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In this study, a water-in-oil-in-water (W1/O/W2) multiple emulsion stabilized by dextran-ferritin-resveratrol (Dex-rHuHF-Res) nanoparticles was prepared by a two-step emulsification method. Its stability and potential for the delivery of bioactive substances were analyzed. The results showed that when the concentration of polyglycerol ricinoleate (PGPR) was 7% (V/V), the ratio of aqueous phase (W1) to oil phase (O) was 3:7, and the ratio of W1/O to outer aqueous phase (W2) was 4:6, the emulsion had homogeneous appearance, uniform droplet size distribution, the smallest particle size (472 nm), and the highest apparent viscosity and storage modulus (G’). At pH 7, 100 mmol/L NaCl concentration and low centrifugal force, the emulsion maintained good stability. In unfavorable environment, compared with free chlorogenic acid, astaxanthin and resveratrol, the retention rates of chlorogenic acid, astaxanthin and resveratrol loaded in the multiple emulsion were significantly improved (P < 0.05). The bioaccessibilities of chlorogenic acid, astaxanthin, and resveratrol loaded in the W1/O/W2 emulsion were significantly increased (P < 0.05), and the antioxidant property of the emulsion was obviously enhanced (P < 0.05). This study provides a theoretical basis for the application of the W1/O/W2 emulsion stabilized by Dex-rHuHF-Res nanoparticles in the delivery of active substances.

Background Knee joint injury is a common military training injury, which seriously affects the combat effectiveness of soldiers. In recent years, the prevention and treatment of military training injury becomes more and more important. Ultrasound therapy and Qingpeng ointment are commonly used to treat sports training injuries. However, the protective effectiveness of ultrasound combined with the external use of Qingpeng ointment for knee injury in sports training injury patients is less reported. Objective To comprehensively assess the clinical efficacy of Qingpeng ointment combined with ultrasound therapy in the treatment of knee injuries caused by military training. Methods Fifty-six patients with knee injury who were treated in the Fifth Pentry Outpatient Clinic, the General Hospital of the Western Theater Command PLA from May to July 2022 were selected and randomly grouped into control group (4 cases fell off during the study, n=24) and treatment group (n=28) using IBM-SPSS 25.0 statistical software to generate random numbers. The control group was given ordinary coupling agent ultrasonic therapy, and the treatment group was given Qingpeng ointment ultrasonic therapy, once a day, 10 times a course, a total of 2 courses. The Lysholm knee joint score, VAS score, Hamilton Depression Scale-17 (HAMD-17), and knee range of motion were compared between the two groups after a twenty-minute intervention. Results Before treatment, there was no significant difference in Lysholm knee joint score, VAS score, HAMD-17 score and knee joint motion between the two groups (P>0.05). After 2 courses of treatment, the passive joint motion of the knee in the treatment group was better than that in the control group (P

Objective: To evaluate the effect of Lactobacillus plantarum CCFM8661 on reducing lead in the human body and its effect on human health. Methods: In total, 60 volunteers suffering from foodborne heavy metal exposure were recruited and divided into two groups, with one orally receiving L. plantarum CCFM8661 powder and the other orally receiving a placebo. The protective effect of L. plantarum CCFM8661 on lead-exposed populations was evaluated comprehensively by analyzing the volunteers’ blood lead levels, blood cells, blood biochemical indexes, serum calcium and iron levels before and after interventions. Results: L. plantarum CCFM8661 intervention effectively reduced the blood lead level in the lead-exposed population, and down-regulated total bilirubin, urea and total serum protein while having no significant effect on blood cells, blood calcium or iron levels. Conclusion: L. plantarum CCFM8661 could protect lead-exposed subjects by effectively reducing lead levels and, thereby, has the potential to be further developed into a biological agent for the bioreduction of heavy metals.

In this study, a luxS-deleted mutant of Vibrio parahaemolyticus was successfully constructed by homologous recombination technology, and the growth capacity, 4,5-dihydroxy-2,3-pentanedione (DPD) production, biofilm formation, motility, drug susceptibility, extracellular protein-secreting capacity, and quorum sensing-related gene expression of the wild and mutant strains were compared to understand the effects of luxS gene deletion in the LuxS/AI-2 quorum sensing system on the biological characteristics of V. parahaemolyticus. The results showed that the deletion of the luxS gene did not affect the drug susceptibility or growth capacity of the strain. Compared with the wild-type strain, the DPD production and mobility of the mutant strain was significantly reduced, while the capacity of biofilm formation and extracellular protease secretion after 24 hours of incubation was significantly enhanced. The real-time polymerase chain reaction (PCR) results showed that the expression of the flagellar synthesis gene flgM significantly increased, while the expression of the hemolysin secretion-related gene toxS, the flagella synthesis gene flaA and the outer membrane protein gene ompW decreased significantly in the mutant strain. This study provides a basis for further research on the regulation mechanism of the LuxS/AI-2 quorum sensing system on the biological characteristics of V. parahaemolyticus, which will be helpful for the prevention and control of V. parahaemolyticus.

On the one hand, the existing knowledge graph entity prediction methods only use the neighborhood and graph structure information to enhance the node information, and ignore the multi-modal information outside the knowledge graph to enhance the knowledge graph information. On the other hand, when comparing positive and negative samples to train the model, the negative sample random ordering results in poor training effect, and there is no additional information to help the training process of negative samples. Therefore, a multi-modal curriculum learning knowledge graph entity prediction model (MMCL) is proposed. Firstly, multi-modal information is introduced into the knowledge graph to achieve information enhancement, and the multi-modal information fusion process is optimized using generative adversarial network (GAN). The samples generated by the generator enhance the knowledge graph information, and at the same time improve the discriminator??s ability to distinguish the truth and falsity of triples. Secondly, the course learning algorithm is used to sort the negative samples from easy to difficult according to the difficulty of the negative samples. By adding the sorted negative samples into the training process hierarchically through the pace function, it is more beneficial to playing the effect of negative samples in identifying the truth and falseness of triples, and at the same time, no label learning avoids the false-negative problem in the late training period. The discriminators share parameters with course learning training models to help improve the training effect of negative samples. Experiments are conducted on two datasets, FB15k-237 and WN18RR. The results show that compared with the baseline model, MMCL is significantly improved in mean reciprocal rank (MRR), Hits@1, Hits@3 and Hits@10. The validity and feasibility of the proposed model are verified.

Objective To report 4 cases of intracranial arterial stenosis stenting via radial artery approach and summarize the experience of treatment. Methods and Results The clinical data and treatment process of 4 patients with ischemic stroke treated by intracranial arterial stenosis stenting via radial artery approach in The Affiliated Hospital of Qingdao University were reviewed in 2022. The stenoses were located in the initial segment of left internal carotid artery (ICA), the initial segment of right vertebral artery (VA), the V4 segment of left VA, and the junction of V4 segment of left VA and the basilar artery, respectively. All the 4 patients underwent transradial approach stenting for ICA stenosis. The surgery was successful and the stenoses were recanalized. No adverse reactions were observed during and after the surgery. Conclusions Intracranial arterial stenosis stenting via radial artery approach is safe and effective in the treatment of ischemic stroke.

A semiconductor nanomaterial was prepared and its degradation efficiency on zearalenone (ZEN) was investigated. The photocatalytic material, graphitic carbon nitride (g-C3N4), was synthesized by the conventional thermal cracking method, and its structure was analyzed by (X-ray diffraction) XRD, Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The photocatalytic degradation experiments showed that g-C3N4 induced photocatalytic effects under ultraviolet light (254 nm, including 185 nm), releasing reactive oxygen radicals to degrade ZEN. The experimental conditions for the photocatalytic degradation of ZEN were explored. The results showed that the degradation rate of ZEN was 96.0% when the mass of the photocatalytic material , the wavelength of the UV lamp, the initial concentration and the irradiation time were 20 mg, 254 nm (50 W), 0.5 μg/mL and 60 min, respectively. Meanwhile, the experimental conditions for the photocatalytic degradation of ZEN powder samples were optimized. The results showed that the degradation rate of ZEN was 80.0% when the mass of the photocatalytic material, the wavelength of the UV lamp, and the irradiation time were 800 mg, 254 nm (50 W) and 50 min, respectively. The results could provide a theoretical reference and practical basis for the photocatalytic degradation of ZEN.

Objective To explore the effect of moderate fatty liver on cardiac function in orthotopic autologous liver transplantation model rats. Methods Sixty SPF-grade healthy male SD rats were randomly divided into three groups (20 rats in each group). Group A was fed ordinary diet for 6 weeks and underwent laparotomy followed by separation of the blood vessels and ligaments around the liver and abdominal closure; group B was fed ordinary diet for 6 weeks and underwent orthotopic autologous liver transplantation; group C was fed high-fat diet for 6 weeks and underwent orthotopic autologous liver transplantation. The body mass, liver wet mass, liver index, and serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) after 6 weeks of feeding, as well as intraoperative blood pressure, pulse rate, respiratory rate, proportion of arrhythmia occurring in the new liver stage, and serum levels of lactate dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (α-HBDH), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), and high-sensitivity cardiac troponin (hs-cTn) at 0, 5, 10, and 60 min in the new liver stage were compared. Results The body mass, liver wet mass, liver index, and serum AST and ALT levels, as well as intraoperative systolic blood pressure, diastolic blood pressure, pulse rate, respiratory rate, and proportion of arrhythmia occurring in the new liver stage in group C were significantly higher than those in groups A and B (F=36.40-4 060.54,χ2 =10.91,P0.05). The serum levels of LDH, α-HBDH, CK, CK-MB, and hs-cTn at different time points in the new liver stage were significantly higher in group C than in groups A and B (F=14.11-1 057.08,P

As static scene 3D reconstruction algorithms become more mature, dynamic scene 3D reconstruction has become a hot and challenging research topic in recent years. Existing static scene 3D reconstruction algorithms have good reconstruction results for stationary objects. However, when objects in the scene undergo deformation or relative motion, their reconstruction results are not ideal. Therefore, developing research on 3D reconstruction of dynamic scenes is essential. This paper first introduces the related concepts and basic knowledge of 3D reconstruction, as well as the research classification and current status of static and dynamic scene 3D reconstruction. Then, the latest research progress on dynamic scene 3D reconstruction is comprehensively summarized, and the reconstruction algorithms are classified into dynamic 3D reconstruction based on RGB data sources and dynamic 3D reconstruction based on RGB-D data sources. RGB data sources can be further divided into template based dynamic 3D reconstruction, non rigid motion recovery structure based dynamic 3D reconstruction, and learning based dynamic 3D reconstruction under RGB data sources. The RGB-D data source mainly summarizes dynamic 3D reconstruction based on learning, with typical examples introduced and compared. The applications of dynamic scene 3D reconstruction in medical, intelligent manufacturing, virtual reality and augmented reality, and transportation fields are also discussed. Finally, future research directions for dynamic scene 3D reconstruction are proposed, and an outlook on the research progress in this rapidly developing field is presented.

Dynamic vulcanized thermoplastic elastomer (TPV)/nickel (Ni) coated glass fiber (NCGF)/vitamin C(VC) composites(TPV/NCGFVC) were prepared by melt blending method. The effects of VC on micromorphology, molecular structure and mecha-nical properties of the composites before and after aging were systematically studied. The mechanism of selective protection of VC on Ni network was discussed. The results showed that the addition of VC in TPV/NCGF composites could effectively inhibit the oxidation of Ni conductive network during the aging process, so that the composites showed stable conductivity and electromagnetic shielding effectiveness with the electromagnetic shielding effectiveness retention rate of over 90%. After VC was introduced into the pure TPV matrix, it could effectively inhibit the fracture of the molecular chain of TPV after thermal oxidative aging. During the aging process of TPV/NCGFVC composite, VC reacted preferentially with the Ni network to reduce the Ni ions generated from by the oxidation of the Ni layer on the surface of NCGF to elemental Ni, indicating that VC had a selective protective effect on the Ni metal network.

General practitioners (GPs) play an important role in diabetes care in primary care as the "gatekeepers" of population health. The management of diabetes can slow its progression, reduce complications and improve patient outcomes, which requires effective communication and collaboration between patients and their doctors. GPs with good communication skills can help to build long-term care relationships with diabetes patients and help them develop effective self-management skills. This paper summarizes the design and development of diabetes communication skills training for GPs guided by research team with multiple theoretical frameworks, including evidence-based findings from systematic review, experiences and ideas of diabetes patients communicating with GPs based on qualitative studies, prioritization of training content for patient-doctor communication in GPs captured by mixed-methods research, in order to provide new ideas for high-quality diabetes management in primary care and inform the design of training programmes for GPs based on evidence and medical education frameworks.

The changes in the main active ingredients and sensory quality of Gastrodia elata during liquid-state fermentation with the traditional Kombucha consortium were analyzed in the study. The results showed that the total acid concentration of the fermentation broth increased, and consequently the pH decreased after 5 days of fermentation, among which acetic acid and succinic acid increased most obviously. Fermentation with the Kombucha consortium significantly increased the contents of total polyphenols, total flavonoids and p-hydroxybenzyl alcohol. The volatile components of the fermentation broth were analyzed by electronic nose combined with solid phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS). It was found that many flavor substances were produced through the fermentation process. Sensory evaluation indicated that Kombucha consortium fermentation significantly reduced the unpleasant odor of G. elata and imparted it a fruity flavor. This study provides a theoretical basis and technical support for the in-depth development and utilization of G. elata.

A water calorimeter based on thermistor is developed in this paper, and for the correction of chemical thermal defects in the absolute measurement of absorbed dose to water from proton beam, the design of gas saturated ultrapure water system is completed. By filling the ultrapure water inside the calorimeter core with high purity gas to form saturation condition, the effect of radiation chemical reaction is minimized. And the irradiation reaction of O2 in the ultrapure water is fully occurred through pre-irradiation experiment after the encapsulation of the calorimeter core, so that the water environment inside reaches a stable state without heat loss,which successfully developed a stable zero heat loss water calorimeter and the influence of heat loss on the absolute measurement of absorbed dose to water is minimized, which provides an important basis for the subsequent absolute measurement of absorbed dose to water.

Background Cognitive impairment can lead to a decline in cognitive function, depression, and loneliness, as well as decreased self-efficacy and quality of life in older adults. Objective To investigate the effects of non-pharmacological integrated interventions on cognitive function, depression, loneliness, self-efficacy, and quality of life in older adults with mild cognitive impairment. Methods Based on risk factors for cognitive impairment, a non-pharmacological integrated intervention program was developed in five dimensions of cognitive training, physical exercise, emotional management, social connection, and healthy lifestyle habits. Using a single-subject A-B-A experimental design, a 3-month intervention, which was conducted once a week for 60 minutes, was performed in three elderly individuals with mild cognitive impairment from June to December 2021. The Montreal Cognitive Assessment (MoCA), Geriatric Depression Scale-15 (GDS-15), 12-item Short Form Health Survey (SF-12), General Self-Efficacy Scale (GSES), and De Jong Gierveld Loneliness Scale (DJGLS) were administered to the 3 older adults at baseline, 3 months of the intervention, and 3 months after the intervention, to assess the scores of each scale from the 5 dimensions of cognitive function, self-efficacy, quality of life, depression, and loneliness, the changes in the scores were analyzed. A semi-structured interview was conducted 3 months after the intervention to evaluate the intervention effects in terms of cognitive function, quality of life, depression, self-efficacy, and loneliness dimensions. Results The 3 older adults included in the study were 74, 70, 73 years old, all married, living with their spouses and grandchildren. The three older adults had MoCA scores of 21, 22, and 24 at baseline, 28, 26, and 27 at 3 months of intervention, and 25, 19, and 23 at 3 months after intervention; GSES scores were 25, 30, and 27 at baseline, 29, 29, and 30 at 3 months of intervention, and 28, 31, and 28 at 3 months after intervention. SF-12 scores were 69, 32, and 51 at baseline, 81, 81, and 83 at 3 months of intervention, and 78, 38, and 59 at 3 months after intervention. The GDS-15 scale scores were 4, 8, and 2 at baseline, 2, 6, and 1 at 3 months of intervention, and 1, 8, and 4 at 3 months after intervention. The DJGLS scores were 8, 7, and 8 at baseline, 5, 5, and 4 at 3 months of intervention, and 5, 5, and 7 at 3 months after intervention. Semi-structured interview data indicated improvement in all five dimensions of cognitive function, quality of life, depression, loneliness, and self-efficacy of the subjects. Conclusion For older adults with mild cognitive impairment, it is of great significance to perform a non-pharmacological integrated intervention in terms of cognitive training, physical exercise, emotional management, social connection, and healthy lifestyle habits. The MoCA, SF-12, GDS-15, and DJGLS scores of older adults with mild cognitive impairment improved at 3 months of intervention, while the GSES scores improved at 3 months after intervention. GSES scores were not as effective after the intervention. All dimension scores showed a decreasing trend at 3 months after the intervention.

Background With the accumulation of high-quality evidence, the clinical effectiveness of acupuncture for migraine has been increasingly recognized. Numerous acupuncture clinical studies in China highlight and validate various acupuncture intervention schemes through clinical trials. Integrating and selecting these advantageous schemes to guide clinical practice has become a new focus in acupuncture research. Objective To conduct multicriteria decision making (MCDM) by using technique for order preference by similarity to an ideal solution (TOPSIS) method based on Meta-analysis, screen optimized treatment plan (OTP) of acupuncture for migraine and explore the ideas for constructing OTPs of acupuncture. Methods Wanfang Data, VIP, CNKI, SinoMed, PubMed, Web of Science, and EmBase were searched by computer for randomized controlled trials (RCTs) on acupuncture treatment for migraine published before April 2022. Two researchers independently screened the literature, extracted basic characteristics of literature〔author, year of publication, sample size, cure rate, efficiency rate and visual analogue score (VAS), etc.〕, and assessed the quality of the RCTs by using modified Jadad scale. Acupuncture treatment plans for migraine were summarized based on the characteristics of the included RCTs, and Meta-analysis was performed. The relative risk (RR) of cure rate and efficiency rate, and the mean difference (MD) of VAS scores for each plan were extracted based on the Meta-analysis results. The treatment frequency and score of the modified Jadad scale were calculated for each plan using sample size as the weight. The data were all included in the MCDM analysis, the weights of different decision criterion were determined using the entropy weight method. The TOPSIS method was finally used to select OTP of acupuncture for migraine. Results A total of 17 RCTs were included and categorized into 8 types of treatment plans of acupuncture for migraine (Tongyuan acupuncture, six-spirit points, bone-nearby acupuncture, conventional acupuncture, Gallbladder Meridian acupoints, head acupoints, penetration needling method and Siguan acupoints) according to the results of Meta-analysis. The TOPSIS evaluation indicated that the treatment plan of acupuncture focusing primarily on head acupoints is OTP, involving needling the head acupoints of Fengfu, Touwei, Toulinqi, Taiyang, Shuaigu, and Fengchi once daily or every other day, with an average treatment number of 11, with the main advantages of shorter treatment time and significant reduction in VAS. Conclusion The OTP of acupuncture for migraine screened and constructed in the study can provide reference for clinical application. The utilization of the entropy weight-TOPSIS method based on Meta-analysis presents a novel approach for constructing the OTPs of acupuncture for migraine.

Primary liver cancer (PLC) is one of the common malignant tumors and the main causes of tumor death in China. Although the diagnosis and treatment technology of PLC in China has made great progress in recent years, its morbidity and mortality have been decreasing year by year, but the low early diagnosis rate and 5-year survival rate of PLC are major public health problems that need to be solved urgently in the field of chronic disease prevention and control. Effective implementation of early screening, detection, diagnosis and treatment of PLC is an important measure to improve the rates of radical treatment and survival. The combination of serum alpha-fetoprotein (AFP) and liver ultrasound is a routine method for screening hepatocellular carcinoma (HCC) in patients with chronic liver disease; the combination of AFP and AFP-L3 and/or abnormal prothrombin can improve the early diagnosis rate of early-stage HCC; the early diagnosis rate of small hepatocellular carcinoma can be improved by Gd-EOB-DTPA-enhanced magnetic resonance imaging or its combination with computerized tomography. With the continuous promotion of hierarchical medical system and improvement of primary medical resources allocation and health service capacity in China, primary care institutions have become an important force for early screening of many cancers. Based on this context, this paper mainly discusses the development opportunities, risk challenges and future thinking of surveillance for liver cancer in primary care institutions in China, in order to provide new ideas and direction guidance for it in the future.

Objective To evaluate the application and value of nanocarbon tracer in the surgical treatment of papillary thyroid microcarcinoma (PTMC). Methods Retrospective analysis of clinical and pathological data of 165 PTMC patients who underwent thyroid cancer surgery at Nanjing Jiangbei Hospital from January 2017 to December 2022 was conducted. Patients were divided into the nanocarbon group (n=87) and the conventional group (n=78) based on whether carbon nanoparticles suspension was used during the surgery. Surgical data (such as operation time, blood loss, drainage volume), pathological data (number of lymph nodes and the number of positive nodes), and serological indicators (parathyroid hormone and blood calcium) were compared between the two groups. Results There was no statistically significant difference between the two groups in terms of drainage volume, length of hospital stay, blood loss, and operation time (P＞0.05). The nanocarbon group had a higher number of cleared lymph nodes (7.9±2.1 vs 5.4±1.3，t=9.069，P＜0.01) and positive lymph nodes (2.1±1.1 vs 1.4±1.0，t=4.259，P＜0.01) than the conventional group, and the levels of parathyroid hormone and blood calcium at 1 day and 1 month after surgery were higher in the nanocarbon group compared to the conventional group (P＜0.05). During the outpatient follow-up at 1 month after surgery, both groups had lower serum thyroglobulin values, but the difference was not statistically significant (P＞0.05). Conclusion Nanocarbon tracer can improve the clinical benefits of PTMC surgery and is safe and effective.

Objective To summarize the clinical and genetic mutation characteristics of a family of early ‑ onset familial Alzheimer's disease (EOFAD) type 3 with spastic paraplegia as the first symptom. Methods and Results A 29 ‑ year ‑ old male patient with spastic paraplegia as the first symptom was admitted to Xuanwu Hospital, Capital Medical University on March 30, 2021. Head MRI showed multiple ischemic foci in bilateral subfrontal cortex and bilateral temporal lobes. Thoracic MRI showed mild atrophic changes. Follow‑up medical history showed the first symptom of the his father were similar and progressed rapidly, including spastic paralysis, speech disorders, dementia, and mental and behavioral abnormalities. The duration from onset to death was 7 years, showing a relatively malignant course. Whole exome sequencing (WES) revealed a missense mutation of PSEN1 gene exon 7 c.668A > G (p.Gln223Arg) in the patient. The results of Sanger sequencing showed the mother and sister of the patient did not carry this mutation, and it was speculated the mutation came from the father of the patient. According to the guidelines of the American College of Medical Genetics and Genomics (ACMG), the above mutation was classified as likely pathogenic (PS3 + PM2 + PS4_Moderate). The patient was diagnosed with spastic paraplegia, and the family was diagnosed with EOFAD3. Conclusions A missense mutation of PSEN1 gene exon 7 c.668A > G (p.Gln223Arg) was identified, which was the pathogenic variant of this family, resulting in a rare EOFAD3 with spastic paraplegia as the first symptom, detailed family investigation combined with WES would help improve the efficiency of early diagnosis.

Objective To investigate the protective effect of Platycodin D (PD) on renal ischemia-reperfusion injury in rats. Methods The rats were divided into sham group, model group, low, middle and high-dose groups with 10 animals in each. The rat model of ischemia reperfusion injury was established by clamping the bilateral renal pedicles in model group, low, middle and high-dose group. The rats in sham group underwent the same modeling operation but did not clamp the renal pedicles. Before 5 minutes of modeling, the rats of low, middle and high-dose group were intra-peritoneally injected with 12.5, 25 and 50 mg/kg PD, respectively. After 24 h of modeling, the serum creatinine (Cr) and blood urea nitrogen (BUN) levels, as well as antioxidant markers[superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA)] levels in kidney tissues were measured. HE staining was used to evaluate renal tissue lesions. Immuno-histochemical staining was used to detect the expression of caspase-3 in renal tissue, the apoptosis index of renal tubular epithelial cells was evaluated by the counting of caspase-3 positive cells. RT-qPCR was used to detect the expression of interleukin-1β (IL-1β), IL-6 and IL-10 mRNA in renal tissues. Western blot was used to detect the expression of Toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), p65, p-p65, inhibitor of nuclear factor kappa B (NF-κB) (IκB) and p-IκB. Results Compared with sham group, the kidney lesions, serum Cr and BUN levels, apoptosis index of renal tubular epithelial cells in model group were all increased (P＜0.05). Compared with model group, the kidney lesions, serum Cr and BUN levels, apoptosis index of renal tubular epithelial cells in low, middle and high-dose group were decreased (P＜0.05). Compared with sham group, the level of MDA and mRNA of IL-1β and IL-6, the protein expression of TLR4/MyD88/NF-κB signaling pathway in kidney tissue in model group were all significantly increased while the level of SOD and GSH-Px and mRNA of IL-10 in rat kidney tissue were decreased(P＜0.05). Compared with model group, the level of MDA, mRNA of IL-1β and IL-6, the protein expression of TLR4/MyD88/NF-κB signaling pathway in kidney tissue in low, middle and high-dose group were all decreased, SOD and GSH-Px and IL-10 mRNA in rat kidney tissue were increased (P＜0.05). Conclusions Platycodin D has a protective effect on renal ischemia-reperfusion injury in rats, and the underlying mechanism may be related to the improvement of antioxidant capacity and inhibition of TLR4/MyD88/NF-κB signaling pathway.

Currently，few studies have been conducted on the AC corrosion behavior of pipeline steel and sacrificial anodes in the marine environment.In order to provide a reference for evaluating the AC corrosion risk of submarine pipeline and the consumption performance of sacrificial anodes under AC interference，the AC corrosion simulation test was employed to study the AC corrosion behavior of X65 pipeline steel，aluminum alloy and zinc alloy sacrificial anodes under different AC current densities in simulated seawater environment.Results showed that the potential of X65 pipeline steel，aluminum alloy sacrificial anode and zinc alloy sacrificial anode samples were negatively shifted after AC interference was applied，and the greater the AC current density，the greater the offset.The corrosion rates of three materials increased with the increase of AC current density，but the corrosion rate of aluminum alloy was much higher than that of zinc alloy and X65 pipeline steel.Moreover，X65 pipeline steel exhibited uniform corrosion under 0～30 A/m2 AC interference，and when the AC current density increased to 100 A/m2，pitting pits appeared on the surface.Aluminum alloy exhibited pitting corrosion on the surface under different AC current densities，while zinc alloy was mainly uniform corrosion.In the marine environment，the service performance of zinc alloy was superior to that of aluminum alloy.

Background During the containment of COVID-19, the traditional face-to-face interventions conducted at the rehabilitation center were plagued by many limitations, while internet-based interventions can overcome the limitations of geographic location, working hours and transportation, with less medical costs. Objective To examine the effects of internet-based interventions on knowledge, attitude/belief and practice (KAP) toward rehabilitation exercises, physical activity (PA) level, and exercise compliance inpatients after PCI. Methods The subjects were 76 patients who received their first PCI in Department of Cardiology, Tangshan Gongren Hospital from November 2021 to June 2022. They were randomly and equally divided into two groups to receive either internet-based intervention with routine nursing (experimental group) or routine nursing (control group) . Before and three months after the intervention, the Rehabilitation Exercise Knowledge-Belief-Practice Scale for Patients with Coronary Heart Disease (REKBPCHD) , the International Physical Activity Questionnaire-Short Form (IPAQ-SF) , and Patients' Exercise Log were used to assess the KAP level, PA level, and exercise adherence, respectively. The impact of network intervention on exercise adherence in patients after PCI by univariate Logistic regression analysis. Results After 3 months of intervention, a significant increase was found in the average total score of REKBPCHD, and the average scores of the knowledge dimension, attitude dimension and practice dimension of the scale in the experimental group (P

Hydroxyl-terminated polybutadiene/polyether (HT-PB/PE), serving as binders and fuel for rocket propellants, has been widely studied and applied. To meet the developing demand of industrialization, the modification of HT-PB/PE based on their structural and functional characteristics has become one of the hot topics. In this study, the modified HTPB and the modified HTPE were prepared by modification of end groups and main chains. After the preparation, the characteristic functional groups of the binders were characterized by infrared spectroscopy (FTIR) to determine the effective end-group modification. Nuclear magnetic resonance hydrogen spectroscopy (1H-NMR) was used to characterize the main chain on modified binders through the variation of chemical environment of hydrogen. The analysis of the pyrolysis properties of the modified binders was performed by thermo gravimetric analyzer (TGA). The results effectively reflected the initial and maximum decomposition temperatures, as well as the pyrolysis stage of the above binders. The above characterization results confirmed the effective synthesis of modified binders and their good thermal properties. However, the present reports lacked the studies on the pyrolysis mechanism of these modified binders. To further investigate the effect of end group and main chain modification on the pyrolysis properties of binders, the pyrolysis of modified binders was conducted in a U-shaped fixed-bed reactor, which was connected to photoionization mass spectrometry (SPI-MS). SPI-MS was used to monitor the dynamic evolution of the pyrolysis product as a function of temperature in real-time. The mechanism of the pyrolysis process of the modified binders was studied based on the above tests. The results showed that the end-groups and main-chain modified binders of HTPB exhibited different thermal stabilities. The influence of main chain modification on the pyrolysis behavior was greater than that of end group modification. The pyrolysis mechanism of modified binders followed random bond breaking of C—C and C—O bonds and the increasing varieties of products. The esters and acids were found in the pyrolysis products of the end-group modified binders. The epoxides and alcohols were found in the pyrolysis products of the main-chain modified binder, showing the more pathways during their pyrolysis process.

为有效提高油脂品质，以亚麻籽、油菜籽、花生、芝麻和葵花籽为原料，对其进行焙炒和湿热预处理并压榨制油，研究焙炒和湿热预处理对5种植物油感官品质、理化指标、主体组分、挥发性组分和微量营养组分的影响。结果表明：焙炒和湿热预处理对植物油的感官品质和理化指标均有影响，总体上可提高植物油的感官品质，但会使酸值和过氧化值有所增加；焙炒和湿热预处理对脂肪酸和甘三酯组成无显著影响（p＞0.05）；5种植物油中共检测出了82种挥发性风味成分，焙炒和湿热预处理后，菜籽油中硫苷降解产物明显增加，葵花籽油中杂环类化合物显著增加；焙炒和湿热预处理能有效提高植物油总酚含量，特别是湿热预处理芝麻油，其总酚含量是未处理的1.9倍；焙炒和湿热预处理葵花籽油的VE含量较未处理的分别增加了12.7%和19.2%，但对其他植物油的VE含量影响不显著（p＞0.05）。综上，焙炒和湿热预处理在不影响油脂理化品质的基础上，提高了其营养品质和感官品质，是理想的油料预处理技术。 To effectively improve the quality of oils, flaxseed, rapeseed, peanut, sesame and sunflower seed were used as raw materials, they were pretreated by roasting and wet-heating and pressed to produce oil, and the effects of roasting and wet-heating pretreatment on sensory quality, physicochemical indexes, main components, volatile components and micronutrient components of five vegetable oils were studied. The results showed that roasting and wet-heating pretreatment had effects on the sensory quality and physicochemical indexes of the five vegetable oils. Overall, sensory quality was improved, but the acid value and peroxide value increased by roasting and wet-heating pretreatment.Roasting and wet-heating pretreatment had no significant effects on the composition of fatty acids and triglycerides (p＞0.05). A total of 82 volatile compounds were detected in five vegetable oils. The content of thioside degradation products significantly increased in rapeseed oil, and heterocyclic compounds significantly increased in sunflower seed oil after roasting and wet-heating pretreatment. Roasting and wet-heating pretreatment could effectively increase the total phenol content in vegetable oils, especially wet-heating pretreatment sesame oil, which was 1.9 times of that in untreated oil. The VE content in roasting and wet-heating pretreatment sunflower seed oil increased by 127% and 19.2%, respectively compared with untreated oil, but they had no significant effect on the VE content of other vegetable oils (p＞0.05). In summary, roasting and wet-heating pretreatment is an ideal pretreatment technology for oilseed to improve the nutritional quality and sensory quality of vegetable oil without affecting the physicochemical quality of the oils.

Objective To investigate the features of patients with spinal gout, and to improve diagnostic accuracy among clinicians. Methods Related clinical data were collected from three patients with spinal gout who were admitted to our hospital, and a literature review was performed. Results All three patients had previously been diagnosed with gout and received surgical treatment for the symptoms of cervical or lumbar nerve involvement. Patient 1 had a normal level of serum uric acid (sUA), while patients 2 and 3 had an increase in the level of sUA. For patients 1 and 3, preoperative spinal magnetic resonance showed decreased T2WI signal, and patient 1 had a high possibility of inflammation of the cervical vertebrae C3-7, while patient 3 had circular high-density shadow and clear sclerotic edge in the cervical vertebrae C4-6. Postoperative pathological examination showed gouty granuloma in patients 1 and 2, and patient 3 was found to have chronic inflammation with hyaline change, granulomatous hyperplasia, and multinucleated giant cell reaction in fibrovascular tissue. All three patients achieved varying degrees of relief of nerve compression symptoms after surgery. Conclusion The possibility of spinal gout should be considered if patients with gout have nerve compression symptoms and the features of typical bone damage in gout found by radiological examination, and it is necessary to complete the examination of sUA and urate crystal deposition in time, confirm the diagnosis of spinal gout before surgery, and make adequate preparation before surgery.

为对红仁核桃的精深加工及其保健功能提供参考，以红仁核桃分离蛋白为原料对其进行酶解制备红仁核桃多肽，采用单因素试验和正交试验优化酶解工艺条件，并经超滤分离得到3个组分的红仁核桃多肽，测定其多肽含量、胰脂肪酶抑制率和胆固醇胶束溶解度抑制率。以高血脂SD大鼠为模型，分别以活性最高的红仁核桃多肽的低、中、高剂量（200、400、800 mg/kg）饲喂大鼠28 d，测定大鼠体质量、脏器质量和血清指标，并进行组织切片观察。结果表明：红仁核桃多肽制备的最佳条件为酶解pH 9.0、底物质量分数4.0%、酶加入量（以反应体系总质量计）4.0%、酶解温度55 ℃，在此条件下水解度达到6.96%；分子质量小于3 kDa的组分活性最高；用红仁核桃多肽灌胃SD大鼠后能显著减缓大鼠体质量及肝脏、肾脏和附睾脂肪组织质量的增加（p

Background Early intervention of blood glucose control in patients with new-onset type 2 diabetes mellitus (T2DM) can help delay the progression of diabetes. As a new form of health management, the effect of human-computer interaction intelligent blood glucose monitoring management on the progression of new-onset T2DM patients has not been clarified. Objective To explore the effect of human-computer interaction intelligent management on blood glucose control and self management capability in new-onset T2DM patients, so as to provide the reference for optimizing the control strategy in new-onset T2DM patients. Methods From June 2016 to December 2016, 200 patients with new-onset T2DM admitted to the Tianjin Medical University, Chu Hsien-I Memorial Hospital were selected by convenient sampling and randomly divided into the control group (n=100) and the monitoring group (n=100). The interventions in the monitoring group were the same as those in the control group except for the human-computer interaction intelligent monitoring. Blood glucose indexes〔fasting blood glucose (FBG), 2 h postprandial glucose (2 hPG) and glycated hemoglobin (HbA1c) 〕and self-management capability indexes〔diabetes management self-efficacy scale (DMSES), summary of diabetes self-care activities (SDSCA), diabetes self-care scale (2-DSCS) 〕were recorded at the time of enrollment and after 3 months of follow-up in the two groups. Results After 3 months of follow-up, the monitoring group included 95 cases, the control group included 97 cases. Compared with the pre-intervention period, FBG, 2 hPG and HbA1c levels decreased in both groups after the intervention (P

Objective: This paper discusses the feasibility of using mineral element fingerprinting technology of to identify tobacco producing areas, screens out the effective indicators, and constructs the discrimination model of tobacco producing areas. Methods: The contents of 20 mineral elements in tobacco leaves from 11 producing areas were simultaneously determined by ICP-MS, and the data were analyzed by variance analysis, cluster analysis, principal component analysis and discriminant analysis. Results: The contents of 16 elements were significantly different among producing areas, and principal component analysis resulted in 6 principal components, with the cumulative variance contribution of 89.253%. Using linear discriminant analysis, four elementsmineral, K, Mn, Se and Ba, were screened as the effective indicators to discriminate the geographical origin of tobacco leaves. The established discriminant model could accurately distinguish tobacco leaf samples from different tobacco producing areas. Conclusion: Significant differences were showed in the contents of mineral elements in tobacco leaves from 11 producing areas. Four elements, K, Mn, Se and Ba, are important indicators for distinguishing tobacco producing areas. Mineral element fingerprinting technology can be used for distinguishing tobacco producing areas.

Intrusion detection system(IDS) is a detection system that can issue an alarm when a network attack occurs.Detecting unknown attacks in the network is a challenge that IDS faces.Deep learning technology plays an important role in network traffic anomaly detection,but most of the existing methods have a high false positive rate and most of the models are trained using supervised learning methods.A gated recurrent unit network(GRU)-based semi-supervised network traffic anomaly detection me-thod(SEMI-GRU) is proposed,which combines a multi-layer bidirectional gated recurrent unit neural network(MLB-GRU) and an improved feedforward neural network(FNN).Data oversampling technology and semi-supervised learning training method are used to test the effect of network traffic anomaly detection using binary classification and multi-classification methods,and NSL-KDD,UNSW-NB15 and CIC-Bell-DNS-EXF-2021 datasets are used for verification.Compared with classic machine learning mo-dels and deep learning models such as DNN and ANN,the SEMI-GRU method outperforms the machines lear-ning and deep learning methods listed in this paper in terms of accuracy,precision,recall,false positives,and F1 scores.In the NSL-KDD binary and multi-class tasks,SEMI-GRU outperforms other methods on the F1 score metric,which is 93.08% and 82.15%,respectively.In the UNSW-NB15 binary and multi-class tasks,SEMI-GRU outperforms the other methods on the F1 score,which is 88.13% and 75.24%,respectively.In the CIC-Bell-DNS-EXF-2021 light file attack dataset binary classification task,all test data are classified correctly.

为了指导生产，实现膨化大豆粉生产线在线检测水分、粗蛋白质和粗脂肪含量，在膨化大豆粉生产线安装近红外光谱仪，并将在线检测数据与国标方法（人工取样）检测数据进行了对比。结果表明：在线近红外光谱仪测定膨化大豆粉样品的水分、粗蛋白质、粗脂肪含量结果与国标方法接近，符合国标允许误差要求；配套的全自动镜头吹扫系统可有效去除黏附在采集窗口上的膨化大豆粉，保证了检测结果的准确性。实践证明，将在线近红外光谱仪应用于膨化大豆粉生产上，完全能满足膨化大豆粉加工行业在线实时监控的需求。 In order to guide for production and realize online detection of moisture, crude protein and crude fat contents in puffed soybean powder production line, a near infrared spectrometer was installed in the production line, and the online detection data was compared with that of the national standard method for manual sampling. The results showed that the results of moisture, crude protein and crude fat contents of puffed soybean powder detected by online near infrared spectrometer were close to those by the national standard method, and met the allowance error of the national standard. The fully automatic lens purging system could effectively remove the puffed soybean powder adhering to the collection window to ensure the accuracy of the detection results. Practice has proved that the application of the online near infrared spectrometer in the production of puffed soybean powder can fully meet the needs of online real-time monitoring.

Objective: To understand the difference of cumulative content and species of volatile organic compounds （VOCs） in five different species of Chrysanthemum morifolium Ramat.. Methods: In this study, five different species of Chrysanthemum morifolium Ramat., namely, Jinsihuangju, Huangju, Hangbaiju, Boju, and Gongju. The differences and variations of the fingerprints of volatile organic compounds （VOCs） in different species of Chrysanthemum morifolium Ramat. were studied by headspace-gas chromatography-ion mobility spectroscopy （HS-GC-IMS）, combined with cluster analysis and relationship matrix in the form of data visualization. Results: There were significant differences in VOCs among different varieties of Chrysanthemum morifolium Ramat. （P＜0.05）, and the similarity between them was less than 70%, and all of them had their own unique volatile organic components; the five kinds of Chrysanthemum morifolium Ramat. in the order of high to low VOCs content were: Gonju, Jinshi Huangju, Huangju, Boju, and Hangbaiju. Conclusion: HS-GC-IMS can make up for the shortcomings of conventional VOCs detection, making detection more data basis and support, and providing theoretical basis and data support for the differentiation and identification of different varieties of Chrysanthemum morifolium Ramat..

ObjectiveTo analyze the case, scene and forensic pathological characteristics of sudden unexpected death in epilepsy （SUDEP）, to provide a practical basis for forensic identification.MethodsA total of 9 autopsy cases of SUDEP were collected. The basic information of the cases, the scene characteristics, the forensic pathological changes, the common drugs and antiepileptic drug test results, and pericardial fluid biochemical test results were analyzed.ResultsAll of the 9 cases were male epilepsy patients died during sleep at night, the age of death was （37.1±8.6） years, and the course of epilepsy was （21.3±5.6） years. Six corpses were in prone position and three in left lateral position. The hemorrhage of the sternocleidomastoid muscle, sternal thyroid muscle and sternohyoid muscle were found with 8 cases, 5 cases and 4 cases, respectively, all of them were unilateral. Six cases had bilateral hemorrhage of pectoralis minor muscle. Brain edema, phagocytosis of frontotemporal neurons and gliosis, cardiac fibers bend in wavy patterns and eosinophilic staining enhancement, pulmonary edema, pulmonary congestion, alveolar hemorrhage, pulmonary small bronchiole wall shrinking, tubular proteinuria and pancreatic parenchymal hemorrhage were the common histopathological changes. The biochemical test results of pericardial fluid indicated that there were myocardial ischemic damage.ConclusionYoung male, early onset, long course of disease, sleep in the prone position, poor drug compliance or combination, epileptic seizure may be the risk factors of SUDEP. Cardiac dysfunction and respiratory depression might be the main death mechanism of SUDEP.

In order to meet the needs of rapid quantitative detection of fumonisin B1 (FB1) in grains, this paper takes fumonisin B1 as the research object, and creates a rapid quantitative detection card of FB1 on the basis of time-resolved fluorescent nanospheres, with no need to adjust the PH of samples before detection. The detection performance of the detection card in grains (rice, corn, wheat) was analyzed and compared with enzyme-linked immunosorbent assay kit and high performance liquid chromatography. The LOD for different samples was in the range of 35.37~37.17 μg/kg, and the LOQ was 117.9~123.9 μg/kg, which meant good sensitivity; the linear range was 250~6 000 μg/kg, while the correlation coefficient R2 was in the range of 0.997 2~0.999 5; the spiking recoveries at 6 spiked levels in different samples were in the range of 83.38%~114.66%, with the coefficient of variation (CV) less than 15%, which meant good accuracy and repeatability. When the national standard liquid chromatography and FB1 fluorescence quantitative rapid detection card simultaneously detects different samples contaminated by FB1, the coincidence of the detection results was in the ranger of 92.53%~106.26%, with the CV less than 10.37%. The cross-reaction rate of other five common mycotoxins was less than 5%. Meanwhile, the difference between the spiked concentration and their average detected concentration was extremely significant, indicating good specificity. Hence, the FB1 fluorescence quantitative detection card prepared in this study could meet the needs of on-site rapid quantitative detection of fumonisin B1 in grains.

Crush syndrome (CS) often occurs in victims of natural disasters, trauma and traffic accidents, which mainly manifests as hypovolemic shock, acute kidney injury (AKI) , hyperkalemia, and acidosis, among which AKI is a major cause of the continuing high mortality of CS. Current treatments for AKI induced by CS include early rehydration, symptomatic treatment and renal replacement therapy, but the effects are not satisfactory. There are no standard treatment options for CS-related AKI, so identifying the pathogenesis of this disease and formulating an effective treatment regimen may be problems need to be solved urgently. This article reviews the latest advances in pathogenesis and treatment strategies of CS-related AKI.

Objective To investigate the baseline and effect of obesity and obesity trajectories on cardiovascular diseases(CVDs) in adult male with incident non-alcoholic fatty liver disease(NAFLD). Methods Adult men with newly diagnosed NAFLD and without CVDs in the Kailuan cohort study from 2006—2013 were enrolled. The subjects were divided into the nonobese group and obese group according to the definition of body mass index(BMI) or waist circumference (WC), then further divided by the obesity trajectories at the first follow-up (1-4 years). Kaplan-Meier method was used to estimate the incidence rate of CVDs for each subgroup. In addition, the Fine and Gray competing risk Cox regression model was used to compare CVDs risk in NAFLD with different baseline or trajectories in obesity measures after 1-4 years of NAFLD diagnosis. Results A total of 8 591 incident NAFLD patients were included. During a median follow-up of 9.41 years, 349 cases were found with CVDs. The 10-year cumulative incidence rates of CVDs were 3.3% and 4.3% in the nonobese and obese groups according to the definition of waist circumference, respectively (log-rank test, P＜0.05). However, the significance disappeared after adjusting the competing risk of death and other covariates. Similar results were observed based on the definition of BMI. Also, further analysis was conducted for the association trajectories in obesity measures and CVDs. The 8-year cumulative incidence rates of CVDs were 2.8%, 3.6%, 4.2%, and 3.3% in the constantly nonobese group, nonobese-obese, obese-nonobese, and constantly obese group, respectively (log-rank test, P＞0.05). Compared to the subjects with constantly nonobese defined by BMI, those who transition from nonobese to obese increased the CVDs risk by 57% (hazard ratio [HR]:1.57; 95% CI:1.03~2.38; P＜0.05). The conclusion remained even after adjusting baseline BMI (HR:1.56; 95% CI:1.02~2.37; P＜0.05). Conclusions Short-term weight gain in men with incident NAFLD led a higher CVDs risk, suggesting the importance of weight control in preventing CVDs once NAFLD occurrence.

Due to the absorption and scattering effects under water,underwater image often suffers from blurring,low contrast,color casting and so on.The degraded images will decline the accuracy and effectiveness in underwater archaeology,marine ecological research,underwater target detection and tracking.On the other hand,underwater image quality assessment plays a key goal in the development and exploration of the ocean.An effective underwater image quality evaluation system can provide a gui-dance for optimizing underwater enhancement and restoration algorithms and promote the progress of underwater vision.Therefore,it is desire to design an effective and robust algorithm for underwater image quality evaluation.Since the atmospheric image quality evaluation methods don’t consider the characteristics of the water absorption of light,they aren’t suitable for evaluating underwater image quality.Additionally,there are few effective metrics for underwater images quality evaluation up to now.To address this problem,we propose a new no-reference underwater image quality measure containing color index,contrast,and sharpness indexes,dubbed CCS,which has stronger correlation with human subjective perception.These attributes not only are sensitive to the physical characteristics of the water,but also the human visual system (HVS) is sensitive to the changes of the visual properties such as color,contrast,and edge structures.To verify the performance of the proposed CCS,we conduct considerable experiments on a small underwater image dataset comparing with the other four non-reference metrics including CPBD,BRISQUE,UIQM and UCIQE.It can be seen that our CCS metric is higher about 13% than UIQM in terms of RMSE,moreover,is higher above 10% than UIQM and UCIQE in terms of PLCC,SROCC,and KROCC.Experimental results demonstrate that the proposed CCS metric has a higher correlation with subjective evaluations,which can effectively and accurately evaluate the underwater image quality.

BackgroundThe prevalence of depressive disorder in adolescents is increasing. Adolescents with depressive disorder in remote counties and their families have a low awareness of the disease, and often are difficult to complete the whole treatment.ObjectiveTo explore the application effect of knowledge-to-action (KTA) framework-based health management in adolescents with depressive disorder in remote counties.MethodsNinety-four adolescents with depressive disorder coming from remote countries were recruited from the Second Affiliated Hospital of Nanchang University from June to December 2020. They were randomly divided into a routine group (receiving a 12-week routine health management) and a KTA group (receiving a 12-week KTA framework-based health management) . At the time of enrollment and 12 weeks after intervention, the status of non-suicidal self-injury was assessed by the Adolescent Non-suicidal Self-injury Assessment Questionnaire (ANSAQ) , mobile phone use was evaluated by the Self-rating Questionnaire for Adolescent Problematic Mobile Phone Use (SQAPMPU) , the anxiety was evaluated with the score of the Screen for Child Anxiety Related Emotional Disorders (SCARED) , and the depression was assessed by the Depression Self-Rating Scale for Childhood (DSRS) .ResultsTwo groups had no significant differences in mean total scores of ANSAQ, SQAPMPU, SCARED, and DSRS before receiving intervention (P>0.05) .Two groups had no significant differences in each dimension score of SQAPMPU before receiving intervention (P>0.05) .After the 12-week intervention, the mean total scores of ANSAQ, SQAPMPU, SCARED, and DSRS decreased significantly in both groups (P

BackgroundKidney is a major extramedullary organ involved in leukemia, but clinicians have insufficient understanding of it due to rare case reports.ObjectiveTo analyze the clinicopathological manifestations of kidney injury in leukemia.MethodsFive patients with kidney injury in leukemia were recruited from Peking University People's Hospital from June 2010 to June 2020. Their demographics, clinical manifestations, ultrasonic and laboratory examination results, pathological examination results of renal biopsy species, therapeutic regimen and follow-up were retrospectively analyzed.ResultsAll these patients were male, with an onset age ranging from 19 to 73 years old. Two of them had B-cell acute lymphoblastic leukemia after allogeneic stem cell transplantation, the remaining three had B-cell chronic lymphocytic leukemia. All of them had acute kidney injury with proteinuria, and pathologically manifestation of acute interstitial nephritis. In addition, two of them also had leukemia-related glomerular disease. Renal pathology indicated extramedullary recurrence in the two cases of B-cell acute lymphoblastic leukemia, and progression in the other three cases of B-cell chronic lymphoblastic leukemia. Four patients received regular chemotherapy, and two of them obtained a reduction in serum creatinine levels, but the other two showed no improvement in renal function.ConclusionKidney injury in leukemia commonly manifests as acute kidney injury clinically, acute interstitial nephritis pathologically, and may be complicated by secondary glomerulopathy. Prompt renal biopsy, especially immunohistochemical staining for renal interstitial infiltrating cells, may be helpful for accurate diagnosis and appropriate treatment guidance.

Objective: To investigate the gut microbiota distribution and antibiotic resistant genes (ARGs) carrying- status in the girls with precocious puberty (PP). Methods: A total of 29 girls were enrolled in the study, including 21 girls with precocious puberty (PP) [11 girls with central precocious puberty (CPP group), 10 girls with premature thelarche (PT group)], and 8 age-matched healthy girls (NC group). The fecal samples were analyzed to explore difference in composition of gut microbiota and ARGs numbers between the PP (CPP+PT) and NC groups using shotgun metagenomic sequencing. Results: The composition and abundance of gut microbiota in the PP girls were different from the NC girls. The relative abundances of top three gut microbiota in CPP, PT and NC girls were 50.03%, 37.73% and 67.61% for Firmicutes, 33.00%, 43.26% and 10.32% for Bacteroidetes, and 4.26%, 4.22% and 11.16% for Actinobacteria. Compared with the NC girls, the PP girls had a significantly higher abundance of Bacteroidetes (P=0.034) and much lower abundance of Firmicutes (P=0.006) and Actinobacteria (P

Background and purpose: Deep inferior epigastric perforator (DIEP) is attracting increasing attention in breast reconstruction surgery. How to safely and effectively locate, choose and anatomize perforating vessels is a huge challenge for the preparation of DIEP flaps. This study aimed to explore the value of computed tomographic angiography (CTA) in delayed DIEP reconstruction after breast cancer surgery. Methods: From January 2016 to January 2021, 298 patients underwent delayed DIEP flap breast reconstruction surgery in The Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. Among them, 92 cases were set as the control group (US group), and the perforation of the flap was evaluated by ultrasound doppler before surgery. A total of 206 cases were selected as the observation group (CTA group). Preoperative perforation of the flap was evaluated by CTA, and the CTA data were imported into HOROS software for processing and analysis, so as to select the preoperatively dominant perforation of the flap and identify the anatomical information such as the diameter of perforation vessel, the way of intramural movement and the position of perforation point, for directing operation. The number of preoperative location perforations, number of intraoperative choice perforations, perforation choice time, perforation anatomy time, donor site flap acquisition time, flap weight, total operation time and incidence of postoperative complications (abdominal incision infection rate, fat necrosis rate, secondary surgical exploration rate and complete flap necrosis rate) were compared and analyzed between the two groups. And the consistency rate of imaging surgery was compared between the two groups. Results: All the 298 patients underwent delayed DIEP flap breast reconstruction, and the flap survival rate was 99.3% (296/298). The number of preoperative located perforations in the two groups was: CTA group (2.90±1.13) vs US group (3.21±1.46) (P0.05). In the comparison of the second surgical exploration rate, the CTA group was lower than the US group (P

BACKGROUND Multi-target geochemical mapping is one of the most important basic regional tasks in multi-target regional geochemical surveys. In order to better reflect changes in the geochemical background, analytical methods are required to have higher accuracy and precision, and lower detection limits. Elements B, Ge, Br, Mo, Sn, I, and W in geochemical survey samples are mainly prepared and determined by smelting ore individually or in groups. The analysis procedure is long and involves 6 methods. OBJECTIVES In order to integrate 6 supporting analysis methods, optimize analysis conditions, and improve the accuracy and precision of the method. METHODS The mixed reagent of sodium peroxide and sodium hydroxide was used for alkali fusion. Citric acid was added to the solution. Cation exchange resin was used for static exchange for 2-3 hours to remove a large amount of cations in the solution and reduce matrix interference. B, Ge, Br, Mo, Sn, I, and W were determined using inductively coupled plasma mass spectrometry. RESULTS The detection limits of B, Ge, Br, Mo, Sn, I, and W were 0.66, 0.096, 0.78, 0.11, 0.15, 0.29, and 0.27μg/g, respectively. Relative standard deviation (RSD, n=12) was between 2.1% and 7.5%, which were all less than 10%. CONCLUSIONS The method is simple, rapid and low-cost, and its precision and accuracy meet the requirements of 《Specification of multi-purpose regional geochemical survey (1:250000)》 (DZ/T 0258-2014). It can quickly and accurately determine B, Ge, Br, Mo, Sn, I, W in geochemical survey samples in a thick coverage area.

According to its actual structure, the steam generator is divided into the hot leg, the cold leg, the steam-water separator, and the steam chamber, where the hot leg and the cold leg are further divided into a descending channel and an ascending channel. Based on the mass, energy, and momentum conservation laws, the distribution parameter models for the hot leg, the cold leg, the steam-water separator, and the steam chamber are established. Combining the physical parameter database of the working medium and the data collection system (DCS) real-time measurement data, the model is solved in real time and the estimated mass flow rate of recirculation water is obtained. The verification results using the operating data of a CPR1000 nuclear power unit show that the calculated temperature, the pressure, and the mass flow rate of the outlet saturated steam of the steam generator agree well with the measured values, which indirectly verifies the correctness of the estimation approach of recirculation water proposed in this paper.

Objective To divide the patients with venous malformation (VM) into three groups based on tissue structure and histopathological characteristics, and analyze results from different treatment scheme in three groups for direction of treatment option according to tissue structure. Methods A retrospective analysis was performed on 170 cases with VM including 73 male and 97 female with mean age of (23.4±9.9) years in Department of Hemangioma this hospital from January 2015 to December 2019. There were 141 cases in enveloped group, 22 cases in non-enveloped group and 7 cases in ossification group with different type of tissue structure of specimens in each group. Patients were examined with image using ultrasonography, magnetic resonance imaging, X-rays and CT angiography. Patients were treated for VM with surgery or minimal invasive techniques. Intraoperative observation and postoperative pathological examination were performed on VM tissue. Visual analogue scale (VAS) and Oswestry disability index (ODI) were detected preoperatively and after discharge. Follow-up was done 163 cases after 1 year discharge and 7 cases lost. Results The data of image, tissue structure, histopathological features, treatment scheme and efficacy evaluation were gotten in three groups. There were 101 cases in enveloped group treated by surgery with 78 (77.2%) cases cured and 2 (2.0%) cases recurred. Remaining 40 cases were treated by minimal invasive operation including sclerotherapy intervention and radiofrequency ablation, in which 23 (57.5%) cases were cured and 2 (5.0%) cases were recurred. The patients in enveloped group had best pattern of tissue structure with best prognosis. Fifteen cases in non-enveloped group were operated with 3 (20.0%) cases cured and 4 (26.7%) cases recurred. Remaining 7 cases were treated by minimal invasive operation with 1 cured case and 3 (42.9%) recurred cases. The recurrence rate was high in non-enveloped group. In ossified group, 7 cases were all treated by surgery and cured without any recurrence. VAS of patients in both enveloped group and non-enveloped group were significantly lower than those before treatment. All patients had lower ODI at discharge than before treatment. There were 6 cases with complication such as delayed incision healing. Conclusions Tissue structure could be an effective index for treatment option and prognosis judgment for VM. The patients in enveloped group would have best results of treatment, while treatment results of patients in non-enveloped group are poor. Ossification of tissue structure is suitable only using surgical treatment.

As a two-dimensional(2D) building block of new materials, graphene has received widespread attention due to its exceptional thermal properties. The thermal properties and recent advances on graphene-based material were reviewed. The intrinsic thermal conductivity of graphene and the effect of layers, defects and edge were briefly introduced. The resent research progress in graphene fiber as thermal conductivity material was analyzed and discussed. A variety of graphene films (graphene film, graphene hybrid film, graphene/polymer composite film) were grouped by category and the influencing factors of the thermal conductivity were reviewed. The structure, thermal conductivity property and current researches of 3D graphene (graphene with random orientation in the polymer matrix, graphene with specific orientation in the polymer matrix) were summarized. Finally, the challenges and prospects of graphene-based materials were also pointed out, especially inhigh power, highly integrated systems such as LED lighting and smart phones, graphene based thermal conductivity materials have a good development prospect.

Due to the existence of a large number of sample data which obey the Gaussian distribution,GMM (Gaussian mixture models) is used to cluster these sample data and get more accurate clustering results.In general,EM algorithm(expectation maxi-mization algorithm) is used to estimate the parameters of GMM iteratively.However,the traditional EM algorithm has two shortcomings:it is sensitive to the initial clustering center;the itera-tive termination condition of iterative parameter estimation is to judge that the distance between two adjacent estimated parameters is less than a given threshold,which can't guarantee that the algorithm converges to the optimal value of the parameters.In order to overcome the above shortcomings,density peaks clustering (DPC) is proposed to initialize EM algorithm to improve the robustness of the algorithm.The relative entropy is used as the ite-ration termination condition of the EM algorithm to optimize the parameters of GMM algorithm.The comparative experiments on artificial datasets and UCI datasets show that the new algorithm not only improves the robustness of EM algorithm,but also outperforms the traditional clustering algorithm.On the datasets which obey Gaussian distribution,the new algorithm greatly improves the clustering accuracy.

Taking the preparation of electrode materials of supercapacitors, the study of properties and the performance of assembled asymmetric supercapacitors as the core contents, and improving the electrochemical performance of supercapacitors as the main purpose, the in-situ polymerization method was used to prepare carboxylated multi-walled carbon nanotubes (PI-MWCNTs) grafted polyimide solution, which is used as the precursor of nitrogen-doped carbon to realize the growth of composites on the surface of carbon cloth and as electrode material.Manganese dioxide-carbon cloth (MnO2-CC) as the positive electrode, Polyimide-carbon cloth grafted with multi-walled carbon nanotubes as negative electrode (PI-MWCNTs-CC), build asymmetric supercapacitors. The structure and electrochemical properties of the electrode materials were characterized by scanning electron microscopy, raman spectroscopy, surface area and pore size testing, X line photoelectron spectroscopy, cyclic voltammetry, galvanostatic charge/discharge and electrochemical impedance spectroscopy. According to the study, when the scan rate is 20 mV/s, asymmetric capacitor potential window can be increased to 1.3 V and its volume specific capacity is 1.80 F/cm3.When the power density is 14.08 mW/cm3, the energy density can reach up to 0.423 mWh/cm3.

Reasonable use of waste rubber and plastic can avoid environmental pollution and improve composite materials performance. Recycled high density polyethylene (PE-HD), salix wood powder and waste tire powder were used as raw materials to prepare wood rubber plastic ternary composite materials (WRPC) by compression molding. The change rules of mechanical properties and heat resistance of WRPC were investigated under different heat oxygen aging time, and aging mechanism and surface topography were analyzed by FTIR and SEM. The study results indicate that heat oxygen aging reduces the mechanical properties of WRPC. After aging for 100 h, the retention rates of static flexural strength, elastic modulus, tensile strength and impact strength are 93.40%, 84.74%, 79.75% and 82.63%. The retention rates of storage modulus and loss modulus are 84.34% and 89.18%. Material rigidity and damping performance are all decreased. The vicat softening temperature and heat distortion temperature show an upward trend and then a downward trend. The ability of materials to resist external deformation is reduced. According to FTIR and SEM analysis, the oxidation reaction occurs on the surface of WRPC during aging. The carbonyl index shows an upward trend and then a downward trend. Cracks and holes appear on the surface of WRPC.

Objective: To investigate structural characteristics of gut microbiome in idiopathic short stature (ISS) children and difference in gut microbiome between ISS and healthy children(HC) children, so as to explore the possible mechanism of action of gut microbiome on ISS. Methods: A total of 16 children aging from 4 to 8, including 16 ISS children (ISS group)and 16 HC (control group) were enrolled in the study. Flora of the collected feces were collected, and V3-V4 of bacterial 16S rRNA was sequenced with high-throughput sequencing. Diversity and abundance of gut microbiome between HC and ISS group were compared. Results: The structure of gut microbiome in ISS children were significantly different from HC children. The Chao1 (diversity index) of ISS group were lower than that of HC group (1109.85±435.23 vs. 1485.68±334.51) (P=0.018) as well as Observed_species index(946.98±374.93 vs. 1 217.69±289.66)(P=0.038), indicating decreased relative abundance of gut microbiome in ISS group. It’s also showed that the relative abundances of Faecalibacterium and Eubacterium were significantly lower in ISS group than HC group (P0.6, P

The experiment aimed to select a forage maize variety with strong adaptability for the dry terraced fields in central Gansu Province. In 2022, 10 forage maize varieties were introduced for screening trials in Yuzhong County, which was representative of the dry terraced fields in central Gansu Province. The main variety Longdan No.4 was used as the control (CK), and a comparative experiment was conducted on the nine introduced forage maize varieties. The experiment determined and analyzed the agronomic traits, grass yield, and nutritional components of the forage maize. The results showed that all 10 forage maize varieties could be harvested on time after spring sowing in the dry terraced fields of central Gansu Province. In 2022, the annual equivalent fresh grass yield of Haoyu No. 2 and Longdan No. 4 (CK) was relatively high, at 40 305.36 kg/hm² and 36 638.33 kg/hm², respectively, with the equivalent dry grass yield being 13 432.48 kg/hm² and 11 652.11 kg/hm², respectively. Among the ten tested forage maize varieties, Xianyu 1483 had the lowest acid detergent fiber content, meeting the national first-class silage corn standard, but its yield was too low. The study indicates that Haoyu No. 2 has the strongest adaptability in the dry terraced fields of central Gansu Province, with the highest yield and better nutritional quality, meeting the national second-class silage corn standard. It is a forage maize variety with potential for promotion. [ABSTRACT FROM AUTHOR]

Objective To investigate the potential factors influencing myocardial fibrosis (MF) in non-ischemic heart failure(HF) patients with an emphasis on the role of right heart catheter (RHC) parameters. Methods This retrospective research collected clinical data from 33 non-ischemic heart failure patients admitted to China-Japan Friendship Hospital who received endomyocardial biopsy (EMB) and right heart catheter (RHC) examination. All the patients were divided into two groups: mild MF (n=17) and severe MF (n=16), by means of K-means cluster analysis. MF was quantitatively evaluated by Masson staining. Potential factors influencing MF were analyzed. Results Compared with that in mild MF group, patients in severe MF group had aggravated cardiac function (cardiac index, 2.15±0.76 vs. 2.94±1.10,P＜0.05), accompanied by higher systolic right ventricle pressure (RVP), systolic pulmonary arterial pressure (PAP), pulmonary arterial wedge pressure (PAWP) and total pulmonary resistance (TPR) (P＜0.05). Hypertension and TPR were independently correlated with the degree of MF in multiple linear regression analysis (Adjusted R2=0.454, P＜0.001). Conclusions Hypertension and TPR, reflecting afterload of left and right ventricle, are found to be independently correlated with degree of MF in non-isch- emic heart failure patients. Cardiologists should pay more attention to high-risk patients in order to retard MF progression through timely intervention.

Aiming at the problem that the excessive friction between the balance tail rope and the branch rope beam of the vertical shaft friction hoist causes serious tail rope wear and affects the safe operation of the main hoist, a friction monitoring system between the balance tail rope and the branch rope beam of the main hoist is designed. The friction monitoring system mainly consists of a host computer, an inductive proximity switch, an active infrared radiation sensor and other equipment. The recognition reliability of the friction monitoring system is improved by adopting the concept of double-layer monitoring. The host computer performs audible and visual alarms and controls the operation of the lifting electric control system by monitoring the change of the signal. The results of field tests show that this system improves the reliability of the safe operation of the hoist and meets the actual requirements.