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Objective To systematically evaluate the efficacy and safety of insulin Icodec in the treatment of type 2 diabetes mellitus (T2DM) in order to provide evidence-based guidance for the rational clinical use of drug. Methods The databases of PubMed, Embase, Cochrane Library, Web of Science, Sinomed, CNKI, Wanfang and VIP were searched by computer to identify randomized controlled trials (RCT) comparing the efficacy and safety of insulin Icodec (trial group) versus placebo or other hypoglycemic agents (control group) in the treatment of T2DM were collected from the date of database inception to August 2023. The efficacy indexes included: glycated hemoglobin A1c (HbA1c) level, HbA1c compliance rate (HbA1c<7%), fasting plasma glucose (FPG) level, body weight level, time in range (TIR) percentage. Safety indicators included: incidence of hypoglycemia events, incidence of injection site reactions, incidence of drug allergic reactions, and incidence of serious adverse events. Two evaluators independently screened the literature, extracted data from the literature and assessed the risk of bias of the studies included, and performed a meta-analysis of the data using RevMan 5.4 software. Results Seven studies with a total of 3 286 patients were included. The results of meta-analysis showed that compared with the control group, insulin Icodec reduced HbA1c (WMD=-0.16%, 95%CI -0.26%-0.07%, P<0.01), increased the rate of HbA1c compliance (OR=1.50, 95%CI 1.29-1.74, and decreased HbA1c compliance (WMD=-0.16%, 95%CI -0.26%-0.07%, P<0.01). However, there was no statistically significant difference between the two groups in reducing FPG levels (WMD=-0.05 mmol/L, 95%CI -0.29-0.20 mmol/L, P=0.71), and it increased the body weight of patients (WMD=0.52 kg, 95%CI 0.22-0.82 kg, P<0.01), but increased the percentage of TIR in patients (WMD=5.86%, 95%CI 2.02%-9.70%, P=0.003). In terms of safety, although the incidence of hypoglycemic events (OR=1.37, 95%CI 1.17-1.61, P<0.01) was higher in the insulin Icodec group than in the control group, the incidence of anaphylaxis was higher in insulin Icodec group than in the control group (OR=0.91, 95%CI 0.64-1.31, P=0.62), injection site reaction (OR=1.03, 95%CI 0.63-1.66, P=0.92) and incidence of serious adverse events (OR=0.97, 95%CI 0.75-1.24, P=0.79), there was no significant difference between insulin Icodec and control groups. Conclusions Insulin Icodec can lower HbA1c levels in patients and increase the rate of HbA1c compliance without increasing the incidence of injection site reactions, allergic events and serious adverse events. [ABSTRACT FROM AUTHOR]

Combining the virtual prototyping technology,finite element analysis techniques and thermal stress analysis theory,virtual prototype model of gear casing is established by UG NX 8.0.The 3-dimensional finite element model of the gear casing is established by using the seamless links of UG and ANSYS Workbench14.5,based on the theory of finite element,thermal-structural coupling analysis is implemented to the finite element model,temperature field distribution and thermal deformation of the gear casing are obtained,and centralized positions of the thermal stress and deformation is determined,and the factors that impact the temperature field distribution and thermal deformation are obtained.Through analyzing the results of the finite element simulation,the model of the heat-structure coupling analysis can provide an important reliable analysis basis for structure design,integrated design and the thermal uniform optimization design of the gearbox that worked in the complex overloaded transmission conditions which generate large amount of heat.

A process of depth reduction-magnetic separation technology research was introduced to pyrite cinder from Hebei. And the factors that influence the process of depth reduction and separation were systematic studied. The means of SEM, XRD were used to analyze the pyrite cinder, the roasted product of pyrite cinder and the iron ore concentrate. The results showed that the pyrite react with desulfurization agent to form metallic iron and calcium sulfide. Under optimal conditions of depth reduction, and only one stage of grinding-magnetic separation, the grade and the recovery rate of iron concentration arrived at 93.13% and 92.21%, respectively, with the sulfur content of 0.06% and it could be directly used in steelmaking after subsequent treatment, which reached the target of efficient use of solid waste, ie pyrite cinder. [ABSTRACT FROM AUTHOR]

The efficient separation of antimony oxide ore has always been a worldwide problem in the field of mineral processing. In order to improve the recovery efficiency of antimony oxide ore flotation, the single mineral test was carried out to optimize the flotation reagents. The condition optimization tests of collector, activator and inhibitor were mainly carried out. Through optimization, the efficient flotation recovery of antimony oxide ore was realized, and the lead content in antimony oxide concentrate was reduced. The experimental results show that the flotation recovery of antimony oxide ore can be effectively improved by using EF105 as collector and the combination of lead nitrate and copper sulfate as activator. Using modified sodium silicate-302 as gangue inhibitor can effectively inhibit the floating of gangue. On the basis of single mineral flotation test, the actual mineral flotation test of antimony oxide was carried out. Under the optimal reagent conditions, the test flowsheet of one roughing, two scavengings and three cleanings was adopted, and the antimony concentrate with Sb grade of 22.31% and Sb recovery of 65.43% was obtained. Compared with the flotation process before optimization, the grade and recovery of antimony were significantly improved. [ABSTRACT FROM AUTHOR]

Objective: To analyze the prognosis of fetuses with cystic hygroma (CH) or nuchal translucency (NT) or nuchal fold (NF) thickening detected by prenatal echography., Methods: From January 2014 to December 2015, 124 fetuses with CH and NT/NF thickening on prenatal echography were enrolled from Women's Hospital of Zhejiang University School of Medicine. The basic clinical information, ultrasonic results, pregnancy outcomes and newborn follow-ups were analyzed. The cases were grouped by prognosis and the factors affecting prognosis were analyzed with logistic regression., Results: There were 85 cases of labor induction including one stillbirth and 39 cases delivered. Except one infant who died after birth, all live births survived with good prognosis. Univariate analysis showed that the gestational age at diagnosis of poor prognosis group was earlier than that of good prognosis group ( P <0.01); and the former group also had higher hydrops fetalis rate and additional structural anomalies rate (all P <0.01). Multivariate regression analysis showed that hydrops fetalis ( OR =90.105, P <0.05) and additional structural anomalies ( OR =61.854, P <0.05) were risk factors of poor prognosis in fetuses with CH and NT/NF thickening., Conclusions: Fetuses with diagnosed CH or NT/NF thickening on prenatal ultrasonography are likely to be associated with chromosomal abnormality. Early gestational weeks, hydrops fetalis and additional structural anomalies may indicate poor prognosis.