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Mycobacteria and their metabolites which participate in the reprogramming of neurogliocytes and neuroprotection were summarized in this article, and the probable signaling pathways were also analyzed. The bacteria from digestive tract including periodontal and intestines involving in central nervous system diseases, such was Alzhermer's disease (AD), multiple sclerosis (MS), autism and so on, was introduced as well. DOI: 10.3969/j.issn.1672-6731.2015.02.016