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Objective: To explore the normal values of vestibular autorotation test (VAT) in young people., Methods: VAT was performed in 31 young people aged 20-30 years. The measured value were analyzed and compared with the reference normal value., Results: The measured values of VAT in healthy young people are almost within the normal range of the general population. Compared with the reference normal values, the horizontal gains at 2.0, 2.3, 2.7, 5.5, and 5.9 Hz, the vertical gains at 2.0 and 5.9 Hz, and the vertical phases at 2.0, 2.3, 2.7, 3.1, 3.5, and 3.9 Hz were significantly different (P < 0. 05). No significant difference was shown in the horizontal phases and asymmetry., Conclusions: The normal values of VAT in young people is within the reference normal range of the general population. The vestibular function of young people may be more sensitive in lower frequency range (2-3Hz).

Objective: To investigate the effect of the gamma-aminobutyric acid (GABA) on rat vestibular end organ., Methods: In the rat inner ear paraffin slides, GABAA receptor alpha 2 subunit mRNA in vestibular end organ has been detected with in-situ hybridization. Digoxigenin-GABAA alpha 2 cDNA prob (549 base pair), Anti-Digoxigenin-AP (Fab fragments) and BM Purple AP Substrate (precipitating) have been used., Results: GABAA receptor alpha 2 subunit mRNA has been found in all vestibular ganglion cells and nerve ending surrounding type I hair cells in rat's cristae ampullaris. GABAA alpha 2 has not been found in hair cells and supporting cells. As a positive control, GABAA alpha 2 mRNA has been found in Purkinje cells and granule cells in rat's cerebellum. GABAA alpha 2 has not been found in OMP negative control, non-prob negative control and non-anti-digoxingenin control in inner ear and cerebellum slides., Conclusions: GABAA alpha 2 receptor has been found in vestibular afferent nerve endings and vestibular ganglion cells. It strongly indicates that GABA is an afferent nerve transmitter in the vestibular end organ and plays an important role in the vestibular afferent nerve transmission.