11 results on '"Xu, Xiao-fang"'
Search Results
2. [Assessment of Medical Waste Disposal Technologies Based on the AHP].
- Author
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Xu XF, Tan QY, Liu LL, and Li JH
- Subjects
- Hot Temperature, Medical Waste, Steam, Disinfection, Incineration, Medical Waste Disposal methods, Microwaves
- Abstract
Five types of medical waste disposal technologies that are currently applied in our country were analyzed and compared such as the rotary kiln incineration method, pyrolysis method, high-temperature steam sterilization method, chemical disinfection method, and microwave disinfection method. The five methods were quantitatively evaluated and screened using an analytical hierarchy process (AHP). Based on this process, the ranking weights of optimal and suboptimal alternatives were studied using sensitivity analysis. The results show that the rotary kiln incineration and pyrolysis methods are presently the most widely used technologies for medical waste disposal in our country. The AHP shows that the comprehensive benefits of high-temperature steam sterilization in medical waste disposal are the best compared with the other four methods in terms of social, environmental, technological, and economic factors, followed by the chemical disinfection method. The sensitivity analysis shows that the change points of the guideline layer factors that lead to the change of the alternatives are the social factors (0.2100), environmental factors (0.3500), technical factors (0.1200), and economic factors (0.2400). Subcriteria factors have less influence on the weight ranking of the alternatives.
- Published
- 2018
- Full Text
- View/download PDF
3. [Clinical application evaluation of clinical practice guideline on traditional Chinese medicine therapy alone or combined with antibiotics for uncomplicated lower urinary tract infection].
- Author
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Yu GY, Xie YM, Gao N, Sun Y, Miao RP, Han SJ, Yang HW, Xiong M, Liu H, Liao X, Wang YX, Su XN, Xu XF, Wang LF, Li YL, Zhang JH, and Zhang BL
- Subjects
- Acupuncture Therapy, Anti-Bacterial Agents, Diagnosis, Differential, Humans, Medicine, Chinese Traditional, Drugs, Chinese Herbal, Urinary Tract Infections
- Abstract
A questionnaire survey of 1 000 clinicians having experience in treating uncomplicated lower urinary tract infections from different levels of hospitals was conducted to mainly evaluate the applicability and effectiveness of clinical application of clinical practice guideline on traditional Chinese medicine therapy alone or combined with antibiotics for uncomplicated lower urinary tract infection(hereinafter referred to as Guideline). The research was conducted with the three-level quality control strictly throughout the process, and the data was real and reliable. The survey's results showed that: most clinicians considered that the Guideline had good clinical applicability. The availability and price of the recommended medicine were moderate. Traditional Chinese medicine had obvious features and advantages in treating lower urinary tract infection for it could reduce the usage of antibiotics and shorten the course of antibiotic application. In the recommendation section, clinicians proposed increasing medication guidance, updating the Guideline timely, as well as increasing treating methods and techniques, strengthen propaganda and promotion, and improve the use of evidence-based methods. In the evaluation of effectiveness, the majority of clinicians agreed that the definition in both traditional Chinese medicine (TCM) and Western medicine and differential diagnosis in the Guideline were accurately described and the basic principle of treatment as well as the treating method of TCM were recommended appropriately. The TCM formulas and Chinese patent medicine had good effect. Some clinicians suggested refining the syndrome differentiation of stranguria. Some clinicians considered that the formulas and herbs recommended in Guideline didn't have obvious effect and some had doubts about the manipulation of fumigation and washing in the part of other methods recommended in Guideline. Moreover, specification and procedure of manipulation of fumigation and washing using herbs and the acupuncture included in characteristic TCM therapy treating uncomplicated lower urinary tract infection remained to be developed., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Chinese Pharmaceutical Association.)
- Published
- 2018
- Full Text
- View/download PDF
4. [Effects of the water channel aquaporin 4 deficiency on bleomycin-induced lung fibrosis in mice].
- Author
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Li XY, Xu XF, Hang J, Liu ZX, Yu SY, Fang SH, Zhang WP, Wei EQ, and Lu YB
- Subjects
- Animals, Male, Mice, Mice, Knockout, Pulmonary Fibrosis genetics, Aquaporin 4 genetics, Bleomycin toxicity, Pulmonary Fibrosis chemically induced
- Abstract
Objective: To evaluate the effect of water channel aquaporin 4 (AQP4) on bleomycin-induced lung fibrosis in mice., Methods: In wild type and AQP4 gene knockout (AQP4-/-) mice, lung fibrosis was induced by injection of bleomycin (3 mg/kg) into the trachea and saline injection was used as a control. At d3, 7, 14, 28 after bleomycin-treatment, mice were randomly sacrificed in batch and the lung coefficient was determined. Serum levels of TGF-β1 and TNF-α were measured by ELISA and hydroxyproline contents in lung tissue were determined by Alkaline hydrolysis method. H-E staining and Masson's staining were performed to examine the pathological changes of lung tissues after bleomycin-treatment., Results: On d14 after bleomycin-treatment, the lung coefficients in wild type mice and AQP4-/- mice were 1.9-fold (12.69 ± 6.05 vs 6.80 ± 0.82, q=4.204, P<0.05) and 2.3-fold (14.05 ± 5.82 vs 6.05± 0.58, q=5.172, P<0.01) of that in control, respectively, but no significant difference was found between wild type and AQP4-/- mice in the lung coefficient value (P>0.05). The hydroxyproline contents in the lung increased after bleomycin-treatment; on d28, the lung hydroxyproline contents in wild type and in AQP4-/- mice were 1.55-fold (0.85 ± 0.22 g/mg vs 0.55 ± 0.14 μg/mg, q=4.313, P<0.05) and 1.4-fold (0.84 ± 0.13 μg/mg vs 0.60 ± 0.14μg/mg, q=4.595,P<0.05) of that in control, respectively, but no significant difference was noticed between wild type and AQP4-/- mice in lung hydroxyproline contents. There was a tendency that serum TGF-β1 and TNF-α levels increased in bleomycin-treated mice, but no significant difference was found between wild type and AQP4-/- mice. AQP4-knockout showed no effects on pathological changes of lung tissues with H-E staining and Masson's staining in mice with bleomycin-induced lung fibrosis., Conclusion: AQP4 might not be involved in bleomycin-induced lung fibrosis in mice.
- Published
- 2014
- Full Text
- View/download PDF
5. [Nicotinamide phosphoribosyltransferase and its roles in cancer].
- Author
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Xu XF and Wu M
- Subjects
- Humans, Nicotinamide Phosphoribosyltransferase physiology, Neoplasms enzymology, Nicotinamide Phosphoribosyltransferase metabolism
- Abstract
Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme for synthesis of nicotinamide adenine dinucleotide in mammalian cells. Recent studies show that Nampt also works as a cytokine that exerts insulin-mimetic effects by binding to the insulin receptor, induces B-cell differentiation, inhibits neutrophil apoptosis, and affects immune and inflammatory functions. This review is focused on current knowledge regarding the structure and function of Nampt and its roles in carcinogenesis.
- Published
- 2014
- Full Text
- View/download PDF
6. [Research on several times of abruptly changes in the ultrafast transient reflectivity in Co films].
- Author
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Xu XF, Gao YF, Lü L, Cao XX, Ren NF, and Zhou M
- Abstract
In the present paper, cobalt films, chromium and cobalt double layer films, and silver and cobalt double layer films were deposited by magnetron sputtering technique. The transient reflectivity response in cobalt thin films and their double layer films was studied by using femtosecond laser pump-probe transient reflection experimental technology. The result shows that, under the condition of the cobalt films of the same thickness, when the pump power increases, the heating time of the electrons in cobalt thin films is independent of the pump power, and is 0. 134 4 ps. And for the cobalt films of different thickness, the electron thermalization time is directly related to the film thickness. In addition, when the laser pulse power is high enough, two or three transient reflectivity decline signals on glass substrate films are found which is different with previous researches, when the cobalt films were thin, there are three times of transient reflectivity abruptly decline signals, and when the cobalt films were thick, there are two times of transient reflectivity abruptly decline signals, so the thickness of the cobalt films determines the times of the changes of the ultrafast dynamics in cobalt films.
- Published
- 2013
7. [Analysis on chemical components from water extract of paeoniae radix alba by high performance liquid chromatography-electrospray ionization-quadrupole-time of flight-mass spectrometry].
- Author
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Sun DD, Xu XF, Cui JC, Song XM, and Li X
- Subjects
- Drugs, Chinese Herbal isolation & purification, Molecular Structure, Spectrometry, Mass, Electrospray Ionization methods, Chromatography, High Pressure Liquid methods, Drugs, Chinese Herbal chemistry, Paeonia chemistry, Tandem Mass Spectrometry methods
- Abstract
This experiment was performed to establish a qualitative analysis on chemical composition in water extract of Paeoniae Radix Alba by HPLC-ESI-Q-TOF-MS. The analysis was conducted on a C18 (Hanbon Lichrospher, 4.6 mm x 250 mm, 5 microm) column with methanol-0.1% formic acid as the mobile phase for gradient elution; ESI ion source was used for mass spectra, and data were collected in both positive and negative modes. The results showed that eleven compounds from water extract of Paeoniae Radix Alba had been identified by analyzing positive and negative ion mass data including element composition and by comparing with data from literatures. Since efficient separation of HPLC and the high sensitive detection of MS was used, this experiment, it will provide evidences for elucidation of the effective substance in the water extract of Paeoniae Radix Alba.
- Published
- 2013
8. [PTEN tumor suppressor gene combined with doxycycline inhibites telomerase activity in human mucoepidermoid carcinoma cell line].
- Author
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Liu B, Wu JZ, Guan SM, Li Y, and Xu XF
- Subjects
- Cell Line, Cell Line, Tumor, Doxycycline, Genes, Tumor Suppressor, Genetic Vectors, Humans, PTEN Phosphohydrolase, Transfection, Carcinoma, Mucoepidermoid, Telomerase
- Abstract
Objective: To investigate the effect of PTEN tumor suppressor gene combined with doxycycline on telomerase activity in human mucoepidermoid carcinoma cell line., Methods: The wild-type PTEN tumor suppressor gene or empty vector was introduced into mucoepidermoid carcinoma cell line in vitro, then the cancer cells were treated with doxycycline. Cancer cell survival was determined by MTT assay. Telomerase activity was determined using telomerase repeat amplification protocol-enzyme-linked immunosorbent assay (TRAP-ELISA)., Results: Compared to the control cells, cancer cells transfected with the wild-type PTEN gene showed growth inhibition and increased sensitivity to doxycycyline, and the ratio of augment of drug sensitivity was 1.65-4.75. The telomerase activity in cancer cells treared with PTEN gene transfection or doxycycline alone decreased, however, telomerase activity in combined group decreased more remarkably., Conclusion: PTEN gene in combination with doxycycline has significant inhibitory effect on telomerase activity in cancer cells.
- Published
- 2010
9. [Purification of mutacin].
- Author
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Yang L, Xu XF, Yang BX, Liu W, and Li S
- Subjects
- Anti-Bacterial Agents, Bacteriocins, Streptococcus mutans
- Abstract
Objective: To purify mutacin produced from isolated Streptococcus mutans (S. mutans) strains in order to, contribute to molecular biological research of mutacin., Methods: The antibacterial activity of 80 isolated strains was tested by the stab culture technique against Streptococcus oralis ATCC 10557. The mutacin produced by strain 1G, was initially purified by solid-phase extraction (SPE) after crude extraction by chloroform. And then the active substances were purified by twice reversed-phase high performance liquid chromatography (RP-HPLC). The purified target peptide (mutacin) was collected and freeze-dried for further study., Results: The greatest active strain of these S. mutans isolates, the strain 1G was obtained. Roughly 15 microg crude mutacin was extracted from 200 mL liquid medium of this strain 1G. The purified mutacin through SPE and twice RP-HPLC was obtained., Conclusion: It was much complex to separate and purify mutacin due to its small molecular mass, and extracting and purifying of mutacin may make an important contribution to the further research of mutacin.
- Published
- 2010
10. [Comparative study on quality of Flos Lonicerae between geo-authentic and non-authentic producing areas].
- Author
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Zhang ZY, Li P, Li HJ, Xu XF, Chen J, Liu YS, and Zhao HN
- Subjects
- China, Chromium analysis, Cluster Analysis, Ecosystem, Flowers chemistry, Lead analysis, Lonicera growth & development, Oleanolic Acid analogs & derivatives, Oleanolic Acid analysis, Plants, Medicinal growth & development, Quality Control, Trace Elements standards, Chlorogenic Acid analysis, Flavonoids analysis, Lonicera chemistry, Plants, Medicinal chemistry, Trace Elements analysis
- Abstract
Objective: To compare the quality of Flos Lonicerae between different producing areas., Method: ICP-AES, UV and HPLC were used to determine the contents of trace elements, chlorogenic acid, total flavonoids, five iridoid glucosides, hederagenin, and oleanolic acid. SAS software system was used to perform data and cluster analyses., Result: The results showed that the geo-authentic crude drug was lower in the contents of Cr and Pb but higher in the contents of chlorogenic acid, total flavonoids, five iridoid glucosides, hederagenin, and oleanolic acid than the non-authentic crude drug., Conclusion: The geo-authentic crude drug of Flos Lonicerae is better in quality than the non-authentic crude drug based on the modern chemical analyses, which confirms the validity of traditional geo-based classification.
- Published
- 2007
11. [Study on the risk factors leading to irregularly anti-pulmonary tuberculosis drug taking in patients with smear positive].
- Author
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Hu DY, Wang T, Liu XY, Chen J, Wang Y, Zeng W, and Xu XF
- Subjects
- China, Humans, Risk Factors, Antitubercular Agents administration & dosage, Patient Compliance, Tuberculosis, Pulmonary drug therapy
- Abstract
Objective: To describe the current situation and explore risk factors to irregularly antipulmonary tuberculosis(TB) drugs taking in smear positive TB patients., Methods: Four out of the forty counties in Chongqing were randomly sampled according to the levels of social and economic development. Totally, 405 new patients with smear positive tuberculosis were systematically sampled and a household survey was carried out. A multiple logistic regression model was fitted to explore the risk factors to irregularly anti-TB drugs taking., Results: Of valid 401 cases, 50 (12.47%) did not take their drugs regularly and the top 3 reasons for irregular drugs taking were: (1) Adverse effects; (2)Economic hardship; (3) Stopped taking drugs when symptom disappeared. Results from multiple logistic regression analysis showed that factors as: self-perceived economical burden, awareness on TB before being infected and awareness on the fact that if anti-TB drugs can be stopped if the symptoms disappeared, were statistically significant to irregularly drugs taking., Conclusion: Strengthening health education program and alleviation of economical burden might serve as two effective measures for regularly drugs taking among TB patients.
- Published
- 2007
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