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The majority of diagnosed cases of gastric cancer are in the middle and late stages, while less than 10% of patients are diagnosed in the early stages in China. The standard treatment strategy for patients with progressive gastric cancer is surgery combined with postoperative adjuvant therapy or preoperative neoadjuvant followed by surgery combined with postoperative adjuvant therapy. Immunotherapy is now recognized as an innovative approach for cancers. It is worth exploring how to best use immunotherapy in neoadjuvant therapy to achieve better clinical benefit. Therefore, this paper reviews the progress of immunotherapy in neoadjuvant therapy for GC. Further studies and the understanding of immune system function by neoadjuvant therapy combined with immunotherapy will help to improve the treatment of gastric cancer.

In order to find out the influence of water immersion and air drying process on the macroscopic characteristics and microstructure changes of coal spontaneous combustion, the low-temperature oxidation characteristics of non-caking raw coal and long-term soaked and air-dried coal were experimentally studied, and the effects of soaking time and particle size on the gas generation and activation energy of coal during the oxidation heating process were analyzed. As an explanation in support of the influence of water immersion on the spontaneous combustion and oxidation characteristics of coal, the variation of relative content of oxygen-containing functional groups and the mechanism of gas generation were analyzed. The results indicated that CO and CO2 are the main components of the gas generated by coal oxidation reaction. Compared with raw coal, the gas production of coal samples after 90 days and 180 days soaking and air-drying is higher in the process of oxidation heating. In the accelerated oxidation stage, the activation energy decreased by 2.72 kJ/mol and 35.74 kJ/mol, respectively, which indicates that the coal sample after long-term soaking has a higher spontaneous combustion tendency than that after short-term soaking. Water plays a promoting role in the formation of oxygen-containing complexes, resulting in the relative content of oxygen-containing functional groups in soaked coal being higher than that of raw coal. Meanwhile, -COOH and C=O are the main sources of CO2 and CO respectively, which could explain the phenomenon of higher concentration of CO2 and CO produced by soaked coal than that by raw coal.

The self-made thread root rolling strengthening device based on common lathe CA6140 was used to perform rolling strengthening process on 45 steel thread samples. The surface integrity parameters such as surface roughness, surface microhardness, residual stress and surface microstructure of thread root after rolling were measured by using three-dimensional topography measurement instrument, microhardness tester, X-ray residual stress detector and ultra-depth of field microscope. The effect of rolling strengthening parameters on the surface integrity of thread root was investigated by single factor test. After the 45 steel thread sample underwent the rolling strengthening process, the surface roughness Sa of the thread root is reduced from 1.71 μm to 0.874 μm; the thread root forms an obvious grain refinement layer with a depth of 120 μm; the microhardness increases from 199.3 HV to 379.5 HV, and the hardening degree N=90.4%; the residual stress of the surface layer is distributed in a spoon shape, and the residual stress reaches a peak value of-542 MPa at 105 μm from the surface, and the depth of the residual compressive stress layer can reach 700 μm. The results show that the rolling strengthening process can significantly improve the surface integrity of the thread root, and the rolling depth has the most significant effect.