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Background The personnel building of public health is the key to improving the public health system and enhancing the emergency response capability of public health emergencies. Objective The study aims to analyse the status, advantages and deficiencies of human resources for public health in Beijing after public health emergencies. Then, the study put forward suggestions to optimise the construction of human resources for public health in Beijing. Methods The data on the sum of public health workforce, disaggregated by age, academic qualifications and job title, was collected from 2016 to 2021 Basic Information Survey on Manpower of Health Institutions in Beijing and the Compendium of Statistics on Community Health Work in Beijing. The data was collated between June and September in 2022 with the aims of analysing the sum, structure and configuration of human resources for professional and grassroots-level public health in Beijing in the context of public health emergencies. Results From 2019 to 2021, the sum of human resources for public health in Beijing's professional public health institutions increased from 15 157 to 16 048. Additionally, the percentage of those with postgraduate qualifications increased by 0.93 percent, while the percentage of those with senior and intermediate titles increased by 2.29 and 3.87 percent, respectively. The sum of human resources for public health at the grassroots level increased from 3 701 to 4 017. Among these, the percentage of those with bachelor's degree or above increased by 5.36 percent, while the percentage of those with senior and intermediate titles increased by 0.72 and 1.70 percent, respectively. And the ratio of CDC force per 10 000 population decreased from 1.68 to 1.57, the number of health personnel in professional public health institutions per 1 000 population increased from 0.70 to 0.73, the number of grassroots public health personnel per 10 000 population increased from 1.72 to 1.84. Conclusion After the public health emergency, the sum of human resources for public health has increased in Beijing, yet staffing gaps persist. The echelon of public health institutions has been reinforced, although the quality of human resources for public health in different institutions varies considerably. Furthermore, the structure of titles of human resources for public health is becoming more logical. It is recommended that public health staffing standards be clarified to fill the gap in human resources for public health. Furthermore, it is essential to enhance the training methodology for human resources for public health and elevate the calibre of them. Additionally, there is a need to refine the mechanism for ensuring the advancement of the human resources for public health, with the objective of attracting and retaining talent.

Objective To understand the cognitive influencing factors affecting the use of epinephrine by medical staff for the treatment of serve allergic reactions and the current state of research at home and abroad. Methods Using searching terms such as “adrenaline” “anaphylactic shock”“severe anaphylactic reaction”“allergic reaction”“epinephine”“anaphylaxis”in Chinese and English. Literature review was performed from China National Knowledge Infrastructure （CNKI）， Wanfang Data， Chongqing VIP Database， PubMed， Web of Science. The retrieval time is from the inception of the databases to July 20， 2024. Literature contents were extracted and analyzed. Results A total of nine articles were retrieved， and eight international studies showed that there were differences in the correct use of adrenaline in patients with severe allergic reactions among medical staff of different professions， levels of hospitals， ages， and years of service. Through targeted training and education， the correct use rate of adrenaline by medical staff in the treatment of severe allergic reactions could be significantly improved. Only one Chinese study suggested that clinicians and nurses had severe cognitive deficiencies in the proper use of adrenaline. Conclusion Medical staff have varying degrees of cognitive insufficiency of correct use of adrenaline for the treatment of severe allergic reactions， which is influenced by multiple factors.

Objective To screen the risk factors of hydrocephalus after decompressive craniectomy in patients with cerebral hernia after traumatic brain injury (TBI), and construct a Bayesian network model based on the risk factors. Methods A total of 77 patients with cerebral hernia after TBI who underwent decompressive craniotomy in Nanjing Tongren Hospital Affiliated to Southeast University from March 2020 to January 2022 were included. They were divided into hydrocephalus group (n = 25) and non - hydrocephalus group (n = 52) according to whether hydrocephalus was complicated after surgery. The risk factors of hydrocephalus after decompressive craniectomy in patients with cerebral hernia after TBI were analyzed by univariate and multivariate Logistic regression analyses. The Bayesian network model was constructed based on the risk factors, and the receiver operating characteristic (ROC) curve and calibration curve were drawn and Hosmer-Lemeshow goodness-of-fit test was conducted. Results In hydrocephalus group, the Glasgow Coma Scale (GCS) score at admission (t = 2.178, P = 0.032), the ratio of cerebrospinal fluid replacement after lumbar puncture (χ2 = 8.675, P = 0.003), and the level of β2 -microglobulin after operation (t = 11.146, P = 0.000) were lower than those in non-hydrocephalus group, while subarachnoid hemorrhage (χ2 = 5.901, P = 0.015), bilateral operation (χ2 = 6.441, P = 0.011), the ratio of dural unstitched during operation (χ2 = 9.759, P = 0.002), postoperative intraventricular hemorrhage (χ2 = 8.938, P = 0.003), postoperative midline displacement > 10 mm (χ2 = 7.589, P = 0.006), and intracranial infection (χ2 = 4.519, P = 0.034), as well as postoperative coma time (t = 2.709, P = 0.008) were higher than those in non - hydrocephalus group. Logistic regression analysis showed that subarachnoid hemorrhage (OR = 1.885, 95%CI: 1.432-2.240; P = 0.012), dural unstitched during operation (OR = 1.468, 95%CI: 1.215-1.930; P = 0.006), long postoperative coma time (OR = 1.574, 95%CI: 1.358-1.926; P = 0.007), postoperative intraventricular hemorrhage (OR = 1.550, 95%CI: 1.254-1.768; P = 0.010), the level of β2- microglobulin increased after operation (OR = 1.622, 95%CI: 1.165-1.840; P = 0.004) were risk factors for hydrocephalus after decompressive craniectomy in patients with cerebral hernia after TBI. Based on these 5 factors, the Bayesian network model was constructed, and the area under ROC curve was 0.886 (95%CI: 0.823-0.925, P = 0.000). The calibration curve showed that there was a good consistency between the predicted probability and the actual probability, while the Hosmer-Lemeshow goodness-of-fit test showed no significant difference (χ2 = 8.760, P = 0.232), which indicated that the model had good discrimination, calibration and accuracy. Conclusions Subarachnoid hemorrhage, dural unstitched during operation, long postoperative coma time, postoperative intra ventricular hemorrhage, and elevated β2 - microglobulin level are the risk factors for hydrocephalus after decompressive craniectomy in patients with cerebral hernia after TBI.

Background Diabetic foot (DF) is one of the most serious chronic complications in patients with diabetes. There is an incidence of DF of 15% in China, with a poor prognosis, an amputation rate of 22%, and a mortality rate of 11%, which greatly reduces the quality of life and life expectancy of patients with DF. DF wound healing may benefit from vitamin D, however, sufficient clinical studies are lacking to confirm this claim. Objective To explore the correlation between serum 25 (OH) D3 and DF wound healing. Methods A nested case-control study method was used to select DF patients with Wagner grading 2-4 who were hospitalized in the Affiliated Hospital of Zunyi Medical University from 2020 to 2021. The patients were discharged from the hospital and followed up for 3 months, and 55 patients whose DF wounds still had not healed were selected as the case group. As the control group, 110 patients whose DF wounds healed within 3 months of discharge were matched 1∶2 according to their age, gender, and Wagner grade with the patients in the case group. In the early stages of treatment, 2 mL of venous blood was obtained and serum 25 (OH) D3 levels were determined before vitamin D supplementation. Detailed basic data, biochemical and imaging indices of the patients were collected, including general demographics (age, gender, place of residence, education), BMI, diabetes duration and family history, hospitalization duration, lifestyle habits (alcohol consumption, smoking status), history of hypertension and Wagner classification. The biochemical parameters included 25 (OH) D3, glycosylated hemoglobin (HbA1c), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). An MRI was performed to determine if the patient had osteomyelitis. Logistic regression was used to analyze the relationship between different 25 (OH) D3 levels and DF wound healing. Results The duration of diabetes in the case group was longer than that in the control group (P0.05). Once age, gender, place of residence, education, BMI, alcohol consumption, smoking, history of hypertension, family history of diabetes mellitus, diabetes duration, length of hospitalization, Wagner grade, osteomyelitis, HbA1c, ESR, and CRP have corrected for, patients with serum 25 (OH) D3 levels of 20 to

With the continuous development of renewable energy, photovoltaic power stations show a trend of large-scale grid connection, but the disorderly development of photovoltaic grid connection induces the static voltage instability in photovoltaic grid-connected system. Firstly, an equivalent model of photovoltaic large-scale grid-connected system using the equivalent admittance of photovoltaics is constructed in this paper, and the impact of photovoltaic grid-connected system on static voltage stability is quantified as the impact of photovoltaic equivalent admittance on the eigenvalue of the admittance matrix. It is concluded that the decrease of the minimum eigenvalue of the admittance matrix reduces the static voltage stability of photovoltaic grid-connected system. Further an evaluation index for static voltage stability of photovoltaic grid-connected system based on eigenvalue-active power sensitivity is proposed. Considering the strong correlation between the admittance matrix and the network topology of photovoltaic grid-connected system, the influence of the network topology on static voltage stability is analyzed. Photovoltaic grid-connected schemes which can improve the static voltage stability are proposed from AC and DC perspectives, and it is concluded that changing the topology of the transmission network reasonably can improve the static voltage stability of photovoltaic grid-connected system. Finally, based on a IEEE 14-node system example, the eigenvalue index and the photovoltaic grid-connected scheme proposed in this paper is validated to ensure the static voltage stability of large-scale photovoltaic grid-connected systems and promote orderly grid connection of photovoltaic system.

Background The reimbursement of outpatient services is an essential part of the reform of medical insurance payment methods. With the comprehensive promotion of the reform on the medical insurance payment methods for inpatient services in China, the reform on insurance payment methods for outpatient services, such as capitation-based reimbursement and ambulatory patient groups (APG) point method, will gradually be put on the agenda. Objective To explore a capitation-based reimbursement scheme for chronic diseases applicable to Beijing based on an analysis of capitation-based reimbursement implemented in different countries and regions and the current situation of chronic disease management in Beijing, to provide a reference for implementing the capitation-based reimbursement reform for chronic diseases in Beijing. Methods This study used information related to essential medical services, reimbursement by health insurance, and essential public health service funds in Beijing's C and H districts. Then through an analysis of the information, the calculation method for capitation-based reimbursement standard for four common chronic diseases (hypertension, diabetes, coronary heart disease and stroke were selected in this study) applicable in the districts was designed to calculate the capitation-based reimbursement standard for major chronic diseases in primary outpatient clinics, providing a reference for promoting the capitation reform for chronic diseases in outpatient clinics. Results By analyzing the above-mentioned information in 2017—2019, the capitation-based reimbursement standard was 4 693.11 yuan/person for hypertension, 6 597.70 yuan/person for diabetes, 5 644.46 yuan/person for coronary heart disease, and 6 437.78 yuan/person for stroke in H district calculated using the bottom-up costing, and was 4 884.18 yuan/person for hypertension, 5 960.63 yuan/person for diabetes, 3 733.93 yuan/person for coronary heart disease, and 3 886.66 yuan/person for stroke in C district calculated using the top-down estimating. Conclusion In calculating the capitation-based reimbursement standard, as different chronic disease patient groups have different outpatient costs, considering the equity of medical insurance reimbursement and the rationality of capitation-based reimbursement, it is necessary to adjust the risk of the benchmark capitation, and develop personalized service packages for different types and severity of chronic diseases. In the promotion of capitation payment for chronic disease patients, it is necessary to provide personalized essential medical service and public health service packages for patients with different chronic diseases, further improve the chronic disease management capacity of community health institutions to improve the contracting rate and establish an effective incentive and assessment mechanism for general practitioners to rationally allocate capitation balance.

Background In China, the governance of public health by the public health committee, a grassroots mass autonomous organization, is a new approach managing public health services in primary care. Many regions are exploring governance models of public health by the public health committee, aiming to make it a key hub to realize the vertical connection and horizontal linkage grid management of grassroots communities. Objective To analyze the policy documents related to the construction of local public health committees of various regions in China using policy document analysis, so as to provide a reference for improving the primary-level public health governance system and governance capacity. Methods In March 2022, we searched policy documents related to the construction of public health committees on the official websites of the local governments and health commissions of eight sample regions (Beijing, Guangdong, Chongqing, Shandong, Anhui, Guizhou, Gansu, and Ningxia Hui Autonomous Region) in which village (residential) public health committees have been constructed using "public health committee" as the key search term. Through literature review and policy document analysis, an analytical framework for the governance system of the public health committee was constructed. Nvivo 11 Plus was used for word frequency and coding analyses of the included policy literature. Results A total of 15 policy documents and 2 guidance manuals for the work of public health committees were ultimately included. Word frequency analysis showed that the five words, "hygiene" "public" "work" "committee" and "health", appeared most frequently, indicating that the selected policy literature conformed to the research theme. By using the analytical framework, the structural dimensions of the policy literature were determined, including four root nodes, namely, governance subjects, governance mechanisms, institutional guarantees, and capacity building, and 13 sub-nodes. There are 208 reference points for governance subjects, 48 reference points for governance mechanisms, 57 reference points for institutional guarantees, and 87 reference points for capacity building. Conclusion The local policy documents of the sample regions cover the contents of the four dimensions, but have different focuses. According to the framework in this study, further construction of the public health committee needs to set certain admission criteria with clear determination of rights and responsibilities for new committee members, establish an effective cooperation and communication mechanism, improve the system guarantee and provide financial and technical support.

This study used the daily temperature and precipitation data from 27 stations in southeast Xizang during 1960-2017 to study the characteristics of climate change in China， by using the linear trend test， Mann-Kendall test， wavelet analysis， and extreme climate index methods.The results demonstrate that： （1） the annual mean， maximum and minimum temperature show obviously rising trends， with the increasing rate of 0.29~0.43 ℃·（10a）-1.The temperature increase in winter is the most obvious.The annual precipitation shows an increasing trend as a whole， with a linear trend of 6.66 mm·（10a）-1， in which it decreases in summer and autumn， and increases in winter and spring.（2） The temperature and precipitation have multi-period changes； and both have a variation period， 28 a， on a large time scale.（3） The times of the abrupt change of average temperature， maximum temperature and minimum temperature were in 1994， 2001 and 1992 respectively， and the precipitation changed from less to more in 1979.（4） The indexes of extreme high temperature， such as TXx， TNn， TNx， TXn， all increase.The frequency indexes of high temperature events， such as TX90p， TN90p， show an increasing trend， while the frequency indexes of low temperature events， such as TX10p， TN10p， show a decreasing trend.The persistence index of high temperature events （WSDI） shows an increasing trend， and the persistence index of low temperature events （CSDI） shows a decreasing trend.（5） Except that the CWD and CDD show a decreasing trend， the other extreme precipitation indexes show an increasing trend.According to the change results of mean and extreme climate， the southeastern Xizang is generally warm and humid， and it is also a sensitive area and an amplifier in Qinghai-Tibet Plateau and even China.

Based on literature analysis, this paper reviews the evolution path of Japan's food education policy and analyzes the content and purpose of the basic law of food education. Based on the perspectives of multiple objectives and multi-subject role division, the author summarizes the experience of Japan's food education policy promotion. Their experiences mainly include: clear division of labor between the central and local governments, central unification and respect for local autonomy. Food breeding roots from a young age; Diversified feeding action plans; Planning food education courses with characteristics.

In order to design and prepare hard coating for the flue gas turbine transition ring，and to ensure the long-term stable operation of the flue gas turbine，three kinds of Cr3C2-NiCr hard coatings were designed and prepared on the surface of 304L alloy substrate by detonation gun spraying process.By means of X-ray diffraction (XRD)，scanning electron microscope (SEM)，energy dispersive X-ray analysis(EDXA)，microhardness tester，surface roughness tester，universal testing machine and contact angle measuring instrument，the microstructure of the coatings was analyzed and observed，and the hardness，porosity，bonding strength，roughness，thermal shock performance and surface free energy of the coatings were characterized respectively.Results showed that as the oxygen-fuel ratio increased，the hardness of the coating increased monotonously，and the porosity of the coating decreased first and then increased.When the oxygen-fuel ratio was 1.5，the quality of the as-prepared coating was the best，with a micro hardness of 810 HV3N，a porosity of 0.58%，a bonding strength of 72.1 MPa，a surface roughness of 4.78 μm and a surface free energy of 25.43 mJ/m2.After being kept at 800 ℃for 10 minutes and quenched with water at room temperature for 20 cycles，the coating had no warping，cracking or peelin.Besides，the oxygen-fuel ratio changed the surface free energy and its component in the coating，thus had an effect on the surface characteristics of the coating.

Liver cancer is one of the most common malignant tumors. In Asia, liver cancer often develops on a background of cirrhosis caused by chronic hepatitis. The procedure of hepatitis, cirrhotic nodules, dysplastic nodules, and then hepatocellular carcinoma is the most common liver cancer evolutionary process. Judging the stage of hepatic nodules in the evolution process and taking intervention measures are critical for reducing the incidence of liver cancer. In this paper, a more accurate support vector machine (SVM) classification algorithm, LFOA-F-SVM, was proposed for radiomics to classify hepatic nodules from 120 patients into four categories based on dynamic enhanced magnetic resonance images. The algorithm uses radius-margin-based F-SVM, and combines the fruit fly optimization algorithm (FOA) of Levy flight (LF) strategy to optimize the parameters. To verify the effectiveness of the method, five UCI classification data sets (hearts, Parkinson’s disease, iris, wine and zoo) were added and compared with SVM, PSO-SVM, FOA-SVM, F-SVM. The results showed that LFOA-F-SVM has the highest classification accuracy in six data sets compared to the other methods. And in the hepatic nodules data set, the classification precision and recall are relatively high.

Objective: Reduce the manufacturing cost of automated mango grading equipment. Methods: The effects of three commonly detection algorithms for mango defect detection were compared, and a defect detection algorithm based on YOLOv5 for mango surface was proposed for the light weight design to work on mobile devices. Results: Compared with the original algorithm, the experimental algorithm can reduce the number of parameters by 45.9%, the number of floating point operations by 46.7%, and the weight file size by 45.2% under the premise of meeting the requirements for mango surface defect detection. Conclusion: the experimental algorithm effectively reduces the performance requirements for deployment equipment, and has potential value in reducing the manufacturing cost of mango grading detection equipment.

In order to overcome the difficulties that current attack graph model cannot reflect real-time network attack events,a method is proposed including a forward risk probability update algorithm and a forward-backward combined risk probability update algorithm,which meets the needs of real-time analyzing network security.It first performs specific quantitative analysis on the uncertainty of each node in the graph,and uses Bayesian networks to calculate their static probabilities.After that,it updates the dynamic probability of each node along the forward and backward paths according to the real-time network security events,instantly reflecting the changes of external conditions and assessing real-time risk levels across the network.Experimental results show that the method can calibrate and adjust the risk probability of each node according to the actual situation,which helps the network operator correctly understand the dangerous levels of the network and make better decision for defense and prevention of the next attack.

The purpose was to establish a characteristic fingerprint of Eucommia ulmoides leaves extract, a feed additive, using high-performance liquid chromatography (HPLC), to provide a reference for its quality control. The HPLC method was used to determine the chemical constituents of 36 batches of Eucommia ulmoides leaves extract on a Sunfire C18 (4.6 mmx250 mm, 5 µm) column, with acetonitrile-0.1% formic acid in water as the mobile phase, at a flow rate of 1.2 mL/min, with an injection volume of 10 µL, a column temperature of 35 °C, and a detection wavelength of 254 nm. Eight peaks with better separation and peak shape in the chromatograms of 36 batches of Eucommia ulmoides leaves extracts were selected as the characteristic peaks to obtain the HPLC chromatograms of Eucommia ulmoides leaves extract. Based on the information of the control product, the precise relative molecular mass and the fragmentation ions, eight characteristic peaks were identified as the constituents of Eucommia ulmoides leaves extract. The results showed that a total of eight characteristic peaks were identified in the HPLC characteristic chromatogram of Eucommia ulmoides leaves extract, and seven chromatographic peaks of aucubin, geniposidic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, quercetin rutin, and isoquercitrin were identified. The study indicates that the characteristic chromatogram of Eucommia ulmoides leaves extract established in the experiment has achieved stable quality control and can provide reference for the quality evaluation of Eucommia ulmoides leaves extract as a feed additive. [ABSTRACT FROM AUTHOR]

Based on typical rural brick-concrete structure buildings in cold rural areas,optimization of various energy-saving measures and local sensitivity analysis are carried out. The economic evaluation and static payback period calculation of various energy-saving measures are carried out using the life cycle cost method and net present value method.The sensitivity of building energy conservation design is in order of building air tightness > exterior wall insulation > roof insulation > heat transfer coeffi cient of exterior window > SHGC of exterior window > floor insulation. The optimal thickness of insulation layer for exterior wall and roof is 110 mm,and the optimal heat transfer coefficient for exterior window is 2.5 W/(m2·K). [ABSTRACT FROM AUTHOR]

ObjectiveTo construct a YOLOv3-based model for diatom identification in scanning electron microscope images, explore the application performance in practical cases and discuss the advantages of this model.MethodsA total of 25 000 scanning electron microscopy images were collected at 1 500× as an initial image set, and input into the YOLOv3 network to train the identification model after experts’ annotation and image processing. Diatom scanning electron microscopy images of lung, liver and kidney tissues taken from 8 drowning cases were identified by this model under the threshold of 0.4, 0.6 and 0.8 respectively, and were also identified by experts manually. The application performance of this model was evaluated through the recognition speed, recall rate and precision rate.ResultsThe mean average precision of the model in the validation set and test set was 94.8% and 94.3%, respectively, and the average recall rate was 81.2% and 81.5%, respectively. The recognition speed of the model is more than 9 times faster than that of manual recognition. Under the threshold of 0.4, the mean recall rate and precision rate of diatoms in lung tissues were 89.6% and 87.8%, respectively. The overall recall rate in liver and kidney tissues was 100% and the precision rate was less than 5%. As the threshold increased, the recall rate in all tissues decreased and the precision rate increased. The F1 score of the model in lung tissues decreased with the increase of threshold, while the F1 score in liver and kidney tissues with the increase of threshold.ConclusionThe YOLOv3-based diatom electron microscope images automatic identification model works at a rapid speed and shows high recall rates in all tissues and high precision rates in lung tissues under an appropriate threshold. The identification model greatly reduces the workload of manual recognition, and has a good application prospect.

Objective To investigate the biological function of RNA binding protein polycytosine-binding protein 1 (PCBP1) in the maintenance of pluripotency of human embryonic stem cells (hESC) and to explore the new mechanism of regulating hESC pluripotency. Methods PCBP1 knockdown technology was used to detect the clonogenicity. The alkaline phosphatase staining profile and the expression of pluripotency/differentiation marker genes were detected by qPCR. Meanwhile, the nucleus and cytoplasm of hESC were isolated for RNA sequencing, and the nucleoplasmic changes of RNA generated by PCBP1 knockdown were analyzed by multi-level analysis. Results PCBP1 knockdown significantly inhibited clonogenesis of human embryonic stem cells (P＜0.01) and reduced the RNA level of pluripotency related genes (P＜0.01). The expression of differentiation related genes increased(P＜0.01)that significantly affected the overall nucleoplasmic distribution of RNA in hESC and the nucleoplasmic distribution of mRNA related to embryonic development and cell differentiation. Conclusions PCBP1 regulates hESC pluripotency by regulating the expression of pluripotency/differentiation marker genes and the nucleoplasmic localization of mRNA.

Objective To investigate the effect of deletion of Sirtuin type 1(Sirt1) gene on liver inflammation of mice and its mechanism. Methods The body weight of C57BL/6J male mice and liver specific Sirt1 deficiency (Sirt1-LKO) male mice were recorded weekly. The sensitivity of inflammatory response was tested by intraperitoneal injection of 20 mg/kg LPS. The survival curve was used to reflect the sensitivity of mice to inflammatory response.The expression of inflammatory factors was detected by Western blot and q-PCR. Results Compared with control wild type mice, Sirt1-LKO mice showed significantly reduced body weight (P＜0.05). In addition, The survival curve was shown by kaplane Meier diagram,Sirt1-LKO mice showed lower sensitivity to LPS (P＜0.05).The protein level of NF-κB in primary liver cells of Sirt1-LKO mice was increased (P＜0.05),Tnfα and IL6 of NF-κB downstream target genes were up-regulated(P＜0.05). Conclusions Hepatocyte-specific Sirt1 deletion aggravates liver inflammation response in mouse model.

Objective: This study focused on the antioxidant and immune enhancing effects of L. barbarum puree. Methods: The antioxidant capacity of L. barbarum puree was measured by establishing an acute liver injury model. The immune activity of L. barbarum protoplasm was evaluated by measuring the index of immune organs, the content of serum hemolysin and the degree of plantar thickening. Results: Both low and medium doses of L. barbarum puree could significantly increase the content of glutathione peroxidase (GSH PX) in serum (P＜0.05, P＜0.01) and glutathione (GSH) in liver tissue (P＜0.05), and significantly decrease the content of protein carbonyl in liver tissue of mice with acute alcoholic liver injury (P＜0.05, P＜0.01) and the content of malondialdehyde (MDA) (P＜0.05, P＜0.01), and this indicate L. barbarum protoplasm had antioxidant activity. After continuous gavage of L. barbarum protoplasm for 45 days, the organ development of normal mice was not affected. Compared to the untreated mice, the content of serum hemolysin (P＜0.01) and the degree of foot thickening (P＜0.05) and phagocytosis index (P＜0.01) increased significantly, indicating that L. barbarum puree could enhance mice immunity. Conclusion: Eating a certain dose of L. barbarum puree can enhance the antioxidant capacity and immune ability.

Nicotine(NIC) plays a role in the brain through nicotinic acetylcholine receptors(nAChRs). nAChRs are ligand-gated ion channel composed of five transmembrane subunits. Mammals contain nine α subunits (α2～α10) and three β subunits (β2～β4). The α4 and the nAChRs subtype of β2 subunit (α4β2-nAChR), in brain tissue mediate many behaviors related to NIC addiction. Recent studies have shown that α7, α5 and α6-nAChR play an important role in regulating NIC addiction. Genetic variations in the CHRNA5-CHRNA3-CHRNB4 gene clusters encoding α5, α3, and β4 increase the susceptibility to tobacco dependence and smoking-related diseases (including lung cancer). The expression of α5 or β4 subunits in mouse brain tissue changes the consumption pattern of NIC. In addition, the effects of NIC on appetite, attention and emotion are related to the establishment and maintenance of smoking habits.

Background and purpose: Tumor necrosis factor-α (TNF-α) not only acts as proinflammatory cytokine conducing to wide spectrum of human diseases including inflammatory diseases, but also can induce tumor development. In the current study, we investigated the relationship between TNF-α gene polymorphisms and the occurrence and development of non-small cell lung cancer (NSCLC) in Han population of Yunnan Province. Methods: A total of 425 lung cancer patients with NSCLC and 438 healthy individuals were included from Han population of Yunnan Province. The genotypes of 5 polymorphism loci, rs1799964 (-1031T>C), rs1800630 (-863C>A), rs1799724 (-857C>T), rs1800629 (-308G>A) and rs361525 (-238G>A) of TNF-α gene were detected by TaqMan assay. The frequency distributions of allele, genotype and haplotype in NSCLC patients and healthy controls were analyzed. Results: There was no significant difference in the allele and genotype frequency among 5 single nucleotide polymorphism (SNP) sites in TNF-α gene promoter (P>0.05). And in stratification analysis, the frequency of rs1799724-T was significantly higher in the adenocarcinoma patients than in the controls (P=0.010, OR=1.56, 95% CI: 1.11-2.19), and the rs1799724-TT+TC carrier showed significantly higher susceptibility to adenocarcinoma in dominant model (P=0.007, OR=1.66, 95% CI: 1.146-2.417). The frequency of rs1800630-A was significantly higher in adenocarcinoma, squamous cell carcinoma and other histological types of carcinoma patients (P=0.013, OR=2.15, 95% CI: 1.16-3.96). The haplotype analysis indicated that the frequency of haplotype rs1799724T-rs1800629G was higher in the adenocarcinoma group than in the control group (P=0.048, OR=1.42, 95% CI: 1.00-2.01). Conclusion: The T allele and TT genotype of rs1799724 (C>T) in TNF-α gene promoter might be associated with the susceptibility to lung adenocarcinoma in Han population of Yunnan Province. And rs1800630 (C>T) -A might be a risk factor of other histological lung cancer in Han population of Yunnan Province.

Objective To explore the biological function of RNA binding protein heterogeneous nuclear ribonucleoprotein A3(hnRNPA3) in the maintenance of pluripotency of human embryonic stem cells(hESCs) and to reveal its new mechanism in RNA transport. Methods The interaction of hnRNPA3 with nuclear pore and localization were examined by immunoprecipitation of nuclear pore complex and cytoplasmic separation in hESCs. After inhibiting the endogenous expression of hnRNPA3, the expression of the pluripotency/differentiation marker genes was detected by qPCR, and the effect on the nucleoplasmic distribution of polyA+ RNA and OCT4 mRNA was tested by RNA fluorescence in situ hybridization to predict the binding of hnRNPA3 to known RNA export associated proteins. Results hnRNPA3 was localized in the nucleus and interacted with the nuclear pore. Inhibiting the endogenous expression of hnRNPA3 significantly inhibited the cloning-formation ability of hESC(P＜0.05) and resulted in the increase of the expression of cell differentiation markers(P＜0.001) and significantly inhibited the export of polyA+ RNA as well as OCT4 mRNA(P＜0.001). The protein interaction network predicted that hnRNPA3 may bind to about one-third of the known RNA export associated proteins. Conclusions hnRNPA3 regulates hESC pluripotency by impacting on mRNA export.

The sequestration of soil inorganic carbon ( SIC) especially pedogenic carbonate ( PC) is one of the important pathways reducing the concentration of atmospheric carbon dioxide and thus mitigating climate change in coastal areas. Using the technology of l3C stable isotope, we analyzed the differences in the composition and storage of SIC, and explored the key physicochemical properties influencing soil PC storage in different horizons (0-10, 11-20, 21-40, 41-60, 61-80 and 81-100 cm) from Suaeda salsa wetland (SS), Spartina alterniflora wetland ( SA), young poplar plantation ( YP), and mature poplar plantation ( MP) in coastal area of the northern Jiangsu Province. The results showed that except for the surface (0-10 cm) soil in MP, the SIC content was higher than SOC in all soil horizons. Overall, neither the soil PC to SIC ratio nor the SIC storage were significantly different in SA and SS soils. Compared to wetland soils (0-40 cm), the soil PC to SIC ratio was reduced by 32.7% and 54.1% and the PC storage was reduced by 40.5% and 59.2%, the lithogenic carbonate ( LC) storage changed little, while the SIC storage was reduced by 21.0% and 17.9%, respectively in the YP and MP soils. Compared to the YP soils (0-100 cm), both the soil PC to SIC ratio and the PC storage were significantly reduced while the LC storage was significantly increased, especially at the 41-100 cm soil horizons, meanwhile, the SIC storage was not significantly changed in the MP soils. Results of the structural equation modeling (SEM) indicated that key factors influencing soil PC storage were the ratio of PC to SIC, followed by the SOC content and bulk density. SOC could inhibit the formation of soil PC. Generally, the coastal wetlands have greater SIC storage and sequestration potential than poplar plantations, and the PC sequestration can be regulated by modulating the ratio of PC to SIC and SOC content. [ABSTRACT FROM AUTHOR]

The Central Jilin-Yanbian metallogenic belt, one of the 12 important nickel mineralization belts in China, containing 13 nickel deposits(occurrences), with nickel reserves of more than 280 000 tons, is an important nickel resource base in China. There are intense multistage tectonomagmatic activities in the metallogenic belt, especially a series of ultramafic-mafic rock groups and related copper-nickel sulfide deposits were formed in the Indosinian post-orogenic extensional background. Through study on the two typical nickel deposits in Hongqiling and Changren, the paper sorts out the geological and metallogenic characteristics of nickel deposits, summarizes the spatiotemporal distribution regularity, and extracts the prospecting indicators. Based on the regional geological characteristics and gravity, aeromagnetic anomalies, the prospecting potential of copper-nickel sulfide deposits in Central Jilin-Yanbian metallogenic belt is analyzed, and the prospecting direction of nickel deposits is discussed to provide scientific basis for the further nickel prospecting deployment in the metallogenic belt. [ABSTRACT FROM AUTHOR]

The paper focuses on the prospecting of cobalt-nickel deposits in Liaoning-Jilin tectonic belt, on the basis of metallogenic geological conditions such as Paleoproterozoic structure-formation, to analyze previous data and research results and systematically discuss the sources of cobalt-nickel ore-forming material, characteristics of typical ore deposits or occurrences and mineralization process in Liaoning-Jilin tectonic belt. The results show that the Langzishan Formation to Gaojiayu Formation of former Liaohe Group is a complex orogenic accretionary series formed under the stable continental margin, active continental margin and even trench-arc-basin system. There is structural contact between the rock slices of different origin, showing the tectonic formation characteristics of overall disorder and locally order. The overlying Dashiqiao Formation-Gaixian Formation is stable residual sea basin sediment, which are in non-conformable contact with the underlying strata, showing the characteristics of ordered strata. Overall, the set of formation can neither be simply divided as ordered strata, nor be regionally correlated by metamorphic deformation degree. It is quite unreliable to judge the protolith formation of some metamorphic rocks and the tectonic environment in which they formed only by geochemical data and diagrams. The Liao-Ji granite(streaky or banded granite) formed by relatively mature continental margin arc, and the rock assemblage of the island arc generally displays the characteristics of TTG, but its ore-controlling significance is still unclear. The intrusive rocks formed under post-orogenic extension are predominantly syntectonic garnet granites or granitic gneisses which were deeply melted or remelted S-type granite. Additionally, there are adakitic granitic diorites that emerged in the context of late orogenic thickening. The ore-forming materials of the Cu, Co and Ni deposits are primarily sourced from basic dykes, continental crust pyroclastic rocks, subduction accretion complexes and abyssal sedimentary rocks. In the process of subduction and extinction for the Liao-Ji Ocean, besides the re-enrichment of original mineral source layer by orogeny and metamorphism, and the mineralization of basic-ultrabasic rocks under extensional action, the high carbonaceous quality and salinity in pelagic environment(seafloor thermal brines) are essential factors for mineral enrichment. In conjunction with regional geochemistry, three cobalt-nickel mineralization zones and six target areas are delineated within the Liaoning-Jilin tectonic belt. With an evaluation for the mineralization potential, the prospecting indicators and directions for cobalt-nickel deposits in the belt are proposed, which offer a novel approach to the prospecting breakthrough strategic action in the region. [ABSTRACT FROM AUTHOR]

Objective To study the protective effect of Ziziphi Spinosae Semen Flavonoids (ZSSF) on liver oxidative damage induced by perfluorooctane sulfonate (PFOS) in mice. Methods Mice were divided into blank control group, model group, positive control group (vitamin C group) and high, medium and low dose ZSSF group by random number table method, with 10 mice in each group. At the same time, PFOS (10 mg/kg) was molded and administered continuously for 30 days.After 6 h after the last delivery, eyeball blood in mice, the liver to join 9 times the volume of 0.9% sodium chloride solution in homogenate is made from 10% of the tissue of slurry, according to the kit instruction alanine transaminase (ALT) in serum and aspirate aminotransferase (AST), superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione peroxidase (gsh-px) and catalase (CAT) and total antioxidant capacity (T -AOC) level; The expression of Nrf2 and HO-1 mrna in liver tissues was detected, and real-time fluorescent quantitative PCR(RT-qPCR) was applied. Results Compared with the control group, the contents of alanine aminotransferase, aspartate aminotransferase, and malondialdehyde increased in the model group, while the contents of superoxide dismutase, glutathione peroxidase, catalase and total antioxidant capacity decreased(P＜ 0.01, P＜0.05); Compared with the model group, the drug intervention group reduced the content of AST, ALT and MDA, and increased the content of SOD, CAT, GSH-Px, T-AOC, Nrf2 and HO-1 mRNA in liver tissue(P＜0.01, P＜0.05). Conclusions Ziziphi Spinosae Semen Flavonoids can improve the oxidative liver injury induced by PFOS in mice, which may be caused by increasing the activity of antioxidant enzymes in vivo and reducing the generation of lipid peroxides by regulating the Nrf2/HO-1 pathway, so as to improve the antioxidant capacity of the body.

Objective To explore the effect of barley plus butter dietary on the symptoms of dextran sodium sulfate induced chronic ulcerative colitis and intestinal microbial distribution in mice. Methods In customized feed(C feed), soybean oil and corn meal in standard mice breeding feed (N feed) were replaced with equal proportion of ghee and raw barley powder.28 male mice were randomly divided into 4 groups(n=7,each group):NW group fed with N feed and water; ND group fed with N feed and 1.8% DSS; CW group fed with C feed and water; CD group fed with C feed and 1.8% DSS. Colitis model was established by three cycles of 10 days supply of distilled water after 7 days supply of 1.8% DSS solution. Finally, the effects were evaluated by DAI score, colon HE staining and 16S rRNA high-throughput sequencing of gut microbes. Results The abundance of bacteria was increased and the diversity of intestinal flora, such as allobaculum, was improved in wild type mice fed on the barley and butter dietary. However, when the mice were treated with DSS, the barley plus butter dietary group had high DAI score(P＜0.05), showed obvious intestinal ulcers and disorganized intestinal glands by histopathological microscopy, and decreased intestinal flora abundance and diversity(P＜0.05). But the quantity of Clostridium and Sartreella was increased in barley and butter dietary group(P＜0.05). Conclusions The barley plus butter dietary increases intestinal flora Allobaculum of wild type mice and improves the composition of intestinal flora, but the dietary intervention fails to show any significant impact on the chronic ulcerative colitis symptoms induced by DSS.

Objective To investigate the role of mammalian sterile line 20-like kinas 1(MST1) and its regulatory mechanism in hepatic gluconeogenesis of mouse. Methods The mRNA expression of MST1 in the liver of db/db mice and db/m mice was detected by RT-qPCR. MST1 was overexpressed with adenovirus to detect glucose output capacity in mouse primary hepatocytes. Luciferase reporter assay was adopted to detect the effect of MST1 on phosphoenolpyruvate carboxykinase (PEPCK) promoter activity in HepG2 cells. Forkhead transcription factor O1 (FOXO1) was knocked down by interfering adenovirus in primary mouse liver cells to detect the effect of MST1 overexpression on the mRNA levels of PEPCK. Results The mRNA level of MST1 was significantly upregulated in the liver of db/db mice (P＜0.001). MST1 overexpression enhanced glucose output in mouse primary hepatocytes (P＜0.05). In HepG2 cells, MST1 overexpression increased the mRNA of PEPCK (P＜0.001) and the activity of PEPCK promoter (P＜0.01). Furthermore, MST1-induced increase in PEPCK mRNA was abolished when FOXO1 was knocked down by interfering adenovirus. Conclusions MST1 promotes hepatic gluconeogenesis by regulating the mRNA expression of PEPCK dependent on FOXO1.

Objective To observe the effects and mechanisms of Apelin-13 on expression of pyroptosis related proteins in aorta of diabetic mice. Methods C57/BL mice of eight weeks old were used as control group;kkAy mice of eight weeks old were used as type 2 diabetic models;osmotic pumps were used to treat kkAy mice with apelin-13 at a rate of 30 μg/(kg·d),and L-NAME(eNOS inhibitor) was injected intraperitoneally at a dose of 10 mg/(kg·d) to kkAy mice. Blood was collected for detection of Hb1Ac. The aortae were harvested and fixed. Morphological changes were observed with HE staining. Expression of eNOS,NLRP3,caspase-1 and gasdermin D were measured with immunohistochemical staining. Results Compared to the control group, the level of eNOS in the aorta of diabetic mice was significantly higher than that in control mice (P＜0.05),the levels of NLRP3,caspase-1 and gasdermin D were also higher than that in control mice. After apelin-13 treatment,the expressions of eNOS,NLRP3,caspase-1 and gasdermin D were further increased (P＜0.05). After L-NAME and apelin-13 treatment, the expressions of eNOS, NLRP3,caspase-1 and gasdermin D were reduced as compared to apelin-13 treatment alone(P＜0.05). Conclusions Apelin-13 may promote the expression of pyroptosis related protein in aortic cells by increasing eNOS/NO pathway,which would induce structural and functional damage in diabetic arteries.

Objective To investigate the effect of sanguinarine on the invasion and migration of lung adenocarcinoma cells and its preliminary molecular mechanism. Methods MTT assay was used to observe the proliferative capacity of A549 and H1975 cells. Wound healing and Transwell assays were performed to determine the invasion and migration abilities of A549 and H1975 cells, respectively. RT-qPCR and Western blot were used to detect the mRNA and protein expression of core genes in Wnt/β-catenin signaling pathway. Results Compared with the control group, sanguinarine(1-10μmol/L) could inhibit the activity of human lung adenocarcinoma cells in a concentration- and time- dependent manner (P < 0.05); the migration and invasion abilities of A549 and H1975 cells were significantly weakened by 1μmol/L sanguinarine after 48 h (P < 0.01); sanguinarine (1, 2.5, 5μmol/L) could significantly down-regulate the protein expression of β-catenin, phosphorylated GSK3β and DVL2 in Wnt/β-catenin pathway, thereby inhibiting the mRNA levels of TCF/LEF and CyclinD1, in a concentration-dependent manner (P < 0.05). Conclusion Sanguinarine may inhibit the migration and invasion of human lung adenocarcinoma cells by down-regulating the Wnt/β-catenin signaling pathway.

Objective To summarize the key elements and shortcomings of relevant policies in the field of mental health in China, so as to provide reference for the formulation and improvement of follow-up policies in the field of mental health in China. Methods Using NVivollPlus software and content analysis method, a two-dimensional analysis framework of "policy tool-policy object" was constructed to quantitatively analyze 141 relevant policy texts in the field of mental health at the national level from 1999 to 2023 in China. Results China has paid growing attention to mental health, and the National Health Commission, the Ministry of Education, and the Ministry of Civil Affairs were the core departments of policy formulation. The internal structure of supply-oriented policy tools was out of balance, and the application of environmental policy tools was insufficient. Demand-based policy tools were the least used, accounting for 49.96%, 28.36%, and 21.68%, respectively. The policy object was concentrated in the whole system, health system, and education system, accounting for 32.81%, 24.59%, and 21.94%, respectively. Conclusion It is suggested that the policy design balance the structure of policy tools, increase the supply of resources, apply strategies and measures, strengthen mental health education and promotion, strengthen community grass-roots mental health services, and standardize the development of social mental health service institutions so as to improve mental health and mental hygiene policy system. [ABSTRACT FROM AUTHOR]

The study was to establish HPLC characterization of Stevia rebaudiana extract. The chemical composition in 21 batches of Stevia rebaudiana extract was determined by HPLC. The results showed that six characteristic peaks were marked and determined in the HPLC characteristic chromatogram of Stevia rebaudiana extract, and the characteristic peaks 1~6 were determined as neochlorogenic acid, chlorogenic acid, crypto chlorogenic acid, isochlorogenic acid B, isochlorogenic acid A and isochlorogenic acid C by comparison with the reference substances. Isochlorogenic acid B was set as the reference peak (S peak), and the specified values of the relative retention time of characteristic peaks 1~6 were 0.388, 0.520, 0.534, 1.000, 1.042 and 1.091, respectively. The study indicates that the established HPLC chromatogram has good precision, stability and repeatability, which can provide a reference for the quality control of Stevia rebaudiana extract. [ABSTRACT FROM AUTHOR]

Polycrystalline Na0.5K0.5NbO3 ceramics were prepared under the condition of 10 GPa and 1 050 T. The compression and shear wave velocities of the samples under various hydrostatic pressures were measured using ultrasonic interferometry. By fitting the third-order finite strain state equation, the bulk and shear moduli of polycrystalline Na0.5K0.5NbO3 and their pressure dependency were determined as 172.6 GPa, 54.6 GPa, 0.3 and 2.1, respectively. The sample shows a positive pressure dependence of Young's modulus. Based on the elastic modulus data, the Poisson's ratio was obtained as 0.342, indicating that the material was ductile and shows brittleness under high pressure. The Vickers hardness and fracture toughness also show positive pressure dependence. Using the empirical models, the Vickers hardness and fracture toughness of the ceramics were obtained as 2.40 GPa and 2.33 MPa⋅m1/2. Meanwhile, based on the elastic wave velocity and density data, the Debye temperature (513.1 K) and the Grüneisen constant (2.113) of Na0.5K0.5NbO3 ceramics were derived. Our results provide an experimental reference for evaluating the acoustic and elastic- related comprehensive properties of Na0.5K0.5NbO3 under high pressure, and a foundation for its engineering applications under extreme high-pressure conditions as well. [ABSTRACT FROM AUTHOR]

The aim of the experiment was to investigate the effect of Chinese herbal compound additive on growth performance, serum biochemical indices and spleen IL-2 mRNA expression of Hy-line Brown egg chicks. A total of 960 one-day-old healthy Hy-line Brown egg chicks were randomly divided into two groups with five replicates per group and 96 chickens per replicate. Egg chicks in control group were fed with basal diet, and those in experimental group were fed with basal diet supplemented with 0.2% Chinese herbal compound additive. The experiment lasted for 42 d. The results showed that compared with control group, the final weight and average daily gain of egg chicks in experimental group were extremely increased (P<0.01), and the feed to gain ratio and mortality rate were extremely decreased (P<0.01). Compared with control group, keel length and tibia length of egg chicks in experimental group were extremely increased (P<0.01), and chest width and hip width were significantly increased (P<0.05). Compared with control group, the content of BUN and TC in serum of egg chicks in experimental group were extremely decreased (P<0.01), the activity of AST was significantly decreased (P<0.05), and the content of IFN-γ and IL-2 were extremely increased (P<0.01). Compared with control group, thymus index, bursa of Fabricius index and spleen IL-2 mRNA expression of egg chicks in experimental group were extremely increased (P<0.01). The study indicates that 0.2% Chinese herbal compound additive in the diet can improve the growth performance, improve the serum biochemical indexes, and promote the development of immune organs and the expression of IL-2 mRNA in spleen of Hy-line Brown egg chicks. [ABSTRACT FROM AUTHOR]

To overcome the shortcomings of existing image inpainting methods, such as the lack of authenticity in the inpainting results, the lack of effective processing of missing region and non-missing region information, and the lack of effective processing of image feature information in different stages, an image inpainting method combining semantic priors and deep attention residual group is proposed. The image inpainting network is mainly composed of semantic priors network, deep attention residual group and full-scale skip connection. The semantic priors network learns the complete semantic priors information of visual elements in the missing region, and uses the learned semantic information to complete the missing region. The deep attention residual group enables the generator not only to pay more attention to the missing area of the image, but also to learn the features of each channel adaptively. The full-scale skip connection can combine the low-level feature map containing the image boundary with the highlevel feature map containing the image texture and detail to inpaint the missing area of the image. In this paper, a full comparison experiment is conducted on CelebA-HQ dataset and Paris Street View dataset, and the experimental results show that the proposed method is superior to the current representative advanced image inpainting methods. [ABSTRACT FROM AUTHOR]

The current research situation and shortcomings of traditional VOCs recycling technology of industrial sources are reviewed. In order to improve the shortcomings of VOCs technology upgrading, the application progress of optimization process parameters of corresponding recycling technology system by simulation is analyzed. This paper can provide some reference for optimization and improvement of industrial VOCs recovery technology simulation. In addition, the optimization trend of VOCs traditional recycling technology system through simulation is prospected, and the future simulation optimization process system is proposed to develop efficient, low cost, diversified recycling technology research hot spots. [ABSTRACT FROM AUTHOR]

In view of the problems such as excessive vibration of unit in the second phase of Yonghu Pumping station, strong vibration of local structure of workshop and serious wear of pump port ring, we carried out on-site inspection. Through the analysis and study of the field test results, the paper draws the conclusion that the high vibration of the unit is caused by the rapid shrinkage of the inlet taper pipe of the water pump, the strong vibration of the local structure is caused by the resonance caused by its natural vibration frequency consistent with the pump blade frequency, and the severe wear of the pump port ring is caused by the improper use of materials. According to the conclusion, the strong vibration of the pump station building disappears, the excessive vibration of the unit and the wear of the mouth ring are improved. [ABSTRACT FROM AUTHOR]

Based on the 1:250 000 land quality geochemical survey data of black land in Northeast China, the soil nutrients, soil environmental quality, comprehensive soil quality and suitability of green food producing area in Nehe City are evaluated according to the Soil Quality Geochemical Evaluation Standard and Soil Environmental Quality Agricultural Land Soil Pollution Risk Control Standard (Trial). The results show that there is fertile land and clean environment in Nehe City, which is suitable for the development of green agriculture. Among the 16 indexes, including N, P, K, organic matter, CaO, MgO, Fe2O3, S, B, Zn, Mn, Cu, Mo, Co, Ge and V, except Cu and Zn are relatively deficient, Ge and B deficient, the others are rich or relatively rich. The comprehensive soil nutrient grades are mainly rich and medium, with distribution areas of 3 666.74 km² and 2 574.11 km², accounting for 56.94% and 39.97% of the total area respectively. The soil environmental quality is dominated by Grade I (risk free), covering an area of 6 435.78 km², accounting for 99.94% of the total; while the Grade II (risk controllable) area is only 4 km², occupying 0.06%. The comprehensive soil quality is largely fine-grade soil, covering 3 806.06 km² and accounting for 59.11% of the total area, with the good-grade of 2 574.11 km² (39.97%) and medium-grade of 59.61 km² (0.92%), no poor- and inferior-grades soil. The soil area conforming to Grade-AA green food production area is 6 461.5 km², accounting for 97.5% of the total area, that conforming to Grade-A 38.1 km² (0.58%), and that does not meet the requirements is 65.6 km² (0.99%). [ABSTRACT FROM AUTHOR]

Industrial cloud service is an important means of intelligent upgrading of industrial internet and realization of digital mine construction. This paper introduces the development of digital simulation model for the important large-scale grinding equipment in the mineral grinding process, and the specific research process of realizing the online self-diagnosis function of a SAG mill via the industrial cloud service. The SAG mill online self-appraisal tool can be used for quantitative calculation of important information such as material movement inside the SAG mill and particle size distribution of grinding products in different processing production periods. The results can be quickly visualized by cloud service mode. This tool can not only provide an intuitive judgment method for the operation state analysis of a SAG mill, but also provide suggestions for the SAG mill operation and process optimization according to the calculation results. [ABSTRACT FROM AUTHOR]

Objective. To evaluate the role of preablative stimulated thyroglobulin (ps-Tg) as an early prognostic marker for patients with differentiated thyroid carcinoma (DTC) complicated with nodular goitre (NG) after operation and determine the corresponding cut-off value. Methods. A total of 268 patients with DTC complicated with NG who underwent the 131I treatment and thyroidectomy were analyzed. Logistic regression analysis were performed to evaluate baseline ps-Tg and other clinicopathologic characteristics in the prediction of distant metastasis. The receiver operating characteristic (ROC) curve analysis was conducted to analyze optimal cut-off point of ps-Tg for predicting the recurrence or metastasis for patients with DTC complicated with NG. Results. In the Logistic analysis, ps-Tg (OR=1.002, P=0.005), N1b (OR=0.235, P=0.001) and the histological-pathological types (OR=0.263, P= 0.012) were predictors of distant metastasis. The cut-off value of ps-Tg for predicting the recurrence or metastasis was 26.97 ng/mL, with sensitivity of 66.7% and specificity of 83.3%. Area under the ROC curve was 0.795. Conclusion. For patients with DTC complicated with NG, ps-Tg, N1b and the histological-pathological types have a significant prognostic implication in early postoperative metastasis or recurrence. The cut off value of ps-Tg could be more useful for the prediction of metastasis or recurrence. [ABSTRACT FROM AUTHOR]

Based on the remote sensing monitoring data of land use in 1985, 2000 and 2017, the spatiotemporal variation characteristics and eco-environmental effects of land use transition in eastern Songnen Plain in the past 30 years are analyzed by means of land use transfer matrix, gravity center model and eco-environment quality index. The results show that the land use is mainly cultivated land and forest land with clear distribution boundary during 1985-2015. The land use intensity continues to increase, fast in early stage and slow in later. The main performances of land use transition involve continuous increase of agricultural land, continuous decrease of ecological land and slight increase of construction land, changing drastically in early stage and slowing down in later. The direction of land use transition is generally stable. The shift trajectory of transfer barycenter varies greatly, of which the largest change is during 1985-2000, with the transfer trajectory of water area shifting 76.34 km northwestward. The regional ecoenvironmental quality index of Songnen Plain continued to decline from 0.395 in 1985 to 0.361 in 2017, indicating the continuous deterioration of eco-environmental quality. In 2017, the spatial distribution is dominated by medium and low-medium quality areas. The mutual transition between agricultural land, grassland and unused land is the main influencing factor of ecological environment quality. [ABSTRACT FROM AUTHOR]

Wetland serves as an important carbon sink in nature, and its carbon stock variation has significant influence on global climate change and greenhouse effect. Selecting the geographically unique Xingkai Lake Nature Reserve in Heilongjiang Province as the study area and collecting the surface soil samples (0-20 cm) in terms of soil types, the research uses remote sensing-interpreted land use map, calculation formula of soil carbon storage and plant carbon sequestration to count the total carbon sequestration amount of ecosystem service in the reserve. Besides, the carbon sequestration service value is estimated to be RMB 490 million by referring to Sweden's carbon tax approach and China s afforestation cost approach. The results show the carbon sequestration service function of wetland is above the national average and that of Momoge wetland on the same latitude in Northeast China Plain, which provides effective reference for protection and management of the study area in the future. [ABSTRACT FROM AUTHOR]

To scientifically evaluate the quality level of existing cultivated land in Hailun City, Heilongjiang Province, the environmental satellite image, Landsat8 remote sensing image and geoehemieal survey data are used to extract the information of soil fertility, water content, heavy metal pollution and other indexes. The temperature vegetation dryness index (TVDl) which has a stronger correlation with soil water content, replacing the traditional difference vegetation index (DVI), is applied to establish a soil quality evaluation method based on pressure-state-response (PSR) model. The analytic hierarchy process (AHP) is used to assign weights to each evaluation index, combined with expert scoring and linear interpolation, to realize the quantitative evaluation of evaluation factors and obtain the minimum evaluation units by spatial weight superposition of all evaluation factors. The results show that the first-grade cultivated land accounts for 28.75%, with 71.17% of second-grade, 0.08% of third-grade and below, and the quality of cultivated land is generally high in Hailun City. Finally, some suggestions for improving cultivated land are put forward by analyzing the spatial distribution of cultivated land of different grades. [ABSTRACT FROM AUTHOR]

A bacterial strain ESY06 with the properties of high efficiency and high tolerant metals, identified as Thiobacillus ferrooxidansi (T.f.), was obtained by isolating and long term cultivating. The bioleaching of the copper, cobalt and nickel in spent lithium ion batteries using strain ESY06 were investigated. And the effect of Fe2+ concentration on the growth of a strain ESY06 was examined. The results show that the tolerant ability of the strain ESY06 to copper, cobalt and nickel are respectively 1.22, 2.21 and 0.29 g/L. Under the condition of Fe2+ concentration of 20 g/L, the growth of the strain ESY06 is the best. The leaching rate of cobalt and nickel in positive electrode can reach 99. 93% and 99. 46%, respectively, and the leaching rate of copper in negative electrode is 99.78%. For the mixed electrodes, the leaching rate of copper, cobalt and nickel are 99. 88%, 99.39% and 99 55%, respectively. The combined process of acid leaching pre-treated and bioleaching has good effect on leaching of copper, cobalt and nickel, and can recovery the valuable metals in battery electrode materials. [ABSTRACT FROM AUTHOR]