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In this study, the prepared dish Kung Pao Chicken with soy protein artificial meat (SPAM-KPC) was developed to satisfy the higher demand for nutritious healthy and diversified convence food, and the changes in storage quality of SPAM-KPC at different storage temperatures (4, 25 and 37 ℃) were compared. The shelf life prediction model of the SPAM-KPC was established based on the total number of bacteria as the key quality factor affecting the shelf life of the product. The results showed that the total colony count of SPAM-KPC samples stored at three temperatures for 15 days increased from 0.67 lg(CFU/g) to 2.73, 3.37 and 4.33 lg(CFU/g), respectively. While pH (from 6.22 to 5.88, 5.87, 5.69) and sensory scores (from 25.12 to 22.67, 19.52, 16.84) gradually decreased, as well as hardness and springiness decreased. The shelf life of SPAM-KPC products at three storage temperatures was 28, 20 and 17 days, respectively. According to the findings, low-temperature storage at 4 ℃ was the best storage temperature for SPAM-KPC products. This work could provide a theoretical reference for the application of plant-based protein meat in the field of prepared dishes processing.

Food is the top priority for the people, and safety is the top priority for food. The quality and safety of food are related to the national economy and people's livelihood. With the development of Chinese economy and the improvement of people's quality of life, the scale of the food industry has also grown year by year, and the society and consumers have more stringent requirements on the quality of food production and its own safety. However, food quality and safety incidents occur frequently, making food quality and safety management an important task for improving people's livelihoods. Machine learning has been widely applied in the field of food quality and safety, with strong self-learning ability, good non-linear fitting ability, and fast modeling. Among them, neural network models and supervised learning methods can accurately and quickly detect and control the quality of food in the production process. This article focuses on the research progress of machine learning in the field of food quality and safety, and discusses it in three directions: Food quality inspection, food process traceability, and food safety warning. In order to clarify the focus, advantages and disadvantages, and future development direction of machine learning algorithms in food regulation, and provide theoretical support and technical guidance for the intelligent development of ensuring food quality and safety.

The rapid development of Chinese potato processing industry can be attributed to the implementation of the potato staple food industrialization strategy. Potato protein, known for its high nutritional value and functionality, exhibits exceptional solubility and contains a significant amount of tyrosines that are scarce in other plant proteins. Consequently, potato protein holds immense potential for various market applications. This paper provides a comprehensive review of the composition, functional properties, modification methods, and modification applications of potato protein. Potato protein exhibits good solubility, foaming and emulsifying properties, gelation, and antioxidant activity. Currently, enzyme treatment and microbial fermentation are the focus of potato protein modification research. Additionally, this article provides an overview of the main issues commonly found in potato protein and proposes future development prospects based on current research progress. In the future, it is necessary to further investigate the relationship between the molecular structure of potato protein and its functional activities. Enhancing the utilization of potato protein and plant proteins, enzymatic methods and microbial fermentation shows promise as a future direction for modification. By harnessing microbial resources, the cost of modification can be effectively reduced.

Objective: To compare the quantitative parameters of lung HRCT and clinical manifestations of anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive idiopathic inflammatory myopathy (IIM) patients with different prognoses. Methods: The clinical and imaging data of 19 MDA5 antibody-positive IIM patients admitted to Beijing Shijitan Hospital Affiliated with Capital Medical University between February 2017 and November 2022 were retrospectively analyzed. According to the prognoses, the patients were divided into the good prognoses group (14 cases) and the poor prognoses (intubation or death) group (5 cases). The clinical and laboratory indexes, types of interstitial lung disease (ILD), and CT quantitative indexes were compared between the two groups. Results: There were significant differences in gender; carcinoembryonic antigen; blood oxygen saturation; and the percentages of lymphocytes, monocytes, neutrophils, lymphocytes, and neutrophils between the good versus the poor prognoses groups. The proportion of abnormal respiratory system changes was higher in the poor prognoses group. In terms of the type of ILD, acute interstitial pneumonia (AIP)-like lesions were the main type in the poor prognoses group, and nonspecific interstitial pneumonia (AIP) lesions were the main type in the good prognoses group. For NSIP-like lesions, there was a statistically significant difference between the two groups. The semi-quantitative score of the poor prognoses group was higher, and the volume of whole lung lesions as well as the proportion of whole lung lesions were also higher. Spearman correlation analysis showed that the blood oxygen saturation, monocyte percentage, semi-quantitative score, whole lung lesion volume, and proportion of whole lung lesion were negatively correlated, while carcinoembryonic antigen, neutrophil percentage, and neutrophils were positively correlated with the semi-quantitative score, whole lung lesion volume, and proportion of whole lung lesion. Conclusions: The lung HRCT quantitative indicators, clinical manifestations, and laboratory indicators are different in MDA5 antibody-positive IIM patients with different prognoses. Early evaluation of HRCT imaging manifestations, clinical manifestations, and laboratory indicators is of great significance in determining the prognosis of MDA5 antibody-positive IIM patients, which provides corresponding support for clinical diagnosis and treatment.

This is an article in the field of metallurgical engineering. In this article, TiH2 powder was selected as the experimental raw material to study the sintering behavior of TiH2 powder under different pressing pressure and holding time in cold isostatic pressing, to reveal the effects of pressing pressure and holding time on the shrinkage as well as the relative density of TiH2 sintered specimens, in order to improve the density of the billet and the performance of the products. The results show that the shrinkage of the sintered sample decreases with the increase of the pressing pressure, and when the pressing pressure reaches 400 MPa, the pressing pressure has little effect on the relative density of the sintered sample. For the consideration of the sample preparation efficiency and the pressing pressure limit of the cold isostatic press, the pressing pressure should not exceed 400 Mpa. The shrinkage of sintered samples decreases with the increase of holding time, and when the holding time reaches 20 min, the relative density of sintered samples changes little with the extension of holding time. For the consideration of sample preparation efficiency, the suitable holding time is 15～20 min.

The matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) diagnostic tool was used to rapidly detect and identify three foodborne pathogens, Salmonella, Staphylococcus aureus and Bacillus cereus in ready-to-eat bulk foods in this study. The best method was identified by optimizing and screening various experimental conditions such as spot sampling method, pre-treatment method, different media and culture time, and its detection limit and stability were evaluated. Meanwhile, the established method was compared with multiplex PCR and the other biochemical identification methods such as VITEK 2 to contrast the consistency of the three identification results. Finally, batch food sample testing was carried out to explore the applicability of using MALDI-TOF MS to test ready-to-eat bulk foods. Results indicated that all the identification scores of the three bacteria were higher than 95% for the same batch and different passages, with a coefficient of variation of less than 2%. It demonstrated that the established method had good repeatability and stability, and the detection limit was 105 CFU/mL. The results of strain identification by MALDI-TOF MS were highly consistent with those of multiplex PCR and biochemical identification methods. Moreover, the MALDI-TOF MS method was more specific and efficient. Regarding spot sampling, the three covering methods showed higher average identification scores than the sandwich and mixed methods, all of which scored 99.9%. The 1 μL+1 μL covering method spot sampling approach obtained higher average peak numbers, and more complex and stronger characteristic peaks. Regarding pre-treatment, the formic-acid-acetonitrile method obtained a higher peak volume and peak intensity than other bacterial treatment methods, with an average identification score of 98% or higher. At the same time, the matching degree with the database spectrum was higher. In summary, MALDI-TOF MS method was not only sensitive, specific, accurate and rapid in foodborn pathogen identification, but also had simple operation and intuitive in results. As a powerful supplement to the national standard method, it provided a viable alternative for analysing, identifying and typing foodborne pathogens.

Different levels of hydroxypropyl methylcellulose (HPMC), xanthan gum (XG) and Glucose oxidase (GOX) were applied to germination brown rice-wheat flour (1:1) to evaluate the effects of improvers on the dough properties and Chinese steamed bread (CSB) quality. With no improver as control, thermo-mechanical and alveograph properties of different dough were analyzed, and the overall quality of different steamed bread was evaluated by color, texture, specific volume, height/diameter ratio and sensory score. The results showed that the addition of HPMC significantly (P

【Objective】In modern vegetable facility cultivation, the quality of vegetable seedlings plays a very important role in the economic benefits of subsequent agricultural production. Continuous light is a common special light mode in artificial light plant factory. Exploring the effect of continuous light combined with light quality on the growth and development of pepper seedlings could provide an important technical reference for efficiently improving the resistance of pepper seedlings.【Method】The pepper backbone parent '6421' was used as the test material, and 6 light treatment groups were set up: normal white light irradiation group (CW), normal blue light irradiation group (CB), normal red light irradiation group (CR), continuous white light irradiation group (TW), continuous blue light irradiation group (TB) and continuous red light irradiation group (TR). The effects of continuous photoperiod treatment combined with red and blue light on the growth and physiological characteristics of pepper seedlings were studied.【Result】(1) TR significantly increased the plant height and stem diameter of pepper seedlings by 20.5% and 10.6%, respectively, compared with the CW group. After TR treatment, the seedling index increased significantly by 2.38 times, while TB significantly reduced the plant height and stem diameter of pepper seedlings by 17.1% and 14.3%, and the root-shoot ratio increased significantly by 2.62 times. (2) There was no significant difference in Pn and Gs of pepper seedling leaves between TR and TB, but Tr and Ci of TB were significantly lower than those of TR. Compared with CW, Tr and Ci of TB were significantly reduced by 62.5% and 51.1%. The chlorophyll fluorescence parameters of pepper seedling leaves showed opposite results after different light treatments. The Fv/Fm, Fv/Fo, NPQ and qP values of pepper seedling leaves in TB group were significantly higher than those in TR group. The qP of TB and TR was significantly higher than that of CW, increasing by 36.1% and 26.1%, respectively. (3) The antioxidant enzyme activity and osmotic substances of pepper seedlings were significantly different after continuous red light treatment and continuous blue light treatment. TB significantly increased SOD, POD and CAT in leaves of pepper seedlings. The POD and CAT activities of pepper seedling leaves were also significantly increased after TR treatment, while the MDA content of pepper leaves after TB and TR treatments was significantly reduced by 55%-56% compared with that of CW.【Conclusion】Continuous light conditions have a positive effect on the growth and development of pepper seedlings at the seedling stage, and the antioxidant enzyme activity and osmotic substances of pepper seedlings under continuous light irradiation combined with monochromatic red and monochromatic blue light treatments increase to different degrees to better counteract the light stress environment and improve the adaptability of pepper seedlings.

Purposes Speech emotion recognition allows computers to understand the emotional information contained in human speech, and is an important part of intelligent human-computer interaction. Feature extraction and fusion are key parts in speech emotion recognition systems, and have an important impact on recognition results. Aiming at the problem of insufficient emotional information contained in traditional acoustic features, a deep feature extraction method based on multi-task learning for optimization of acoustic features is proposed in this paper. Methods The proposed acoustic depth feature can better characterize itself and has more emotional information. Then, on the basis of the complementarity between acoustic features and spectrogram features, spectrogram features through convolutional neural network are extracted. Then, the multi-kernel principal component analysis method is used to perform feature fusion and dimension reduction on these two features, and the obtained fusion features can effectively improve the system recognition performance. Findings Experiments are carried out on the EMODB and the CASIA speech databases. When the DNN classifier is used, the multi-kernel fusion feature of the acoustic depth feature and the spectrogram feature achieve the highest recognition rates of 92.71% and 88.25%, respectively. Compared with direct feature splicing, this method increased the recognition rate by 2.43% and 2.83%, respectively.

Objective: Objective: To explore and analyze the clinical features and chest thin-slice non-enhanced computed tomography (CT) imaging features of patients with coronavirus disease 2019 (COVID-19) at initial diagnosis in a fever clinic. Methods: A retrospective analysis was performed on 140 patients with COVID-19 at initial diagnosis in a fever clinic, including 101 and 39 cases in the moderate and severe and critical groups , respective-ly. Baseline, clinical characteristics, complete blood count + C-reactive protein (CBC+CRP), and chest thin-slice non-enhanced CT imaging characteristics of the patients were analyzed. Results: (1) The comparison between the moderate and severe and criti-cal groups showed that there were statistically significant differences in age (66.05±14.38 vs. 77.90±13.12,), course of initial diagnosis (5.40±3.81 vs. 3.97±3.12), SPO2 (97.88±1.73 vs. 92.92±4.01), and Tmax (38.32±0.66 vs. 38.68±0.63).(2) CT features between the two groups showed statistically significant differences in semi-quantitative volume (18.85±13.51 vs. 34.41±19.34). (3) The comparison between the moderate and severe and critical groups showed that there were statistically significant differ-ences in CRP (29.42±26.93 vs. 80.67±48.01), LYM (1.64±0.68 vs. 0.95±0.64), and NLR (3.48±2.46 vs. 9.36±10.42). (4) Six indicators, namely age, the course of initial diagnosis, SPO2, semi-quantitative volume, CRP, and LYM, were screened for multivariate logistic regression analysis. The result show that age (OR=1.090, 95%CI 1.006 ~ 1.181), semi-quantitative (OR=1.086, 95%CI 1.086 ~ 1.019), and SPO2 (OR=0.261, 95%CI 0.089 ~ 0.762), are related to the occurrence of severe and critical COVID-19 infection, and the difference is statistically significant; CRP (OR=1.054, 95%CI 1.023 ~ 1.087) and LYM (OR=0.039, 95%CI 0.04 ~ 0.391) are related to the occurrence of severe and critical COVID-19 infection, and the difference is significant statistically significant. Conclusion: Age, lower SPO2 and LYM, a shorter course; a higher Tmax, semi-quantitative volume, CRP, and NLR are associ-ated with severe and critical cases and required early identification.

Objective: To investigate the clinical value of thin-section chest computed tomography (CT) in the typing of coronavirus disease 2019 (COVID-19). Methods: A retrospective analysis was performed on 134 patients diagnosed with COVID-19 in our hospital’s Department of Infectious Diseases from December 20, 2022, to December 31, 2022. All patients underwent thin-section chest CT scan with complete clinical data. According to clinical classification, patients were divided into the non-severe and severe groups. Clinical data and imaging features of the two groups were compared and analyzed, and statistical analysis was conducted. Results: There was a statistically significant difference with respect to diabetes mellitus between the two groups, and the incidence of diabetes mellitus in the severe group (45.8%) was higher than that in the non-severe group (25.5%); There were no significant differences in sex, age, average course of disease, and clinical symptoms between the two groups; There were significant differences in the number of lesions, symmetrical distribution, predominant peripheral distribution, diffuse distribution, blurred edge, morphology of large flake and band, vascular bundle thickening, paving stone sign, arcade sign, and fried egg sign between the two groups, the number of lesions >10, diffuse distribution, morphology of large flake and band, vascular bundle thickening, paving stone sign, and arcade sign were more common in the severe group than in the non-severe group, while predominant peripheral distribution, blurred edge, and fried egg sign were more common in the non-severe group than in the severe group. Conclusions: Thin-section chest CT scan can identify the abnormal imaging manifestations of the lung in patients with COVID-19 and evaluate the number, distribution range, and morphological characteristics of the lesions. Combined background diseases, number, distribution characteristics, blurred edge, large flake and band morphology, vascular bundle thickening, paving stone sign, arcade sign, and fried egg sign can effectively indicate the classification of patients with COVID-19. This can provide imaging evidence for the diagnosis and treatment of COVID-19.

With the development of society, the idea of healthy diet and the green sustainable development are widely recognized. Compared with traditional meat product, with advantages of rich nutrition and environment-friendly factors of production, plant-based protein meat substitutes has become the research focus. In this report, both domestic and overseas research status and development process of plant-based protein meat substitutes in recent years are briefly analyzed, it also systematically introduced the raw materials needed, extrusion technology and quality evaluation methods. In the end of this report, the existing main problems are summarized, and corresponding expectations are putted forward based on the actual research process. In the future, the appearance, flavour, texture and other sensory attributes should be deeply studied, while taking the nutrition and food safety into account. As the development trend in the future, in addition to water content adjustment, extrusion temperature and other process parameters, high moisture extrusion technology should also focus on the improvement of cooling die.

Bacterial spores are extremely resistant to various processing techniques attributable to its special structure and physiological processes, and often lead to the spoilage of thermally sterilized food. Therefore, it is of great significance to inactivate spores or control spore germination in the food industry. This review summarizes the structure and the sporulation regulation mechanism in the formation process of bacterial spores, germination process and the factors of spore germination; then reviews the effects and mechanisms of action of some physical technologies (i.e., heat treatment, ultrasonic treatment, high pressure treatment and plasma treatment), chemical technologies (i.e., surfactants and chemical preservatives) and natural bio-antibacterial agents individually or in combination with other treatments against spore. This review is expected to provide reference for the development of safer and more efficient control technology of bacterial spores.

Objective: To compare and analyze the clinical and chest computed tomography (CT) imaging features of COVID-19 patients with different disease courses. Methods: A retrospective analysis was performed for 161 cases with confirmed COVID-19 and positive chest CT lung infections from December 2022 to January 2023 at the fever clinic of Beijing Shijitan Hospital affiliated with Capital Medical University. The patients were divided into two groups based on the time of CT examination:

Objective: To investigate the imaging characteristics of coronavirus disease 2019 (COVID-19) patients with diabetes mellitus using deep learning-based quantitative computed tomograpgh (CT) indicators. Materials and methods: The clinical and imaging data of 112 COVID-19 patients admitted to the Department of Infection, Beijing Shijitan Hospital, Capital Medical University, from December 2022 to January 2023 were retrospectively collected. The patients were divided into diabetic and non-diabetic groups according to their diabetes history, and the clinical and quantitative CT imaging characteristics of the two groups were analyzed using univariate analysis. Results: A total of 112 patients with COVID-19, aged 26-95 years (mean, (70.4±14.4) years), were included in the study, and 44.6% (50/112 cases) were female. In terms of clinical features, C-reactive protein levels were significantly higher in the diabetic group. In terms of CT quantitative indicators, patients in the diabetic group had higher number of whole lung and left lung lesions, lesion volume, and mediastinal lymph nodes than patients in the non-diabetic group. In addition, patients in the diabetic group had a larger volume of ground glass opacity and solid opacity, and patients in the diabetic group had a smaller volume ratio of ground glass opacity and solid opacity in terms of imaging signs, patients in the diabetic group had a higher proportion of lesions with large patchy and banded patterns, and they had a higher proportion of halo signs, air bronchial signs, air trapping signs, mosaic perfusion signs, and subpleural black bands. Conclusion: Pulmonary lesions in patients with diabetes combined with COVID-19 have characteristic features, and deep learning-based quantitative CT indicators, particularly the solid opacity observed in the lungs, can provide valuable information on the extent and severity of lesions in these patients.

Objective: This study aimed to investigate the correlation between the neutrophil-to-lymphocyte ratio (NLR) and chest high-resolution computed tomography (HRCT) findings of coronavirus disease 2019 (COVID-19). Materials and Methods: NLR and chest HRCT findings of 132 patients diagnosed with COVID-19 in the department of infectious diseases of Beijing Shijitan Hospital Capital Medical University from December 1, 2022 to February 1, 2023 were retrospectively analyzed. The patients were divided into two groups with NLR cut-off value of 3.0, and their HRCT characteristics and imaging manifestation patterns were analyzed. For the measurement data of normal distribution, the t-test of continuous variables was used between the groups. The data of non-normal distribution are expressed as median and quartile and compared using Mann-Whitney U test. The counting data are expressed as frequency, and the chi-squared or Fisher's exact test was used for comparison between the groups. P10 and the proportion of lesions >50% were higher in the high NLR group than that in the low NLR group. The high NLR group was prone to mixed density shadow, crazy-paving pattern, mosaic sign, anti-halo sign, subpleural black belt, arcade-like sign than that in the low NLR group. The high NLR group was most likely to have nonspecific interstitial pneumonia-like, organizing pneumonia-like, and diffuse alveolar damage-like patterns than that in the low NLR group. Conclusion: Different NLRs have different manifestations of COVID-19 chest HRCT. The high NLR group is more prone to mixed density shadow, crazy-paving pattern, mosaic sign, anti-halo sign, subpleural black belt, and arcade-like sign, as well as most likely to have radiologic patterns of nonspecific interstitial pneumonia, organizing pneumonia, diffuse alveolar damage.

To explore the effect of slightly acidic electrolyzed water (SAEW) on the storage quality of postharvest broccoli, firstly, broccoli was cut into florets, randomly divided into five groups, and treated with different concentrations (25, 50, 75 and 85 mg/L) of SAEW for 15 min and then drained, using tap water as control. Then, broccoli was stored at 15±1 ℃ for 4 days. The effects of different concentrations of SAEW on the appearance quality, total chlorophyll and malondialdehyde (MDA) of postharvest broccoli were analyzed, then the suitable SAEW concentration was selected for further investigation. The results showed that 50 mg/L SAEW could better maintain the appearance quality and total chlorophyll content, and inhibit the accumulation of MDA in postharvest broccoli as compared with the control and other concentrations of SAEW. Further studies indicated that 50 mg/L SAEW could effectively maintain the sensory quality, inhibit the increase of total bacterial count, delay the decrease of vitamin C, soluble sugar, soluble protein, titratable acid, total glucosinolates and sulforaphane, and suppress the increase of nitrite content in postharvest broccoli compared to the control group. These results suggest that 50 mg/L SAEW can be used as an effective treatment method due to its ability to maintain the storage quality and delay the senescence process of postharvest broccoli.

Objective: To explore the characteristics findings of early COVID-19 on chest thin-slice non-enhanced CT. Materials and methods: From November to December 2022, data from 153 patients with COVID-19 with positive chest CT findings confirmed by the Department of Infectious Diseases of our hospital were collected. All patients had relatively complete clinical data and underwent chest CT 1-14 days after the onset. The patients were divided into two groups according to their age (≤60 years old and >60 years old) and the time interval between the onset and CT examination (≤7 days old and >7 days old), and the differences in CT features between the two groups were compared. Result: Among 153 patients with COVID-19, the lung (100%), blood vessels (93.5%), airways (73.4%), and pleura (70.1%) were involved. The comparison between the age groups showed statistically significant differences in the number, location, size, volume, and band shadow of the lesions. There were statistically significant differences in the shape, density, organization, fibrosis, and pleural involvement of the lesions between the patients in the time interval between the onset and CT examination. Conclusion: Chest thin-slice CT can clarify the location and scope of early COVID-19. Some characteristics findings can help for accurate diagnosis and differentiation, such as the diversity of morphology, intrapleural and perivascular distribution, interstitial lesions with alveoli as a unit, early mixed ground-glass shadow often accompanied by obvious organization and fibrosis, localized thickening of the pleura, and few pleural effusions.

With the continuous evolution of 5G network, 5GtoB solution for industrial users is also more flexible.Data offloading can well meet the urgent needs of customers for data not leaving the park, local unloading, local support, low delay and so on.The demand background of data offloading capability in 5G network and the relevant principles of diversion technology were introduced.At the same time, combined with the actual deployment of operators' existing network, the application scenarios and technical implementation of two kinds of data offloading schemes based on multi data network name (DNN) and uplink classifier (UL CL) were expounded, and the advantages and limitations of different schemes were compared and analyzed.Finally, the feasibility of the scheme was verified by an actual case.

In order to expand the utilization of germinated brown rice and enrich the types of whole grain food, germinated brown rice flour was used in biscuits instead of some wheat flour. The effects of formula and baking process parameters on the quality characteristics of tough biscuits were studied, and the manufacturing process of biscuits was optimized. The results showed that with the increase of germinated brown rice flour, the color of biscuits decreased, the hardness increased, and the ductility and sensory score increased first and then decreased. When the amount of butter was increased, the change of ductility and bulkiness was small. The hardness and ductility increased with the addition of sugar powder. The hardness and adhesion decreased gradually with the increase of the amount of whole egg liquid. After formula optimization, when germinated brown rice flour: low gluten wheat flour, butter, sugar powder and whole egg liquid were added 57:43, 36%, 25% and 20% respectively, the sensory score of biscuit was the highest, which was 90.7. With the increase of surface fire and primer temperature, the color of biscuits gradually deepened, and the sensory score increased first and then decreased; With the extension of baking time, the color gradually deepened and the hardness increased; After orthogonal optimization, when the surface fire, primer and time parameters were 190 ℃, 190 ℃ and 13 min respectively, the biscuit had golden color, crisp and delicious, moderate sweetness, and the highest sensory score of biscuit was 91.6. This experimental study can provide a theoretical basis for the development of whole grain baking products.

Background and objective Lung cancer is the highest incidence of cancer in the world, which seriously threatens human health. Early diagnosis and treatment of lung cancer is particularly important for the survival of lung cancer patients. Serum tumor markers have been widely used as an important method for early diagnosis of tumor. However, there are few early diagnostic markers for lung cancer. Therefore, the aim of this study was to investigate the expression level of Lipocalin-2 and its clinical significance in serum of patients with lung cancer. Methods The serum levels of Lipocalin-2 in 60 lung cancer patients and 63 healthy people were detected by enzyme-linked immunosorbent assay (ELISA), and the relationship between the expression level of Lipocalin-2 and the clinical characteristics of lung cancer was analyzed. Results The expression level of Lipocalin-2 in peripheral blood serum of patients with lung cancer was significantly higher than that of healthy people, and the difference was statistically significant (P

China Telecom’s selection of SD-WAN application scenarios and technical solutions was analyzed.At the same time,system architecture of China Telecom’s on-demand network and key technologies involved in R＆amp;D were elaborated,including EVPN technology,Devops platform technology,selection of VxLAN relay drainage technology and application.

Studies were conducted on the dynamic processes of hydrocarbon migration and accumulation in the west part of the northern margin of the Qaidam Basin, based on previous studies on basin evolution and hydrocarbon system. Based on the dynamics of petroleum accumulation, basin analysis and the numerical stimulation method were applied to reconstruct the basin evolution. Simulation analysis of petroleum accumulation in the main reservoir-forming stages were conducted in the light of source rock properties in different stages, fluid potential field and seepage property distribution of carrier beds. Controlling factors of reservoir formation in the northern margin of the Qaidam Basin were summarized. Studies showed that the Miocene is the main period of oil generation for the Jurassic source rocks in the studied area. The oil generation and migration volume were large. However, Saishiteng Sag was just on the slope in the northern part of Yiliping Sag. Structural traps were distributed at the margin of the basin. There was abundant oil migration to the north margin and a dissipation of the oil there during the later strong tectonic activities. During the late reservoir formation stage after the Pliocene, the source rocks generated mainly gas and not oil, and structural traps were well developed and provided good conditions for the natural gas reservoir formation. Deep structural traps in the basins were conducive to the formation of a large-scale low-permeability gas reservoir. Key words: northern margin of Qaidam Basin, petroleum accumulation dynamics, basin evolution, carrier bed, fluid potential, migration pathway

Background and objective Currently, there are only limited number of diagnostic tumor markers for non-small-cell lung cancer (NSCLC). The aim of this study is to screen and identify non-small-cell lung cancer associated antigens, by using of cancer sera containing antibodies which react with autologous cellular antigens (tumor-associated antigens TAAs), which can be used in NSCLC early screening or target treatment. Methods Two T7 phage display cDNA libraries were panning against the sera from 24 patients with NSCLC. Then the enriched libraries were screened with the pool of sera from NSCLC patients, the positive clones encoding antigenic genes were obtained after screening, and the nucleotide sequences of positive were identified and analyzed with BLAST software in GenBank. Results After immunoscreen two T7 phage display cDNA libraries with serum from patients with NSCLC, thirty-one positive clones were obtained and sequence results showed they were derive from 15 genes, 12 of 15 genes were homologous to the genes known in GenBank, such as RHOA, ITGB4, and HNRNPA2/B1 et al . The other three genes expressed sequence tags (ESTs) were not found in GenBank. Conclusion Fifteen NSCLC associated antigen genes and three candiated gene were obtained by SEREX from T7 phage display cDNA libraries.

Objective To explore the pharmacological efiects and regulatory mechanisms of Carthami Flos water extract and its main constituent, hydroxysafilower yellow A ( HSYA), on primary dysmenorrhea rats with cold coagulation and blood stasis. Methods Forty-two female specific pathogen-free grade rats aged 6-8 weeks were divided into blank, model, HSYA( 0. 01 g/kg), ibuprofen( 0. 04 g/kg), and low (0.06 g/kg), medium (0.20 g/kg), and high (0.40 g/kg) Carthami Flos water extract dose groups using the random number table method, with six rats per group. A rat model was established using ice water bath stimulation combined with estradiol benzoate and oxytocin. Continuous gavage was administered for 6 days from the seventh day of modeling. After the intervention, the writhing reaction test was conducted. The rats, uteri, and ovaries were weighed to calculate the organ index. An enzyme-linked immunosorbent assay and radioimmunoassay were used to detect the prostaglandin E2 ( PGE2) and prostaglandin F2a ( PGF2a) contents in the uterus, thromboxane B2( TXB2 ) and 6 -keto-prostaglondin F1a ( 6-keto-PGF1a) in plasma, and estradiol (E2) in the serum. Hematoxylin and eosin staining were used to detect the pathological changes in uterine tissue. Immunohistochemistry was used to determine cyclooxygenase-2 ( COX - 2 ) expression in uterine tissue, whereas immunofluorescence was used to measure follicle-stimulating hormone receptor ( FSH-R) expression in ovarian tissue. Western blotting was used to detect gonadotropin-releasing hormone receptor ( GnRH-R) and FSH-R expression in uterine tissue. Results Compared with the blank group, the rats in the model group exhibited an increase in uterine and ovarian indices and increased PGE2 and PGF2a in the uterus. TXB2 in the plasma and E2 in the serum were also evaluated. Additionally, 6 -keto-PGF1a decreased, and COX - 2, GnRH-R, and FSH-R expression in the uterus and FSH-R expression in the ovaries also increased ( P <0.05). The morphology of the uterine tissue was disordered. Compared with the model group, the low Carthami Flos water extract dose group showed a decrease in uterine index ( P < 0. 05 ) . In the medium and high Carthami Flos water extract dose groups, the writhing response decreased, as did the uterine and ovarian indices and PGE2 and TXB2 contents. The 6 - keto-PGF1a content increased, whereas the GnRH-R protein expression in the uterus decreased ( P<0. 05). The high Carthami Flos water extract dose group also showed a decrease in PGF2a and FSH-R protein expression in the uterus (P<0. 05). In the HSYA group, the writhing response decreased, the uterine and ovarian indices decreased, the PGE2, PGF2a, and TXB2 contents decreased, and GnRH-R and FSH-R protein expression decreased in the uterus ( P< 0.05). The serum E2 levels of the groups that received Carthami Flos water extract at various doses and those of the HSYA group were reduced, and the uterine morphology was improved. COX-2 expression in the uterus and FSH-R protein expression in the ovaries were also reduced (P <0.05). Conclusion Carthami Flos water extract and HSYA can improve the pathological state of primary dysmenorrhea rats with cold coagulation and blood stasis. Its mechanism may be related to regulating the hypothalamic-pituitary-ovary axis. [ABSTRACT FROM AUTHOR]

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Scholars have begun to examine how print publishers with extensive capital operated their businesses during the Republican era; however, studies of how publishers with reduced capital survived in the same market are relatively rare. Taking Linloon Magazine and Movie Radio News as examples, two of the periodicals collected in the database of “Early Chinese Periodicals Online,” this article investigates San Ho Company and its founder, Lin Zecang, the background of the publishing house, and the most important figures on its editorial boards. This study further outlines the publishing history and marketing strategies of the San Ho Company by comparing these two periodicals with other periodicals of the day and archival materials. Lin Zecang, manager of San Ho Company, received an excellent bilingual education at a church school and church university in Shanghai, and was familiar with the cultural trends of modern society. With outstanding instincts and the innovative spirit of the print market, he published a series of popular periodicals: Pictorial Weekly (Sheying huabao) (a cheaper version of the previous periodical entitled Juantongzhi huabao), Common Knowledge (Changshi), Linloon Magazine (Linglong), and Movie Radio News (Diansheng ribao), among others. His publishing enterprise exhibited what Appadurai conceptualized as “mediascapes” and “technoscapes” in the global cultural flow. Furthermore, Lin Zecang consciously promoted not only the role of “female editors,” but also the themes of gender relations in general. In this context, “Ms. Chen Zhenling,” most likely a pseudonym, was performed as an expert on “women’s questions”; in contrast, the gender of Liang Xinxi, the actual female editor of Movie Radio News as well as editor of Linloon for a few issues, was deliberately disguised. While San Ho Company gradually shaped Linloon Magazine to be a journal for modern urban women, the magazine title “Linglong” was commoditized as a brand. Under this brand, various San Ho products were sold, including a series of books related to the content of Linloon Magazine, as well as products related to the lifestyle intensively promoted by the journal. [ABSTRACT FROM AUTHOR]

Crustacean products are popular for its rich nutritional value, despite causing serious allergy symptoms. The presence of allergens is one of the main factors restricting the further development of the consumer market of crustacean products. The Maillard reaction widely exists in the processing and storage of aquatic products and can affect the allergenicity of foods. This review systematically introduces readers to the Maillard reaction, and summarizes the recent progress in research on the structure and epitopes of crustacean allergens. More importantly, it reviews the changes in the allergenicity of crustacean allergens after Maillard reaction and the underlying mechanism. It is our hope that this paper will provide a reference for controlling and reducing the allergenicity of crustacean products by Maillard reaction.

Policy search is an efficient learning method in the field of deep reinforcement learning (DRL), which is capable of solving large-scale problems with continuous state and action spaces and widely used in real-world problems. However, such method usually requires a large number of trajectory samples and extensive training time, and may suffer from poor generalization ability, making it difficult to generalize the learned policy model to seemingly small changes in the environment. In order to solve the above problems, this paper proposes a policy search DRL method based on latent space. Specifically, this paper extends the idea of state representation learning to action representation learning, i.e. learning a policy in the latent space of action representations, and then mapping the action representations to the real action space. With the introduction of representation learning models, this paper abandons the traditional end-to-end training manner in DRL and divides the whole task into two stages: large-scale representation model learning and the small-scale policy model learning, where unsupervised learning methods are employed to learn the representation models and policy search methods are used to learn the small-scale policy model. Large-scale representation models can ensure the capacity for generalization and expressiveness, while small-scale policy model can reduce the burden of policy learning, thus alleviating the issues of low sample utilization, low learning efficiency and weak generalization of action selection in DRL to some extent. Finally, the effectiveness of introducing the latent state and action representations is demonstrated by the intelligent control task CarRacing and Cheetah.

In this study, 17 deoxynivalenol (DON) contaminated wheat samples were assessed for safety and quality index such as unit weight, water absorption of gluten, crude protein content, unsound kernel content, sprouted kernel content, gibberella damaged kernel content and insect infested kernel content as well as the pollution status of DON and heavy metals. Furthermore, the relationship between the content of DON in wheat grains and other parameters was analyzed. The impact of the processing of gluten and starch in the break and reduction systems on the level of DON contamination was examined. The results showed that the pollution level of DON in wheat samples had a good linear correlation with unit weight, water absorption of gluten, crude protein content, unsound kernel content, sprouted kernel content, gibberella damaged kernel content and insect infested kernel content. The correlation between gluten water absorption and the content of DON was not significant, indicating that DON content could not affect the storage quality of wheat. Additionally, it was found that the heavy metals As and Cd as well as the elements Ca and P were not significantly correlated with DON content, but only Ca in whole wheat flour was correlated with the content of DON. The levels of DON in gluten and starch from the break and reduction systems, respectively were both lower than 200 µg/kg, indicating that wheat with DON over-standard can be used commercially for the preparation of gluten or starch.

In this study, the differences in the aroma substances, major flavor substances and sensory quality of different grades of charcoal-baked and electrically baked white tea were studied by gas chromatography-mass spectrometry (GC-MS) and high performance liquid chromatography (HPLC) combined with chemometrics methods. The results showed that a total of 262 volatile compounds were detected, with terpenes, heterocyclic compounds, alcohols, esters and ketones being the major components, and 2-phenyl ethanol, linalool, geraniol, methyl salicylate, laurene, and (E)-linalool oxide accounting for a higher proportion of the total amount of volatile compounds. Compared with electrically baked white tea, 77, 16 and 93 differential volatile substances were identified from charcoal-baked Yinzhen, Baimudan and Shoumei tea, respectively. Odor activity value (OAV) analysis showed that linallinol, geraniol, 2-phenyl ethanol and laurene were important aroma substances of charcoal-baked white tea, which contribute to natural refreshing, floral and fruity or sweet aromas. Analysis of non-volatile compounds showed that there were significant differences in the content of total and individual catechins, tea polyphenols, caffeine and water extract between charcoal-baked and electrically baked white tea. The results of sensory evaluation were consistent with those of volatile and non-volatile substances. This study is helpful to understand the aroma and flavor quality of charcoal-baked white tea and provides theoretical support for improving the quality of white tea.

To explore the effect of slightly acidic electrolyzed water (SAEW) on chlorophyll degradation in postharvest broccoli, the pattern of changes in the color, total chlorophyll content, chlorophyll derivative content, chlorophyll degrading enzyme activities, and key chlorophyll metabolism-related gene expression of postharvest broccoli after treatment with 50 mg/L SAEW was analyzed. The results showed that SAEW treatment could effectively slow down the degradation of total chlorophyll, maintain the contents of chlorophyll derivatives chlorophyll a, chlorophyll b, chlorophyllide a, chlorophyllide b, pheophorbide a, and pheophytin a, and delay the increase in the activities of chlorophyll metabolizing enzymes, Mg-dechelatase, pheophytinase, and pheophorbide an oxygenase in postharvest broccoli. Meanwhile, it significantly inhibited the expression of the genes encoding chlorophyll b reductase, chlorophyllase 1, chlorophyllase 2, chlorosis protein, pheophytinase, pheophorbide an oxygenase, red chlorophyll catabolite reductase, and aging specific cysteine protease, thereby allowing color protection and freshness preservation. In conclusion, SAEW can be used as an effective method to delay postharvest chlorophyll degradation and inhibit yellowing and senescence in broccoli.

BackgroundThe establishment and improvement of hierarchical medical system will help optimize health resource allocation and develop a sound healthcare-seeking pattern. As the key practitioners of hierarchical medical system, primary care workers' perception of the system is vital to the implementation of the system, so studying their perception of the system and associated factors is of great significance.ObjectiveTo analyze primary care professionals' perceptions of hierarchical medical system and associated factors based on the results of 2018 Sixth China National Health Survey, providing a reference for further improvement of the system.MethodsFrom April to October 2019, one representative urban district and one suburban county were chosen from each of six selected provinces in which hierarchical medical system has been implemented. Then by stratified random sampling, about six community health centers/township health centers were extracted from each district (county) (46 community health centers and 30 township health centers in total) , in which primary care professionals who were on duty on the day of survey were invited to attend a questionnaire survey for understanding their demographics, perceptions of the importance and effectiveness of, as well as barriers to the implementation of hierarchical medical system.ResultsAltogether, 1 308 cases who effectively completed the survey were included for final analysis. According to the analysis, the benefits of implementing hierarchical medical system were: improving the health service system〔approved by 1 231 cases (94.11%) 〕, improving the healthcare services for patients and residents〔agreed by 1 219 cases (93.20%) 〕; improving the quality of medical services〔1 209 (92.43%) 〕; improving the efficiency of medical services〔1 189 (90.90%) 〕; improving doctor-patient relationship〔1 087 (83.10%) 〕; reducing the medical risk〔786 (60.09%) 〕; reducing medical expenses〔611 (46.71%) 〕. As for the outcome of implementing hierarchical medical system, its implementation would not hinder the development of health institutions〔982 (75.08%) 〕. When it comes to the barriers to the implementation of hierarchical medical system, there were no relevant incentives〔759 (58.03%) 〕, patients and their families' were unwilling to accept hierarchical medical system due to getting used to free healthcare-seeking pattern〔753 (57.57%) 〕, there were no unified bi-directional referral criteria and system〔712 (54.43%) 〕, the implementation of hierarchical medical system may lead to conflict of interests between medical institutions〔451 (34.48%) 〕, there was no an effective referral route〔403 (30.81%) 〕, their medical institutions had insufficient capacities to effectively implement hierarchical medical system〔387 (29.59%) 〕. Univariate analysis revealed that primary care professionals' perceptions of hierarchical medical system differed significantly by province, sex, educational background, professional title, type of their medical institution, and type of post (P

In the long-term practice of cybersecurity talent cultivation, the teaching team of School of Cyber Science and Technology of Beihang University, aiming at the knowledge goal, ability goal and quality goal of talent cultivation of cybersecurity discipline and related majors, puts forward the innovative teaching idea of “fine teaching, strong practice, excellent assessment, abundant resources” according to the knowledge characteristics, thinking characteristics and psychological characteristics of students. The teaching team integrates political teaching, research teaching, inspiration teaching, seminar teaching and example teaching methods, puts forward the PRIDE teaching mode，which has been widely applied in the teaching of core professional courses such as “Information Network Security” and “Modern Cryptography”, and has got remarkable teaching achievement. Through the practice of PRIDE teaching mode, a high-level teaching team with high political quality and strong teaching ability has been also built.

Objective: To analyze the surveillance data after schistosomiasis transmission interruption from 1985 to 2018, so as to provide scientific basis for the future prevention and control of schistosomiasis., Methods: The data pertaining to snail survey, surveillance of schistosomiasis in humans and livestock, and health education were collected and analyzed in Songjiang District after schistosomiasis transmission interruption from 1985 to 2018., Results: From 1985 to 2018, there were 8 townships, 68 villages and 1 462 settings with snails in Songjiang District, covering an area of 96.399 hm 2 . There were 4 townships and 59 villages with snails newly identified in previously schistosomiasis non-endemic areas, with emerging snail habitats of 60.161 hm 2 . A total of 26 148 snails were captured, and no infections were detected. The snail habitats were mainly distributed in the river course, ditches and farmlands, which accounted for 45.28%, 33.17% and 21.55% of total snail habitats, respectively. A total of 245 955 humans were subjected to the serological test, with a positive rate of 0.03%, and 37 humans were subjected to the parasitological test, with 3 positives detected. These three egg-positives were all imported chronic cases with schistosomiasis. A total of 9 109 livestock were detected using the serological test, and no infection was found. Most of the awareness rate of schistosomiasis control knowledge and the rate of correct behavior formation were over 80% in residents and students., Conclusions: The achievements of schistosomiasis control are consolidated in Songjiang District; however, there are still risk factors of schistosomiasis transmission, including residual snails, snail diffusion and importation of external source of infection. The future surveillance of schistosomiasis should focus on snails and sources of infection.

Objective: To understand the risk situation of imported schistosomiasis and its main influencing factors in Shanghai City from 2005 to 2015., Methods: A retrospective survey was performed, and the database was established based on the data collection of imported schistosomiasis, Oncomelania hupensis snail situation and mobile population in Shanghai City from 2005 to 2015., Results: From 2005 to 2015, the mobile population in Shanghai City increased by 123.92%, which reached about 9 816 500, and 54.70% of them were located in the inner suburban districts. The accumulated areas with snails of 7.13 hm 2 were found in 16 towns of 4 outer suburbs (excluding Chongming District). A total of 23 cases of imported schistosomiasis were found in Shanghai City, and the number of the imported schistosomiasis cases was on the downward trend ( rs = -0.782, P = 0.004). From 2005 to 2009, 11 out of 13 imported schistosomiasis cases (84.62%) were distributed in the inner suburban districts where no O. hupensis snails were found at the same time. From 2010 to 2015, 9 out of 10 imported schistosomiasis cases (90%) were distributed in the outer suburban districts where O. hupensis snails were found at the same time., Conclusions: The number of imported schistosomiasis cases in Shanghai is on the downward trend. However, the threat of imported schistosomiasis to the prevention and control of schistosomiasis in Shanghai City should not be ignored.

Objective: To analyze the current research status of rehabilitation nursing for adult burn patients in China, and to disuss the related strategies., Methods: Chinese scientific articles on adult burn patients' rehabilitation nursing published from January 2003 to December 2013 were retrieved from 3 databases namely China Biology Medicine disc, Chinese Journals Full-text Database , and Chinese Science and Technology Journals Database . From the results retrieved, data with regard to publication year, journal distribution, research type, region of affiliation of the first author, and the main research content were collected. Data were processed with Microsoft Excel software., Results: A total of 417 articles conforming with the criteria were retrieved. During the 11 years, the number of the relevant articles per year was on the rise, and the increasing rates in 2005, 2008, 2009, and 2013 were all above 30% . Regarding the distribution among journals, these 417 articles were published in 151 journals, with 188 articles in Source Journal for Chinese Scientific and Technical Papers , accounting for 45.08%. Regarding the research type, 173 out of the 417 articles were dealing with clinical experiences, accounting for 41.49% ; 172 out of the 417 articles were dealing with experimental studies, accounting for 41.25% . The regions of affiliation of the first author were mainly situated in Guangdong province, Shandong province, Hunan province, and Jiangsu province, with Guangdong province contributing 58 articles, accounting for 13.91%. The research content of these articles was mainly focused on psychological nursing, nursing model, and health education, respectively 188,101, and 85 articles, accounting for 45.08%, 24.22%, and 20.38%., Conclusions: The research on rehabilitation nursing for adult burn patients in China has been carried out nationwide. Although the number of relevant papers is on the rise, the quality of these papers needs to be further improved. There is an urgent need for the guideline on rehabilitation nursing for adult burn patients in China so as to standardize the content and procedure of rehabilitation nursing.