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This article summarized the postoperative nursing of integrated traditional Chinese and Western medicine for an elderly patient undergoing surgery for thyroid cancer. Comprehensive nursing interventions such as basic nursing, acupuncture massage, dietary nursing, exercise guidance and psychological care were carried out. A comprehensive nursing plan of integrated traditional Chinese and Western medicine had been made to relieve the negative emotion and pain of the patient, and improve the sleep quality and quality of life during rehabilitation. (本文总结1例老年甲状腺癌患者术后中西医结合护理经验。根据患者术后症状, 完善基础护理, 中西医联合用药, 并采用针灸按摩、饮食调护、运动指导、心理干预等护理方法, 内外结合, 提升患者治疗信心, 缓解其负性情绪, 减轻疼痛, 改善睡眠质量, 提高患者的生活质量。)

Until now, mesenchymal stem cells (MSCs) are the most important candidates for calcified tissue regeneration and injury repair, showing broad clinical application prospects. Therefore, the mechanism of fate determination and differentiation regulation has been the fundamental question in the field. However, due to many reasons, such as the heterogeneity and limited knowledge of regulatory mechanisms, the further investigation and clinical application of MSCs are restricted. In recent years, emerging studies have proved that epigenetic modification plays an important regulatory role in the process of osteogenic differentiation of MSCs. Abnormal epigenetic regulation is associated with the development of osteoporosis, and small molecules that interfere with epigenetic modifications have the potential to improve osteoporosis. On the other hand, nutrient metabolism, especially glucose metabolism, is a necessary energy source for cell physiological activities and a regulatory factor for stem cell proliferation and differentiation. They are closely related and play a crucial role in the biological characteristics and fate determination of MSCs. In this paper, we briefly describe the research progress of glucose metabolism and epigenetic modifications in regulating osteogenic differentiation of MSCs and the prospect of clinical application of epigenetics in osteoporosis.

This paper focuses on the network equipment fault monitoring and diagnosis software, and studies the fault diagnosis of the monitored AFDX network based on the network algorithm. Firstly, the range fault characteristic parameters are designed to identify the fault type, and the correlation between the detection results and the fault characteristic parameters at each location can be obtained. Secondly, the data storage management scheme of the first level filtering and the second level caching mechanism is designed for the data collected in the detection. Then, according to the designed fault classification, fault diagnosis methods are given respectively, and the occasional anomalies are identified and suppressed. Finally, the network fault diagnosis verification module is designed, and the experimental verification is carried out from the perspectives of real-time and concurrency. The verification results prove the effectiveness of the method.

Objective To evaluate the effectiveness of shared decision-making (SDM) interventions to improve the quality of dialysis decision-making in patients with end-stage renal disease. Methods A randomized controlled was carried out in 72 patients with end-stage renal disease recruited between October 2021 and December 2021. The patients were randomly assigned into the intervention group (n=36) or the control group (n=36). The intervention group was given SDM interventions in which the nurses used patient decision aids (PDA) for decision-making counseling, while the control group was given routine pre-dialysis education. All patients received the surveys of Decision Conflict Scale, Treatment Choice Questionnaire, Hospital Anxiety and Depression Scale, and Decision Readiness Scale in 1 week after the intervention, and 36-Item Short Form Health Survey (SF-36) and Decision Regret Scale in 3 months after dialysis. The primary endpoint indicator was the score of Decision Conflict Scale, and the secondary ones were treatment choice, and scores of anxiety and depression, decision readiness, quality of life, and decision regret. Results After 1 week of intervention, the scores of decision conflict (P < 0.01) and anxiety (P=0.005) were significantly lower, while that of decision preparation (P < 0.01) was obviously higher in the intervention group than the control group. The proportion of uncertainty to dialysis in the intervention group was significantly lower than that of the control group (15.15% vs 34.29%, P=0.026). In 3 months after dialysis, the intervention group obtained statistically higher total physiological score (P=0.004) and lower decision regret score (P=0.002) when compared with the control group. Conclusion SDM interventions can effectively reduce decision conflict and decision regret, reduce anxiety level, and improve decision preparation and physiological health for the patients with end-stage renal disease.

Conversational question generation (CQG) is different from the question generation task of generating single-round questions based on paragraphs and answers.CQG additionally considers the conversational information composed of historical question and answer pairs,and the generated questions inherit the historical content of the conversation and maintain high consistency.In response to this feature,the article proposes word-level and sentence-level attention mechanism modules to enhance the ability to extract conversation history information,ensuring that the current round of questions integrates the characteristics of each word and sentence in the conversation history,thereby generating a coherent,high-quality question.The accuracy of the question word is more important.The generated question needs to match the answer type corresponding to the original question in the data set.An additional loss function is constructed in the question word prediction module as a limitation of the question word type.The conversational comprehension network (CCNet) model is obtained by synthesizing each module.Experiments show that this model is higher than the baseline model in most evaluation indicators.On the CoQA dataset,Bleu1 and Bleu2 reach 39.70 and 23.76,respectively,and the quality of the generated questions is higher.The model is proved to be effective in ablation experiments and cross-dataset experiments,indicating that the CCNet model has strong general capabilities.

Objective To observe the effect of Baduanjin exercise on bed (abdominal acupoint massage with Shuangtong Qihai technique) in relief of constipation among patients with acute myocardial infarction(AMI). Methods Totally 80 AMI patients with constipation were randomly divided into control group and intervention group, with 40 cases in each group. All patients received routine care and dietary instruction. Routine abdominal massage was carried out in the control group, while abdominal acupoint massage with Shuangtong Qihai technique of Baduanjin exercise was performed in the intervention group. To assess the constipation symptom and bowel sounds before intervention, 3 days and 7 days after intervention, and to compare the effect of intervention between two groups. Results The total score of constipation symptom assessment in the intervention group was lower than that in the control group at 3 days and 7 days after intervention (P＜0. 01). the frequency of bowel sounds in the intervention group was higher than that in the control group at 3 days and 7 days after intervention(P＜0. 01). The overall effective rate in the intervention group was higher than that in the control group (87. 50% vs, 67. 50%, P＜0. 05). Conclusion The abdominal acupoint massage with Shuangtong Qihai technique of Baduanjin exercise is potentially effective in in relief of constipation among AMI patients. (目的 观察床上八段锦中双通气海手法腹部穴位按摩改善急性心肌梗死患者便秘的效果。方法 选取科室收治的急性心肌梗死患者80例为研究对象, 均伴有不同程度便秘。随机分为对照组和干预组, 各40例。2组均给予常规护理和饮食指导, 对照组给予常规腹部按摩, 干预组采用床上八段锦中双通气海手法进行腹部穴位按摩。干预前、干预后3 d、7 d评估患者便秘症状总积分、肠鸣音等指标, 评价临床疗效。结果 干预后3 d和干预后7 d天, 干预组便秘症状总积分低于对照组, 肠鸣音次数高于对照组, 差异有统计学意义(P＜0. 01)。干预组总有效率87. 50%(35/40), 高于对照组的67. 50%(27/40), 差异有统计学意义(P＜0. 05)。结论 运用床上八段锦中双通气海手法进行自主腹部穴位按摩能, 有效改善急性心肌梗死患者便秘。)

In the 2021 WHO Classification of Tumors of the Central Nervous System (fifth edition), the term "circumscribed" was used to classify astrocytic gliomas with localized growth characteristics. So far, the descriptions of "diffuse" and "circumscribed", which define the growth mode, have been applied to the classification of gliomas. This paper interprets the content of circumscribed astrocytic gliomas in the new edition tumors classification, introduces the definitions and clinical characteristics of high ⁃ grade astrocytoma with piloid features and astroblastoma, MN1⁃altered, and analyzes the value and significance of molecular markers and gene changes in the diagnosis and treatment of circumscribed astrocytic gliomas.

The biological scaffolds of tissue engineering are required to have good biocompatibility, matched mechanical properties, as well as morphology and microstructure for cell growth and reproduction. Although a large number of biomaterials have been developed to prepare tissue-engineering scaffolds, the forming problems and poor mechanical properties of the scaffolds still seriously limit the development of tissue engineering. The sodium alginate was used as raw material, and its mechanical properties were enhanced by agarose. The structure and morphology of sodium alginate/agarose composite hydrogels with different ratios were studied,the mechanical properties were tested. In addition, the composite hydrogel scaffold was formed by direct ink writing, and the size of the microscopic pores in composite hydrogels were designed and observed. The results show that the composite hydrogels with different ratios have little difference in water content, all around 90%. Apart from the pure agarose gel and the composite gel with a volume ratio of 1：2, the surface and cross section of the composite gel in other ratios are relatively rough. Agarose can enhance the composite gel to a certain extent, and the composite gel with the volume ratio of sodium alginate to agarose of 2：1 has the highest compression modulus, which can reach 0.353 MPa. The decomposition of calcium carbonate created submicron pores in the composite hydrogel,therefore the prepared composite hydrogel has rough surface and micro-pores,which is conducive for cell growth and reproduction.

Objective: This study aimed to investigate the protective effect and mechanism of solid beverage with vine tea combined with and cassia on alcoholic liver injury in rats. Methods: SD rats were given 43%vol aging by gavage to establish model of alcoholic liver injury. The model was fed with low, medium and high doses of solid beverage. The appropriate ratio of solid beverages was detected by cell test, the physiological and biochemical indicators of rats were detected by using kits, and the expression of related differential genes was studied by transcriptomic analysis to assessing the effect of vine tea extract combined with cassia extract solid beverage on alcoholic liver injury in rats and revealing the mechanism of action. Results: Compared with the model group, the activities of ALT, AST and LDH in the solid beverage group were significantly decreased; the levels of IL-6 and TNF-α was significantly reduced; the activities of GSH and SOD in the liver were significantly increased, while the contents of MDA and TG were significantly decreased; finally the oxidative stress and inflammatory response in rat liver were significantly improved. Compared to the model group, the inflammatory cell infiltration and vacuolar degeneration of liver cells in the liver pathological sections of the solid beverage group were significantly reduced; transcriptomic analysis speculated that the regulation of genes such as spermidine synthase, Sirt7, RT1-A2, RT1-CE1 and other pathways and amino acid metabolism are related to vine tea extract combined with cassia extract solid beverage to alleviate alcoholic liver injury. Conclusion: Vine tea extract combined with cassia extract solid beverage can alleviate alcohol-induced liver injury by improving liver function, reducing liver inflammation and oxidative stress.

In order to study the lightning damage characteristics of CFRP with fastener, this paper established a three-dimensional finite element model of CFRP with fastener and CFRP without fastener, and analyzed the lightning damage morphology of CFRP through electrothermal coupling simulation by finite element software. The lightning current damage test was carried out and the damage characteristics of the two kinds of CFRP under different lightning current peaks were compared. The results show that when the peak value of lightning current is low, the surface damage degree of CFRP with fastener is lower than that of CFRP without fastener. As the peak value of the lightning current increases, the longitudinal damage of the CFRP with fasteners gradually increases along the carbon fiber, and eventually exceeds the CFRP without fasteners. In the experimental, when CFRP without fastener is struck by lightning, linear damage is appeared on the surface perpendicular to the direction of carbon fiber, but the linear damage of CFRP with fastener perpendicular to the direction of carbon fiber is not obvious.

GH4720Li superalloy has been widely employed in high-performance aero engines turbine disks and other rotating component due to the excellent high temperature strength, anti-fatigue, corrosion resistance and long-term structural stability. The mechanism of function and evolution rule of γ'phase in GH4720Li superalloy was summed up in this paper. The relationship between γ'phase and high-temperature properties and the interaction law of γ'phase and residual stress were analyzed. In addition, the research progress of the new superalloy which was designed on the basis of GH4720Li superalloy was summarized, the future application of partitioned cooling technology and dual-organization dual-performance disk preparation technology was prospected.

This study introduces the practice of modularized teaching in “core competency” training of the Clinical Postdoctoral Program of the Peking Union Medical College Hospital; moreover, taking the example of medical humanities model course, to compare the 2016 and 2017 module courses outcome by questionnaire and interview. The result shows that set up the “medical humanities model course” and the continuous optimization have greatly improved the course satisfaction. The Clinical Postdoctoral trainees believe module course is helpful to the accomplishing the “core competency”, to identifying the goal of training and enhancing the process management. However, the improvement of course content, format and its long-term effect, needs further exploration and discussion.

Photocurable coal-series kaolin slurry was prepared based on photocurable resin system. The rheological properties of the slurry were characterized by a rheometer. The effect of dispersant and plasticizer addition on the rheological properties of the slurry was studied. The results show that oleic acid as a dispersant has the effect of reducing the viscosity of the slurry. When the mass fraction of oleic acid added is 1% of the kaolin powder, the viscosity of the slurry is the lowest, while the viscosity of the 40%(volume fraction) kaolin slurry is 49.56 Pa·s. Adding plasticizer PEG-300 can further reduce the viscosity of the slurry. The viscosity of the slurry decreases with the addition of plasticizer. When the plasticizer is added in the mass fraction of 20% of the photosensitive resin, the viscosity of the slurry decreases to 19.77 Pa·s, at which the requirement for good recoating is well met. The slurry with optimized rheological properties is formed in a stereolithography apparatus. After debinding and sintering, kaolin ceramics with complex shape are obtained.

With the spray-dried SiC-Al2O3-Y2O3 powder as raw material, composite powder prepared by mechanical mixing was used to fabricate SiC ceramics by selective laser sintering/cold isostatic pressing combined with liquid phase sintering.The material phase composition, microstructure, flexural strength and density of SiC ceramics were characterized. The results show that spray-dried powder has an average diameter of 39.43μm with fine sphericity and flowability, which is suitable for SLS process. With the optimum parameters (laser power of 7W, scanning speed of 2200mm/s, scanning space of 0.15mm and layer thickness of 0.15mm) and CIP pressure of 80MPa, the green bodies show the superior quality with flexural strength of (2.23±0.10)MPa and bulk density of (1.31±0.05)g/cm3. After being sintered at 1950℃ for 2h, samples are densified that the bulk density and relative density of SiC ceramics are (1.95±0.17)g/cm3 and (60.81±5.31)%, respectively and the flexural strength is (55.43±4.04)MPa.

Photocurable coal-series kaolin slurry was prepared based on photocurable resin system. The rheological properties of the slurry were characterized by a rheometer. The effect of dispersant and plasticizer addition on the rheological properties of the slurry was studied. The results show that oleic acid as a dispersant has the effect of reducing the viscosity of the slurry. When the mass fraction of oleic acid added is 1% of the kaolin powder, the viscosity of the slurry is the lowest, while the viscosity of the 40%(volume fraction) kaolin slurry is 49.56 Pa·s. Adding plasticizer PEG-300 can further reduce the viscosity of the slurry. The viscosity of the slurry decreases with the addition of plasticizer. When the plasticizer is added in the mass fraction of 20% of the photosensitive resin, the viscosity of the slurry decreases to 19.77 Pa·s, at which the requirement for good recoating is well met. The slurry with optimized rheological properties is formed in a stereolithography apparatus. After debinding and sintering, kaolin ceramics with complex shape are obtained.

Porous ceramics with complex structure were prepared by selective laser sintering (SLS) method using coal-series kaolin as raw materials. The effect of SLS process parameters and sintering temperature on properties of porous coal-series kaolin ceramics was investigated. The phase composition and microstructure of porous coal-series kaolin ceramics were characterized by X-ray diffractometer (XRD) and scanning electron microscope (SEM). The results indicate that the coal-series kaolin/E12 composite powders can be formed well through SLS method. The green bodies show the superior quality. Z direction error is 10.43%, relative density is 37.89% and bending strength is 0.984MPa under laser power of 5W, scanning speed of 2000mm/s, scanning space of 0.13mm and layer thickness of 0.15mm. With the increase of sintering temperature, the linear shrinkage and bending strength of the porous coal-series kaolin ceramics increase gradually, while the open porosity decreases. The porous coal-series kaolin ceramics possess a high open porosity of 44.55% and a good bending strength of 6.1MPa when the sintering temperature is 1450℃. The main phase in the prepared porous ceramics is mullite phase, and they have a typical three-dimensional skeleton structure.

Materials, processing and property of metallic glasses by 3D printing were reviewed. Two common 3D printing methods-selective laser melting and laser solid forming were introduced. The effect of process optimization, substrate preheating and re-scanning strategy on crystallization and micro-cracks was discussed. It was pointed out the balling and pore defects and elimination methods such as re-scan, anneal, preheating of powder and substrate and scan strategy can be applied to improve the properties of metallic glasses. The metallic glasses with high relative density, crack-free and fully amorphous alloy are expected to be prepared.

View of the shortcomings of the traditional lubrication system design,a design method based on Flowmaster software is put forward. Taking a certain type of wind turbine gearbox as an example,the power loss and the amount of oil supply are calculated,the lubrication system is simulated and the design is optimized.The experimental test of the lubrication system is carried out,which proved the validity of the lubrication system. The results show that,by using the Flowmaster software to design the wind turbine gearbox,the accurate control of flow and pressure can be achieved. When design the system,it must be noted that the temperature variety has a big effect to the gearbox oil pressure.

K-Ar and U series disequilibria methods have been applied to geochronology research of young volcanic rocks in Tengchong, China. Previous K-Ar dating methods yielded ages of 0.013 to 17.84 Ma and isochron ages of 0.13 to 2.9 Ma in this area. The U series disequilibria method was applied mainly to volcanic rocks that erupted over the past 0.23 Ma. These traditional dating methods could not constrain ages of the volcanic rocks because of their limited accuracy. In recent years, a U-Pb dating method using ion microprobe has shown great potential in geochronology of very young geological bodies, and has been performed on the late Mid-Pleistocene geological bodies abroad. Three dacite samples of Mid-Pleistocene ages from Qushi in Tengchong were obtained by SHRIMP in Beijing SHRIMP Center and they are consistent within uncertainties. After discussing the analytical condition of three tests, such as choice of primary ion species and their intensity, collecting time of secondary ions and some other secondary ion extraction conditions, synthetical analysis on secondary ion counts of all three tests were conducted, indicating that Test 3 (T3) yields the most precise zircon U-Pb age of 0.41±0.01 Ma, which is currently the youngest high precise zircon U-Pb age known in China.

In view of resource problem caused by using two timers/counters of single-chip microcomputer to realize PWM, the paper proposed a method of using single timer/counter to realize PWM. It gave characteristics of PWM signal and timer/counter of MCS-51 single-chip microcomputer, and detailedly introduced implementation of the method by an example of PWM control of hydraulic proportion valve and analyzed performances of the PWM. The analyzing result showed that the PWM can meet with general application and solves problem of resource shortage of timers/counters in single-chip microcomputer, but frequency, phase accuracy and stability of PWM signal are influenced by interrupt response time in some degree.

In order to real-timely get running state information of experiment system of gas extraction in goaf, a monitoring and control system of goaf gas extraction experiment was designed. The system uses EDA9017 and EDA9150 to collect gas flow, gas concentration, static pressure of airflow, value of air velocity and running state information of fan, and sends the collected data to PC through RS485 bus to make operator know running state of the experiment system of gas extration in whole goaf through monitoring and control interface. The actual application verified validity, stability and reliability of the system.

Sparse matrix-vector multiplication (SpMV) is one of the key operators in the field of high performance computing and also has significant applications in emerging deep learning domains. Existing research on SpMV often focuses on square sparse matrices, while there is still a lack of in-depth exploration for irregularly shaped sparse matrices (with unequal numbers of rows and columns). The characteristic of unequal numbers of rows and columns results in different storage features for these sparse matrices compared to square sparse matrices, leaving room for further optimization. Therefore, this paper establishes an SpMV performance model for irregularly shaped sparse matrices with unequal rows and columns, and analyzes that the performance bottleneck is caused by insufficient bandwidth for data exchange between cache and memory. At the same time, this paper carried out the following two optimization tasks: (1) Based on the commonly used CSR storage format for sparse matrices, a new RCSR storage format is proposed, which transforms and compresses a performance-limiting array in the CSR storage format, making SpMV more efficient; (2) An optimized SpMV algorithm based on the RCSR format is designed in conjunction with the SIMD instruction set extension of domestic processors. Thi paper tests regular and irregular sparse matrices on domestic Phytium processors. For regular sparse matrices, the comprehensive application of RCSR storage format, SIMD instructions, and OpenMP parallelization technology increases GFLOPS by 83.35% on average. For irregular sparse matrices, the performance improvement is related to the row-to-column ratio, and when the row-to- column ratio is not equal, the optimization effect is more obvious. [ABSTRACT FROM AUTHOR]

The mechanism for water-saving and high-yield of wide-range precision sowing technology remains unclear. We investigated the impact of wide-range precision sowing on the physiological characteristics of root system, water consumption, and grain yield of wheat 'Jimai 22' during the growing seasons of 2017-2019. We set up two planting modes : wide precision sowing and conventional strip sowing, and three row spacings of 20 cm, 25 cm, and 30 cm under water-saving cultivation with supplemental irrigation to examine the effects of planting modes on root biomass and senescence characteristics of wheat, water utilization characteristics, interplant evaporation, grain yield, and water utilization efficiency. The results showed that the 25 cm treatment (K25) led to an increase in root weight density, root soluble protein content, and root activity by 7.2%-23.9%, 8.7%-25.1%, 10.7%-29.9%, and 7.3%-27.6%, 8.0%-38.5%, 15.2%-32.7%, respectively, compared to the other treatments. At the same row spacing, the wide-range precision sowing treatment showed a significantly higher soil water storage consumption and proportion to total water consumption compared to the conventional strip-tillage treatment. Additionally, irrigation and interplant evaporation were lower in the wide-range precision sowing treatment. The K25 treatment exhibited significantly higher water consumption and modal coefficient of water consumption from flowering to ripening than other treatments. Furthermore, it had significantly higher seed yield, water utilization efficiency, and irrigation utilization efficiency than the other treatments. We found that a 25 cm spacing in the lower rows and density of 180-270 plants • m-2 was the water-saving and high-yielding planting pattern of wide-range precision sowing wheat in Huang-Huai-Hai region. [ABSTRACT FROM AUTHOR]

Objective lo explore the application value ot a recombinant antigen-based capture enzyme immunoassay (KAg-CEIA) in detection of recent human immunodeficiency virus type 1 (HIV-1) infection in the sentinel surveillance population. Methods Among the HIV/AIDS sentinel surveillance population in Yunnan province in 2015, the confirmed HIV-1 antibodies positive plasma specimens matching the detection criteria for recent HIV-1 infection were tested by HIV-1 RAg-CEIA. The recent HIV-1 infection specimens were classified by the normalized optical density (ODn) values, and then the HIV-1 incidence in population were estimated. The detection and analysis data were compared with those by BED capture enzyme immunoassay (BED-CEIA) and limiting antigen avidity enzyme immunoassay (LAg-Avidity EIA), respectively. Results A total of 51 313 plasma specimens were tested for HIV antibodies, in which 1 255 specimens were HIV-1 antibodies positive. 253 out of 373 specimens matching the detection criteria for recent HIV-1 infection were tested by the 3 assays, respectively. By RAg-CEIA, BED-CEIA and LAg-Avidity EIA, 88, 78 and 54 specimens were classified as recent HIV-1 infections, and the HIV-1 incidence in the sentinel surveillance population was 0.33% (95% CI: 0.26%~0.39%), 0.31% (95% CI: 0.24%-0.38%) and 0.31% (95% CI: 0.22%-0.39%), respectively. The differences between the HIV-1 incidence by the 3 assays were not statistically significant (P = 0.927). Among the sub-populations, the HIV-1 incidence in men who have sex with men (MSM) were 3.50% (95% CI: 2.48%-4.52%), 3.92% (95% CI: 2.76%-5.08%) and 4.17% (95% CI: 2.79%-5.55%), respectively. The differences between the HIV-1 incidence by the 3 assays were not statistically significant (P = 0.763). The ODn values by RAg-CEIA were linear correlation with those by BED-CEIA (Spearman's rank correlation coefficient was 0.911), and those by LAg-Avidity EIA (Spearman' s rank correlation coefficient was 0.755), respectively. Conclusion HIV-1 RAg-CEIA can be effectively used in classification of recent HIV-1 infections and estimation of HIV-1 incidence, indicating that this approach has a good application prospect in detection of recent HIV-1 infection. [ABSTRACT FROM AUTHOR]

To clarify the appropriate rate of phosphorus application and physiological mechanism for promoting wheat tillering and efficient utilization of phosphorus fertilizer with supplementary irrigation, we used 'Jimai 22' wheat variety as the test material, to set up three phosphorus application treatments, including low (90 kg P2O5 • hm-2, P1), medium (135 kg P2O5 • hm-2, P2), and high (180 kg P2O5 • hm-2, P3) application rates, with no phosphorus application as the control (P0). We increased the relative soil water content of each treatment at jointing stage and anthesis stage to 70%, and measured the area of tiller node, the content of endogenous hormones, the number of tillers in each tiller position, photosynthetic parameters, the distribution of 13C assimilates in each stem and tiller, as well as the grain yield and partial productivity of phosphate fertilizer. The results showed that compared with P0 and P1 treatments, P2 significantly increased the area of tiller node and the trans-zeatin (tZ), the photosynthetic parameters of the uppermost expanded leaves of the main stem, the total tillers per plant, and the distribution of 13C assimilates in each tiller. The number of ears per plant was increased by 0.51 and 0.36, and grain yield was increased by 40.3% and 13.2%, respectively. In P3 treatment, the number of tillers increased, but the panicles per plant, and the grain yield and phosphate fertilizer partial productivity decreased. Our results suggested that the moderate phosphorus treatment (135 kg • hm-2) under supplementary irrigation was suitable for high yield and high efficiency of wheat. [ABSTRACT FROM AUTHOR]

Clarifying the appropriate application rates of N, P, and K fertilizers and the physiological mechanisms of wheat under water-saving recharge irrigation in the North China Plain would provide a theoretical basis for formulating reasonable fertilization plans for high-yield and high-efficiency wheat production. We established four treatments with different amounts of nitrogen (N), phosphorus (P2O5), and potassium (K2O) application: 0,0, and 0 kg • hm2(F0), 180, 75, and 60 kg • hm-2(F2), 225, 120, and 105 kg • hm-2(F2), and 270, 165, and 150 kg • hm2(F3). During the jointing and anthesis stages of wheat, the relative water content of each treatment in the 0-40 cm soil layer was replenished to 70%, to investigate the differences in wheat flag leaf photosynthetic characteristics, distribution of 13C assimilates, grain starch accumulation, and fertilizer utilization. The results showed that the relative chlorophyll content of flag leaves, photosynthetic and chlorophyll fluorescence parameters, 13C assimilate allocation in each organ, enzyme activities involved in starch synthesis, and starch accumulation in the F, treatment were significantly higher than that in F0 treatment, which was an important physiological basis for the 20.9% increase in grain yield. The above parameters and yield in the F2 and F3 treatments showed no significant increase compared to F (treatment, while fertilizer productivity and agronomic efficiency of N, P, and K decreased by 17.5%-58.4% and 12.7%-50.7%, respectively. Therefore, F (could promote flag leaf photosynthetic assimilate production and grain starch accumulation under water-saving supplementary irrigation conditions, resulting in higher grain yield and fertilizer utilization efficiency. [ABSTRACT FROM AUTHOR]

To provide a theoretical basis and technical support for the high-yield and high-efficiency production of wheat, we examined the effects of different tillage patterns on wheat grain yield of Jimai 22 and the physiological mechanisms in an experiment with three treatments: 14 years in rotary tillage (R), minimal and no tillage (S), and minimal and no tillage with a 2-year subsoiling interval (SS). We assessed the light interception by wheat plant canopy, the distribution of photosynthate transport, and grain yield for the three cultivation modes. The results showed that leaf area index was significantly higher for SS treatment than the other treatments at 14-28 days after anthesis. The interception rate and amount of photosynthetically active radiation in the upper and middle layers of wheat canopy were significantly higher for SS treatment than R and S treatments at 21 days after anthesis. The contribution rate of grain assimilation and the distribution proportion of 13C assimilated in grain, and the maximum and average filling rates, were the highest under SS treatment. The 1000-kernel weight for SS treatment increased by 8.7% and 9.6%, and the grain yield increased by 14.2% and 19.4% compared with R and S treatments, respectively. SS treatment significantly improved light energy utilization by wheat canopy, promoted the accumulation and transport of dry matter, increased the grain-filling rate, increased grain weight, which together contributed to the highest grain yield. Therefore, SS was the optimal tillage pattern under the conditions of this experiment. [ABSTRACT FROM AUTHOR]

The bHLH (basic Helix-Loop-Helix) transcription factor plays an important role in plant growth and development. In this study, wheat gene TabHLH112-2B was cloned, which consists of seven exons and six introns, encoding 444 amino acids, and has a typical HLH conserved domain at 315-364 amino acids. The tissue expression pattern analysis showed that TabHLH112-2B was expressed in all tissues at seedling stage, jointing stage, heading stage, and flowering stages. Among them, the relative expression levels in leaves and roots were higher. The cis-acting element analysis showed that the promoter region of TabHLH112-2B contained a variety of cis-acting elements related to plant hormone responses, stress responses, and meristem development. The qRT-PCR exhibited that the relative expression level of TabHLH112-2B was responsive to plant hormones (such as ABA, IAA, MeJA) and abiotic stresses (such as drought, salt, low and high temperatures). Two SNPs were detected in its promoter region by genomic sequence polymorphism, which were classified into two haplotypes. A molecular marker was developed based on SNP-682, and association analysis showed that the marker was significantly correlated with the number of spikelet per spike in various environments such as drought and high temperature. Hap-2B-2 was a favorable haplotype with more spikelets per spike. These results of this study provide the valuable genetic resources and technical support for molecular marker-assisted breeding of wheat varieties with high yield and wide adaptability. [ABSTRACT FROM AUTHOR]

[Objective] This study investigated the effects of different phosphorus supply levels on photosynthetic characteristics and mineral element absorption of green pepper seedlings to provide basis for further improving precise fertilization and high-quality production of green pepper. [Method] The experiment was carried out by hydroponic method with green pepper seedlings of Audrey Red Silk spear. Four treatments of T1(50% P), T2(75% P), T3(100% P), T4(125% P) were included and biomass, root activity, photosynthetic pigment content, photosynthetic characteristics, mineral element content and accumulation of green pepper seedlings were measured. Then, the effects on growth characteristics of green pepper seedlings were analyzed and the comprehensive performance was evaluated using principal component analysis. [Result] Compared to T3, fresh quality of root, dry quality of root, root activity, chlorophyll a, carotenoid, chlorophyll a+b, net photosynthetic rate (Pn), transpiration rate (Tr) and stomatal conductance (Gs) of grafted green pepper seedlings in T1 treatment were significantly decreased by 35.03%, 33.33%, 4.32%, 38.65%, 61.83%, 22.01%, 50.48%, 36.50% and 40.16%, while intercellular CO2 concentration (Ci) was increased significantly by 18.43%. In T2 treatment, fresh quality of shoot, dry quality of shoot, root activity, chlorophyll b, Tr and Gs were significantly increased by 51.76%, 54.02%, 14.76%, 40.49%, 2.02% and 124.76%, respectively. In T4 treatment, fresh quality of root, dry quality of root, root activity, hlorophyll a and Pn were significantly decreased by 26.60%, 32.00%, 17.87 %, 9.81 % and 28.83%, respectively. Compared with T3, the accumulation of Fe, Zn, Ca, K, Mg and N in T2 was increased significanty by 62.67%, 44.56 %, 42.33%, 24.00%, 33.97% and 41.41 %, while that of Mn and P was decreased sigificantly by 20.85% and 34.99%, respectively. The principal component analysis showed that the comprehensive performance of green pepper seedlings was in the order of T2>T3>T4> T1. [Conclusion] The application of 75% phosphorus fertilizer (T2) had good effects on growth, photosynthesis and mineral element absorption of green pepper seedlings. [ABSTRACT FROM AUTHOR]

Objective To understand the utilization situation and influencing factors of community home medical care combined service, so as to provide scientific basis for achieving accurate service and improving the quality of medical care combined service. Methods From September to November 2021, stratified cluster random sampling method was adopted to conduct a questionnaire survey among the elderly in 8 community home care institutions in Suzhou, Guangzhou and Qingdao. Chi-square test was used for single factor analysis, and Chi-squared automatic interaction detector (CHAID) model was used to analyze the influencing factors of service utilization. Results A total of 1 310 valid questionnaires were collected, including 218 in Guangzhou, 334 in Suzhou and 758 in Qingdao. The prediction accuracy of medical service, health management service and life care service were 82.4%, 81.0% and 81.7%, respectively. CHAID model analysis showed that indoor voluntary participation, region, main economic source and number of children were influencing factors of medical service utilization (P < 0. 05). The region, social autonomous participation, main economic source and number of chronic diseases were the factors affecting the utilization of health management services (P < 0. 01). Social autonomous participation and age were the factors influencing the utilization of life care services (P <0. 001). Conclusion The utilization of medical services, health management services and life care services still need to be improved, differentiated services should be provided for the elderly with different characteristics, and the quality of combined medical and nursing services should be effectively improved to meet the needs of the elderly. [ABSTRACT FROM AUTHOR]

The objective of this study is to clarify the effect of soil water content on wheat grain yield and the physiological reasons for its formation. During the winter wheat growing season from 2019 to 2021, four kinds of soil water content treatments were set under the field conditions of the wheat test station in Shijiawangzi village, Xiaomeng town, Yanzhou district, Shandong province: No-irrigation (W0), and the relative water content of the soil in the 0--40 cm soil layer was supplemented to 65% (W1), 75% (W2), and 85% (W3) at jointing and anthesis stages, and the winter wheat variety was Jimai 22. The effects of soil water content on water consumption, leaf and root senescence, and grain yield of wheat were studied. The results showed that the number of kernel number and 1000-kernel weight of W2 treatment were significantly higher than those of other treatments, and the highest grain yield and water use efficiency were obtained. Compared with W0, W1, and W3, the grain yield was 48.49%, 20.80%, 8.68% (2019--2020) and 46.87%, 17.36%, 7.53% (2020--2021), respectively. The water use efficiency was 21.70%, 14.25%, 15.59% (2019--2020) and 25.44%, 11.90%, 13.39% (2020--2021), respectively. Compared with the other treatments, root length density in the 40--100 cm soil layer, superoxide dismutase activity and root activity in the 40--60 cm soil layer in W2 treatment were significantly higher than those in other treatments after anthesis, and the content of malondialdehyde was significantly lower than those in other treatments. After anthesis, the superoxide dismutase activity of flag leaves in W2 treatment was significantly higher than that in W0 and W1 treatments, but there was no significant difference in W3 treatment, and the content of malondialdehyde was significantly lower than that in W0 and W1 treatments, but there was no significant difference in W3 treatment. W2 treatment increased significantly water consumption, daily water consumption, water consumption model coefficient, and soil water storage consumption in the 40--120 cm soil layer from anthesis to maturity. In conclusion, the appropriate soil moisture content could promote root growth, delay plant aging, and then improve the absorption and utilization of deep soil moisture, ensure the supply of water during grain filling, and improve significantly grain yield in wheat. Under the conditions of this experiment, the effect of W2 treatment was the best when the relative water content of 0--40 cm soil layer was increased by 75% at the jointing and anthesis stages in wheat. [ABSTRACT FROM AUTHOR]

Objective In order to solve the lag problem of current passive detection methods in detecting the obstacles in the area directly related to train running (hereinafter referred to as train running area or TRA), reserve more reaction time for train braking, reduce the incidence of train accidents, and mitigate the consequence of the train accidents, it is necessary to study the onboard active TRA obstacle detection technology. Method Through uniting the combination of multiple sensors and detection sub-tasks with the train signal system units, an active onboard detection system is proposed to actively detect whether there are obstacles intruding in the TRA boundary. Through testing the above system in the straight TRA with different obstacles, the effective identification distances of the obstacles are obtained. Result & Conclusion The above system can provide the train with autonomous perception ability, timely sending alarm messages or starting train braking when obstacles intruding in the boundary appear in the front TRA.

Cerebral vascular bypass is a key method for the treatment of complex intracranial aneurysms. After nearly 60 years of exploration, its application range now covers the whole cerebral vascular region. With the advent of detachable coils and the mature application of related assistance techniques, endovascular intervention treatment is highly favored in the treatment of routine intracranial aneurysms due to its minimally invasive and rapid characteristics. The introduction of flow diverter (FD) has further ushered in a new era in the treatment of intracranial aneurysms. This article reviews the history and development of cerebral vascular bypass in the treatment of intracranial aneurysms, elaborates on the application and promotion of flow diverter, and discusses the limitations of endovascular intervention treatment in the flow diversion era. It also explores the application and prospects of a comprehensive cerebral vascular bypass system, reaffirming the application value of the whole - region cerebral vascular bypass technique.

Objective To explore the efficacy and safety of intracranial-intracranial bypass for the treatment of complex intracranial aneurysms. Methods and Results A total of 32 patients with complex intracranial aneurysms who were hospitalized for treatment at Huashan Hospital, Fudan University from January 2015 to December 2023 were included. Surgical methods included in-situ bypass, reimplantation, reanastomosis and bypass with interposition graft. For middle cerebral artery (MCA) aneurysms (n = 16), there were 5 cases of in-situ bypass, one case of reimplantation, 3 cases of reanastomosis, and 7 cases of bypass with interposition graft. For anterior cerebral artery (ACA) aneurysms (n = 8), there were 5 cases of in-situ bypass and 3 cases of reimplantation. For anterior communicating artery (ACoA) aneurysms (n = 2), both cases were in-situ bypass. For posterior circulation aneurysms (n = 6), there were 3 cases of in-situ bypass, 2 cases of reanastomosis, and one case of bypass with interposition graft. The intraoperative graft vessels patency rate was 100%. Among the 23 patients who participated in follow-up imaging for more than 6 months postoperatively, no obvious recurrence was indicated by imaging. Among the 28 patients who participated in modified Rankin Scale (mRS) follow-up, there was one case of 5, 5 cases of 3, 2 cases of 2, one case of 1, and 19 cases of 0. Postoperative hemorrhagic complications occurred in 3 cases (9.37%), and ischemic complications occurred in 10 cases (31.25%), with no patients requiring unplanned secondary surgery for complication treatment. Conclusions Intracranial-intracranial bypass has good efficacy and safety for the treatment of complex intracranial aneurysms and has unique advantages in the microsurgical treatment of complex intracranial aneurysms.

Objective To effectively prevent lining damage and water leakage in tunnels, research is carried out on minimizing lining structure bending moment for tunnel cross-section in upper-soft lower-hard composite strata. Method Soft soil-hard soil and soil-rock two types of loading modes for composite strata tunnel lining structures are proposed based on composite strata tunnel surrounding rock pressure characteristics and reasonable assumptions. Following the ideal optimization approach for a zero bending moment composite strata tunnel, a semi-structural mechanics model of tunnel cross-section is established. The rational axis equation of the zero bending moment tunnel cross-section and the analytical expressions of diameters at both composite strata boundary lines and the horizontal tunnel cross-section mid-line are calculated. The process of minimizing bending moment in composite strata tunnel cross-section is outlined briefly. Result & Conclusion The rational axis of the zero bending moment cross-section in soft soil-hard soil tunnel is pear-shaped, while in soil-rock tunnel, it is horseshoe-shaped. In practical engineering, based on the rational axis equation of tunnel cross-section, key parameters for tunnel cross-section design can be determined through comprehensive evaluation and weighted averaging method. This approach enables the design of new tunnel cross-sections in upper-soft and lower-hard strata, aiming to minimize lateral deformation in composite strata tunnels.

ObjectiveNowadays most no contact body size measurement studies are based on point cloud segmentation method, they use a trained point cloud segmentation neural network to segment point cloud of pigs, then locate measurement points based on them. But point cloud segmentation neural network always need a larger graphics processing unit (GPU) memory, moreover, the result of the measurement key point still has room of improvement. This study aims to design a key point generating neural network to extract measurement key points from pig's point cloud. Reducing the GPU memory usage and improve the result of measurement points at the same time, improve both the efficiency and accuracy of the body size measurement.MethodsA neural network model was proposed using improved Transformer attention mechanic called Pig Back Transformer for generating key points and back orientation points which were related to pig body dimensions. In the first part of the network, it was introduced an embedding structure for initial feature extraction and a Transformer encoder structure with edge attention which was a self-attention mechanic improved from Transformer's encoder. The embedding structure using two shared multilayer perceptron (MLP) and a distance embedding algorithm, it takes a set of points from the edge of pig back's point cloud as input and then extract information from the edge points set. In the encoder part, information about the offset distances between edge points and mass point which were their feature that extracted by the embedding structure mentioned before incorporated. Additionally, an extraction algorithm for back edge point was designed for extracting edge points to generate the input of the neural network model. In the second part of the network, it was proposed a Transformer encoder with improved self-attention called back attention. In the design of back attention, it also had an embedding structure before the encoder structure, this embedding structure extracted features from offset values, these offset values were calculated by the points which are none-edge and down sampled by farthest point sampling (FPS) to both the relative centroid point and model generated global key point from the first part that introduced before. Then these offset values were processed with max pooling with attention generated by the extracted features of the points' axis to extract more information that the original Transformer encoder couldn't extract with the same number of parameters. The output part of the model was designed to generate a set of offsets of the key points and points for back direction fitting, than add the set offset to the global key point to get points for pig body measurements. At last, it was introduced the methods for calculating body dimensions which were length, height, shoulder width, abdomen width, hip width, chest circumference and abdomen circumference using key points and back direction fitting points.Results and DiscussionsIn the task of generating key points and points for back direction fitting, the improved Pig Back Transformer performed the best in the accuracy wise in the models tested with the same size of parameters, and the back orientation points generated by the model were evenly distributed which was a good preparation for a better body length calculation. A melting test for edge detection part with two attention mechanic and edge trim method both introduced above had being done, when the edge detection and the attention mechanic got cut off, the result had been highly impact, it made the model couldn't perform as well as before, when the edge trim method of preprocessing part had been cut off, there's a moderate impact on the trained model, but it made the loss of the model more inconsistence while training than before. When comparing the body measurement algorithm with human handy results, the relative error in length was 0.63%, which was an improvement compared to other models. On the other hand, the relative error of shoulder width, abdomen width and hip width had edged other models a little but there was no significant improvement so the performance of these measurement accuracy could be considered negligible, the relative error of chest circumference and abdomen circumference were a little bit behind by the other methods existed, it's because the calculate method of circumferences were not complicated enough to cover the edge case in the dataset which were those point cloud that have big holes in the bottom of abdomen and chest, it impacted the result a lot.ConclusionsThe improved Pig Back Transformer demonstrates higher accuracy in generating key points and is more resource-efficient, enabling the calculation of more accurate pig body measurements. And provides a new perspective for non-contact livestock body size measurements.

Objective To explore the safety and feasibility of the application of day surgery management model under enhanced recovery after surgery (ERAS) concept in patients undergoing gynecologic laparoscopic surgery. Methods A non-randomized concurrent control trial was conducted on the patients who underwent laparoscopic surgery in our department from January to August 2021. A total of 92 patients admitted on odd date were assigned into Ward B of our department and served as the control group, and another 96 patients hospitalized on even date were subjected into Ward A and served as the observation group. The control group was given the routine treatment schedule, including the relevant examinations after admission and general operation procedure during hospitalization. The observation group was under a day surgery management model based on the concept of ERAS, with aid of a day surgery team and optimized perioperative management measures, including pre-hospital rehabilitation, shortening water fasting before surgery, multi-mode analgesia, preventive antiemesis, intraoperative warmth, prevention of deep vein thrombosis, immediate postoperative eating and activity, and follow-up after discharge. Postoperative subjective comfort, intestinal function recovery, social and economic benefits, postoperative complications and inflammatory indicators were compared between the 2 groups. Results In 0~6, 7~12 and 13~24 h after operation, the scores of thirst, hunger, nausea, pain, abdominal distension and pharyngeal discomfort were significantly lower in the observation group than the control group (P < 0.01). The observation group had obviously shorter length of hospital stay and ealier bowel sound recovery and first anal exhaust than the control group (P < 0.01). No postoperative complication, such as fall, unplanned secondary operation or wound infection was observed in both groups. The postoperative inflammatory indicators, including procalcitonin (PCT), neutrophil percentage (Neu%) and white blood cell count (WBC) were all in the normal ranges in the 2 groups at 24 h and 3 and 7 d after surgery. Statistical differences were found in firstly postoperative mobilization, length of hospital stay, hospitalization cost and patient satisfaction between the 2 groups (P < 0.01). Conclusion ERAS-based day surgery management model has the advantages of shortening hospital stay, reducing medical costs, promoting postoperative rehabilitation, and improving the comfort and satisfaction in patients undergoing gynecologic laparoscopic surgery.

The historic origin of quantum entanglement in particle physics is studied systematically and in depth. In 1957, Bohm and Aharonov noted that the 1950 Wu-Shaknov experiment had realized the discrete version of the Einstein-Podolsky-Rosen correlation. Indeed this experiment was definitely the first experimental realization of spatially separated quantum entanglement in history. Such an experiment had been proposed by Wheeler, as a test of quantum electrodynamics, but his calculation was erroneous. The correct theoretical calculations were made by Ward and Pryce and also by Snyder, Pasternack and Hornbostel. The entangled state of the photons also satisfies the selection rule of C. N. Yang in 1949. After the publication of Bell inequality in 1964, discussions on whether Wu-Shaknov experiment can be exploited in testing the inequality inspired the progress of this field, and a new experiment was done by Wu's group. In 1957, Lee, Oehme and Yang established the quantum mechanical formulation of the kaons, and discovered that neutral kaon is a two-state system. The following year,Goldhaber, Lee and Yang wrote down entangled states of a pair of kaons for the first time, in which each kaon is allowed to be charged or neutral, as the entanglement in internal degrees of high energy particles beyond photons written down for the first time. In 1960, as an unpublished work, Lee and Yang discussed an entangled state of a pair of neutral kaons. Such entangled kaons widely exist in meson factories later on. Several physicist are also introduced, especially Ward. [ABSTRACT FROM AUTHOR]

Cichorium intybus L. contains a large number of nutrients, including carbohydrates, amino acids, proteins, mineral elements, biologically active phenolic, volatile, sesquiterpene lactones. It is widely used in animal feed because of its high fresh grass yield and high nutritional value. Cichorium intybus L. tastes delicious, and has the medicinal value of clearing liver, benefiting gallbladder, strengthening stomach and digestion, and has become the raw material for food and medicine extraction. The paper focuses on the feeding value of Cichorium intybus L. and its application progress in animal production, to provide reference for further popularization and application of Cichorium intybus L. in animal production. [ABSTRACT FROM AUTHOR]

The experiment was to explore the effect of fermented feed on growth performance and gut microbiota of Cipangopaludina cahayensis. A total of 60 Cipangopaludina cahayensis with an average weight of 25 g were selected and randomly divided into two groups, with three replicates in each group and 10 Cipangopaludina cahayensis in each replicate. Group A and group B was fed with basic feed and fermented basic feed, respectively. The experimental period was 20 d. At the end of the experiment, the intestinal content of snails were taken, detected the intestinal flora diversity by 16S rDNA high-throughput sequencing technology. The results showed that the survival rates of both groups of Cipangopaludina cahayensis were 100%. Compared with group A, the WGR, SGR, and PER of group B were all increased, feed coefficient was reduced ( P>0.05). A total of 375 141 effective sequences were obtained by highthroughput sequencing, with the sequence length ranging from 416~455 bp. Clustering and partitioning effective sequences, and conducting OTU statistics, it was found that OTU coverage rate of each group of samples was above 99.9%. In group A and group B, the first six bacterial phyla with the highest abundance in two groups were Proteobacteria, Bacteroides, Planctomycetes, Acidobacteria, Actinomyces and Chloroflexi. At the phylum classification level. In group A and group B, the top 5 genera were Proteobacteria, Bacteroidetes, Firmicutes, Softicutes, and Chlamydia. Compare with group A, the relative abundance of the top 5 genera in group B was increased, with Firmicutes and Chlamydia significantly increased ( P<0.05). The number of OTU, Chao1 index and Simpson index of group B were higher than those of group A. The study indicates that fermented feed can enhance the diversity and abundance of the gut microbiota community of Cipangopaludina cahayensis. [ABSTRACT FROM AUTHOR]

ObjectiveWe conducted a drug resistance and homology analysis of diarrheagenic Escherichia coli （DEC） in Fengxian District of Shanghai in order to provide a basis for clinical rational drug use， risk monitoring and early warning.MethodsDEC were isolated from diarrheal patients in Fengxian District， Shanghai from 2019 to 2022. The minimum inhibitory concentrations （MIC） of 21 drugs to the DEC were determined. Genotyping and homology analysis were conducted with pulsed-field gel electrophoresis （PFGE）.ResultsThe DEC detection rate of diarrhea cases was 18.99% （131/690）， including enteroaggregative E.coli （EAEC） 64.89% （85/131）， enterotoxigenic E.coli （ETEC） 22.14% （29/131）， enteropathogenic E.coli （EPEC） 12.21% （16/131）， and enterohemorrhagic E.coli （EHEC） 0.76%（1/131）. The DEC detection showed obvious seasonal characteristics with a high incidence in summer. The DEC multidrug resistance rate was 66.41% with a total of 65 drug resistance profiles. The five antimicrobial drugs with the highest resistance rate were ampicillin （60.31%）， nalidixic acid （51.91%）， cefazolin （50.38%）， tetracycline （44.27%）， and cotrimoxazole （35.11%）. The rate of DEC resistance to levofloxacin was significantly increased from 2019 to 2022. Cluster analysis showed that the similarity of 85 EAEC cluster was 58.4%‒100.0%， and 69 band patterns were obtained. The similarity of 29 ETEC cluster was 58.5%‒100.0%， and 13 band patterns were obtained， including 2 dominant band types. The similarity of 16 EAEC clusters was 53.9%‒100.0%， and 15 band patterns were obtained. Five groups of homologous strains were found， consistent with the resistance phenotypes.ConclusionAmong the diarrhea cases， the DEC epidemic intensity is high， the drug resistance situation is severe， and the risk of outbreak infection is high in Fengxian District， Shanghai. Therefore， health monitoring and prevention need to be strengthened.

Background Older adults are at high risk for atrial fibrillation (AF). Improving the efficiency of AF screening among the community-based elderly population can help to reduce the risk of AF-related stroke. Objective To compare the screening efficiency of different AF screening methods in the elderly population. Methods A total of 1 300 cases of older adults were selected from three neighborhood committees of Xiangshan, Huangshan, and Luoshan in Jinyang Community, Pudong New Area, Shanghai from July 2022 to January 2023. AF screening was detected using palpation of radial artery pulse, electronic sphygmomanometer with AF detection function, and single-lead ECG recorder. A positive result of any one of the three methods was considered positive for AF, and finally an electrocardiogram (ECG) was performed and interpreted by a physician in the ECG room. The receiver operating characteristic (ROC) curves of the subjects with different screening methods were plotted, the area under the ROC curve (AUC) was calculated to evaluate the screening value; the association between AF stroke score (CHA2DS2-VASc score) and AF was analyzed using the chi-square test for trend. Results AF was detected in 93 of the 1 300 people, including 57 asymptomatic people; 375 people had a positive palpated pulse, 331 people had a positive electronic blood pressure monitor with AF detection function, and 128 people had a positive result of single-lead ECG recorder. The AUCs for the diagnostic value of palpation pulse, electronic sphygmomanometer with AF detection function and single-lead ECG recorder in the elderly was 0.750 (95%CI=0.697-0.803, P

Objective: This study aimed to optimize the process parameters of fermentative Cynanchum auriculatum (CA) tablets to develop a new type of fermented product of CA. Methods: Taking complete slices of CA as raw materials, the process parameters of fermentative CA tablets were optimized by response surface methodology based on single factor experiments with sensory score and total acid content as indicators, and the antioxidant activity and amino acid content of fermentative CA tablets were tested. Results: The optimal process parameters for fermentative CA tablets were material liquid at ratio 1∶1, fermentation at 31 ℃, inoculation amount 9.6% and fermenting for 25 h. The sensory score was 89.33, and the total acid content was 0.726 g/100 g under the control of theoptimal processing conditions. At the concentration of 10 mg/mL, the total antioxidant capacity of the fermentative CA tablets alcohol extract was 2.05 U/mL, and the scavenging rate of DPPH and ABTS+ free radicals was 32.18% and 45.89% respectively. Test results of the amino acid content showed that the content of aromatic amino acids in CA tablets increased by 47.22% after fermentation. Conclusion: Fermentative CA tablets obtained under the control of the optimal processing conditions have complete morphology and structure, uniform color, harmonious sourness and sweetness, pleasant wine aroma and characteristic flavor of CA and high antioxidant activity, indicating the product has achieved the expected effect.