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In January 2024, Cancer Statistics, 2024 was published in CA: A Cancer Journal for Clinicians. This report estimated cancer cases and deaths in 2024 and described the secular trends of major cancers over recent decades. We summarized the report and integrated the latest data on the cancer burden in China to compare the prevalence cancer between two countries. We also comprehensively interpreted the underlying reasons for these trends to provide insights for cancer prevention and control strategies in China.

In order to promote energy conservation and facilitate the utilization of solid wastes, red mud, coal metakaolin, and alkaline activators were used as main raw materials to prepare red mud-coal metakaolin based geopolymer (RCG). The effects of glass fiber, basalt fiber, polypropylene fiber, and polyvinyl alcohol fiber on the compressive strength, peak strain, elastic modulus, compressive toughness, energy absorption, flexural strength, and microstructure of RCG were investigated. The toughening mechanism of four kinds of fiber on RCG was expounded, and the results indicate that incorporation of fibers can enhance the mechanical properties of RCG and improve its toughness and ductility. Among them, basalt fibers and polyvinyl alcohol fibers have similar effects on strength enhancement, but polyvinyl alcohol fibers can effectively change the brittle failure modes of RCG and enhance the compression toughness and energy absorption capacity of RCG. Through microscopic morphology analyses, polyvinyl alcohol fiber has high moisture regain, and the bonding effect with the matrix was found to outperform other fibers, so the physical and mechanical properties of RCG are improved better.

In order to solve the problems of 5G network handover authentication and key update mechanism， such as lacking of forward security， being vulnerable to bypass attack and having signaling congestion， for 5G enhanced （B5G） network， an efficient handover authentication and security key-updating mechanism based on no certificate was proposed.The certificateless key agreement mechanism was introduced in the network edge side， which made the mobile terminals in-itiate the key-updating request actively and complete the whole certificateless key-updating process on the fly.The security of the key-updating mechanism was proved theoretically based on the Diffie-Hellman problem under the eCK security model.Simulation results demonstrate that the proposed mechanism not only meets the forward security of mobile terminal key management， but also has lower communication and computing overheads compared with other similar handoff authentication.

Aiming at the problem of inefficient use of spectrum resources,a fusion spectrum sensing algorithm based on eigenvalues was proposed to effectively achieve dynamic spectrum sharing.The test statistics were constructed by employing the maximum eigenvalue,the trace and the geometric mean of all eigenvalues of the sample covariance matrix.The detection probability and false alarm probability of the proposed method were analyzed using the random matrix theory,and the analytical representation of the theoretical threshold was obtained.In addition,the parameter selection of the proposed algorithm was analyzed theoretically.Simulation results show that the proposed algorithm has better detection ability than the existing eigenvalue detection algorithm.

Background Myelosuppression is one of the most common adverse effects of chemotherapy for lung cancer, in response to chemotherapy-related myelosuppression, modern medicine mostly adopts symptomatic treatment, but there are many limitations. Objective To investigate the effects of press-needle therapy on pevention of myelosuppression after chemotherapy of lung cancer patients based on the midnight-noon ebb-flow point selection theory. Methods A total of 142 non-small cell lung cancer (NSCLC) patients during first chemotherapy hospitalized in the respiratory department of Northern Jiangsu People's Hospital from July 2020 to June 2022 were selected and randomly divided into the control group (n=47) , press-needle group (n=48) and timing group (n=47) according to a prior computer-generated random number table and the developed allocation scheme. The control group received routine care measures, the press-needle group received press-needle therapy at acupoints such as Geshu acupoint, Pishu acupoint and Weishu acupoint on the basis of routine care measures, the timing group received press-needle therapy between 7 a.m. and 11 a.m on the day using midnight-noon ebb-flow method on the basis of routine care measures. The changes of blood routine indicators reflecting myelosuppression and the comfort scores before chemotherapy and 3rd, 7th, 14th, 21st days of chemotherapy were observed in the three groups. Results The white blood cell count and neutrophil count in the press needle group and timing group were higher than the control group, and the white blood cell count and neutrophil count in the timing group were higher than the press needle group on the 7th and 14th days of chemotherapy (P< 0.05) ; the platelet count in the press needle group and timing group were higher than the control group on the 7th and 14th days of chemotherapy (P< 0.05) . The comfort scores in the press needle group and timing group were higher than the control group on the 7th and 14th days of chemotherapy (P< 0.05) , the comfort scores in the timing group were higher than the press needle group on the 14th day of chemotherapy (P< 0.05) . Conclusion The timing press-needle therapy based on the midnight-noon ebb-flow point selection theory can effectively prevent myelosuppression, improve blood routine indicators including white blood cell count, neutrophil count and platelet count, and promot comfort in NSCLC patients after chemotherapy.

Objective: To detect the antifungal effect of the novel imidazoles 2-imidazole-2, 4-pentadienone 19 and 44 on Candida albicans, and explore the mechanism of the antifungal effect preliminarily. Methods: The inhibitory effects of 2-imidazole-2, 4-pentadienone 19 and 44 on Candida albicans standard strains SC5314, ATCC90028 and clinical isolates were observed through susceptibility test in vitro (the concentration gradients of fluconazole, 2-imidazole-2, 4-pentadienone 19 and 44 were all set in 0.25-128.00 μg/mL), hyphal inhibition test (the concentration gradients of fluconazole, 2-imidazole-2, 4-pentadienone 19 and 44 were all set in 0, 2.00, 8.00, 16.00 μg/mL) and crystal violet staining cell coun-ting test (the concentration gradients of fluconazole, 2-imidazole-2, 4-pentadienone 19 and 44 were all set 2.00, 8.00, 16.00, 64.00 μg/mL). The morphological changes of membrane and organelles in Candida albicans were observed by transmission electron microscopy when they were cultured with 2-imidazole-2, 4-pentadienone 19 (0.50 μg/mL) and 44 (2.00 μg/mL). Results: The susceptibility test in vitro showed that the minimal inhibitory concentrations (MIC) of fluconazole, new drug 19, and new drug 44 on Candida albicans SC5314 were 1.00, 0.50, and 2.00 μg/mL, respectively. The clinical isolates of Candida albicans 21897, 210 and 141 were all fluconazole-resistant strains (MIC>128.00 μg/mL). The MICs of new drug 19 on three type isolates were 64.00 μg/mL,> 128.00 μg/mL and 64.00 μg/mL, and the MICs of new drug 44 on them were 8.00 μg/mL, 16.00 μg/mL and 16.00 μg/mL, respectively. The mycelial inhibition experiment showed that the mycelial growth of Candida albicans SC5314 was significantly inhibited in the culture medium containing fluconazole and the novel drugs 19 and 44, and the higher the drug concentration (≤64.00 μg/mL). The inhibitory effects of new drugs 19 and 44 were better than fluconazole as the drug concentrations were 8.00 μg/ml or 64.00 μg/mL. Transmission electron microscopy showed that fluconazole and the novel drugs 19 and 44 led the cell membrane of SC5314 to become uneven and coarse in texture, which was obviously different from that of drug-free control. Conclusions: The new imidazoles 2-imidazole-2, 4-pentadienone 19 and 44 show strong inhibitory effects on Candida albicans by changing the structure of cell membrane.