1. [Effect of neutralizing anti-VEGF antibody on genesis of murine type II collagen-induced arthritis].
- Author
-
Lu J, Shen H, Yang PT, Xiao WG, and Zhao LJ
- Subjects
- Animals, Antibodies administration & dosage, Arthritis, Experimental pathology, Cell Proliferation drug effects, Fibroblasts cytology, Fibroblasts drug effects, Male, Mice, Synovial Membrane cytology, Antibodies pharmacology, Arthritis, Experimental drug therapy, Collagen Type II pharmacology, Neovascularization, Pathologic drug therapy, Vascular Endothelial Growth Factor A immunology
- Abstract
Aim: To understand the effect of neutralizing anti-vascular endothelial growth factor (VEGF) antibody on the genesis of murine type II collagen (CO II)-induced arthritis (CIA)., Methods: mice DBA/1J (8-10 weeks) were given intradermal injection chick tape II collagen to set up the murine CIA model. The incidence of CIA and arthritis index were measured and the pathologic changes of articular tissue were observed after the injection of neutralizing anti-VEGF antibody., Results: The anti-VEGF antibody could notably inhibit the genesis and severity of arthritis (P<0.05) at the early stage of CIA formation; while it made no difference after CIA was completely formed., Conclusion: Anti-VEGF neutralizing antibody can significantly inhibit synovial fibroblast proliferation, neovascularization and angeitis genesis, which made it a promising agent for RA treatment.
- Published
- 2005