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Objective To review and summarize the efficacy of surgery versus non surgical treatment in patients with hypo pharyngeal cancer. Methods Eligible studies were retrieved in databases, including Pub Med, Em base, Cochrane, CNKI, CQVIP and Wanfang Data. The pooled hazard ratios( HR ) of survival outcomes and relative risk(RR) of larynx preservation were calculated to compare the value of t he two treatments in hypopharyngeal cancer. Results Eleven studies were included, including 2 randomized controlled trials and 9 cohort studies. Surgical treatment could improve overall survival( HR= 0. 78,95 %CI: 0. 63 - 0. 96), however, there was no significant difference of overall survival in patients with locally advanced hypopharyngeal carcinoma (HR = 0. 73, 95 % CI: 0. 51 - 1. 03) and progression free survival of all patients (HR = 0. 83, 95 % CI : 0. 42-1. 65), between surgery group and non surgery group. Non surgical treatment could increase larynx preservation rate(RR = 0. 5 2, 9 5 % CI : 0. 31 - 0. 87). Conclusion Compared with non surgical treatment . surgical treatment could imp rove the overall survival in patient with hypopharyngeal cancer. However,considering the obvious heterogeneity of the related researches, more randomized prospective trials should be performed in the future. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical value of oligoclonal bands (OB) in patients with multiple myeloma (MM)., Methods: The laboratory test and clinical data of 624 newly diagnosed MM patients admitted to Blood Diseases Hospital of Chinese Academy of Medical Sciences from January 2013 to December 2019 were retrospectively analyzed, including 30 patients with OB, and the clinical characteristics, treatment effects and survival of OB and non-OB patients were analyzed and compared., Results: OB occurred in 11.8% (22/187) of patients who received autologous stem cell transplantation(ASCT) and only 1.8% (8/437) of patients who did not receive ASCT (P=0.000). The median time to the appearance of oligoclonal bands was 3.2(0.6-10.5) months after transplantation. The M protein types of oligoclonal bands mainly include IgG κ, IgG λ, IgM λ and λ light chains. In the presence of oligoclonal bands, 90% of patients were evaluated as complete remission (CR) and above. There were no statistically significant differences in disease stage, tumor burden, and genetic abnormalities between OB and non-OB patients. Among the all patients, the prognosis of OB patients was significantly better than that of non-OB patients, and OB patients showed deeper disease remission (significantly higher CR rate, MRD negative rate, and longer MRD negative duration). Among patients who underwent ASCT, OB patients showed earlier immune recovery, but the depth of treatment response and survival outcomes were similar between OB and non-OB patients, it was no statistically difference. Although OB patients showed earlier immune reconstitution, this did not translate into better survival, suggesting that the better prognosis of OB patients was mainly related to deeper and durable remission rather than early immune reconstitution. Further analysis in patients who received ASCT and obtained MRD negative indicated that there was no additional survival benefit in patients with OB., Conclusion: The better prognosis of OB patients may be related to the deeper treatment response, but not to the early immune reconstitution. The appearance of OB is only a sign of deep remission and early immune reconstitution in patients, it cannot be translated into survival benefit of MM patients.

Objective: To investigate the expression of PCGF1 in rectal adenocarcinoma (READ) and the effect of PCGF1 silencing on proliferation READ cells in vitro., Methods: The UALCAN and ENCORI online databases were used to analyze the expression level of PCGF1 in READ tissues and normal tissues and its association with the clinicopathological parameters and survival outcomes of patients with READ. The expression levels of PCGF1 were detected in two READ cell lines and a normal rectal epithelial cell line (HcoEpiC cells) using qPCR and Western blotting. Lentiviral vectors were used to construct PCGF1-overexpressing and PCGF1-silenced cell lines, and the proliferative activity of the cells was assessed using CCK-8 assay. The effect of PCGF1 silencing on tumor proliferation in vivo was also evaluated by observing tumorigenicity of the cells in nude mice., Results: PCGF1 was highly expressed in READ tissue ( P < 0.001), and its expression levels was correlated with READ stage, differentiation and lymph node metastasis ( P < 0.001). A high PCGF1 expression level was associated with a poor survival outcome of READ patients ( P < 0.05). In SW837 and SW1463 cells, PCGF1 silencing significantly lowered the proliferative activity of the cells both in vitro ( P < 0.05) and in nude mice ( P < 0.01)., Conclusion: PCGF1 is highly expressed in READ tissue and may potentially serve as a prognostic biomarker as well as a therapeutic target for READ.