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Microglia are resident immune cells in the central nervous system(CNS), it play an important role in both physiological and pathological conditions of the CNS, and can be activated by a variety of physicochemical factors to produce pro-inflammatory phenotype (M1 type) and anti-inflammatory phenotype (M2 type). Milk fat globule epidermal growth factor 8(MFG-E8) is closely related to the biological function of microglia, which can regulate microglia neuroprotective effects such as promoting phagocytosis, anti-inflammatory, and inhibiting oxidative stress in CNS related diseases. It also regulates microglia pro-tumor effect, which in turn affects the outcome of the disease. This article reviews the role of targeting MFG-E8 in regulating the function of microglia, and provides a basis for finding therapeutic targets for CNS related diseases in the future. [ABSTRACT FROM AUTHOR]

Most salt lakes of Chaidamu circular economy pilot area in Qinghai Province are chloride-type lakes, and many chlorine-contained by-products will be formed during the developing process. How to utilize and transform these by-products has an important significance for the chlorine balance in industry chain of salt lake area. The industrial metabolism process of chlorine element is analyzed from the main planed products in Chaidamu circular economy pilot area master plan. Two main problems that affect the utilization of chlorine element are chlorine element balance and potential pollution to the salt lake caused by calcium chloride. Three transforming and converting approaches are put forward, which are immobilization process that converts chlorine to solid products, transformation process that transforms chlorine to organic products and clean storage of calcium chlorine. If the above approaches can be put into practice, the balance of chlorine element will be achieved in the pilot area. [ABSTRACT FROM AUTHOR]

Objective: To compare the efficacy differences between manual acupuncture (MA) and electroacupuncture (EA) in the treatment of hemiplegia after acute ischemic stroke., Methods: Sixty-eight patients of hemiplegia after acute ischemic stroke were randomized into a MA group (34 cases) and an EA group (34 cases). The routine western medication and bilateral Dingnieqianxiexian (MS 6) were adopted in the two groups. The needles were retained for 30 min. In the MA group, the even-needling technique was used for 3 times during the needle retaining, 1 min each time. In the EA group, on the basis of manual stimulation, EA therapy was added, with disperse-dense wave, 5 Hz/20 Hz. The treatment was given once every day, 6 treatments a week, totally for 2 weeks. US National Institutes of Health stroke scale (NIHSS) score, the simplified Fugl-Meyer motor function (FMA) score and Barthel index (BI) were observed before and after treatment in the two groups. The clinical efficacy was compared between the two groups., Results: NIHSS score was reduced apparently after treatment in the two groups (both P <0.01). The score in the EA group was lower than that in the MA group ( P <0.05). After treatment, FMA score and BI score were all increased apparently in the two groups (all P <0.01) and the scores in the EA group were higher than those in the MA group (both P <0.01). The total effective rate was 94.1% (32/34) in the EA group and was 85.3% (29/34) in the MA group. The efficacy in the EA group was better than that in the MA group ( P <0.05)., Conclusions: EA acts on the rehabilitative effect on nerve defect function in the patients of hemiplegia after acute ischemic stroke. It improves limb motor function and the ability ofdaily life activity. The efficacy is better than that of MA.