value of high temperature index-damage model, the high temperature disaster of hairy crab was further divided into five grades: mild, relatively mild, moderate, relatively severe and severe. Taking the HTI≥1.529°C·d as the trigger value of claims, the average amount of claims payable in the years when claims can occur is 294.04 yuan·667m-2, and the amount of claims ranges from 58.59 to 651.00 yuan·667m-2. The Yellow Estuary hairy crab high temperature weather index pure insurance rate was 6.61%, and the premium was 43.03 yuan·667m-2. [ABSTRACT FROM AUTHOR]

Flavonoids, as one of the essential active components in alfalfa, possess various beneficial effects such as anti-inflammatory, antibacterial, antiviral, antioxidant, and immune-regulating properties. These flavonoids have the potential to enhance animal growth performance, boost immunity, improve livestock product quality, reduce stress, and prevent and treat diseases, making them widely applicable in the field of animal husbandry. The article introduces the commonly used extraction methods and biological activities of alfalfa flavonoids, reviews the research progress on the application of alfalfa flavonoids in ruminant, poultry, and pig farming, providing a reference for the further development and utilization of alfalfa flavonoids in livestock and poultry production. [ABSTRACT FROM AUTHOR]

The experiment was conducted to study the effect of compound plant essential oils on the production performance and egg quality of laying hens. A total of 13 664 Dawu Jinfeng laying hens with similar body weight and late laying period (362~368 days of age ) were randomly divided into two groups, a control group and a compound plant essential oil group, with four replicates in each group and 1 708 laying hens in each replicate. The laying hens in the control group were fed a basal diet, and the laying hens in the compound plant essential oils group were fed a basal diet supplemented with compound plant essential oils. The trial period was 14 days. The results showed that compared with the control group, the laying rate of laying hens in the compound plant essential oils group was significantly increased (P<0.05), the average egg weight showed an increasing trend (P>0.05), the sand shell egg rate was significantly decreased (P<0.05), and the feed to egg ratio was decreased (P>0.05). Compared with the control group, the egg yolk ratio of the compound plant essential oils group was significantly decreased (P<0.05), and the eggshell intensity had a rising trend. The egg yolk color, hardness, and wetness in the compound plant essential oils group were significantly increased (P<0.05). The study indicates that adding compound plant essential oils to the diet can increase the production performance and egg quality of laying hens. [ABSTRACT FROM AUTHOR]

In China, the total area of rocky desertification covers 1.01x107 hm², accounting for 22.3% of the karst area. Nowadays, rocky desertification has become one of the three major land degradation problems in our country, which has seriously affected our economic development and environmental governance. Naturally, rock weathering in the karst area is so long that it takes from a few decades to a hundred years to form a centimeter think of red soil. Because the karst area is rich in calcium and barren in soil, ecological restoration of this area is urgent in both rocky desertification control and karst carbon sink. Carbonic Anhydrase (CA), one of the fastest catalyzing enzymes, can promote the weathering of carbonate rocks by accelerating the hydration reaction of CO2, thus providing soil matrices for plant colonization. At the same time, CA can also be used to absorb CO2 in the atmosphere to fix the carbon source, thereby participating in the carbon cycle process of karst dynamic system. The CA-producing microorganisms are considered to have good application prospects in the restoration of degraded karst habitats. However, for the target strains isolated from favorable habitat, their weak adaptability to the extreme environment may constrain them from exerting their expected effects. In order to select the strain with high CA activity in the extremely degraded karst habitat, CA-producing strains were isolated from the samples of severely degraded rocky karst habitats in this study. The study area is located in Hechi City, Guangxi Zhuang (23°41'--25°37' N, 106°34'-109°09' E). It has a subtropical monsoon climate, with an average annual temperature of 16.9-21.5 °C. The area is typically developed with karst, scattered with thin soil and highly exposed with rocks. From September to October 2021, four different habitat samples were collected, including lichen in the area with extreme rocky desertification weathered materials under moss, soil under moss, and weathered materials under moss in karst native forest. The source of isolation was a mixture of the four different habitat samples, 1g of each. CA-producing strains were isolated and screened from karst rocky habitats by inoculating suspension of isolation source in calcium carbonate medium with a sprayer. The field emission scanning electron microscope was used for morphological identification of the strain. The physiological and biochemical characteristics of the strain were confirmed by carbohydrate decomposition test, V-P test, methyl red test, citrate utilization test, nitrate reduction test, starch hydrolysis test and contact enzyme test. Strains were identified by 16S rRNA sequence analysis. The CA activity of single strain and mixed strain was determined by electrode method. The sequence alignment was performed in the National Center for Biotechnology Information Database. In MEGA6, Neighbor-Joining method is used to construct the phylogenetic tree. SPSS software was used to analyze whether there were significant differences in CA activity among different strains/microflora. The results show that six CA-producing strains were isolated by calcium carbonate medium, namely, Flavobacterium resistens, Delftia acidovorans, Stenotrophomonas rhizophila, Pseudomonas oleovorans, Agrobacterium cavarae and Bacillus albus. The CA activity of Stenotrophomonas rhizophila was the highest, up to 4.27 U½mL-1½OD600-1, while that of Bacillus albus was only 0.46 U½mL-1½OD600-1, which indicated that although CA commonly existed in prokaryotes, the activity of different species of bacteria varied greatly. Mixed culturing of Stenotrophomonas rhizophila whose CA activity is high with other strains led to a decrease in CA activity, indicating the great potential application of Stenotrophomonas rhizophila in the extremely oligotrophic environment. The results provide a new bacterial source for ecological restoration of extremely degraded karst habitats. However, all the CA activity decreased when the isolated Stenotrophomonas rhizophila strain N6 with high CA activity is mixed with other 5 strains. Because of the complex living environment, the competition of indigenous microbial community will reduce the survival efficiency of the added microorganisms, make it difficult to form a stable community structure, and then reduce the repair effect. In restoration of degraded karst habitat, whether there is a kind of dominant bacteria that is symbiotic with Stenotrophomonas rhizophila N6 to jointly promote carbonate dissolution is a research focus. Therefore, future studies should identify the core species that drive the restoration of degraded habitats, and explore the relationship between the isolated and culturable CA dominant bacteria and the core species. These study focuses will promote the research and development of biological fertilizer for the rapid restoration of degraded karst habitats. [ABSTRACT FROM AUTHOR]

The stigma associated with functional neurological disorder (FND) is greater than that associated with other neurological conditions, seriously affecting the quality of life of patients and increasing the burden on caregivers. This article reviews the concept, the current situation and harms, the influence factors and intervention strategies of FND stigma. The aim is to further develop our country as a reference for the study of stigma in FND.

BackgroundAgitated behaviour in male patients with schizophrenia can lead to serious consequences for the individual and the society. Non-invasive drug delivery may help to rapidly control agitation and improve the overall patient satisfaction， but there are limited studies on the efficacy of olanzapine oral soluble film for the treatment of agitated behaviour in patients with schizophrenia.ObjectiveTo compare the efficacy and safety profile of olanzapine oral soluble film versus intramuscular haloperidol against agitated behaviour in male patients with schizophrenia， so as to provide a reference for the treatment of agitated behaviour.MethodsFrom May 2022 to July 2023， a consecutive sample of schizophrenic patients （n=44） with agitated behaviour who met the Diagnostic and Statistical Manual of Mental Disorders， fifth edition （DSM-5） were recruited in the male psychiatric closed ward of the Third People's Hospital of Fuyang. Patients were assigned into two groups using the random number table method， each with 22 cases. Study group was treated with olanzapine oral soluble film 10 mg/d， while control group was given intramuscular haloperidol 8 mg/d. The severity of agitated behaviour was determined using Positive and Negative Syndrome Scale-Excited Component （PANSS-EC） and Agitation Calmness Evaluation Scale （ACES） at the baseline and after 6 h of drug administration. The treatment response rate was calculated based on the reduction of PANSS-EC score， and the drug side effects were assessed using Rating Scale for Extrapyramidal Side Effects （RSESE） and Barnes Akathisia Rating Scale （BARS） after 6 h of drug administration.ResultsAfter 6 h of drug administration， no statistical difference was reported in PANSS-EC score and ACES score between two groups （F=0.039， 0.082， P>0.05）， and the treatment response rate yielded no statistical difference between two groups （χ2=0.419， P=0.517）， while study group reported a lower incidence rate of adverse reactions compared with control group， with statistically significant difference （P=0.031）. BARS scores noted no statistical significant difference between two groups （t=0.587， P=0.561）， whereas study group scored lower on RSES compared to control group， with a statistical difference （t=-7.367， P

Objective To understand the perception of the training process of specialized nurses in Traditional Chinese Medicine (TCM) nursing, and to provide ideas and basis for optimizing the training mode of TCM nursing personnel. Methods Objective sampling method was used to conduct semi-structured in-depth interviews with 22 nurses who participated in the training of TCM nurses in Jiangsu Province from August to October 2023, and the interview data were integrated and analyzed by Colaizzi seven-step analysis method. Results Three themes were extracted: the relationship between emotional change and course progress, perceived differences in professional competence, and the dilemma of application and popularization of appropriate technology of TCM nursing. Conclusion Scientific and reasonable training program can improve nurses' skills of TCM nursing and relieve the pressure during training. Personalized teaching according to the needs of nurses and help them to assess their own professional ability will help to improve nurses' professional identity of TCM nursing level and promote the promotion of appropriate techniques of TCM nursing to a certain extent. (目的 了解中医护理专业化护士培训过程的感知情况, 为优化中医护理人才培养模式提供思路和依据。方法 采用目的抽样法, 对2023年8月—10月参加江苏省中医护理专业化护士培训的22名护士进行半结构式深入访谈, 运用Colaizzi七步分析法对访谈资料进行整合与分析。结果 共提炼出3个主题: 情绪转变与培训进度间的联系, 专业能力的感知差异, 中医护理适宜技术应用和推广的困境。结论 科学合理的培训方案能提高护士的中医护理技能, 缓解培训期间的压力。根据护士的需求进行个性化教学, 帮助其进行自我专业能力的评估, 有助于提升护士的中医护理水平职业认同, 在一定程度上促进中医护理适宜技术的推广。)

Objective To investigate the role of PSMA4 in the prognosis, diagnosis and immune infiltration of lung adenocarcinoma (LUAD), and explore its underlying mechanism. Methods The expression profiles and clinical data of LUAD patients were sourced from the Cancer Genome Atlas (TCGA) database. The expression level of PSMA4 in LUAD tissues (n=539) and normal tissues (n=59) were compared using the Wilcoxon rank-sum test. The expression levels of PSMA4 in LUAD tissues and normal tissues were validated by analyzing the GSE40791 and GSE10072 LUAD datasets obtained from the Gene Expression Omnibus (GEO) database. In addition, tumor and adjacent non-cancerous tissues were collected from 10 LUAD undergoing lung biopsy by fiberoptic bronchoscopy in Second Affiliated Hospital of Army Medical University from January to December 2023. The PSMA4 expression in above samples was further verified using RT-qPCR. RT-qPCR was performed to detect the expression of PSMA4 in lung cancer cells and normal lung epithelial cells. Functional enrichment analysis and immune cell infiltration analysis were conducted on the cells with high and low expression of PSMA4. Cox regression analysis and Kaplan-Meier (KM) survival analysis were used to determine the diagnostic and prognostic value of PSMA4 for LUAD, and a nomogram was constructed to predict the overall survival rate at different time points. Results The analysis of TCGA datasets, GSE40791, and GSE10072 LUAD data revealed that PSMA4 expression was significantly higher in LUAD tissues than in normal tissues (P < 0.01). RT-qPCR further confirmed that the expression of PSMA4 was obviously elevated in LUAD tissues and lung cancer cells than adjacent non-cancerous tissues and normal lung epithelial cells (P < 0.01). High PSMA4 expression could be regarded as a marker for LUAD diagnosis and poor prognosis, and was associated with reduced proportions of Tem cells, TFH cells, B cells, NK cells, Tcm cells, and mast cells in the tumor microenvironment. Conclusion PSMA4 presents significant diagnostic performance for LUAD, and is closely associated with the prognosis and immune infiltration of this malignancy.

Objective At present, there are relatively few studies on the safety assessment of maintenance and construction of urban rail transit operation lines. In order to reduce the operation safety risk of urban rail transit lines, the safety level of urban rail transit line maintenance construction should be comprehensively evaluated to guide the operation production and management. Method Targeting the 19 maintenance work areas on 4 lines in Shanghai rail transit network, a 4 hierarchy-structured safety effectiveness evaluation index system for urban rail transit line maintenance and construction is established. Based on the actual situation of line maintenance construction indexes, the entropy weight method is improved and combined with the mutation progression theory, and a linear combination evaluation method based on improved entropy weight and mutation progression is proposed as the result. The safety effectiveness of maintenance construction in 19 mainten-ance work areas is evaluated and analyzed with this method. Result & Conclusion The linear combination evaluation method based on improved entropy weight-mutation level passes the consistency test, and the evaluation results are stable and reliable. This method effectively expands the applicability of entropy weight method and mutation level theory in the evaluation of urban rail transit maintenance construction, and realizes the dynamic comprehensive evaluation in the field of rail transit line maintenance construction.

In order to explore the dissolution effect and properties of tobacco leaf and tobacco stem particles, and to achieve the maximum retention of effective substances in the production of paper-making process reconstituted tobacco, the effects of dissolution conditions on the dissolution effect of tobacco leaf and tobacco stem particles were investigated, and the changes of components, thermal weight loss behavior, and aroma components of tobacco leaf and tobacco stem particles before and after dissolution were compared and analyzed. The results showed that under the conditions of 40~80 mesh, 0~10 min, 20~40 °C, and low addition ratio, the dissolution rate of particles was the fastest. The components of water-soluble sugars, total alkaloids, and chlorine of tobacco leaves and stalk particles showed a decreasing trend after dissolution, which deceased with the increasing dissolution time. In addition, there were some differences in the amount of each dissolved component. Before and after dissolution, the tobacco leaf and tobacco stem particles experienced four and five weightlessness stages with close temperature range, and the temperature range of the second stage of tobacco leaf roughly included the second and third stages of tobacco stem particles, and the residual mass of each stage was lower than that of tobacco stem, and the components and thermal decomposition process of tobacco stem were more complex than that of tobacco leaf. 69 and 71 kinds of aroma components were retrieved from tobacco leaf and tobacco stem particles before and after dissolution, respectively, and the total amount of aroma components in tobacco leaf particles was higher than that in tobacco stem particles. The most aroma components in tobacco leaf and tobacco stem particles were ketones, followed by aldehydes, alcohols, heterocycles, acids, and esters, while phenols were the least. The dissolution rate of each type of aroma components was also different. [ABSTRACT FROM AUTHOR]

Objective The AC-DC (alternating current-direct current) dual-power traction power supply system depot features densely distributed tracks and relatively close catenary clearance. Different power supply modes can affect the distribution of electromagnetic fields in depot spatially. Therefore, it is necessary to analyze the electromagnetic field of rail transit depot dual-power traction power supply systems under AC-DC switching power supply mode. Method Taking the Shuangfu Depot on Tiaodeng-Jiangjin Line of Chongqing City Railway as the basis, a simulation model of depot AC-DC dual-power traction power supply system is constructed using CDEGS software, and the characteristics of spatial electric and electromagnetic field intensity distribution in the depot under different operating conditions are analyzed. Regarding the abnormal voltage phenomenon on catenary in depot garages, the impact of electromagnetic field spatial distribution in dual-power traction power supply system depot on the induction voltage of catenary is comprehensively evaluated, and corresponding suppression measures are proposed. Result & Conclusion Under both AC and DC power supply modes, the spatial electric field of catenary is symmetrically distributed around the charged conductors in general, but the spatial magnetic field is not entirely symmetrically distributed. The more charged conductors there are, the greater intensity of spatial electric and electromagnetic fields. Under AC power supply mode, the magnitude of static induction voltage of surrounding conductors is related to the spacing between conductors and the voltage. Electromagnetic induction voltage is proportional to current. When using DC power supply mode, the conductor static induction voltage under various working conditions all exceeds the human safety limit of 36 V.