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Purpose: To investigate the effect of premolar extraction on Bolton index overall ratios., Methods: Bolton index overall ratios were measured in 198 randomly chosen dental casts of three types of Angle's malocclusions before and after 4 combinations of hypothetical premolar extractions. The data was processed using SPSS 17.0 software package., Results: The overall ratios decreased in each class of Angle's malocclusion after all combinations of premolars extraction, and the decreases in combinations of 5/5 and 5/4 extractions were significantly greater than that of 4/4 and 4/5 combinations (P<0.05), but no significant difference was found between different types of malocclusion (P>0.05)., Conclusions: When formulating a treatment plan involving premolar extractions, orthodontists should consider that the Bolton overall ratios may decrease.

Aim: To explore the effects of Syringa extract, IFN and ganyanling on the the survival rate of HepG2.2.15 cells and the secretion of HBsAg and HBeAg by HepG2.2.15 cells., Methods: (3)H-TdR incorporation and ELISA were used to detect respectively the survival rate of HepG2.2.15 cells and levels of HBsAg and HBeAg in culture supernatant of HepG2.2.15 cells after stimulation with 3 drugs., Results: (1)All of the three drugs decreased the survival rate of HepG2.2.15 cells to the various extent with the increase of doses. The effect of the Syringa extract was between those of IFN and ganyanling. (2)All of the three drugs might suppress the secration of HBsAg and HbeAg by HepG2.2.15 cells in dose-dependent manner, while the the effect of the syringa extract was between those of IFN and ganyanling., Conclusion: The Syringa extract is an effective and low toxic anti-hepatitis B drug.