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Background The family-centered and community-based community home-based elderly care has gradually become the main trend in the context of increased population aging in China. As an important component of the primary care service system, community health services play a cornerstone role in community home-based elderly care. Understanding the experience of home-dwelling old adults on community health services will help to improve the healthcare quality and promote the development of combined medical and nursing care. Objective To understand the reasons for the home-dwelling old adults to prefer community home-based elderly care and their experience, analyze the existing problems, so as to provide reference for developing needs-oriented community health services. Methods From February to June in 2022, the home-dwelling old adults aged ≥65 years old were selected from 10 community health centers in Chengdu as the study subjects by using purposive sampling method. 10 focus groups were set up to conduct face-to-face, semi-structured interviews. Data collection was performed by audio recording and text transcription. NVivo 12 software was used for the coding and categories extracting of interview content and the thematic framework analysis method was used to organize and analyze the interview data to extract the themes. Results A total of 40 home-dwelling old adults were enrolled, including 20 males and 20 females aged 65-86 years with an average age of (74.4±5.6) years, 31 cases from urban areas and 9 cases from suburban areas. The interview data were analyzed and 3 themes were extracted: Comprehensive factor of the old adults is the primary factor affecting their choice of pension modes and health needs; Community health service is an important way to provide health services for home-dwelling old adults, which cannot completely meet the health needs of the old adults; Optimizing service modes, enriching service programs and increasing external support can increase the sense of contentment and promote the health of old adults. Conclusion Home-dwelling old adults are basically satisfied with the health services provided in the community, but the personal factors of old adults, the modes and programs of community health services have influenced the experience of home-dwelling old adults with community health services, inducing their growing health needs unmet. Providing professional, diversified and precise community health services, improving the quality of medical services and the mode of medical services combining the health situation of home-dwelling old adults, are of great significance to improve the community health service system and and promote the health of older adults.

Objective To investigate the expression changes of G-protein-coupled receptor kinase-interacting protein 1 (GIT1) in lithium-pilocarpine-induced epileptic rat model and explore its role in the genesis and development of epilepsy. Methods The lithium-pilocarpine-induced model of status epilepticus (SE) was established in 42 specific pathogen free (SPF) male adult Wistar rats, and those rats were randomly divided into control group and 6 epilepsy groups (1, 3, 7, 14, 30, 60 d after SE). The expression of GIT1 mRNA was detected by fluroescent quantitative polymerase chain reaction (PCR), while the expression of GIT1 protein was examined by Western blotting and immunohistochemistry was applied to test the expression of CA1 region, dentate gyrus and parahippocampal cortex in rat hippocampus at different time points. Results GIT1 mRNA level rised in acute phase on 1st and 3rd day after SE (P = 0.012, 0.002), then increased continously in latency on 7th and 14th day (P = 0.003, 0.001), and reached the peak in chronic phase on 30th and 60th day (P = 0.000, for all). GIT1 protein expression rised in acute phase and increased continously in chronic phase, but there was no significant difference compared with control group (P > 0.05, for all). Then, it reached the peak in chronic phase (P = 0.000, for all). Until the 30th day, the GIT1 expression of CA1 region, dentate gyrus and parahippocampal cortex in the hippocampus of rats in 6 epilepsy groups was significantly higher than that of control group (P = 0.000, for all). Conclusions The up-regulated expression of GIT1 in the hippocampus of epileptic rat was probably involved in the formation process of chronic epilepsy by regulating cytoskeleton dynamic regrouping to influence excitatory neural networks. DOI: 10.3969/j.issn.1672-6731.2015.06.011

Pumilio2 (Pum2) is one of the newly discovered transcription regulatory factors in recent years, which exhibits similar function to microRNA (miRNA). Pumilio2 hinders the formation of translation initiation complexes and represses target gene expression from the combination of its specific structure domain with mRNA. Recent studies suggest that Pumilio2 is closely related to the morphogenesis and function of central nervous system. The different expression levels of Pumilio2 are involved in various biological processes of central nervous system diseases. This article mainly reviews the research progress of Pumilio2 and its role in central nervous system. doi: 10.3969/j.issn.1672-6731.2014.12.005