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Objective: Paraaortic lymph nodes dissection in advanced gastric carcinoma is controversial. Investigation of micrometastasis in these critical lymph nodes is important in the evaluation of prophylactic lymphadenectomy., Methods: A total of 2 339 lymph nodes, including 390 paraaortic nodes, obtained from 47 patients with advanced gastric carcinoma were examined immunohistochemically using cytokeratin antibody., Results: Paraaortic lymph node metastasis was found in 95 of 390 nodes of 14 patients by routine histological examination. Micrometastasis in the paraaortic lymph nodes was immunohistochemically detected in 45 of 295 negative nodes from 15 of 33 patients. The 5-year-survival rate in patients with paraaortic lymph node metastasis was 56.0% in the node negative group, 25.2% in the cytokeratin positive group and 9.0% in the hematoxilin and eosin positive group., Conclusions: We have demonstrated a high rate of micrometastasis in the paraaortic lymph nodes of patients with advanced gastric carcinoma and have confirmed that prophylactic lymphadenectomy of these nodes is effective for such patients.

Two steroidal alkaloids were isolated from the bulb of Fritillaria pallidiflora Schreb by column chromatographic techniques. One of them was identified as known alkaloid sinpeinine A, another alkaloid was found to be a new compound named yibeinoside A, which is the Sinpeinine-3-O-beta-glucoside. Its structure was confirmed on the basis of chemical and spectral data (IR, MS, 1HNMR, 13CNMR).