Search

Integrated energy system (IES) is the key to achieve the “dual carbon goals” in face of the current energy industry transformation and low-carbon development. In order to improve the carbon emission reduction capacity of the IES, it is necessary to make full use of the load resources on the demand side and the generalized energy storage resources such as traditional energy storage equipment to participate in the optimization of the IES. First, an IES optimization operation model considering renewable energy, energy conversion equipment, generalized energy storage equipment, and energy market transaction is established. Then, the life cycle assessment (LCA) method is used to calculate the carbon emission of the whole process of energy cycle and equipment cycle in the IES, and the carbon emission cost is included in the total cost of the system. The results of simulation experiments show that the proposed model is not only conducive to reducing the total scheduling cost of the IES, but also able to reduce the carbon emissions of the system and effectively promote the low-carbon development of the IES.

To further improve the simulation and estimation accuracy of the supply and demand process of agricultural products, a large number of agricultural data at the national and provincial levels since 1980 were used as the basic research sample, including production, planted area, food consumption, industrial consumption, feed consumption, seed consumption, import, export, price, GDP, population, urban population, rural population, weather and so on, by fully considering the impact factors of agricultural products such as varieties, time, income and economic development, a multi-agricultural products supply and demand forecasting model based on long short-term memory neural network (LSTM) was constructed in this study. The general thought of supply and demand forecasting model is packaging deep neural network training model as an I/O-opening modular model, reserving control interface for input of outside data, and realizing the indicators forecasting of supply and demand and matrixing of balance sheet. The input of model included forecasting balance sheet data of agricultural products, annual price data, general economic data, and international currency data since 2000. The output of model was balance sheet data of next decade since forecasting time. Under the premise of fully considering the mechanical constraints, the model used the advantages of deep learning algorithms in nonlinear model analysis and prediction to analyze and predict supply and demand of 9 main types of agricultural products, including rice, wheat, corn, soybean, pork, poultry, beef, mutton, and aquatic products. The production forecast results of 2019－2021 based on this model were compared and verified with the data published by the National Bureau of Statistics, and the mean absolute percentage error was 3.02%, which meant the average forecast accuracy rate of 2019－2021 was 96.98%. The average forecast accuracy rate was 96.10% in 2019, 98.26% in 2020, and 96.58% in 2021, which shows that with the increase of sample size, the prediction effect of intelligent learning model would gradually get better. The forecasting results indicate that the multi-agricultural supply and demand prediction model based on LSTM constructed in this study can effectively reflect the impact of changes in hidden indicators on the prediction results, avoiding the uncontrollable error introduced by manual experience intervention. The model can provide data production and technical support such as market warning, policy evaluation, resource management and public opinion analysis for agricultural production and management and macroeconomic regulation, and can provide intelligent technical support for multi-regional and inter-temporal agricultural outlook work by monitoring agricultural operation data in a timely manner.

Traditional polyethylene (PE) agricultural mulching film is difficult to degrade, which is harmful to the environment and irreversible. Poly(lactic acid) (PLA) and poly(adipic acid-butylene terephthalate) (PBAT) can be blended to prepare high strength and high flexibility degradable composites, which can effectively improve environmental pollution when used as agricultural mulching film. In this paper, the preparation technology of PLA/PBAT mulching film was summarized, and the modification of materials by inorganic fillers and organic fillers was summarized. Finally, the application and development prospect of PLA/PBAT mulching film in current agricultural production were introduced. The research shows that the preparation technology of PLA/PBAT mulching film has entered a new development stage from excellent to excellent. The addition of organic fillers or inorganic fillers can reduce the cost of PLA/PBAT mulching film, improve the compatibility of materials, and enhance many key indexes such as mechanical properties, crystallization properties and barrier properties. In practical application, PLA/PBAT plastic film can promote crop growth and increase crop yield, but its uncontrollable degradation cycle affects its development. In the future, PLA/PBAT degradable plastic film with adjustable degradation cycle can be developed according to different crop growth factors. [ABSTRACT FROM AUTHOR]

For the problem that it is difficult to extract fault features of vibration signals of transmission shaft system and the actual situation that it is difficult to obtain a large number of fault samples in fault diagnosis，a fault diagnosis method for transmission shafting based on variational mode decomposition（VMD）sand particle swarm optimization support vector machine （PSO-SVM）is proposed. Firstly, the vibration signal of transmission shaft system is subjected to VMD decomposition, and intrinsic mode function IMF is obtained. Then, the energy value of IMF and the corresponding energy entropy are calculated. Finally, Particle swarm optimization（PSO） is used to optimize the parameters of support vector machine（SVM）, and the energy value and energy entropy of normalized IMF are input into the PSO-SVM to identify the working state and fault type of transmission shaft system. The experimental results show that the accuracy of the method is 94.44%, and it can diagnose the fault of transmission shaft system accurately and effectively.

With improving vehicle stability as objective, an in-wheel motors / hydraulic brake system combined-control strategy is designed for four-wheel motor driven vehicles. The controller adopts layered control structure : the upper layer applies sliding mode variable structure theory to obtain the generalized force, while the lower layer uses quadratic programming method to optimize torque distribution, with consideration of the position and speed constraints of actuators. A CARSIM / MATLAB co-simulation is conducted for algorithm verification. The results show that under critical conditions, vehicles without control or controlled only with in-wheel motors can not complete the simulated operation, while the vehicle with in-wheel motor / hydraulic brake system combined-control strategy can assure the handling stability of vehicle. [ABSTRACT FROM AUTHOR]

Based on motion tracking control algorithm, the effects of two typical estimation errors, i. e. offset error and proportional error, of CM sideslip angle estimation on vehicle stability control is analyzed by simulation. The results show that for ensuring light driver's operation intensity and high stability of vehicle, the offset error of CM sideslip angle should not exceed 2 degrees and its proportional error should not exceed 20% of its real value. Providing there is no much effects on vehicle stability, reasonably underestimated CM sideslip angle can improve the maneuverability of vehicles. [ABSTRACT FROM AUTHOR]

Objective: To investigate the occurrence and the risk factors of stroke complicated by venous thromboembolism., Methods: A total of 2709 stroke patients who received treatment at our hospital between January 2018 and June 2021 were selected. The incidence of stroke complicated by venous thromboembolism was analyzed and the risk factors of stroke complicated by venous thromboembolism were investigated by logistic regression., Results: Among the 2709 stroke patients, 390 had venous thromboembolism, resulting in 14.39% incidence of venous thromboembolism. Among them, 383 patients (14.14%) had deep venous thrombosis (DVT), 4 patients (0.15%) had pulmonary thromboembolism (PTE), and 3 cases (0.11%) had DVT combined with PTE. According to the analysis of unconditional multivariate logistic regression model, age>60 years, concomitant hypertension, concomitant diabetes, bedrest time after admission≥3 days, D-dimer (D-D)≥0.95 mg/mL, triglyceride (TG)≥1.83 mmol/L, Barthel Index (BI) score≤9 points, and Padua score>4 points after admission were independent risk factors for stroke complicated by venous thromboembolism ( P <0.05), while anticoagulation therapy was a protective factor ( P <0.05)., Conclusion: Stroke complicated by venous thromboembolism is associated, to some degree, with age, concomitant hypertension, concomitant diabetes, bedrest time, D-D, TG, BI score, Padua score, and whether anticoagulant therapy is administered or not. Interventions in line with relevant risk factors should be strengthened to effectively reduce the risk of stroke complicated by venous thromboembolism., (Copyright© by Editorial Board of Journal of Sichuan University (Medical Sciences).)

A method combining QuEChERS with liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the determination of higenamine in Chinese herbal medicine, condiments, and topical medicine. The sample was subjected to extraction using a formic acid-ethanol mixture, followed by purification of the QuEChERS sorbents; then, the extraction solution was introduced into the LC-MS/MS system for detection in multiple reaction monitoring (MRM) mode. Under the optimal conditions, the detection limit of the developed method was 0.03 ng/g, and the linear range was 0.10-100 ng/g with a relative standard deviation (RSD) of 4.33% (0.5 ng/g, n =7). The method was then applied to the determination of higenamine in 13 kinds of Chinese herbal medicine, four kinds of condiments, and a topical medicine. Higenamine was detected in dried lotus leaf, dried lotus seed, Chinese yam, Yuzhu, Yam, Sichuan pepper, Cassia, and the topical medicine at 9667.6, 1183.8, 21.5, 8.2, 8.5, 148.6, 21.3, and 173.3 μg/kg, respectively. The recoveries of higenamine in Sichuan pepper and cassia was 92.6%-109.8%. In conclusion, the method is fast, simple, reliable, and suitable for use in batch operation.

Objective: To investigate the effect of transfusion of necrotic cells on regulatory T (Treg) and Th17 cell balance in septic mice., Methods: Thirty-four C57BL/6 mice were randomized into PBS group (n=5), sham-operated group (n=5), sepsis group (n=12), and necrotic cell transfusion group (n=12) and subjected to intraperitoneal PBS injection, sham operation by separating the cecum only, cecal ligation and puncture (CLP), and injection of 2 × 10⁷ necrotic cells 5 days before CLP, respectively. All the mice were sacrificed 2 weeks after CLP for analyzing the proportion of CD4⁺Foxp3⁺Treg cells and CD4⁺IL17A⁺Th17 cells in the peripheral blood, spleen and thymus by flow cytometry., Results: The percentage of Th17 cells and Treg/Th17 ratio in the spleen was significantly higher in CLP group than in the sham-operated group and PBS group (P<0.01). The percentage of Treg cells in the thymus was significantly lower in CLP group than in the sham-operated group (P<0.01). Pre-infusion of necrotic cells redressed the abnormality of Treg and Th17 cell percentages and Treg/Th17 imbalance in mice following CLP (P<0.05)., Conclusion: Pre-infusion of necrotic cells can reverse Treg/Th17 imbalance in septic mice.

Objective: To develop a method for detecting the topical concentration of hydrocortisone (HC) in the subcutaneous adipose of rats using microdialysis sampling technique and liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS)., Methods: Topical samples were collected by applying the probe into the subcutaneous adipose of rats, with alcohol (5%)-ringers solution as the perfusion solution. A LC-MS/MS method was established for detecting the HC concentration in the dialysates., Results: The protonated precursor to produce ion transitions monitored for HC was m/z 363.2→121.1. The calibration curve was linear over the range of 0.5-1000 ng/ml, with the intra- and inter-day precision and accuracy within ∓15%, and no significant matrix effect was noted. The in vivo recovery of the probe was about 59%., Conclusion: A selective and sensitive method has been successfully established for the on-line HC detection in the subcutaneous adipose of rats.

Aim: To investigate the value of Brn-3a immunocytochemistry of liquid-based ThinPrep cytology test(TCT) in early diagnosis of cervical process., Methods: Patients(192) were investigated in the present study. TCT was used in all the patients. Immunohistochemistry was per-formed to examine the expressions of Brn-3a. The pathological results were used as the gold standard to evaluate the results of TCT method and Brn-3a in combination with LCT., Results: Compared with the pathological results, the accuracies of TCT method were 76.9% (30/39) , 80.5% (33/41)and 96.8% (30/31) in LSIL, HSIL, SCC respectively. The accuracies of Brn-3a in combination with TCT were 76. 9%(30/39), 78.6%(33/42) and 97.1% (30/31) in LSIL, HSIL and SCC respectively. The difference was significant in the diagnosis of LSIL and HSIL (P <0.05)., Conclusion: The detection of Brn-3a is of important clinic value in early diagnosis of cervical process.

Objective: To investigate the biofilm formation of Enterococci from the intestinal tract of normal people, to study the relationship between esp and the ability of biofilm formation in Enterococci., Methods: PCR was applied to detect the esp gene in 84 isolates. And the biofilm formation was performed in 96 well polystyrene plates., Results: The detection rate of esp in Enterococci was 14.3%, the rate of biofilm formation was 25.0%, the rate of biofilm formation of esp positive isolates was 83.3%, and that of esp negative isolates was 15.3%., Conclusion: Biofilm formation is not very common in Enterococci from the intestinal tract of normal people, esp is an important factor of biofilm formation, and the ability of biofilm formation is not limited to the esp positive isolates.

Antiangiogenic therapy can generate a "normalization window" for tumor vasculature. This normalization process prunes immature vessels and improves the integrity and function of the remaining vasculature by enhancing the perivascular cell and basement membrane coverage in tumor, therefor creates a window of opportunity for improved sensitivity to ionizing radiation and the delivery of chemotherapeutic drugs. It provides a rational basis for the combination therapy of traditional Chinese drugs with radiation and perhaps other forms of chemotherapy. Antiangiogenic therapy with the traditional Chinese drug interfering in the the mechanisms of the normalization window in humans maybe harness a new approach to improve the sensitivity of tumors to radio- and chemotherapy.

To examine the histological changes of diabetic rats' skin and the effects on the percutaneous absorption of hydrocortisone (HC, a glucocorticoid), male Wistar rats were randomly divided into five groups: control group, diabetes one-week group (W1), two-week group (W2), three-week group (W3), and four-week group (W4), while each group contained 6 rats. Diabetes mellitus (DM) rat model was prepared with the method of streptozocin (STZ, 40 mg x kg(-1)) intraperitoneal injection. Abdominal skin was cut to carry out an in-vitro penetration experiment on an improved Franz diffusion cells, and phosphate buffer (PBS, pH 7.4) was used as receptor solution. The solution was analyzed with HPLC, and then the penetrating rate can be calculated. Meanwhile, rats' abdominal skins of different DM periods were HE stained and made into tissue slices to find if any histological changes occurred. The penetrating rate of control, W1, W2, W3, and W4 groups were 2.39 +/- 1.25, 3.22 +/- 1.72, 3.02 +/- 1.89, 3.63 +/- 2.02 and 5.00 +/- 3.36 microg x h(-1) x cm(-2), respectively. There was significant difference between the control and the W4 group (P < 0.05), but no significant differences were found between any other two groups (P > 0.05). The tissue slices showed that compared to the normal rats' skin, little change was observed in one-week DM rats' skin, but the skin of one-month DM rats' skin was observed thinner, and it became much thinner than that of rats with two-month diabetes, especially the epidermis. After making a rat into diabetic, the rats' skin goes through a pathological change, and this change is closely interrelated with the increase of the permeation of HC. Therefore, it is necessary to adjust the dose while some drug was applied on the skin in case of diabetes mellitus.

4-nitrobenzoic acid and hydraxine sulfate were cyclized with H3PO4/P2O5 to afford 2,5-bis(4-nitrophenyl)-1, 3,4-oxadiazole(1), then(1)was reduced to 2,5-bis(4-aminophenyl)-1,3,4-oxadiazole using Zn/CaCl2 as reduction reagent, and at last, a series of novel di-schiff base derivatives containing oxadiazole ring were obtained by the reaction of 2,5-bis(4-aminophenyl)-1, 3,4-oxadiazole with aromatic aldehydes (yield: 65%-81%). The structures of these compounds were confirmed by 1H NMR, FTIR and MS. Their UV-Vis spectra as well as fluorescence spectra were studied and the electrochemical properties were tested with cyclic voltammetry. The UV-Vis spectroscopy results show that the characteristic absorption peaks of 1, 3, 4-oxadiazole unit and di-schiff base unit disappeared. The maximum absorption wavelength was detected at 345-357 nm because conjugation effect made the two energy bands partially hybrid and form a new energy band structure. Fluorescence spectroscopy results show that they emit strong blue and purple fluorescence, and the emission maximum wavelengths of di-schiff base are from 390 to 407 nm. Electrochemical properties results show that they have higher affinity energy (2.36-3.04 eV) and ionic potential (5.35-6.06 eV), which indicated that they have better electron-transporting properties than PBD except 3 a and 3 h. The results give a reference to further application to organic electroluminescent devices of the target compound.

Background: It has been known that there are declines of dendritic cell (DC) count and its function in the peripheral blood of patients with non-small cell lung cancer (NSCLC), which are remarkably related to the proceeding and prognosis of NSCIC. The aim of this study is to investigate the relationship and clinical significance between the DC subsets (CD11c+DC and CD123+DC) and immunology state of patients with advanced NSCLC., Methods: Flow cytometry was used to detect DC subsets, T cell subsets, NK cell percentage in the peripheral blood of 40 patients with advanced NSCLC and 10 healthy controls., Results: The expression of CD11c+DC (0.38%±0.18%) in the peripheral blood of advanced NSCLC patients, was decreased significantly compared with that of normal controls (0.66%±0.24%) (P < 0.01). The expression of CD123+DC in the peripheral blood of advanced NSCLC patients was (0.28±0.17)%, with no significant difference compared with that of normal controls (0.27%±0.11%) (P > 0.05). The percentage of CD3+ T cell and CD4+/CD8+ of patients with advanced NSCLC were significantly lower than those of normal controls (P < 0.01 and P < 0.05), and the percentage of CD8+ and NK cell of patients were higher than those of normal controls (P < 0.05). The correlation analysis showed that CD123+DC percentage was positively correlated to CD3+T cell percentage (P < 0.05) and negatively correlated to NK cell percentage (P < 0.01). The expression of DC subsets correlated with KPS and chemotherapy history of patients (P < 0.01)., Conclusions: The advanced NSCLC may induce significant decreasing expression of CD11c+DC and may induce significant decrease of immunology state. There are close relationship among the expression of DC subsets and the immunology state of patients as well as the clinical biological behaviors of patients with advanced NSCLC.