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Objective To observe the effects of ginkgolides drops on anginal attacks and peripheral blood levels of microRNA-29 a（ miR-29a） and intercellular adhesion molecule-1（ ICAM-1） in patients with stable angina pectoris. Methods 78 patients with stable angina pectoris patients， who had visited the cardiology department of our hospital during the period of January 2022 to December 2023， were selected. The patients were divided in a Chinese medicine group or a conventional group by using the random number table method， 39 in each group. The conventional group received conventional Western medicine treatment， while the Chinese medicine received ginkgo ketone ester drip pills on the basis of conventional Western medicine therapies. Occurrence of angina attack， treadmill electrocardiogram test indexes， blood rheology， 6-minute walking distance， TCM symptom scores and changes in peripheral blood miR-29a and ICAM-1 were observed in the two groups. The rate of nitroglycerin discontinuation or reduction and the incidence of adverse reactions were counted. Results Before treatment， there was no statistically significant difference in occurrence of angina attacks between the two groups （P > 0.05）. After treatment， the number of attacks per week， weekly glyceryl trinitrate uses， and duration of each attack decreased in both groups， with a greater decline in the Chinese medicine group than in the conventional group （P < 0.05）. Before treatment， there was no statistically significant difference in the indicators of treadmill electrocardiogram test between the two groups （P > 0.05）. After treatment， induction positive time， exercise termination time， and maximum ST depression time increased in both groups， with longer induction positive time and maximum ST depression time in the Chinese medi-cine group than in the conventional group， while exercise termination time， as compared with the baseline， did not differ statistically （P > 0.05）. Maximum ST depression amplitude and ST recovery time decreased in both groups， with a greater decrease in the Chinese medicine group than in the conventional group （P < 0.05）. Before treatment， there were no statistically significant differences in miR-29a， ICAM-1， and rheology between the two groups （P > 0.05）. After treatment， ICAM-1 and whole blood high/low shear viscosity， FIB， platelet aggregation rate， and plasma viscosity decreased in both groups， with a bigger drop in the Chinese medicine group than in the conventional group （P < 0.05）. As compared with the baseline， miR-29a did not differ statistically between the two groups （P > 0.05）. Before treatment， there were no statistically significant differences in 6min walking distance and Chinese medicine symptom scores between the two groups. After treatment， 6 min walking distance increased in both groups， with a greater increase in the Chinese medicine group than in the conventional group （P < 0.05）； Chinese medicine symptom scores decreased in both groups， with a greater decrease in the Chinese medicine group than in the conven-tional group （P < 0.05）. The glyceryl trinitrate reduction rate was higher in the Chinese medicine group （79.49%， 31/39 cases） than in the conventional group （56.41%， 22/39 cases）， and the incidence of adverse reactions did not differ statistically between the Chinese medicine group and the conventional group （7.69% vs. 5.13%， 3/39 vs. 2/39 cases； P > 0.05）. Conclusions Ginkgolides drops for stable angina improve the degree of myocardial ischaemia and blood rheology， reduce angina attacks， lower ICAM-1 levels， and increase the rate of nitroglycerin discontinuation or reduction. [ABSTRACT FROM AUTHOR]

Objective To investigate the safety and feasibility of using coronary arterycomputed tomography-fractional flow reserve (CT-FFR) as an alternative to invasive coronary angiography (ICA) for selecting patients for coronaryintervention.Methods ICA and retrospective CT-FFR were performedin patients with stable chest pain and coronary artery stenosis exceeding 50% diagnosed through coronary arterycomputed tomography angiography in this hospital from April 2021 to August 2022.The impact of CT-FFR and ICA on decision-making and clinical outcomes were compared inone-year follow-up.Results UsingCT-FFR threshold＞0.80 for intervention demonstrated high diagnostic accuracy in identifying coronary artery stenosis (the area under the curve was 0.85),and at the same time, up to 40% of diagnostic ICA program operation search could be avoided.In patients with CT-FFR≤0.80 undergoing revascularization, the incidence of major adverse cardiovascular events was 18.8%,similar to ICA-guided intervention (21.1%) .Conclusion The results indicate that CT-FFR can be used as an alternative tool to guide coronary revascularization, with high cancellation rate of coronary intervention and low incident rate.. [ABSTRACT FROM AUTHOR]

Objective　To evaluate the clinical effects of short-term (3-6 months) and long-term (12 months) dual antiplatelet therapy (DAPT) after the implantation of coronary drug-eluting stents (DES). Methods　The eligibilities of the patients included stable angina, acute coronary syndrome and silent ischemia. The lesions were in a native coronary vessel. The clinical observation endpoints were all-cause death, cardiogenic death, myocardial infarction, stroke, stent thrombosis, target lesion revascularization, severe bleeding, and true adverse clinical events. The clinical observation endpoints were all-cause death, cardiogenic death, myocardial infarction, stroke, stent thrombosis, target lesion revascularization, severe bleeding, and true adverse clinical events. By searching Pubmed, Chinese biomedical literature and other Chinese and English databases and manual search, qualified randomized controlled studies were evaluated and data were extracted for meta-analysis. Results　A total of 12 randomized controlled studies were conducted. Detsky scores were all greater than 5 points. There were a total of 25949 patients in the study with a follow-up rate of 97.9%. There were no significantly different in all cause death (OR = 0.86，95%CI 0.71-1.05，P = 0.14), cardiac death (OR = 0.94，95% CI 0.70-1.25，P = 0.67), stent thrombosis (OR = 1.36，95%CI 0.94-1.98，P = 0.11), stroke (OR = 1.01，95%CI 0.71-1.42，P = 0.98), target lesion revascularization (OR = 0.121，95%CI 0.94-1.55，P = 0.14),and true adverse clinical events (OR = 0.98，95%CI 0.83-1.14，P = 0.75). The incident rate of myocardial infarction during the follow-up period was higher in the short-term group than in the long-term group (OR = 1.27, 95% CI 1.02-1.59, P = 0.04). The proportion of severe bleeding in the long-term group increased significantly (OR = 0.69, 95% CI 0.50-0.95, P = 0.02). Asian population studies showed that all-cause mortality was higher in the long-term treatment group than in the short-term group (OR = 0.72, 95% CI 0.53-0.97, P = 0.03), and there was no significant difference in severe bleeding between the two groups. Conclusion　According to the defined clinical observation endpoints, the short-term dual antiplatelet effect is not inferior to the long-term group. Seven asian group studies have shown that the long-term group has high all-cause mortality. It can not rule out the deviation and/or population caused by the small sample size or individual variation. The results need to be further verified. This result can be used as a clinical warning to adjust the dual antiplatelet cycle based on the individualized risk of bleeding and coronary lesions. [ABSTRACT FROM AUTHOR]