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Finding natural antioxidants for reparing skin photoaging is one of the research focuses at present. Poly-γ-glutamic acid (γ-PGA) is a natural polymer material prepared by microbial fermentation. γ-PGA has the ability of scavenging free radicals, but the relationship between the antioxidative effect, skin photoaging effect and molecular weight of γ-PGA has not been clarified in this paper, the scavenging ability of γ-PGA with different molecular weights on superoxide anion free radical, hydroxyl free radical and DPPH free radical was investigated. γ-PGA with different molecular weights exhibited scavenging activity on the above three free radicals with the scavenging rate of 31. 36%, 97.55% and 74.64%, respectively. In addition, by constructing ultraviolet-induced photoaging models in L929, γ-PGA with different molecular weights could repair photoaging cell damage and reduce ROS, NO in photoaging cells. γ-PGA with molecular weight 3.0x10 γ-PGA had the best effect in repairing photoaging cell damage. [ABSTRACT FROM AUTHOR]