1. 白内障超声乳化联合人工晶状体植入术后感染性眼内炎的影响因素及其预测模型构建.
- Author
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边俊杰, 蒋慧中, 张 健, 戴惟葭, and 刘大川
- Abstract
Objective: To investigate the influencing factors of infective endophthalmitis after cataract phacoemulsification combined with intraocular lens implantation and establish a predictive model. Methods: A retrospective analysis was performed on the clinical data of 12,308 cataract patients admitted to our hospital from February 2015 to February 2023, and all patients underwent phacoemulsification of cataract combined with intraocular lens implantation surgery, and the occurrence of postoperative infectious endophthalmitis was statistically counted. Multivariate Logistic regression analysis was conducted to analyze the influencing factors of infective endophthalmitis after cataract phacoemulsification combined with intraocular lens implantation. The predictive model was constructed according to the regression model, and the predictive efficiency of the predictive model was verified by receiver operating characteristic (ROC) curve. Results: Infectious endophthalmitis occurred in 32 of 12 308 patients (0.26%). The results of univariate analysis showed that the infection group was older than the control group (P<0.05), the proportion of diabetes mellitus, operation time≥30 min, incision≥3.2 mm, PMMA implantation, posterior capsule rupture was higher than the control group (P<0.05), and the proportion of preventive antibiotic use and post-lens irrigation was lower than the control group (P<0.05). Multivariate Logistic regression analysis showed that age≥70 years old, combined diabetes mellitus, posterior capsule rupture and PMMA intraocular lens implantation were risk factors for infective endophthalmitis after cataract phacoemulsification combined with intraocular lens implantation(P<0.05), and intraoperative antibiotic use and post-lens irrigation were protective factors (P<0.05). The prediction model was constructed with the retained variables of Logistic regression, and the Hosmer-Lemeshow goodness of fit test was P>0.05. ROC analysis predicted the area under the curve of infective endophthalmitis after phacoemulsification combined with intraocular lens implantation was 0.832, and the sensitivity and specificity were 81.25% and 85.12%, respectively. Conclusion: Age≥70 years old,combined diabetes mellitus, posterior capsule rupture and implantation of PMMA intraocular lens are risk factors for postoperative infectious endophthalmitis. Intraoperative antibiotic use and post-lens irrigation can reduce the risk of infectious endophthalmitis. The prediction model based on multivariate Logistic regression analysis has better energy efficiency in predicting infectious endophthalmitis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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