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The flight load test technology is of great importance for load designing, strength flight test and life monitoring of the aircraft. In order to realize the real-time distributed aerodynamic load test on the complex wing surface, the data-driven load estimation method based on refine finite element simulation is proposed. The artificial neural network is established with deep-learning method. The data set of the structural response is constructed by the high-precision finite element method, which is used to train the model. The wing load estimation results based on deep learning method is compared and verified with the finite element calculation results. The results show that the average error of the total load is about 0.2%, and the position error of the pressure center is about 1%. The method using several strain test points can estimate and reconstruct the load distribution of the whole wing in real time.

Objective: To study if the increase of levels of neurofilament (NF)-M and NF-L in brain of Alzheimer's diseases (AD) is caused by increase of NF-M and NF-L., Methods: Semi-quantitative reverse transcription PCR was used to measure the NF-M and NF-L mRNA levels in the brain gray matter obtained by autopsy from 8 patients with AD and 7 age-matched patients with Huntington's disease (HD) used as controls. The mutation of NF-M and NF-L was detected by single strand DNA conformation polymorphism technique., Results: The levels of NF-M mRNA and NF-L mRNA were significantly lower in the brains of AD patients (0.3 +/- 0.03 * OD(NF-M)/OD(GAPDH) or OD(NF-L)/OD(GAPDH) and 0.44 +/- 0.16 * OD(NF-M)/OD(GAPDH) or OD(NF-L)/OD(GAPDH) respectively) than in the brains of HD patients (0.42 +/- 0.07 OD(NF-M)/OD(GAPDH) or OD(NF-L)/OD(GAPDH) and 0.79 +/- 0.09 OD(NF-M)/OD(GAPDH) or OD(NF-L)/OD(GAPDH) respectively) (P < 0.005 and P < 0.007 respectively). NF-M mutation was detected in one AD patient. No NF-L mutation was found in the samples examined., Conclusion: The increase of neurofilament protein observed in the brains of AD patients is related neither to increased gene transcription nor to mutation of NF mRNA.