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BACKGROUND: Osteoporosis is often accompanied by sarcopenia and an increased risk of fractures from falls. Recent studies have indicated a close relationship between lipid metabolism and sarcopenia. Abnormal lipid metabolism may directly impact muscle physiological function and metabolism. OBJECTIVE: To investigate the relationship between lipid metabolism and sarcopenia and evaluate their causal relationship using Mendelian randomization. METHODS: Mendelian randomization was used to explore the causal relationship between low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and muscle mass. Research data from genome-wide association studies were used and a sensitivity analysis was conducted to verify the reliability of the results. Approximate indicators of muscle mass, including trunk lean mass and appendicular lean mass, were used as outcome measures. RESULTS AND CONCLUSION: The study found a negative correlation of low-density lipoprotein cholesterol and triglycerides with muscle mass, while no correlation was observed between high-density lipoprotein cholesterol and muscle mass. The results of the sensitivity analysis indicated a robust causal relationship. Using Mendelian randomization, this study provides evidence of a causal relationship between low-density lipoprotein cholesterol and triglycerides and muscle mass. This finding deepens our understanding of the effects of lipids on sarcopenia and has important clinical implications for the prevention and treatment of sarcopenia and osteoporosis. [ABSTRACT FROM AUTHOR]

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Background and objective A reasonable and standardized dietary plan and procedure can help patients recovering quickly from lung cancer surgery. The aim of this study is to optimize the diet plan and procedure mainly based on medium chain triglyceride (MCT) diet and explore its clinical advantages for postoperative lung cancer patients. Methods From October 2023 to December 2023, a total of 156 patients were collected, who underwent lung cancer surgery in Lung Cancer Center, West China Hospital of Sichuan University. The patients were randomized into MCT group (76 cases) and routine diet (RD) group (80 cases). Clinical symptoms, biochemical index, postoperative hospitalization time and cost, dietary satisfaction and hospitalization comfort between the two groups were analyzed. Results The mean anus exhausting time in MCT group [24.00 (9.75, 36.97) h] was significantly shorter than that in RD group [28.50 (24.00, 48.00) h] (P<0.001). And the incidence of dizziness (18.42%), nausea and vomiting (6.58%) in MCT group were remarkably lower than those in RD group (51.25%, 31.25%) (P<0.001). Hospitalization comfort score in MCT group [(16.74±1.70)] was significantly higher than that in RD group [(14.83 ±2.34)] (P=0.016). Meanwhile, the average hospitalization cost in MCT group [(39,701.82±8105.47)¥] showed an obvious decrease compared with RD group [(44,511.79±9593.19)¥] (P=0.007). Conclusion Optimizing the dietary plan and procedure mainly based on MCT diet for postoperative lung cancer patients can help the recovery of gastrointestinal function and improve hospitalization comfort, which promoted overall postoperative rehabilitation of patients with lung cancer surgery. [ABSTRACT FROM AUTHOR]

Objective　To investigate the influence of triglyceride （TG）/high-density lipoprotein cholesterol （HDL-C） ratio on the onset of primary liver cancer. Methods　A prospective cohort study was conducted. Physical examination data were collected from 99 750 cases of on-the-job and retired employees of Kailuan Group who participated health examination from July 2006 to December 2007， and they were followed up till December 31， 2021 to observe the onset of primary liver cancer. A one-way analysis of variance was used for comparison of normally distributed continuous data between multiple groups， and the Kruskal-Wallis H test was used for comparison of continuous data with skewed distribution between multiple groups； the chi-square test was used for comparison of categorical data between groups. According to the tertiles of TG/HDL-C ratio， the subjects were divided into Q1， Q2， and Q3 groups， and the incidence density of primary liver cancer was calculated for each group. The Kaplan-Meier method was used to calculate the cumulative incidence rate of primary liver cancer in each group， and the log-rank test was used to compare the difference in cumulative incidence rate between groups. The Cox proportional hazards model was used to analyze the influence of TG/HDL-C ratio on the onset of primary liver cancer. Results　There were significant differences between the three groups in age， proportion of male subjects， waist circumference， body mass index， fasting blood glucose， systolic pressure， diastolic pressure， triglyceride， total cholesterol， HDL-C， low-density lipoprotein cholesterol， alanine aminotransferase， high-sensitivity C-reactive protein， chronic liver diseases， hypertension， diabetes， the family history of malignant tumor， drinking， smoking， physical exercise， and educational level （P<0.05）. During the mean follow-up time of 14.06±2.71 years， there were 484 cases of new-onset liver cancer， among whom there were 446 male subjects and 38 female subjects. The incidence density of primary liver cancer was 0.39/1 000 person-years in the Q1 group， 0.35/1 000 person-years in the Q2 group， and 0.30/1 000 person-years in the Q3 group， and the cumulative incidence rates of primary liver cancer in the three groups were 6.03‰， 5.28‰， and 4.49‰， respectively， with a significant difference between the three groups based on the long-rank test （χ²=6.06， P=0.048）. After adjustment for the confounding factors considered， the Cox proportional hazards model showed that compared with the Q3 group， the Q1 group had a hazard ratio of 2.04（ 95% confidence interval［ CI］： 1.61 — 2.58， Pfor trend<0.05）， and the Q2 group had a hazard ratio of 1.53（ 95%CI： 1.21 — 1.92， Pfor trend<0.05）. Conclusion　The reduction in TG/HDL-C ratio is associated with an increase in the rask of primary liver cancer， especially in people with chronic liver diseases. [ABSTRACT FROM AUTHOR]

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the correlations of triglyceride glucose index(TyG) levels at different baselines with the risk of new-onset acute pancreatitis (AP) among the workers at Kailuan Group. Methods A total of 124 516 subjects were enrolled from 2006 to 2009 and followed up by health examinations of the workers in the group. The subjects with a history of AP or incomplete information on TG and FPG data were excluded. The cumulative incidence rate was determined by Log-Rank method. Multivariate Cox proportional hazards regression model was used to calculate hazard ratios (HR) for AP related to baseline TyG level after adjusting for the effects of multiple confunding factors. Results The subjects were divided into four groups (TyG ≤ 6.59, 6.59 < TyG ≤ 6.98, 6.98 < TyG4 ≤ 7.46, TyG > 7.46) according to the TyG levels, and the incidence of new-onset AP was observed in all the groups. For a follow-up of (12.59 ± 0.98 )years, 399 cases of AP were observed. The corresponding incidence of AP in each tertile was 1.67, 2.32, 2.53, and 3.65 events per 10,000 person-years, respectively. After Cox analysis and correction of multiple confounding factors, the risk of AP incidence was increased in the TyG > 7.46 group, with an HR of 1.94 [(95%CI(1.42, 2.65), P < 0.01]. Conclusion TyG at its baseline of above 7.46 can increase the risk of AP. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationship between triglyceride glucose (TyG) index and the total load of cerebral small vessel disease (CSVD) and its different imaging markers. Methods A total of 202 patients with CSVD admitted to The Third Hospital of Hebei Medical University from January 2020 to May 2022 were selected. The clinical data of all patients were collected and TyG index was calculated. The lacunes, cerebral microbleeds (CMBs), white matter hyperintensity (WMH) and enlarged perivascular space (EPVS) were evaluated by MRI, and total load of CSVD score was calculated. Results 1) TyG index and total load of CSVD score: Logistic regression analysis showed the male (OR = 2.245, 95%CI: 1.017-4.957; P = 0.045), increase of age (OR = 1.084, 95%CI: 1.046-1.124; P = 0.000), hypertension (OR = 2.457, 95%CI: 1.189-5.078; P = 0.015) and increase of TyG index (OR = 2.657, 95%CI: 1.353-5.216; P = 0.005) were risk factors for moderate and severe total load of CSVD. 2) TyG index and imaging markers of CSVD: Logistic regression analysis showed the increase of TyG index was the risk factor of moderate and severe WMH (OR = 2.313, 95%CI: 1.095-4.885; P = 0.028), CMBs (OR = 1.690, 95%CI: 1.011-2.824; P = 0.045), lacunes (OR = 2.087, 95%CI: 1.235-3.525; P = 0.006), moderate and severe EPVS in basal ganglia (OR = 2.005, 95%CI: 1.190-3.378; P = 0.009). Conclusions TyG index is associated with the total load and various imaging markers of CSVD, which can be used as a valuable biomarker to evaluate CSVD and its severity.

Objective To investigate the influence of preoperative lipids and glucose on the postoperative recovery of patients undergoing total knee arthroplasty (TKA) for knee osteoarthritis (KOA). Methods Clinical data were collected from 492 patients with KOA who were hospitalized and underwent surgical treatment in Department of Joint Surgery, The Affiliated Hospital of Qingdao University, from January 2021 to January 2022, including general clinical data and related blood biochemical para-meters in the fasting state before surgery. American Knee Society (AKS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were recorded for the patients at six months after surgery, and WOMAC score 35 was considered poor postoperative recovery; AKS score >70 was consi-dered good postoperative recovery, and AKS score

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The position distribution of fatty acids in triglycerides from different parts of freshwater fish was investigated in this paper. The position distribution of fatty acids on triglycerides Sn-1,2,3 in four parts (head, tail, back, and viscera) from three freshwater fish species (grass, black, and crucian carp) was analyzed by gas chromatography after the solid phase extraction, enzymatic hydrolysis. The results showed that a total of 21 fatty acids were monitored on triglycerides of three freshwater fish species. The content of monounsaturated fatty acids (MUFAs) ranged from 29.58% to 49.48%, and MUFAs located in Sn-1,3 positions were significantly higher than those in the Sn-2 position in all samples (P

Objective To explore the risk factors of non-alcoholic fatty liver disease (NAFLD) in young adults and to establish a model for prediction, in order to provide reference for the early prevention of the disease in young people. Methods A retrospective analysis was performed on the young adults who underwent routine physical examination in the Department of Physical Examination from January 2018 to June 2022. Totally 365 adults with NAFLD were divided into the NAFLD group(observation group), and 273 healthy adults were divided into the Healthy group (control group). The differences in general information and blood drawing results between the two groups were analyzed. Results The proportion of male, smoking and hypertension in the NAFLD group was significantly higher than that in the Healthy group; The mean values of BMI and low density lipoprotein-cholesterol in the NAFLD group were significantly higher than those in the Healthy group; The median values of triglyceride, total cholesterol, uric acid, alanine aminotransferase, aspartate aminotransferase and glycosylated hemoglobin in the NAFLD group were higher than those in the Healthy group, with significant difference(P＜0. 05). Multivariate regression analysis showed that BMI increased (OR=1. 429; 95%CI=1. 306～1. 563; P=0. 001), triglyceride (OR=1. 524; 95%CI=1. 086～2. 137; P=0. 015), serum uric acid (OR=1. 005; 95%CI=1. 001~1. 008; P=0. 019), alanine aminotransferase (OR=1. 049; 95%CI=1. 026~1. 071; P=0. 001), aspartate aminotransferase (OR=0. 986; 95%CI = 0. 972～0. 999; P=0. 038), glycosylated hemoglobin (OR=7. 800; 95%CI=3. 666～16. 597; P=0. 001) were independent risk factors for NAFLD(P

In this work, we established a HepG2 cell model of hypercholesterolemia in order to investigate the cholesterol-lowering activity and underlying mechanism of sterols. The levels of total cholesterol (TC), triglycerides (TG) and cholesterol regulation-related proteins were measured in HepG2 cells treated with nothing, simvastatin as a positive control or sterols. The results showed that the four sterol compounds tested could reduce TC and TG levels and mitigate the increase of lipids levels and lipid metabolism disorder in hypercholesterolemic cells. Moreover, they reduced the biosynthesis and absorption of cholesterol, decreased cholesterol esterification and promoted cholesterol excretion to the intestine by down-regulating the expression of Niemann-Pick C1-like 1 (NPC1L1), acetyl-coenzyme A acetyltransferase 2 (ACAT2), 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMGCS1) and sterol-regulatory element-binding proteins (SREBP2), and up-regulating the expression of ATP-binding cassette transporter G5/8 (ABCG5/8). We concluded that sterols improve lipid levels in hypercholesterolemic cells by affecting the expression of proteins related to cholesterol absorption and metabolism.

Objective To investigate the association between body fat percentage (PBF), fat mass index (FMI) and lipid profile in the first trimester with gestational diabetes mellitus (GDM). Methods The retrospective analysis was performed on 1 578 pregnant women who received prenatal care in the Third Affiliated Hospital of Sun Yat-sen University from May 2020 to May 2021. All subjects were measured by bioelectrical impedance analysis in the first trimester to obtain PBF and fat mass, height and weight, and at the same time plasma fasting blood glucose (FPG), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) were measured. 75 g oral glucose tolerance test (OGTT) was conducted between 24 and 28 weeks, FPG, 1 h plasma glucose (1hPG) and 2 h plasma glucose (2hPG) were detected, and the subjects were divided into GDM group (318 cases) and control group (1 260 cases) according to OGTT results. Independent sample t-test, Mann-Whitney U and χ² test were used for comparison between groups, logistic regression model was used to analyze the association between observation index and GDM. Results The prevalence of GDM was 20.15% (318/1 578). The age, BMI, PBF, FMI, FPG, TC, TG, LDL-C, 75 g OGTT-FPG, 1hPG and 2hPG, the proportion of gravidity≥3 times in the GDM group were higher than those in the control group (P< 0.05). The risk of GDM in those aged≥25 years increased 183.2% (OR=2.832, 95%CI 1.414-5.672, P< 0.05), BMI≥24.0 kg/m² was 123.9% (OR=2.239, 95%CI 1.674-2.997, P<0.001), and PBF≥25% was 91.2% (OR=1.912, 95%CI 1.462-2.501, P<0.001). The pregnant women were grouped according to the quartile of FMI, FPG, TC, TG, HDL-C and LDL-C (Q1, Q2, Q3 and Q4 group). The Q4 group of FMI increased the risk of GDM by 97.7% compared with the Q1 group (P<0.05); the Q3 group and Q4 group of TC increased the risk of GDM by 63.3% and 55.7% compared with the Q1 group (P<0.05); the Q4 group of TG increased the risk of GDM by 54.8% compared with the Q1 group (P<0.05). Conclusions Age≥25 years, BMI≥24.0 kg/m² and PBF≥25% are closely related to the incidence of GDM. The levels of PBF, FMI, TC and TG in the first trimester can provide a reference for early prediction of GDM. [ABSTRACT FROM AUTHOR]

旨在为羊脂的精深加工提供参考，以绵羊脂和山羊脂为研究对象，分析了两种羊脂理化性质、营养品质与风味特性的差异。两种羊脂的理化性质按国标方法测定，脂肪酸组成及胆固醇的含量由气相色谱测定，甘油三酯组成由超高效液相色谱联用Q-Exactive HFX高分辨轨道阱质谱仪测定，挥发性风味物质采用顶空-固相微萃取结合全二维气相色谱-飞行时间质谱法测定。结果表明：绵羊脂与山羊脂均检测出22种脂肪酸，主要脂肪酸均为C16∶ 0、C18∶ 1n-9c和C18∶ 0，饱和脂肪酸含量分别为38.69、54.39 g/100 g；两种羊脂均检测出30种甘油三酯，绵羊脂中三饱和、单不饱和、单饱和与三不饱和脂肪酸甘油三酯含量分别占总甘油三酯含量的2.66%、26.76%、36.89%和3369%，山羊脂的分别为15.87%、45.59%、26.47%和12.07%；绵羊脂与山羊脂鉴定出挥发性化合物共95种，含量分别为122.11、32.68 μg/g，关键风味化合物34种，其中癸醛、6-甲基-2-庚酮、乙酸戊酯、2-正丁基呋喃仅在绵羊脂中被检测出，3-甲基-2-戊酮仅在山羊脂中被检测出，主成分分析表明两种羊脂可完全分离，差异显著。综上，两种羊脂具有一定的品质差异，绵羊脂的营养与食用价值高于山羊脂，其特征风味强度显著高于山羊脂。 In order to provide a reference for the deep processing of mutton fat, the differences in physical and chemical properties, nutritional qualities and flavor characteristics of sheep fat and goat fat were investigated. The physical and chemical properties of two mutton fats were determined according to the national standard method. The content of fatty acids and cholesterol content were analyzed using gas chromatography. The composition of triglycerides of two mutton fats was evaluated by ultra performance liquid chromatography-Q-Exactive HFX orbitrap mass spectrometer. Furthermore, headspace-solid phase microextraction combined with comprehensive two dimensional gas chromatography-time of flight mass spectrometry was used to analyze the differences in volatile flavor compounds of two mutton fats. The results showed that 22 kinds of fatty acids were detected in two kinds of mutton fats, the main fatty acids were C16∶ 0, C18∶ 1n-9c and C18∶ 0. The content of saturated fatty acids of sheep fat and goat fat were 38.69 g/100 g and 54.39 g/100 g, respectively. Thirty kinds of triglycerides were detected in two mutton fats. The triglycerides of SSS, SSU, SUU and UUU in sheep fat accounted for 2.66%, 26.76%, 36.89% and 33.69%, respectively, and goat fat was 15.87%, 45.59%, 26.47% and 12.07%, respectively. The content of volatile compounds in sheep fat and goat fat were 122.11 μg/g and 32.68 μg/g, respectively. A total of 95 volatile compounds and 34 key aroma compounds were identified. Decanal, 6-methyl-2-heptanone, amyl acetate and 2-n-butyl furan were only detected in sheep fat, 3-methyl-2-pentanone was only detected in goat fat. The two kinds of mutton fats were completely separated by principal component analysis, which had significant difference. In conclusion, the two kinds of mutton fats have certain quality differences. The nutritional and edible value of sheep fat is higher than that of goat fat, and its characteristic flavor intensity is significantly higher than that of goat fat.

Background Hypertriglyceridemia has been increasingly valued as a risk factor for acute pancreatitis (AP) . However, the relationship between obesity and AP has not yet been confirmed, whether baseline triglyceride (TG) affects the risk of AP in non-obese people is still inconclusive. Objective To explore the association between baseline serum triglyceride (TG) and the risk of AP in a nonobese cohort from Kailuan Group. Methods A prospective cohort study was performed among in-service and retired workers of Kailuan Group (non-obese, without a history of AP, with complete TG information) who first attended the annual health screening for workers of the group as a benefit conducted between 2006 and 2007 or between 2008-2009. The cumulative incidence of AP across serum TG tertile groups: 〔Q1 group (TG≤0.96 mmol/L) , Q2 group (0.96 mmol/L

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Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the relationship between serum interleukin-6 (IL-6), brain-derived neurotrophic factor (BDNF), triglycerides (TG), 5-hydroxytryptamine (5-HT) and cognitive function in patients with schizophrenia (SZ), and to analyze the influencing factors of aggressive behavior in patients with SZ, and to study the relationship between serum IL-6, TG, BDNF, 5-HT and aggressive behavior. Methods: 112 patients with SZ who were admitted to our hospital from January 2020 to January 2022 were selected as SZ group, they were divided into aggressive behavior group with 31 cases and non-aggressive behavior group with 81 cases according to whether they had aggressive behavior. 41 healthy physical examination people in the same period were selected as the control group. The levels of serum IL-6, BDNF, TG and 5-HT were measured, and the cognitive function was evaluated by the MATRICS Consensus Cognitive Battery (MCCB). Pearson/spearman correlation was used to analyze the correlation between the levels of serum IL-6, BDNF,TG, 5-HT and MCCB score in patients with SZ. Multivariate logistic regression was used to analyze the influencing factors of aggressive behavior in patients with SZ. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of the levels of serum IL-6, BDNF, TG, 5-HT on aggressive behavior in patients with SZ. Results: The levels of serum IL-6 and TG in the SZ group were higher than those in the control group, while the levels of BDNF, 5-HT and MCCB score were lower than those in the control group (P＜0.05). Pearson/Spearman correlation analysis showed that the levels of serum IL-6 and TG in patients with SZ were negatively correlated with MCCB score (r/rs=-0.569,-0.528, all P＜0.001), while the levels of BDNF and 5-HT were positively correlated with MCCB score (r/rs=0.587, 0.602, all P＜0.001). Multivariate Logistic regression analysis showed that the total score of PANSS increased (OR=1.958, 95%CI: 1.035～3.704), IL-6 increased (OR=1.015, 95%CI: 1.041～1.172), TG increased (OR=1.007, 95%CI: 1.023～1.135) were the independent risk factor for aggressive behavior in patients with SZ, with MCCB score increased (OR=0.911, 95%CI: 0.848～0.979）and BDNF increased (OR=0.792, 95%CI: 0.656～0.955) and 5-HT increased (OR=0.979, 95%CI: 0.965～0.994) were independent protective factors (all P＜0.05). ROC curve analysis showed that the area under the curve (AUC) of serum IL-6, BDNF, TG and 5-HT levels alone and in combination to predict aggressive behavior in patients with SZ were 0.765, 0.754, 0.750, 0.748 and 0.920, respectively. The AUC of the four combined to predict aggressive behavior in patients with SZ was greater than that of each index alone. Conclusion: The increased levels of serum IL-6 and TG and decreased levels of BDNF and 5-HT in patients with SZ are associated with cognitive dysfunction and aggressive behavior. Serum levels of IL-6, BDNF, TG and 5-HT can be used as auxiliary predictors of aggressive behavior in patients with SZ. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the predictive value of the National Institutes of Health Stroke Scale (NIHSS) score combined with serum high -sensitivity C -reactive protein (hs-CRP) on admission to ischemic stroke. Methods A total of 487 patients with acute ischemic stroke admitted to the Department of Neurology of Tangshan Gongren Hospital from May 2018 to December 2019 were selected. The clinical data of patients were collected such as gender, age, hypertension, diabetes, coronary heart disease, previous stroke history, smoking and drinking history, serum low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG), hs-CRP, homocysteine (Hcy), fasting blood glucose (FBG). The NIHSS scale was used to evaluate the degree of neurological deficit at admission, and the modified Rankin Scale (mRS) was used to evaluate the prognosis when the patient was discharged. The mRS score ≤ 2 was defined as good prognosis, and the mRS score > 2 was defined as poor prognosis. Univariate and multivariate forward Logistic regression analysis were used to screen risk factors for poor prognosis of ischemic stroke, and the receiver operating characteristic (ROC) curve was used to compare the predictive value of NIHSS and hs-CRP levels at admission alone or in combination for patient prognosis. Results Compared with the good prognosis group, the poor prognosis group had higher proportions of male patients (χ² = 4.729, P = 0.030), previous history of stroke (χ² = 13.665, P = 0.000), and drinking alcohol (χ² = 8.326, P = 0.004). The NIHSS score at admission (Z = -9.316, P = 0.000), serum FBG (Z =-3.234, P = 0.001), Hcy (Z =-3.652, P = 0.000) and hs-CRP (Z =-8.780, P = 0.000) level in poor prognosis group were higher than those in good prognosis group. Logistic regression analysis showed that the NIHSS score increased at admission (OR = 1.316, 95%CI: 1.223-1.417; P = 0.000), and the serum hs-CRP level increased (OR = 1.045, 95%CI: 1.032-1.058; P = 0.000) were risk factors for the prognosis of ischemic stroke. The area under the curve (AUC) predicted by the two combined (AUC = 0.903; 95%CI: 0.873-0.928, P = 0.000) exceeded than that of the NIHSS score at admission alone (AUC = 0.818; 95%CI: 0.781-0.852, P = 0.000) and the serum hs-CRP alone (AUC = 0.806; 95%CI: 0.768-0.840, P = 0.000); pairwise comparison found that the combination of the two was better than the NIHSS score at admission alone (Z = 3.187, P = 0.001) and serum hs-CRP alone (Z = 4.418, P = 0.000). Conclusions NIHSS score and high level of serum hs-CRP at admission are risk factors for poor prognosis of ischemic stroke. Combining NIHSS score and serum hs-CRP can provide an effective reference for clinical prediction of poor prognosis of ischemic stroke. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Science & Technology of Cereals, Oils & Foods is the property of Science & Technology of Cereals, Oils & Foods Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the risk factors of type 2 diabetes mellitus (T2DM) complicated with metabolic inflammatory syndrome (MIS). Methods According to the inclusion and exclusion criteria, 110 patients with T2DM were selected as the research objects. According to the presence or absence of metabolic inflammatory syndrome, they were divided into the control group and MIS group, with 53 cases in the control group and 57 cases in the MIS group. The influencing factors and risk factors for T2DM combined MIS were analyzed by Univariate analysis and Multivariate Logistic regression analysis method. Results Significant differences were found in the disease course, body mass index (BMI), waistto- hip ratio, serum low-density lipoprotein cholesterol, triglycerides (TG), free fatty acids, C-reactive protein (CRP), and total bilirubin (TB) levels between these two groups (all P<0. 05). Multivariate analysis showed that high BMI, waistto- hip ratio, and serum TG, TB, and CRP were independent risk factors for T2DM complicated with MIS (all P<0. 05). Conclusion High BMI, waist-to-hip ratio, and serum TG, TB, and CRP levels are risk factors for T2DM complicated with MIS. [ABSTRACT FROM AUTHOR]

Objective: To explore and analysis the relationship between serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) levels and elderly ovarian benign and malignant tumors. Methods: From August 2018 to April 2021, 72 cases of elderly patients with ovarian cancer and 72 cases of elderly patients with benign ovarian tumors who were diagnosed and treated in this hospital were selected as the malignant group and the benign group, and 72 cases of elderly peoples who underwent physical examination in this hospital were selected as the normal group during the same period. The three groups of serum TC, TG, LDL-C levels were detected, and the serum tumor marker levels were detected and correlation analysis were performed. Results: The serum TC, TG and LDL-C levels of the malignant group and the benign group were different with the normal group(P<0.05), and the malignant group were higher than that of the benign group (P<0.05); the dyslipidemia rates of the three groups were 77.8 %, 44.4 % and 6.9 % respectively (P<0.05). The levels of serum CA125, CA153 and CA199 in the malignant group and the benign group were different with the normal group (P<0.05), and the malignant group were higher than the benign group (P<0.05). In the 144 elderly patients with ovarian tumors, partial correlation analysis showed that TC, TG, LDL-C, CA125, CA153, CA199 were correlated with ovarian cancer (P<0.05); Pearson analysis showed that TC, TG, LDL-C were corrlated to the CA125, CA153, CA199 (P<0.05). Binary Logistic regression analysis shows that TC, TG, LDL-C were all influencing factors leaded to the occurrence of ovarian cancer(P<0.05). Conclusion: Elderly patients with benign and malignant ovarian tumors are mostly accompanied the abnormalities in serum TC, TG, LDL-C levels, which are correlated with serum tumor marker levels, and are the important factors leading to the occurrence of ovarian cancer in the elderly. [ABSTRACT FROM AUTHOR]

Copyright of Food & Machinery is the property of Food & Machinery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mycosystema is the property of Mycosystema Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To observe the effect of blood lipid related indexes on arterial stiffness in middle-aged and el⁃ derly hypertensive patients with blood pressure up to standard. Methods A total of 168 middle-aged and elderly hyper⁃ tensive patients with blood pressure up to standard were enrolled. The brachial-ankle pulse wave velocity（baPWV）was detected，and the age，sex，systolic blood pressure，body mass index（BMI），past history，smoking history，drinking his⁃ tory，lipid-lowering drugs and biochemical indexes［fasting blood glucose（FBG），triglyceride（TG），total cholesterol （TC），high-density lipoprotein cholesterol（HDL-C），low-density lipoprotein cholesterol（LDL-C），uric acid（UA）and homocysteine（Hcy），creatinine（CREA），glomerular filtration rate（eGFR）］were recorded. Non-high density lipopro⁃ tein cholesterol（non-HDL-C），TC/HDL-C，TG/HDL-C，and non-HDL-C/HDL-C were calculated. According to the baP⁃ WV cut-off point，the clinical data of patients with normal arterial stiffness and abnormal arterial stiffness were compared， and Binary Logistics regression analysis was used to analyze the effect of various blood lipid indicators on arterial stiffness. Results In all 168 subjects，97 cases had normal arterial stiffness and 71 cases had abnormal arterial stiffness. Age， systolic blood pressure，non-HDL-C and TG/HDL-C of patients with abnormal arterial stiffness were all higher than those of patients with normal arterial stiffness，while smoking，drinking，male proportion，BMI，eGFR and HDL-C were all low⁃ er（all P<0. 05）；other data had no statistical significance between two groups（P>0. 05）. The abnormal rates of arterial stiffness were 31. 3% and 49. 5% in patients with normal TG and abnormal TG，30. 7% and 44. 0% in patients with normal non-HDL-C and abnormal non-HDL-C，and 29. 5% and 49. 5% in patients with normal TG/HDL-C and abnormal TG/ HDL-C，respectively（all P <0. 05）. Binary Logistics regression showed that non-HDL-C（OR = 7. 183，95%CI：1. 172- 44. 030）and TG/HDL-C（OR = 1. 460，95%CI：0. 024-0. 909）were risk factors for abnormal arterial stiffness in middleaged and elderly hypertensive patients with blood pressure up to standard（both P <0. 05）. Conclusion In middle-aged and elderly hypertensive patients with blood pressure up to standard，the abnormal rate of arterial stiffness increases with abnormal TG，non-HDL-C and TG/HDL-C，and increased non-HDL-C and TG/HDL-C are the risk factors for abnormal ar⁃ terial stiffness. [ABSTRACT FROM AUTHOR]

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Objectives: To explore the effect mechanism of moxibustion with wheat-grain size cone at "Zusanli" (ST 36) on vascular injury and oxidative stress in hyperlipidemia through mammalian target of rapamycin (mTOR)/hypoxia inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway., Methods: Forty healthy male SD rats with SPF grade were randomly divided into a normal group, a model group, a moxibustion group, and an inhibitor group, with 10 rats in each one. The hyperlipidemia model was established by feeding a high-fat diet for 8 weeks in rats of the model group, the moxibustion group and the inhibitor group. The moxibustion with wheat-grain size cone was delivered at bilateral "Zusanli" (ST 36) of each rat in the moxibustion group and the inhibitor group, with 3 cones on each acupoint in each intervention, once daily for 4 weeks. In the inhibitor group, before each intervention with moxibustion, rapamycin solution was injected intraperitoneally, 2.0 mg/kg. After modeling and intervention, using ELISA, the levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in the serum of rats were determined. After intervention, with HE staining and oil red O staining adopted, the abdominal aortic morphology and peripheral lipid deposition were observed. Separately, using WST-1, TBA and micro-plate method, the superoxide dismutase (SOD) activity and the levels of malondialdehyde (MDA) and nitric oxide (NO) in the serum were detected. The protein expression of mTOR, HIF-1α and VEGF in abdominal aorta were measured by Western blot method., Results: Compared with those in the normal group, the levels of TC, TG and LDL-C increased ( P <0.01) and HDL-C decreased ( P <0.01) in the serum of the rats in the model group, the moxibustion group and the inhibitor group after model establishment. When compared with the normal group after intervention, in the model group, the serum levels of TC, TG, LDL-C and MDA increased ( P <0.01), HDL-C level, SOD activity and NO level were reduced ( P <0.01); the cell structure of the abdominal arota was abnormal, the peripheral lipids deposited seriously; and the protein expression of mTOR, HIF-1α and VEGF of abdominal aorta was elevated ( P< 0.01, P< 0.05). In comparison with the model group, the levels of TC, TG, LDL-C and MDA were reduced ( P <0.01), HDL-C levels, SOD activities and NO levels elevated ( P <0.01, P <0.05), as well as the protein expression of mTOR, HIF-1α and VEGF of abdominal aorta ( P< 0.01, P< 0.05) in the moxibustion group and the inhibitor group; besides, the vascular structure was ameliorated and the lipid deposition reduced in the moxibustion group, while, the vascular structure was still abnormal and the lipid deposition declined in the inhibitor group. When compared with the inhibitor group, the serum SOD activity and NO level increased ( P <0.05) and MDA decreased ( P <0.05); and the protein expression of mTOR, HIF-1α and VEGF of abdominal aorta was elevated ( P< 0.01, P< 0.05) in the moxibustion group., Conclusions: The vascular injury due to hyperlipidemia is repaired by moxibustion with wheat-grain size cone at "Zusanli" (ST 36) through ameliorating oxidative stress, which is associated potentially with the modulation of mTOR/HIF-1α/VEGF signaling pathway.

Objective: To analyze the clinical application value of serum heme oxygenase (HO)-1expression level in non-alcoholic fatty liver disease (NAFLD) and, based on that, establish a diagnostic model combined with glucose regulatory protein 78 (GRP78) so as to clarify its diagnostic effectiveness and application value. Methods: A total of 210 NAFLD patients diagnosed by abdominal B-ultrasound and liver elastography were included, and at the same time, 170 healthy controls were enrolled. The general clinical data, peripheral blood cell counts, and biochemical indicators of the research subjects were collected. The expression levels of HO-1 and GRP78 were detected using an enzyme-linked immunosorbent assay. Multivariate analysis was used to screen independent risk factors for NAFLD. Visual output was performed through nomogram diagrams, and the diagnostic model was constructed. Receiver operating characteristic curve (ROC), calibration curve, and decision curve analysis (DCA) were used to evaluate the diagnostic effectiveness of NAFLD. Measurement data were analyzed using a t -test or Mann-Whitney U rank sum test to detect data differences between groups. Enumeration data were analyzed using the Fisher's exact probability test or the Pearson χ (2) test. Results: Compared with the healthy control group, the white blood cell count, aspartate aminotransferase (AST), alanine aminotransferase, gamma-glutamyl transferase (GTT), fasting blood glucose (Glu), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), serum HO-1, and GRP78 levels were significantly increased in the NAFLD group patients ( P  < 0.05). Binary logistic analysis results showed that AST, TG, LDL-C, serum HO-1, and GRP78 were independent risk factors for NAFLD ( P  < 0.05). A nomogram clinical predictive model HGATL was established using HO-1 (H), GRP78 (G) combined with AST (A), TG (T), and LDL-C (L), with the formula P =-21.469+3.621×HO-1+0.116 ×GRP78+0.674×AST+6.250×TG+4.122 ×LDL-C. The results confirmed that the area under the ROC curve of the HGATL model was 0.965 8, with an optimal cutoff value of 81.69, a sensitivity of 87.06%, a specificity of 92.82%, a P  < 0.05, and the diagnostic effectiveness significantly higher than that of a single indicator. The calibration curve and DCA both showed that the model had good diagnostic performance. Conclusion: The HGATL model can be used as a novel, non-invasive diagnosis model for NAFLD and has a positive application value in NAFLD diagnosis and therapeutic effect evaluation. Therefore, it should be explored and promoted in clinical applications.

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effect of Myriocin on high fat diet induced integrated stress response and further explore the mechanism. Methods A total of 18 ApoE-/- mice were fed a high- fat diet and randomly divided into control group (n = 9, phosphate buffer solution) and Myriocin group (n = 9, phosphate buffer solution + Myriocin). The drugs were administered orally for 12 weeks. Serum lipids [total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein- cholesterol (VLDL-C) and high density lipoprotein-cholesterol (HDL-C)] were measured. Flow-cytometric analysis was used to determine the proportion of lymphocyte antigen 6 complex (Ly - 6c)high phenotype monocytes. HE staining was performed to compare the size and detailed composition of atherosclerotic plaques and immunofluorescence staining was used to observe the expression of monocyte chemotactic protein-1 (MCP-1). Real-time fluorescence quantitative polymerase chain reaction (PCR) was used to detect the mRNA expression levels of inflammation related molecules [including pro - inflammatory factors, interleukin-1β and 6 (IL-1β and IL-6), tumor necrosis factor-α (TNF-α), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), vascular endothelial growth factor (VEGF) and anti- inflammatory factor, IL-10]. In addition, the mRNA expression levels of integrated stress response related molecules [including glucose regulated protein 78 (GRP78), protein kinase R-like endoplasmic reticulum kinase (PERK), eukaryotic translation initiation factor 2 α (eIF2 α), activating transcription factor 4 and 6 (ATF4 and ATF6), endoplasmic reticulum stress - related apoptosis protein C/EBP homologous protein (CHOP) and Caspase12] were tested. The expression levels of integrated stress response related protein [including eIF2α, ATF4, inositol-requiring enzyme 1α (IRE1α) and phosphorylated IRE1α, p65 nuclear factor (p65 NF) and phosphorylated p65 NF, Caspase12 and cleaved Caspase12] were explored by Western blotting. Results 1) Treatment with Myriocin led to lower level of serum LDLC (t = 2.830, P = 0.012). 2) Myriocin suppressed monocytes differentiating toward a Ly-6chigh phenotype (t = 2.866, P = 0.011). 3) HE staining showed less atherosclerotic lesions at 200 and 300 μm distance away from the aortic valve (t = 2.281, P = 0.045; t = 3.506, P = 0.003) and less necrotic core areas (Z = - 2.870, P = 0.004) in the Myriocin group. 4) Immunofluorescence staining showed the reduction of MCP-1 protein expression in the Myriocin group; real-time fluorescence quantitative PCR showed that IL-1β mRNA (t = 3.968, P = 0.005), TNFα mRNA (t = 7.696, P = 0.000), ICAM mRNA (t = 3.294, P = 0.013), VCAM mRNA (t = 5.449, P = 0.001) and VEGF mRNA (t = 2.574, P = 0.037) were generally decreased in the Myriocin group, while IL-10 mRNA was increased (t = - 3.132, P = 0.017) in the Myriocin group. 5) Myriocin downregulated PERK mRNA (t = 4.174, P = 0.004-, eIF2α mRNA (Z = - 2.692, P = 0.007), ATF4 mRNA (t = 3.342, P = 0.012), ATF6 mRNA (t = 5.841, P = 0.001) and Caspase12 mRNA (t = 7.270, P = 0.000). 6) Western blotting showed that Myriocin suppressed the protein expression of eIF2α (t = 2.175, P = 0.047) and ATF4 (t = 2.923, P = 0.011), and the phosphorylation of p65 NF - B (t = 2.909, P = 0.011). Conclusions Myriocin could alleviate atherosclerosis progression of ApoE-/- mice by reducing integrated stress response and inflammatory response in the arterial walls. [ABSTRACT FROM AUTHOR]

Objective To investigate the association between triglyceride (TG) to high-density lipoprotein-cholesterol (HDL-C) ratio and sarcopenia in patients with type 2 diabetes mellitus (T2DM). Methods A total of 1 104 inpatients with T2DM admitted to Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University from June 2013 to December 2015 were enrolled in this retrospective cross-sectional study. The basic information, medical history, chronic complications of diabetes and biochemical indicators of all patients were collected. According to the latest consensus diagnostic criteria of the Asian sarcopenia working group in 2014, sarcopenia was defined as skeletal muscle index (SMI) <7.0 kg/m2 for males and <5.4 kg/m2 for females. After exclusion, 1 002 cases were enrolled and divided into four groups according to the quartiles of TG/HDL-C ratio: Q1: ≤0.80 (n=250), Q2: 0.81-1.23 (n=250), Q3: 1.24-2.11 (n=253), Q4: ≥2.12 (n=249). The detection rate of sarcopenia in each quantile group was measured by Chi-square test, the clinical characteristics of the population were tested by one-way ANOVA, Chi-square test and K-W test. Odds ratio of muscle mass reduction was calculated by binary logistic regression analysis of the quartile of TG/HDL-C ratio. Results In patients with T2DM, with the increase of TG/HDL-C ratio, the detection rate of sarcopenia gradually decreased, which were 27.6% (69/250), 19.2% (48/250), 18.2% (46/253) and 12.0% (30/249) respectively. There was a significant difference between the quartile arrays (χ² =19.22, P<0.01). People with the lowest quartile of TG/HDL-C ratio had the lowest low-density lipoprotein cholesterol (H=46.239, P<0.01), total cholesterol (H=37.949, P<0.01), skeletal muscle index (F=13.059, P<0.01). Compared with the lowest quartile of TG/HDL-C ratio, the odds ratio value (95% confidence interval) of the highest quartile of the TG/HDL-C ratio for muscle mass reducing was 0.39 (0.22-0.70, P=0.016) after adjusting multiple confounding factors. Conclusion The lower TG/HDL-C ratio is associated with increased risk of muscle mass reducing in patients with T2DM, and this trend persists after adjusting for multiple confounding factors. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oil Crop Sciences is the property of Oil Crops Research Institute of Chinese Academy of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the association of hypertriglyceridemic waist(HTGW) phenotype with the severity and prognosis of acute pancreatitis(AP). Methods A total of 356 patients with AP who were admitted to The Affiliated Hospital of Southwest Medical University from September 2018 to August 2019 were enrolled as subjects and were divided into normal-waist-normal-triglyceride(NWNT)group, normal-waist-elevated-triglyceride(NWET) group, enlarged-waist-normal-triglyceride(EWNT) group, and HTGW group. The four groups were compared in terms of the clinical features including age sex, laboratory markers, disease grade, and complications. A one-way ANOVA was used for comparison of normally distributed continuous data between groups, and the least significant difference t-test was used for further comparison between two groups; the Kruskal-Wallis H test was used for comparison of non-normally distributed continuous data between multiple groups and between any two groups. The chi-square test was used for comparison of dichotomous variables between multiple groups and between any two groups; the Kruskal-Wallis H test was used for comparison of ordered polytomous variables between multiple groups, and the Mann-Whitney U rank sum test was used for comparison between two groups. Univariate and multivariate logistic regression analyses were performed to investigate the influencing factors for organ failure and pancreatic infection and necrosis. Results The HTGW group had a significantly higher neutrophil count than the NWNT group, a significantly higher C-reactive protein level than the NWNT group and the NWET group, a significantly higher creatinine level than the NWNT group, significantly higher levels of total cholesterol, triglyceride, and low-density lipoprotein than the NWNT group and the EWNT group, a significantly lower level of high-density lipoprotein than the NWNT group and the EWNT group, and a significantly higher level of blood glucose than the NWNT group(all P<0.05). The HTGW group had a significantly higher incidence rate of severe AP(SAP) than the other three groups(χ2= 189.519, P<0.001), as well as significantly higher incidence rates of infectious pancreatic necrosis and organ failure than the other three groups(χ2=11.770 and 19.457, P = 0.008 and P<0.001). The univariate logistic regression analysis showed that sex, recurrence history were the risk factors for infectious pancreatic necrosis, and after the adjustment for these risk factors, the risk of infectious pancreatic necrosis in the HTGW group was 3.347 times that in the NWNT group(95% confidence interval [CI]: 1.538-7.283, P = 0.002; body mass index, WTI, smoking, diabetes mellitus, and HTGW were the risk factors for organ failure(P<0.05), and after the adjustment for these risk factors, the risk of organ failure in the HTGW group was 4.143 times that in the NWNT group(95% CI: 1.299-13.219, P = 0.016). Conclusion HTGW is an independent risk factor for the development of SAP and may affect patients’ disease severity and complications. Such patients should be identified and diagnosed as early as possible, and improvement of dyslipidemia should be performed to improve patients’ conditions and prognosis. [ABSTRACT FROM AUTHOR]

Copyright of China Surfactant Detergent & Cosmetics (1001-1803) is the property of China Surfactant Detergent & Cosmetics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Coronary artery disease is associated with unhealthy lifestyles such as smoking, lack of physical activity, and consuming an unhealthy diet. Other risk factors include family history and comorbidities such as hypertension, diabetes, smoking, obesity, and hypercholesterolemia. Purpose: This study aims to investigate the effectiveness of mobile health care in improving the physiological index of patients with coronary artery disease. Methods: This study used an experimental design. Convenience sampling was used to enroll 129 patients with coronary heart disease as participants, who were randomly assigned into the intervention group (n = 64) and control group (n = 65). The intervention group participants received a 12-week mobile health care intervention, while the control group participants received routine care in the outpatient department. The physiological index outcome variables included body mass index (BMI), lipid profile, and blood pressure. Data were analyzed using generalized estimating equation curve analysis. Results: The mean triglyceride (TG) reduction value after the intervention in the experimental group was significantly higher (reduction of 39.27 mg/dl; p < .05) than in the control group. Moreover, mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) reduction values in the experimental group were significantly higher (reductions of 8.32 mmHg and 4.24 mmHg; p < .01) than in the control group. Furthermore, the mean reduction in BMI value in the experimental group was significantly higher (reduction of 0.48 Kg/m²; p < .05) than in the control group. Finally, only the mean reduction in low density lipoprotein (LDL) values was greater (by 1.11 mg/dl) in the experimental group than in the control group. However, this reduction did not reach statistical significance. Conclusions: Mobile health care has the potential to reduce TG, blood pressure, and BMI in patients with coronary artery disease. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate whether the changes of serum lipid levels existing in type 2 diabetes (T2DM) complicating subclinical thyroid dysfunction. Methods The clinical data in 605 cases of T2DM treated in the hospital from December 2012 to December 2015 were retrospectively analyzed, including 308 cases of normal thyroid function (normal thyroid function group), 205 cases of complicating subclinical hypothyroidism (subclinica l hypothyroidism group) and 92 cases of complicating subclinical hyperthyroidism (sub clinical hyperthyroidism group). The cases were divided into the < 30 years old group, 30-< 40 years old group, 40 -<50 years old group, 50-<60 years old group, 60- < 70 years old group and ≥70 years old group according to the age. The thyroid function, glycated hemoglobin and blood lipids were detected in each group. Results The levels of serum triglycer ides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) had no statistical difference between the subclinical hypothyroidism group and the normal thyroid function group(P >0. 05). Only the TC and TG levels in the subclinical hyperthyroidism group were markedly lower than those in the normal thyroid function group (P<0. 05), and the HDL-C and LDL-C levels had no statistical difference compared with the normal thyroid function group (P >0. 05). In the 30- 40 year old group, the TG level of the subclinical hyperthyroidism group was significantly lower than that of the normal thyroid function group, and the difference was statistically significant(P< 0. 05). In the other age groups, the TC, TG, HDL-C and LDL-C levels of the subclinical subclinical hyperthyroidism group group were not statistically significant compared with those of the normal thyroid function group(P >0. 05). Conclusion In the comparison between the patients with T2DM complicating subclinical hypothyroidism and the patients with normal thyroid function, the metabolic abnormality of TC, TG, HDL-C and LDL-C is not found. But the patients with T2DM complicating subclinical hyperthyroidism have low total cholesterol and hypotriacylglyceremia. [ABSTRACT FROM AUTHOR]

Objective To systematically evaluate the effects of low-carbohydrate diet on BMI and glucose and lipid metabolism in patients with type 2 diabetes mellitus. Methods Electronic literature search was performed on PubMed，EMBASE，Cochrane Library，CNKI database for the efficacy of low-carbohydrate diets on glucose and lipid metabolismin patients with type 2 diabetes mellitus since the database established to October 2018．We set the inclusion and exclusion criteria, used JADAD scale to evaluate clinical trial methodological quality， collected data and useed Revman 5.3 software to statistical analysis．Results (1)14 articles and 989 cases were included in the literature，498 cases in the experimental group and 491 cases in the control group. (2) Low-carbohydrate diet reduced the waist(MD=-2.27， 95% CI: -3.91 to -0.63， =0.007)； (3) <4 months low carbohydrate diet reduced BMI (MD=-2.43，95%CI: -3.70 to -1.17， P= 0.0002)，FPG (MD=-1.68，95%CI: -2.64) ~-0. 72， P= 0.0006) ， HbA1c ( MD=-1.22， 95% CI: -3.22~-0.12， P=0.03) ， was better than non-low-carbohydrate diet， the difference was statistically significant; but ≥6 months low Carbohydrate diet BMI (MD=-1.42， 95% CI: -4.17 to 1.33， P=0.31)， FPG (MD=-0.94， 95% CI: -2.06 to 0.18， = 0.10) and HbA1c (MD=-) 0.76， 95%CI: -1.77 to 0.24， = 0.14) There was no significant difference between the two groups； (4) ≥ 6 months low carbohydrate diet reduced TG (MD = -0.26， 95% CI: -0.40 ~ -0.13， P= 0.0002)， HDL elevation was not as good as non-low carbohydrate diet (MD=0.20， 95% CI: 0.14~0.26， < 0.00001)；there was no statistical difference between the two groups (MD= 0.01， 95% CI: -0.08 to 0.09， = 0.91) . Conclusions Compared with non-low-carbohydrate diets， (1) short-term low-carbohydrate diets can reduce waist circumference， BMI， FPG， and HbA1c， but there is no long-term effects； (2) long-term low-carbohydrate diet can reduce TG levels， but HDL rises not as high as a non-low-carbohydrate diet， both of which have no effect on LDL. [ABSTRACT FROM AUTHOR]

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Objective: To investigate the relationship between cardio-metabolic abnormalities in the first trimester and adverse pregnancy outcomes (APO). Methods: This cohort study recruited singleton pregnancies in the first trimester (6-13 +6 weeks of gestation) from Shenzhen Maternal and Child Health Care Hospital between January 1, 2021, and October 31, 2022. Cardiometabolic markers, including body mass index (BMI), blood pressure, fasting plasma glucose (FPG), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG), were recorded during the first trimester. Incidence of APO, including gestational hypertension, preeclampsia, gestational diabetes mellitus, preterm birth, fetal growth restriction, small for gestational age infant, and placental abruption, was documented. Cardiovascular metabolic abnormalities in the first trimester were defined as meeting one or more of the following criteria: elevated BMI (BMI≥24 kg/m²), elevated TG (TG≥1.7 mmol/L), decreased HDL-C (HDL-C<1.0 mmol/L), elevated blood pressure (systolic pressure≥130 mmHg (1 mmHg=0.133 kPa) and/or diastolic pressure≥85 mmHg), elevated FPG (FPG≥5.6 mmol/L). Enrolled women were categorized into abnormal cardio-metabolic and normal cardio-metabolic groups. Poisson regression was employed to analyze the association between cardio-metabolic abnormalities in the first trimester and APO. Results: The study included 14 197 pregnant women with an age of (32.0±4.1) years. There were 8 139 women in the normal cardio-metabolic group and 6 058 women in the abnormal cardio-metabolic group. Women with cardio-metabolic disorders in the first trimester had a younger gestational age and higher incidence rates of preterm birth, gestational hypertension, preeclampsia, and gestational diabetes mellitus (all P <0.05). In multivariable Poisson regression, elevated BMI ( RR =1.22, 95% CI 1.15-1.29), elevated FPG ( RR =1.59, 95% CI 1.38-1.82), elevated TG ( RR =1.22, 95% CI 1.13-1.31), and elevated blood pressure ( RR =1.50, 95% CI 1.39-1.63) were independent risk factors for APO, while decreased HDL-C ( RR =0.93, 95% CI 0.70-1.23) was not. Elevated blood pressure ( RR =5.57, 95% CI 4.58-6.78), elevated BMI ( RR =1.71, 95% CI 1.40-2.09), and elevated TG ( RR =1.38, 95% CI 1.10-1.74) had the greatest impact on the risk of developing preeclampsia. Elevated FPG ( RR =1.70, 95% CI 1.45-1.99) had the greatest impact on the risk of gestational diabetes. Conclusions: Elevated blood pressure, BMI, TG and FPG in the first trimester are closely related to APO.