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For reduce the carbon emissions of grain transportation, improve ment the efficiency of grain transportation and ensurance the safety of grain transportation, this paper constructed a location-routing optimization model of grain transshipment hub driven by low carbon according to the perspective of quantitative analysis. An improved genetic algorithm was designed to solve the model, which could improve and optimize the layout of China's existing grain transportation network. Finally, some provincial capital cities on the key line of grain logistics were selected for analysis and verification. The results showed that The model and algorithm of hub node sitting-route optimization in hub-spoke multimodal transport network could reduce the total grain transportation cost by 13.87%. Carbon emissions were reduced by 11.70%, and the average transfer saturation of hubs was increased by 9.66%. This method was suitable for the actual grain transportation process, and can realize the low-carbon and efficient transportation of grain, which could provide reference for the location and path planning of Chinese grain transport hub under low-carbon drive.

The weight-loading swimming assay, liver glycogen and serum urea nitrogen tests in mice were used to evaluate the alleviating physical fatigue effects of Lijiang and Peru Maca. The mouse mating assay, sperm quantity, survival rate and gonadal organ index tests were used to observe the improving sexual function between them. The acute toxicity test was used to evaluate the safety of two samples. The result showed that compared with the blank control group, Lijiang and Peru Maca can significantly increase the swimming time and the level of liver glycogen, as well as reduce the level of urea nitrogen in mice. Compared with the blank control group, Lijiang and Peru Maca can obviously improve the mating ability, sperm quantity and testis index in mice, but it has no obvious effect on sperm viability, seminal vesicles and Foreskin gland index. Compared with the Peru Maca group, there was no significant difference in the activity of anti-fatigue and improving sexual function. The acute toxicity test showed that the maximum dose of Lijiang and Peru Maca was 17.48g/kg. There was no toxicity or death after administration.

Objective: Excessive daytime sleepiness (EDS) is associated with cardiovascular events in patients with obstructive sleep apnea (OSA). Our study explored the correlation between objective daytime sleepiness assessed with daytime multiple sleep latency tests (MSLT) and heart rate variability (HRV) in OSA patients. The results may provide insight into possible mechanisms underlying increased risk of cardiovascular events in patients with OSA., Methods: A retrospective analysis was conducted with the data of 139 patients with OSA and 35 patients with primary snoring. All subjects underwent polysomnography (PSG) and MSLT at West China Hospital between January 2019 and May 2022. We used mean sleep latency (MSL) to measure the severity of EDS and to categorize OSA patients into three groups, severe EDS, light EDS, and non-EDS, with MSL of less than 5 minutes, 5 to 10 minutes, and greater than 10 minutes as the respective defining criteria for classification. A comparison of sleep structure, clinical characteristics, and HRV parameters was performed in order to evaluate the difference between OSA subgroups with varying levels of objective EDS and the primary snoring group. In addition, we also analyzed the correlation between MSL and HRV parameters., Results: Severe EDS patients had higher values of standard deviation of all N-N intervals (SDNN), total spectral power (TOT), and low-frequency power (LF) as compared to non-EDS patients, which was indicative of sympathetic stimulation ( P <0.05). Additionally, high-frequency power (HF) was also higher in severe EDS patients, which indicated decreased parasympathetic drive. A significantly positive correlation was found between MSL and the values of SDNN, TOT, LF, and HF in OSA patients., Conclusion: OSA patients with objective EDS have elevated sympathetic drive and decreased parasympathetic drive. A positive correlation was found between this change in neural activity and the shortening of MSL., (Copyright© by Editorial Board of Journal of Sichuan University (Medical Sciences).)