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Objective To analyze the effect and prognosis of COMP gene mutation on the treatment of carpal tunnel syndrome with ultrasound-guided dental crochet knife. Methods A total of 35 carpal tunnel syndrome patients with Cartilage oligomeric matrix protein gene mutation (COMP) who were treated in the outpatient department from June 2022 to June 2023 were selected as the control group. Another 40 patients with carpal tunnel syndrome without mutation of COMP gene who received treatment during the same period were selected as the observation group. All patients were treated with ultrasound-guided lower tooth crochet knife. The Transverse carpal ligament thickness, paresthesia score, muscle loss score and transverse carpal ligament thickness were compared between the two groups. Pisiform cross section median nerve cross section area, pisiform cross section median nerve cross section area, CSA), Anterior and posterior diameter of median nerve in cross section of uncinate bone (D), clinical efficacy and incidence of adverse events. Results After treatment, compared with observation group, paresthesia score, hand function satisfaction score, TTCL, CSA and D in control group were all increased, while muscle loss score was decreased, with statistical difference (P < 0.05). In addition, the total clinical efficiency increased significantly and the incidence of adverse effects decreased significantly in the observation group. The prognosis of carpal tunnel syndrome patients with COMP gene mutation was evaluated according to the satisfaction degree of hand function, which showed that compared with the good prognosis group, the hand function score of the poor prognosis group increased significantly, with statistical difference (P < 0.05). Before treatment, there was no significant difference in clinical manifestations between the two groups (P > 0.05). Conclusions The application of ultrasound-guided crochet in carpal tunnel syndrome patients with COMP gene mutation plays an important role in the development of carpal tunnel syndrome. [ABSTRACT FROM AUTHOR]

Objective: To investigate the influence of hibernation drugs on postburn stress and inflammatory reaction in severely scalded rats., Methods: Sprague-Dawley rats inflicted with 30% TBSA deep partial thickness scalding were employed as the model. The rats were divided into A (scalding with immediate resuscitation), B (scalding with immediate resuscitation and lytic cocktail), C (scalding with delayed resuscitation), D (scalding with delayed resuscitation and lytic cocktail) and E (sham injury) groups. The rat plasma levels of NE (norepinephrine), E (epinephrine) and DA (dopamine) were determined by HPLC (high performance liquid chromatography) at 3, 6, 12, 24 and 48 postburn hours (PBHs), and the plasma IL-1alpha and PGE(2) levels were detected by ELISA (enzyme-linked immunosorbent assay) and RIA (radioimmunoassay) methods. The NF-kappaB activity in PBMCs (peripheral blood mononuclear cells) was determined by laser scanning confocal microscope., Results: The plasma NE and E levels reached summit at 6 PBH, while those in B group were lowest. But the plasma DA level was similar among all groups at all time points. The plasma IL-1alpha and PGE(2) levels increased continuously, however, the levels were were lower in B than A groups at the same time points, and also that of D were lower than C groups. At the same time points, the levels in B group were lower than those in D group. The NF-kappaB was located in the cytoplasma of PBMCs in E group and in the nucleus in A group at 6 PBH. Furthermore, the NF-kappaB was concentrated more in the cytoplasm than that in the nucleus in B group, while it was more concentrated in the nucleus in C and D groups., Conclusion: The secretion of stress hormones could be attenuated by hibernation drugs. The plasma cytokine levels and the nuclear translocation of NF-kappaB in PBMCs could also be modulated by the drugs.