1. [A new spirocyclic cycloartane triterpenoid from Souliea vaginata].
- Author
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Zhang SY, Fang ZJ, Wang YL, Zhou CX, Mo JX, and Gan LS
- Subjects
- Actaea chemistry, Glycosides, Lipopolysaccharides, Molecular Structure, Triterpenes analysis, Actaea metabolism, Triterpenes metabolism
- Abstract
The 70% ethanol extract of the whole plant of Souliea vaginata was purified by multi-chromatographic methods including macroporous resin,silica gel,Sephadex LH-20,and C18-reversed-phase column chromatography. A new spirocyclic cycloartane triterpenoid was isolated and identified as( 16 R*,20 R*,23 S*,24 R*,25 S*)-16,23: 23,26-diepoxy-15α,24,25-trihydroxy-9,19-cycloart-3β-O-β-D-xylopyranoside( 1),and named as soulieoside S. Its planar structure and relative configuration were determined by spectroscopic techniques including 2 D NMR and HRESI-MS. As one of the main components of S. vaginata,compound 1 was evaluated for its anti-inflammatory activity by a lipopolysaccharide( LPS)-stimulated NO production model in RAW264. 7 macrophages,but it didn't show NO production inhibitory effect.
- Published
- 2019
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