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The centrifugal separation of waste oil-based drilling fluid under the synergistic effect of ultrasonic irradiation and chemical demulsification was investigated, and the effects of demulsifier dosage, heating temperature, ultrasonic time and centrifuge speed on the deoiling ratio were analyzed. The BASF-L62 was proved to be the best demulsifier by the pre-experiment. The single factor experiment and orthogonal experiment were applied for studying the influencing actors on ultrasonic irradiation and chemical demulsification centrifugally separating the waste oil-based drilling fluid. The experimental results showed that the deoiling rate was 81.78% under the conditions of heating time of 20 min, demulsifier dosage of 200 mg/L, heating temperature of 70 °C, ultrasonic irradiation time of 9 min, centrifuge speed of 8 000 r/min and centrifugal time of 1 0 min. [ABSTRACT FROM AUTHOR]