23 results on '"Yu GD"'
Search Results
2. [Incidence and prognosis of olfactory and gustatory dysfunctions related to infection of SARS-CoV-2 Omicron strain: a national multi-center survey of 35 566 population].
- Author
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Liu MF, Ma RX, Cao XB, Zhang H, Zhou SH, Jiang WH, Jiang Y, Sun JW, Yang QT, Li XZ, Sun YN, Shi L, Wang M, Song XC, Chen FQ, Zhang XS, Wei HQ, Yu SQ, Zhu DD, Ba L, Cao ZW, Xiao XP, Wei X, Lin ZH, Chen FH, Shan CG, Wang GK, Ye J, Qu SH, Zhao CQ, Wang ZL, Li HB, Liu F, Cui XB, Ye SN, Liu Z, Xu Y, Cai X, Hang W, Zhang RX, Zhao YL, Yu GD, Shi GG, Lu MP, Shen Y, Zhao YT, Pei JH, Xie SB, Yu LG, Liu YH, Gu SS, Yang YC, Cheng L, and Liu JF
- Subjects
- Female, Humans, Adolescent, SARS-CoV-2, Smell, Cross-Sectional Studies, COVID-19 Vaccines, Incidence, Taste Disorders epidemiology, Taste Disorders etiology, Prognosis, COVID-19 complications, Olfaction Disorders epidemiology, Olfaction Disorders etiology
- Abstract
Objective: This cross-sectional investigation aimed to determine the incidence, clinical characteristics, prognosis, and related risk factors of olfactory and gustatory dysfunctions related to infection with the SARS-CoV-2 Omicron strain in mainland China. Methods: Data of patients with SARS-CoV-2 from December 28, 2022, to February 21, 2023, were collected through online and offline questionnaires from 45 tertiary hospitals and one center for disease control and prevention in mainland China. The questionnaire included demographic information, previous health history, smoking and alcohol drinking, SARS-CoV-2 vaccination, olfactory and gustatory function before and after infection, other symptoms after infection, as well as the duration and improvement of olfactory and gustatory dysfunction. The self-reported olfactory and gustatory functions of patients were evaluated using the Olfactory VAS scale and Gustatory VAS scale. Results: A total of 35 566 valid questionnaires were obtained, revealing a high incidence of olfactory and taste dysfunctions related to infection with the SARS-CoV-2 Omicron strain (67.75%). Females(χ2=367.013, P <0.001) and young people(χ2=120.210, P <0.001) were more likely to develop these dysfunctions. Gender( OR =1.564, 95% CI : 1.487-1.645), SARS-CoV-2 vaccination status ( OR =1.334, 95% CI : 1.164-1.530), oral health status ( OR =0.881, 95% CI : 0.839-0.926), smoking history ( OR =1.152, 95% CI =1.080-1.229), and drinking history ( OR =0.854, 95% CI : 0.785-0.928) were correlated with the occurrence of olfactory and taste dysfunctions related to SARS-CoV-2(above P <0.001). 44.62% (4 391/9 840) of the patients who had not recovered their sense of smell and taste also suffered from nasal congestion, runny nose, and 32.62% (3 210/9 840) suffered from dry mouth and sore throat. The improvement of olfactory and taste functions was correlated with the persistence of accompanying symptoms(χ2=10.873, P =0.001). The average score of olfactory and taste VAS scale was 8.41 and 8.51 respectively before SARS-CoV-2 infection, but decreased to3.69 and 4.29 respectively after SARS-CoV-2 infection, and recovered to 5.83and 6.55 respectively at the time of the survey. The median duration of olfactory and gustatory dysfunctions was 15 days and 12 days, respectively, with 0.5% (121/24 096) of patients experiencing these dysfunctions for more than 28 days. The overall self-reported improvement rate of smell and taste dysfunctions was 59.16% (14 256/24 096). Gender( OR =0.893, 95% CI : 0.839-0.951), SARS-CoV-2 vaccination status ( OR =1.334, 95%CI: 1.164-1.530), history of head and facial trauma( OR =1.180, 95% CI : 1.036-1.344, P =0.013), nose ( OR =1.104, 95% CI : 1.042-1.171, P =0.001) and oral ( OR =1.162, 95% CI : 1.096-1.233) health status, smoking history( OR =0.765, 95% CI : 0.709-0.825), and the persistence of accompanying symptoms ( OR =0.359, 95% CI : 0.332-0.388) were correlated with the recovery of olfactory and taste dysfunctions related to SARS-CoV-2 (above P <0.001 except for the indicated values). Conclusion: The incidence of olfactory and taste dysfunctions related to infection with the SARS-CoV-2 Omicron strain is high in mainland China, with females and young people more likely to develop these dysfunctions. Active and effective intervention measures may be required for cases that persist for a long time. The recovery of olfactory and taste functions is influenced by several factors, including gender, SARS-CoV-2 vaccination status, history of head and facial trauma, nasal and oral health status, smoking history, and persistence of accompanying symptoms.
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- 2023
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3. [Expression of pepsin in nasopharyngeal carcinoma and its correlation with quality of life after radiotherapy].
- Author
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Zhang T, Yu GD, Jin FW, Zhou J, Tang ZP, Xian ZM, and Wu Z
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Nasopharyngeal Carcinoma radiotherapy, Quality of Life, Saliva chemistry, Nasopharyngeal Neoplasms pathology, Nasopharyngeal Neoplasms radiotherapy, Pepsin A analysis
- Abstract
Objective: By analyzing the expression of pepsin in nasopharyngeal carcinoma (NPC) tissues, to investigate the correlation between laryngeal reflux (LPR) and NPC, as well as the effect of LPR on the quality of life of patients with NPC after radiotherapy. Methods: A total of 133 patients with NPC who underwent radiotherapy at the Department of Otorhinolaryngology of the Affiliated Hospital of Guizhou Medical University and the Affiliated Cancer Hospital of Guizhou Medical University from 2005 to 2019 were enrolled consecutively, including 90 males and 43 females, aged (44.32±7.47) years old. At the same period, 58 patients with chronic nasopharyngitis who underwent nasopharyngeal biopsy were selected as the control group. Immunohistochemical method was used to detect the expression of pepsin in nasopharyngeal specimens of the two groups. In addition, 188 normal individuals were selected as the normal group in the same period. NPC patients before and within 6 months after radiotherapy were inverstigated by the General Information Questionnaire and the Quality of Life Scale, and the pepsin levels in saliva of NPC patients before and after radiotherapy and the individuals in normal group were measured. SPSS 21.0 software was used for statistical analysis. Results: Pepsin expression in 133 specimens of NPC patients was strongly positive in 24 cases (18.05%), positive in 21 cases (15.79%), weakly positive in 69 cases (51.88%), and negative in 19 cases (14.29%). The specimens of control group had 10 cases of weakly positive (17.24%), 48 cases of negative (82.76%), but no strong positive or positive pepsin expression. The rate of positive pepsin expression in the NPC group was higher than that in the control group, with a statistically significant (χ
2 =83.15, P< 0.001). The pepsin content in the saliva of NPC patients after radiotherapy ((30.31±7.82) ng/ml) was higher than that before radiotherapy ((20.47±8.21) ng/ml) and the normal group (5.11±2.13) ng/ml), and the pepsin content in saliva before radiotherapy was higher than that in the normal group, and all differences were statistically significant (all P< 0.05). After radiotherapy, the five functional domains of quality of life and overall quality of life of NPC patients decreased, while the related symptom scores increased (all P< 0.05). Multiple linear regression analysis showed that pepsin content in saliva was the influential factor of five functional domains of quality of life, related symptoms and overall quality of life in NPC patients after radiotherapy (all P< 0.05). Conclusion: The positive rate of pepsin expression in NPC tissues is high, and the pepsin in saliva before and after radiotherapy of NPC patients is significantly higher than that in normal, suggesting that LPR may be involved in the process of NPC and affect the quality of life after radiotherapy in NPC patients.- Published
- 2022
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4. [Analysis of differences and influencing factors of liver injury associated with different strains of 2019-nCoV infection].
- Author
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Yu GD, Lian JS, Ye CY, Ding F, Lu YF, Hao SR, Yu J, and Yang YD
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- Critical Illness, Dyspnea, Fever, Humans, Liver, Male, Pain, Retrospective Studies, SARS-CoV-2, COVID-19
- Abstract
Objective: To analyze whether there are differences and related influencing factors in liver injury associated with different strains of 2019-nCoV/SARS-CoV-2 infection. Methods: Data of epidemiology, clinical symptoms, laboratory tests, and treatment outcomes of patients with COVID-19 infection confirmed with Alpha and Delta virus strain in Zhejiang Province were retrospectively collected. Statistical analysis was performed using independent samples t-test or Mann-Whitney U test, χ
2 test or Fisher's exact test, and logistic regression analysis. Results: A total of 788 and 381 cases with Alpha and Delta virus strain were included. Vaccination ratio was 0% in Alpha and 85.30% in Delta group ( P <0.001), The proportion of patients with fever (80.71% vs . 40.94%, P <0.001) was significantly higher in Alpha than Delta strain group. The proportion of critical ill patients was significantly higher in Delta group (9.90% vs . 1.57%, respectively, P <0.001). The virus negative conversion time was significantly longer in Delta than Alpha group (22 d vs. 11 d, P <0.001), but the incidence of liver injury was significantly higher in Alpha than Delta group (20.05% vs . 13.91%, P =0.011). Univariate analysis showed that Alpha virus strain infection, male sex, body mass index, chronic liver disease, fever, diarrhea, shortness of breath, severe/critical illness, elevated creatine kinase (CK), elevated international normalized ratio (INR) and an elevated neutrophil/lymphocyte ratio was significantly associated with an increased risk of liver injury occurrence, and in patients with pharyngeal pain the risk of liver injury occurrence was significantly reduced. Multivariate analysis showed that shortness of breath [ OR , 2.667 ( CI : 1.389-5.122); P =0.003], increased CK [ OR , 2.544 ( CI : 1.414-4.576); P =0.002] and increased INR [OR, 1.721] ( CI : 1.074-2.758); P =0.024] was significantly associated with an increased risk of liver injury occurrence, and in patients with pharyngeal pain the risk of liver injury occurrence was significantly reduced [ OR , 0.424 ( CI : 0.254-0.709); P =0.001]. Conclusion: Although the virulence of the Delta is stronger than Alpha strain, most patients infected with Delta strain vaccinated against COVID-19 in Zhejiang province had milder clinical symptoms and a lower incidence and degree of liver injury. Notably, the infection risk even remains after vaccination; however, symptoms and the incidence of severe and critical illness can be significantly reduced.- Published
- 2022
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5. [Effects of NLRP3-mediated pyroptosis on olfaction dysfunction in allergic rhinitis].
- Author
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Zhou FW, Zhang T, Jin Y, Ma YF, Xian ZP, Wu ZM, and Yu GD
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- Animals, Caspases pharmacology, Caspases therapeutic use, Disease Models, Animal, Humans, Inflammasomes metabolism, Inflammasomes pharmacology, Inflammasomes therapeutic use, Mice, NLR Family, Pyrin Domain-Containing 3 Protein genetics, NLR Family, Pyrin Domain-Containing 3 Protein metabolism, Ovalbumin, Smell, Pyroptosis, Rhinitis, Allergic drug therapy
- Abstract
Objective: To explore the relationship between NLRP3-mediated pyroptosis and olfactory dysfunction (OD) in allergic rhinitis (AR), and to evaluate the therapeutic potential of CY-09, a selective NLRP3 inhibitor for OD. Methods: An AR mouse model was established with ovalbumin, and the olfactory function of AR mice was detected by the buried food pellet test. Mice with OD were intraperitoneally injected with CY-09 or saline. The activation of microglia and astrocytes in olfactory bulb was detected by immunohistochemistry. The expression level of pyroptosis associated protein was detected by Western blot. The level of pyroptosis associated proinflammatory factor mRNA was determined by real-time PCR. SPSS 24.0 software was used for statistical analysis. Results: After the test, ovalbumin successfully established AR mice model, in which 52.5% (21/40) of them showed OD. The number of activated microglia and astroglia in olfactory bulb tissue in OD group were more than those in non-OD group (all P <0.05). Compared with the control group, the expression of NLRP3, caspase-1 and gasdermin D (GSDMD) was significantly increased in the olfactory bulb of the OD group (all P <0.05). CY-09 could significantly reduce the level of NLRP3, caspase-1, GSDMD, IL-1β and IL-18 expression, and inhibite the activation of microglia and astrocytes in the olfactory bulb tissues (all P <0.05). Conclusion: NLRP3-mediated pyroptosis is closely related to the OD associated with AR. CY-09 could improve the olfactory function in AR mice, which may be related to blocking the NLRP3-mediated pyroptosis.
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- 2022
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6. [Predictive diagnostic value of serum 25-hydroxyvitamin D3 in eosinophilic chronic rhinosinusitis with nasal polyps].
- Author
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Zhou FW, Zhang T, Jin Y, Ma YF, Xian ZP, He XC, Wu ZM, Wang Y, Zhu L, Yuan XZ, and Yu GD
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- Adult, Calcifediol, Chronic Disease, Eosinophils, Female, Humans, Male, Maxillary Sinus, Middle Aged, Nasal Polyps complications, Nasal Polyps diagnosis, Rhinitis complications, Rhinitis diagnosis, Sinusitis complications, Sinusitis diagnosis
- Abstract
Objective: To compare the value of 25-hydroxyvitamin D3 (25-(OH)D3) with other clinical parameters in the prediction and diagnosis of eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). Methods: Eligible chronic rhinosinusitis with nasal polyps (CRSwNP) patients and healthy subjects in the Affiliated Hospital of Guizhou Medical University from January to April of 2021 were included for this study. The age, gender, past history and other basic characteristics of all subjects were recorded. The CRSwNP patients were classified into ECRSwNP and non-eosinophilic chronic rhinosinusitis with nasal polyps (nECRSwNP) endotypes by the percentage of tissue eosinophils. Serum 25-(OH)D3 levels measurements were performed in all subjects. Paranasal sinus CT scans, blood eosinophil counts, and determination of total immunoglobulin E (total IgE), Th1/Th2 plasma cytokines and nasal nitric oxide (nNO) levels were performed before surgery. Logistic regression analysis was used to evaluate the related factors of ECRSwNP. Receiver operating characteristic (ROC) curves was used to evaluate the predictive potential of the clinical parameters. Results: One hundred and twenty-seven CRSwNP patients and 40 healthy subjects were recruited, including 74 males and 93 females of the patients, with the age of (38.73±13.05) years. In patients with ECRSwNP, serum 25-(OH)D3 levels were significantly lower than those in nECRSwNP patients ((26.14±4.58) ng/ml vs (35.71±7.86) ng/ml, t =-8.564, P <0.01). The prevalence of asthma, prevalence of allergic rhinitis, peripheral blood eosinophil counts, total IgE levels, nNO levels and CT scores ratio for ethmoid sinus and maxillary sinus (E/M ratio) of ECRSwNP patients were significantly higher than those in nECRSwNP patients (all P <0.05). However, there was no significant difference in Th1/Th2 cytokines levels between the histological types of CRSwNP (all P >0.05). Among the predictive indicators, 25-(OH)D3 had the highest predictive value, with ROC area under curve (AUC) value of 0.882. The best cut-off point of 28.5 ng/ml for 25-(OH)D3 demonstrated a sensitivity of 0.871 and a specificity of 0.762 for ECRSwNP. Conclusion: Measurement of serum 25-(OH)D3 level may be used as an effective method to distinguish between ECRSwNP and nECRSwNP.
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- 2021
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7. [Wooden foreign body in maxillary sinus: a case report].
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He XC, Zhang T, Jin Y, Wu ZM, Xian ZP, and Yu GD
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- Humans, Tomography, X-Ray Computed, Foreign Bodies diagnostic imaging, Maxillary Sinus diagnostic imaging
- Published
- 2021
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8. [Evaluation and analysis of anxiety, depression and quality of life in vasomotor rhinitis].
- Author
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Zhang T, Yu GD, Gu P, Tang Q, Jin Y, and He XC
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- Adolescent, Adult, Aged, Anxiety psychology, Depression psychology, Female, Humans, Male, Middle Aged, Quality of Life, Young Adult, Rhinitis, Allergic psychology, Rhinitis, Vasomotor psychology, Rhinitis, Vasomotor therapy
- Abstract
Objective: To evaluate the mental state and quality of life in patients with vasomotor rhinitis (VMR) before and after treatment, and to provide guidance for improving the overall health of VMR patients. Methods: Two hundred and twenty VMR patients (VMR group, 118 males, 102 females; aged from 18 to 72 years old), three hundred and twenty allergic rhinitis (AR) patients (AR group, 178 males, 142 females; aged from 18 to 79 years old) from January 2016 to September 2019 were selected in the otolaryngology clinic of Affiliated Hospital of Guizhou Medical University, four hundred and twenty-three healthy people (control group, 243 males, 180 females; aged from 19 to 70 years old) were selected in physical examination center at the same time by continuous enrollment method, symptom check list (SCL-90), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to evaluate the mental state of VMR patients before and after treatment, and 12-item short form health survey version 2.0 (SF-12v2) was used to evaluate their quality of life, statistical data were collected and analyzed by ANOVA and t -test. Results: The scores of eight factors (physical function, role physical function, general health, vitality, role-emotional, mental health) of SF-12v2 in VMR patients before treatment were lower than that of posttreatment, that of AR patients and the control group, the differences were significant (all P< 0.05), the scores of somatization, obsession, depression, anxiety and psychosis in SCL-90 in VMR patients before treatment were significantly higher than that of posttreatment, that of AR patients and the control group (all P< 0.05), the SAS and SDS in VMR patients before treatment (51.28±16.32; 53.28±18.55) were significantly higher than that of posttreatment (38.53±13.21; 39.35±13.34), that of AR patients (42.23±14.32; 43.32±13.78) and the control group (29.78±10.07;33.46±10.55; t (SAS) were 9.007, 6.813 and 20.59; t (SDS) were 9.043, 7.154 and 17.260, all P< 0.05). Conclusion: VMR patients generally suffer from psychological damage, which seriously affects the quality of life of the patients. On the basis of routine treatment, we should attach more importance to the negative psychology of VMR patients and intervene when necessary.
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- 2020
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9. [Observation of Flupentixol and melitracen on curative effect of sudden deafness patients with anxiety and depression in different stages].
- Author
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Zhang T and Yu GD
- Subjects
- Anxiety drug therapy, Depression drug therapy, Depressive Disorder, Hearing Loss, Sudden complications, Humans, Tinnitus, Anxiety complications, Depression complications, Dopamine Antagonists therapeutic use, Flupenthixol therapeutic use, Hearing Loss, Sudden drug therapy
- Abstract
Objective: To investigate the efficacy of flupentixol melitracen on different stages of sudden deafness patients with anxiety and depression. Method: Totally one hundred and sixty-three sudden deafness patients with anxiety and depression were randomly divided into two groups: experimental group(81 cases) and control group (82 cases). All patients were given routine treatment for 2 weeks. The experimental group was given oral flupentixol melitracen (1 tablet/day)for a period of 3 months. The hearing, tinnitus effect and vertigo treatment course were observed and compared. Curing rate of tinnitus at 2 weeks, 3 months and 6 months after treatment, self-rating anxiety scale (SAS) and depressive state scale (self-rating depression scale, SDS) score were collected and compared. Result: Total efficiency of hearing and tinnitus of experimental group(86.42%,84.21%)were higher than that of the control group(67.07%,61.29%);the vertigo cured the average treatment time of experimental group days was less than that of the control groupdays,all the differences were statistically significant.After treatment,the average hearing threshold value of the two groups of patients were lower than that before treatment,the low frequency descent type, high-frequency descent type,flat down type and total deafness type thresholds of the experimental group were lower than of the control group,all the differences were statistically significant.The tinnitus cure rate of experiment group were higher than the control group at 3months and 6 months after treatment,the differences were statistically significant;and after 3months and 6 months treatment tinnitus cure rate higher of the experimental group than that of after 2 weeks the treatment,the difference was statistically significant.After 2 weeks,3 months and 6 months treatment,the SAS and SDS scores of two groups were lower than that before treatment.The SAS and SDS scores of the experimental group decreased after 2 weeks,3 months and 6 months treatment, and the difference was statistically significant at different time points,the SAS,SDS scores of experimental group after treatment were lower than the control group at the same time,the differences were statistically significant. Conclusion: For the sudden deafness patients with anxiety and depression , the combination of flupentixol melitracen on the basis of conventional therapy can improve the clinical efficacy, the patient's mental status and long-term therapeutic effect of tinnitus.., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)
- Published
- 2018
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10. [Esophageal foreign body combined with internal jugular vein thrombosis: a case report].
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Bao QM, Tang Q, and Yu GD
- Subjects
- Humans, Esophagus, Foreign Bodies complications, Jugular Veins, Venous Thrombosis complications
- Published
- 2017
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11. [Population Status of Centropus sinensis in Guangxi Province].
- Author
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Yu LJ, Yu GD, Liao XW, Lu Z, Xu YL, and Zhou F
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- Agriculture, Animals, China, Forests, Population Density, Birds, Ecosystem
- Abstract
Objective: T0 understand the population distribution, species abundance and habitats requirement of a medicinal animal, Centropus sinensis, in Guangxi Province., Methods: Line transect methods were used to census population number and habitat types in 18 counties or cities of Guangxi., Results: Centropus sinensis distributed in all study area, with a higher population density in the south than in the north. Among seven habitat types, the species preferred living in forest-farmland ecotone, while seldom in broad-leaves forest or plantations., Conclusion: The results of habitat preference show an advantage to the population recovering for forest-farmland ecotone commonly existing in Guangxi Province. But the speed of population recovering is slowly under illegal hunting pressure. More attention should be paid to protect this species.
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- 2015
12. [Construction of anti-lung tumor gene differentially expressed bank of wild mouse].
- Author
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Wang FS, Gao YT, Yang JS, Guan T, Mu RD, Qi ZL, Yu GD, and Jing L
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- Animals, DNA, Complementary genetics, Female, Gene Expression Profiling, Male, Mice, Oligonucleotide Array Sequence Analysis, RNA, Messenger genetics, Tumor Cells, Cultured, Gene Library, Lung Neoplasms genetics, Mice, Inbred Strains genetics
- Abstract
Objective: To construct the anti-lung tumor gene differentially expressed bank of wild mouse and to explore the mechanisms of the TW wild mouse suppressing the occurring of lung tumor., Methods: Using suppression subtractive hybridization (SSH) technique, the differentially expressed genes between TAF1 mouse and A/wy mouse were selected out and the subtracted cDNA bank was constructed. 166 clones were performed DNA sequencing and then were assayed by blast programme., Results: Among the blast results of 166 differentially expressed clones, 87 known genes (mRNA or cDNA) were in homology with 134 clones and were divided into 7 classifications according to the biological role.14 DNA fragments were in homology with 32 clones, in which 20 clones were in homology with 9 mouse DNA sequences, 2 clones were in homology with one bacterial gene sequences and 3 clones were clone vector., Conclusion: With SSH technique, the anti-lung tumor gene differentially expressed bank of wild mouse are successfully constructed.
- Published
- 2007
13. [Detection of hepatotoxic pyrrolizidine alkaloids in Ligularia Cass. with LC/MSn].
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Pu SB, Xu DR, Zhang M, Zhou HH, Wang ZT, and Yu GD
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- Asteraceae classification, Chromatography, Thin Layer, Molecular Structure, Pyrrolizidine Alkaloids chemistry, Species Specificity, Spectrometry, Mass, Electrospray Ionization, Asteraceae chemistry, Plants, Medicinal chemistry, Pyrrolizidine Alkaloids analysis
- Abstract
Aim: To detect the hepatotoxic pyrrolizidine alkaloids (HPA) in the genus Ligularia Cass.., Methods: The alkaloid extracts of Ligularia plant materials were detected and analyzed by the method of combination of TLC, and LC/MSn., Results: Among 22 species of Ligularia Cass., HPA were detected in 18 species with LC/MSn, and no HPA was detected in the remaining 4 species., Conclusion: HPA was first detected with LC/MSn in L. tongelensis and other 15 species of Ligularia Cass.; HPA from these plants should be isolated, separated and identified and it is necessary to study the activities and toxicities of the HPA. The types and kinds of HPA from different species and sources are different, they should be detected separately.
- Published
- 2004
14. [Resource investigation and quality evaluation on wild Corydalis yanhusuo].
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Xu XH, Yu GD, and Wang ZT
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- Aporphines analysis, China, Ecosystem, Pharmacognosy, Quality Control, Rhizome chemistry, Berberine Alkaloids analysis, Conservation of Natural Resources, Corydalis chemistry, Plants, Medicinal chemistry
- Abstract
Objective: To study the resource and the quality of wild Corydalis yanhusuo distributed in China., Method: Distribution was observed and samples of wild C. yanhusuo were collected and qualities were evaluated by determining six main alkaloids contained in the samples., Result: The main distribution of wild Corydalis yanhusuo was in the hills around middle and lower reaches of Yangtze River. Its distributive areas were continuously decreasing. The alkaloids contents in the samples varied among different populations., Conclusion: The alkaloids contents in wild populations of C. yanhusuo are diverse. The main kinds of alkaloids in some wild populations are higher than cultivated ones, which are valuable for breeding. The wild C. yanhusuo propagate well, however they are endangered due to environment problem, and should be protected.
- Published
- 2004
15. [The hypothalamic suprachiasmatic nucleus and pineal gland in the circadian rhythmic organization of mammals].
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Zhou XJ, Yu GD, and Yin QZ
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- Animals, Humans, Melatonin physiology, Photoperiod, Receptors, Melatonin, Circadian Rhythm physiology, Pineal Gland physiology, Receptors, Cell Surface physiology, Receptors, Cytoplasmic and Nuclear physiology, Suprachiasmatic Nucleus physiology
- Abstract
The hypothalamic suprachiasmatic nucleus (SCN) is a most important circadian pacemaker, which controls physiological and behaviour rhythm in mammals. SCN owns a intrinsic rhythm itself, and is entrained by photoperiodic signal and some endogenous chemical substances. Melatonin (MEL) is secreted by pineal gland, which is regulated by SCN. MEL triggers the second and third message systems, and regulates SCN circadian activity through high affinity MEL receptor within SCN. This regulation is time-sensitive.
- Published
- 2001
16. [Effect of dorsal raphe nucleus stimulation on unit discharges of light-sensitive neurons of suprachiasmatic nucleus in rats].
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Yu GD, Wei XP, Zhang HQ, Xu S, Yin QZ, Tang PL, and Qian ZM
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- Animals, Cyproheptadine pharmacology, Electrophysiology, Female, Male, Monoamine Oxidase Inhibitors pharmacology, Neurons physiology, Pargyline pharmacology, Photic Stimulation, Rats, Rats, Wistar, Serotonin Antagonists pharmacology, Raphe Nuclei physiology, Serotonin metabolism, Suprachiasmatic Nucleus physiology
- Abstract
The effect of dorsal raphe nucleus (DR) stimulation on the unit discharge of suprachiasmatic nucleus (SCN) neurons was studied and analyzed pharmacologically in the Wistar rats. Experimental results showed that DR stimulation could significantly inhibit the light-induced discharge of SCN neurons. Pharmacologically, this inhibition could be enhanced by monoamine oxidase inhibitor pargyline, attenuated by 5-hydroxytryptamine (5-HT) synthesis inhibitor parachlorophenylalanine and blocked by 5-HT receptor antagonist cyproheptadine. It was suggested that the inhibitory effect of DR stimulation on the light-sensitive SCN neuron discharge might be mediated by 5-HT.
- Published
- 1997
17. [Inhibitory effects of hypothalamic arcuate nucleus or anterior pituitary stimulation on the nociceptive responses of thalamic parafascicular neurons].
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Jiao YY, DuanMu ZX, Yu GD, and Yin QZ
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- Animals, Electric Stimulation, Female, Male, Neurons physiology, Rats, Rats, Wistar, Arcuate Nucleus of Hypothalamus physiology, Nociceptors physiology, Pituitary Gland, Anterior physiology, Thalamic Nuclei physiology
- Abstract
The effects of hypothalamic arcuate nucleus (ARC) or anterior lobe of pituitary (AL) stimulation on the nociceptive responses of thalamic parafascicular (Pf) neurons were studied in rats with electrophysiological technique. The results showed that ARC stimulation could inhibit the nociceptive discharges of Pf neurons, namely, the immediate inhibition because of its very short latency and duration. AL stimulation could also inhibit the nociceptive discharges of Pf neurons, but this inhibition was a delayed one because of its longer latency and duration. Hypophysectomy diminished the immediate inhibition due to ARC stimulation, while ARC lesion diminished the delayed inhibition due to AL stimulation. Both kinds of inhibition were blocked by dexamethasone pretreatment. The above results suggest that neuroendocrine relationship between ARC and AL is involved in pain modulation.
- Published
- 1995
18. [Involvement of solitary tract nucleus in analgesic effect produced by paraventricular nucleus stimulation].
- Author
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Jiang XH, Yu GD, and Yin QZ
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- Animals, Electric Stimulation, Male, Microinjections, Nociceptors physiology, Rats, Rats, Inbred Strains, Sensory Thresholds, Medulla Oblongata physiology, Pain physiopathology, Paraventricular Hypothalamic Nucleus physiology, Vasopressins pharmacology
- Abstract
This study was undertaken to evaluate the analgesic effect of paraventricular nucleus (PVN) stimulation with tail stimulation-vocalization test. The mechanism of this analgesia was analysed with nuclear lesion and microinjection technique. The main results were as follows: (1) Electrical stimulation of the PVN could significantly enhance the pain threshold and increase the content of AVP in brainstem measured by radioimmunoassay. (2) Solitary tract nucleus (STN) lesion could eliminate the analgesic effect induced by PVN stimulation. (3) Intranuclear microinjection of AVP-antagonist and AVP-antiserum into the STN could block the analgesic effect of PVN stimulation. (4) Intranuclear microinjection of AVP into the STN could mimick the analgesic effect similar to that of PVN stimulation. These results suggest that electrical stimulation of the PVN could produce an analgesic effect. This effect might be mediated by the activation of VP-ergic neurons in PVN and upon releasing VP from the descending fibers, the activities of neurons in the STN are influenced.
- Published
- 1991
19. [Effect of locus coeruleus stimulation and electroacupuncture on nociceptive response of spinal dorsal horn neurons in rats].
- Author
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Yu GD, Cui CD, Zhang HQ, Yin WP, and Yin QZ
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- Animals, Clonidine pharmacology, Female, Male, Naloxone pharmacology, Neurons, Afferent physiology, Phentolamine pharmacology, Raphe Nuclei physiology, Rats, Rats, Inbred Strains, Electroacupuncture, Locus Coeruleus physiology, Nociceptors physiology, Spinal Cord physiology
- Abstract
Previous studies have demonstrated that locus coeruleus (LC)-noradrenergic neuronal system plays an important role in pain modulation and electroacupuncture (EA) analgesia. In the present experiment, the effect of LC stimulation and EA on nociceptive response of spinal dorsal horn neurons was investigated. The main results were: 1) LC stimulation and electroacupuncture produced a significant inhibitory effect on nociceptive response of dorsal horn neurons; 2) The inhibitory effect of LC stimulation was not affected by the lesion of nucleus raphe magnus or by the injection of naloxone; 3) These inhibitory effects of LC stimulation and electroacupuncture could be enhanced by alpha 2-agonist clonidine, and decreased slightly by alpha-antagonist phentolamine. These results suggest that the inhibitory effect of LC stimulation and electroacupuncture on the nociceptive response of dorsal horn neurons might be mediated by alpha 2-receptors.
- Published
- 1990
20. [Medicinal plants used for abortion and childbirth in eastern Africa].
- Author
-
Yu GD
- Subjects
- Africa, Eastern, Female, Humans, Labor, Induced, Pregnancy, Abortifacient Agents, Labor, Obstetric drug effects, Plants, Medicinal
- Published
- 1982
21. [Effect of dorsal raphe nucleus stimulation on nociceptive response of dorsal horn neurons and efferent pathway analysis in rats].
- Author
-
Yu GD, Guo SY, Zhang HQ, and Yin QZ
- Subjects
- Animals, Efferent Pathways, Electric Stimulation, Electrophysiology, Female, Male, Neurons, Afferent physiology, Rats, Serotonin physiology, Spinal Cord physiology, Acupuncture Therapy, Nociceptors physiology, Pain physiopathology, Raphe Nuclei physiology
- Published
- 1988
22. [Effect of locus coeruleus stimulation on unit discharge of the hypothalamic arcuate nucleus in rats].
- Author
-
Yu GD, Chen JS, Yin WP, and Yin QZ
- Subjects
- Animals, Clonidine pharmacology, Electric Stimulation, Electrophysiology, Isoproterenol pharmacology, Male, Phenoxybenzamine pharmacology, Propranolol pharmacology, Rats, Arcuate Nucleus of Hypothalamus physiology, Hypothalamus physiology, Locus Coeruleus physiology, Pain physiopathology
- Published
- 1985
23. [Suggestions on some Latin names and terms in the newly revised textbook, "Pharmaceutical Botany"].
- Author
-
Yu GD
- Subjects
- Textbooks as Topic, Botany, Plants, Medicinal, Terminology as Topic
- Published
- 1987
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