Search

Mucinous epithelial ovarian cancer (mEOC),as a special subtype of epithelial ovarian cancers, has its own unique characteristics, including low incidence of primary mEOC, unilaterality, large size, low rate of lymphatic metastases, platinum resistance, worse prognosis in advanced stage, and distinct mutational profiles, as KRAS mutations are common,butp53 and BRCA mutations are infrequent. These characteristics lead to specific guide in clinical management. In apparent early stage disease, fertility preservation is allowed by the conservation of the normal appearing uterus and contralateral ovary. Appendectomy is not essential as long as the appendix appears normal and there is no evidence of pseudomyxoma peritonei. New directions include the combination use of Oxaliplatin and 5-FU in chemotherapy. [ABSTRACT FROM AUTHOR]