Search

Objective: To investigate the association between serum vascular endothelial growth factor (VEGF)-B and insulin resistance in pre-diabetes and newly diagnosed type 2 diabetes mellitus (T2DM) patients. Methods: Fasting serum VEGF-B levels were measured using ELISA in 160 normal glucose tolerance (NGT), 142 pre-diabetes, and 117 newly diagnosed T2DM subjects, and their association with insulin secretion, insulin sensitivity, parameters of adiposity, glucose and lipid metabolism was studied. Results:Fasting serum VEGF-B levels did not differ among NGT (130.8 pg/mL [IQR 61.3-227.5]), pre-diabetes (146.7 pg/mL [84.1-214.9]), and T2DM patients (135.3 pg/mL [58.3-214.8]) (all P>0.05). Correlated analysis showed that no significant association was found with body mass index (BMI), waist-to-hip ratio (WHR), lipid profiles, insulin secretion and sensitivity, as measured by a 75-g oral glucose tolerance test. Conclusions: Fasting serum VEGF-B levels are not related to adiposity, lipid profiles, insulin secretion and sensitivity in humans. These findings demonstrated that VEGF-B may be dispensable for insulin resistance and type 2 diabetes in humans. [ABSTRACT FROM AUTHOR]

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The objective of this study is to investigate the methylation status of vascular endothelial cell growth factor B (VEGF-B) gene and to indentify the roles in pathogenesis,development and classification of nasal polyps. Method: The methylation status of VEGF-B gene of 28 nasal polyp tissues and 12 samples of inferior turbinate tissues were detected by methylationspecific-polymerase chain reaction (MS-PCR) and gene sequencing. Result: There was significant statistic diference between nasal polyp tissue group and control group (χ ²=4.096, P <0.05). The results of gene sequencing suggest that the VEGF-B gene promoter were hypomethylation status in the nasal polyps. Conclusion: Methylation status of VEGF-B promoter may play an important role in the pathogenetic mechanism of nasal polyps., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)