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Crohn's disease (CD) is a chronic inflammatory bowel disease with complicated pathogenesis and prolonged condition. In recent years, with the development of targeted therapy, biological agents have been widely used in the treatment of CD, which has significantly improved the prognosis of CD patients. If the efficacy evaluation can be carried out at the early stage of targeted therapy, it may help to figure out the patients who can benefit from the treatment and optimize the treatment plan for the ineffective patients in time. In the evaluation of CD activity and efficacy, ultrasound has the advantages of high accuracy, no radiation and high patient acceptance, and therefore has potential clinical application value in the early efficacy evaluation of CD targeted therapy. This article reviews the research progress to provides a reference for optimizing the treatment plan for CD patients.

Crohn's disease(CD)is a kind of inflammatory bowel disease, and its incidence rate is increasing year by year. Mesenteric creeping fat, a special sign of CD closely related to its intestinal inflammation and stenosis, has become a research hotspot in recent years. The formation mechanism of mesenteric creeping fat may be related to the migration of adipocytes and the translocation of intestinal microbiota. MRI, CT and US are commonly used imaging evaluation methods for CD, which can show the sign of creeping fat and evaluate the inflammation of intestinal wall and intestinal stenosis. However, the relationship between mesenteric creeping fat and inflammatory activity, stenosis and prognosis of CD needs to be further studied. The purpose of this review is to introduce the pathogenesis and clinical significance of mesenteric creeping fat, as well as the evaluation indicators of different imaging methods, and to further explore the relationship between mesenteric creeping fat and CD inflammatory activity and stenosis.

Breast cancer, as the most common malignant tumor in women worldwide, has become the focus of global attention. Axillary lymph node tumor burden is an important prognostic indicator of it. Ultrasound is the most commonly used imaging method, but its sensitivity is not high, especially for the diagnosis of small and micro lymph node metastasis. In recent years, the emerging Radiomics in machine learning field has been widely used in the field of medical imaging. Because it can extract high-level information of images that is difficult to be recognized by human eyes, it has been used to establish clinical prediction models. This paper introduced the value of preoperative sonography, sketched Radiomics, and summarized the research progress of this method in predicting lymph node metastasis of breast cancer. This new method is expected to provide a reliable basis for individualized and accurate diagnosis and treatment of breast cancer.

Breast cancer is the most common malignant tumor in Chinese women. Early diagnosis, treatment, and prognosis assessment are important clinical problems to be solved. Radiomics is a non-invasive method for high-throughput extraction and analysis of lesion features of images to provide more potential information of tumors, and guide precise diagnosis and treatment. Recently, it has been widely concerned and studied in breast cancer, covering every stage in the care of patients with breast cancer. In terms of diagnosis, the research has reached the level of maturity and gradually proceeded to the clinical setting. Regarding efficacy evaluation and prognostic prediction, although in its infancy, radiomics shows promising potential. This paper mainly reviews the application of radiomics in the diagnosis, response evaluation, and prognosis prediction of breast cancer.

The effects of copper tailings sand on the workability, compressive and flexural strength, elastic modulus, shrinkage property, chloride penetration resistance, pore structure and micro-structure of high strength cement grouts were studied by replacing nature sand with different amount of copper tailings sand. The obtained results showed that the higher replacement ratio of copper tailings sand in cement grouts, the lower the fluidity, the higher compressive and flexure strength, as well as the higher elastic modulus of cement grouts. When the replacement ratio of copper tailings sand was 10%, it had little effect on the shrinkage performance of the grouts. However, when the replacement ratio of copper tailings sand increased to more than 20%, the shrinkage property of the grouting material had been significantly improved, as shown bya significant increase in the volume expansion rate. Copper tailings sand could improve the structure of interfacial transition zone and the compactness of the matrix of cement grouts, therefore reduce the porosity of grouts and refine its pore size as well. The proportions of detrimental pore and much detrimental pore were reduced and the chloride ion permeability resistance of cement grouts were also improved. [ABSTRACT FROM AUTHOR]

To solve the problems of easy pilling and static electricity of wool and ordinary polyester blended fabrics, double-resistant polyester and wool with relatively low strength and good antistatic properties were selected for blending and spinning. The results show that the wool and double-resistant polyester dyeing and recombing dyeing process, over washing process and blended spinning process were optimized, double dyeing of polyester and wool strips were achieved, the dyeing residual oligomers of double resistant polyester was reduced, and the phenomenon of fly spinning around blended yarns was improved. Therefore, not only the problem of pilling and static electricity of the fabric is solved, but also the spinning and weaving production due to the low strength of the fiber is not affected, and the development and application of double-resistant polyester in worsted woolen products is expanded. [ABSTRACT FROM AUTHOR]

In order to improve the covering effect and the quality of elastic core-spun yarns, Siro spinning technology was used to spin cotton/spandex core-spun yarns. Aiming at the problem of yarn defects such as partial yarn and non-wire in the production process of core-spun yarn, the types and hazards of the unique yarn defects of Siro-spun cotton/spandex core-spun yarn were introduced, and the main causes of yarn defects such as partial wire, no wire, bare wire, uneven elasticity and cut yarn were analyzed. Starting with raw materials, processes, equipment, etc., measures were taken to prevent and eliminate yarn defects, such as the selection of high-quality raw materials of cotton and spandex, optimization of roving and spun yarn processes, strict control of winding process indicators, strengthening of periodic maintenance of key components of the equipment, and strict control of operation management. Practice shows that through reasonable selection of raw materials, optimization of process parameters, strengthening of fine equipment management and strict control of daily operation management, the problems of partial thread breakage of core-spun yarn due to poor coating effect can be better solved, which improves the quality of Siro spunning cotton/spandex core-spun yarn. [ABSTRACT FROM AUTHOR]

Objective To explore the protective mechanism of geraninn on acute lung injury (ALI) induced by lipopolysaccharide (LPS) in mice. Methods Forty-eight BALB/c mice (female, 4 weeks old, 18~22 g) were randomly divided into 6 groups (n=8): the blank group(control group), the LPS group, the dexamethasone group (Dex group, 2mg/kg), the geraninn low dose group (LD group, 10 mg/kg), the geraninn medium dose group (MD gruop, 20 mg/kg) and the geraninn high dose group (HD group, 40 mg/kg). The mice in blank group and LPS group were fed with normal saline, the mice in the Dex group were fed with dexamethasone and the mice in geraniin groups were given corresponding dose of drugs. Normal saline and all tested drugs were given once a day for 3 d. In 1 h later after the last administration, the acute lung injury model was established by using intranasal drip of LPS (4 mg/kg) in all groups except the blank group. In 6 h after modeling, the wet-to-dry (W/D) weight ratio of the lung tissues of mice in each group was collected. The pathological changes of lung tissue were observed by HE staining, and the number of inflammatory cells in broncho alveolar lavage fluid (BALF) and blood was measured; The levels of interleukin-6 (IL-6), interleukin-1β and tumor necrosis factor α (TNF-α) in plasma and BALF were detected by ELISA. The amount of p-NF-κBp65 was detected by immunohistochemical method. Results Compared with the blank group, the alveolar structure in LPS group was destroyed, inflammatory cell infiltrated, and the contents of IL-6, IL-1β and TNF-α in serum and BALF in the LPS group increased; The W/D weight ratio of the lung tissues, the number of macrophages and neutrophils in BALF and serum, the relative expression of p-NF-κBp65 in lung tissue also increased(P < 0.01). Compared with the LPS group, pathological state of the lung tissues improved obviously among the groups (except the blank group); The contents of IL-6, IL-1β, TNF-α in the serum and BALF, the W/D ratio of the lung tissues, the numbers of macrophages and neutrophils in BALF and the relative expression of p-NF-κBp65 of the lung tissue decreased evidently(P < 0.05). Conclusion Geraninn has a protective effect on acute lung injury in mice, and its mechanism may be related to the effect that geraninn leads to repression of p-NF-κB p65 and reduces the expression of inflammatory factors (IL-6, IL-1β and TNF-α).