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Objective: To verify the effect of PRP and its combination with rhBMP-2 as a controlled delivery system during sagittal suture distraction osteogenesis. Methods: Thirty six-week white rabbits were randomly assigned to sagittal suture distraction osteogenesis groups treated with group one PRP gel alone; and group two PRP gel mixed with 10 μg rhBMP-2 (PRP/rhBMP-2), and a control group untreated. The suture morphology was evaluated by Micro-CT and histology. Results: The amount of suture separation in the control group and the PRP gel group were statistically greater (P＜0.05) than in the PRP/rhBMP-2 gel group. The average degree of suture fusion in the PRP/rhBMP-2 gel group was 15.3 ± 9.5 % of bone thickness. And the average thickness of cranium bone in the PRP/rhBMP-2 gel group was statistically greater (P＜0.05) than in the control group and the PRP gel group. Conclusion: This study showed that both PRP gel and PRP/rhBMP-2 gel are effective in improving new bone formation in suture distraction osteogenesis. PRP gel induces suture bone formation without suture fusion and accelerates the suture wound healing, while the PRP/rhBMP-2 gel group, in which the sutures fused prematurely, showed powerful bone formation ability aided by rhBMP-2. [ABSTRACT FROM AUTHOR]