1. [Methylenetetrahydrofolate reductase [correction of reducatase] polymorphism and asthma].
- Author
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Zou CC, Tang LF, Jiang MZ, Zhao ZY, Hirokazu T, and Mitsufumi M
- Subjects
- Adult, Asthma enzymology, Case-Control Studies, Female, Gene Frequency, Genotype, Humans, Male, Point Mutation, Polymerase Chain Reaction, Asthma genetics, Methylenetetrahydrofolate Reductase (NADPH2) genetics, Polymorphism, Restriction Fragment Length
- Abstract
Objective: To evaluate the association between the methylenetetrahydrofolate reductase C/T polymorphism and the prevalence and course of asthma., Method: Genotypes were determined in 433 asthmatic patients and 1 249 healthy subjects by the polymerase chain reaction and restriction fragment length polymorphism method., Results: The frequencies of the three genotypes were 40.27% for CC, 48.44% for CT, 11.29% for TT and the frequency of allelic T was 35.51% in controls. The frequency of TT genotype in atopic asthmatic patients was significantly higher than that in controls (P = 0.026). The OR for the TT genotype compared with all CC and CT genotypes was 1.61 (95% CI 1.06 approximately 2.47)., Conclusion: These results imply that homozygosity for this common mutation significantly increases the risk of atopic asthma.
- Published
- 2003