1. [An epidemiological survey of the prevalence of thyroid diseases in mild iodine deficiency city after salt iodization].
- Author
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Peng NC, Shi LX, Zhang Q, Xu SJ, Li H, Zhang M, Zhang S, Zhuang HJ, Gong MX, Wang R, Wu DR, Hu Y, and Liu L
- Subjects
- Adult, Aged, Child, China epidemiology, Female, Humans, Iodine administration & dosage, Male, Middle Aged, Thyroid Diseases prevention & control, Young Adult, Iodine deficiency, Sodium Chloride, Dietary administration & dosage, Thyroid Diseases epidemiology
- Abstract
Objective: To investigate the current status of iodine nutrition and the prevalence of thyroid diseases in Guiyang, a mild iodine deficiency city practiced salt iodization for 25 years., Methods: A representative sample of 1509 adults aged 20 years old or above in Guiyang, selected by a multistage stratified sampling method, participated in the study. After an overnight fasting, serum thyroid hormones, serum thyroid autoantibodies, and urine iodine were measured. B-mode ultrasonography of the thyroid was performed in the population. Meanwhile, urine iodine of 80 children aged 8 - 10 years old in the same community were measured after an overnight fasting., Results: The median of 8-10 years old children's urinary iodine was 228.7 µg/L. The prevalence of overt hypothyroidism, subclinical hypothyroidism, overt hyperthyroidism and subclinical hyperthyroidism was 1.79%, 14.12%, 1.52% and 1.06% respectively. The prevalence of subclinical hypothyroidism was significantly higher than overt hypothyroidism (P < 0.05) and was significantly higher in female than that in male (P < 0.05). The prevalence of positive thyroid peroxidase antibody, positive thyroglobulin antibody and autoimmune thyroiditis was 14.38%, 13.59% and 4.44% respectively, which were significantly higher in female than that in male (all P values < 0.05). The prevalence of diffuse goiter and nodular goiter was 0.86% and 0.20% respectively, with a significant difference (P < 0.05)., Conclusion: After 25 years of salt iodization, the iodine nutrition in Guiyang is more than adequate with high prevalence of overt hypothyroidism, subclinical hypothyroidism and autoimmune thyroiditis.
- Published
- 2013