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BackgroundThe high-quality development of manufacturing in China has spurred industrial transformation and upgrading, placing higher demands on the skills of employees in the electronic manufacturing industry. This situation may induce psychological health problems such as job burnout and depressive symptoms in the employees, and also lead to insomnia, which has become a public health problem that urgently needs attention and solution. ObjectiveTo investigate the relationship between job burnout, depressive symptoms, and insomnia among employees in the electronic manufacturing industry. MethodsA total of 3034 employees from four electronic manufacturing companies in Beijing City, Shanghai City, and Guangdong Province were selected using judgment sampling from September to November 2019. The Maslach Burnout Inventory-General Survey, Patient Health Questionnaire-9, and Self-Administered Sleep Questionnaire were used to collect data. The correlation between job burnout, depressive symptoms, and insomnia was evaluated by hierarchical regression. ResultsA total of 3034 survey questionnaires were distributed, and 2614 valid questionnaires were collected, with a response effectiveness rate of 86.2%. The reporting rates of job burnout, depressive symptoms, and insomnia among employees in the electronic manufacturing industry were 47.2%, 19.5%, and 29.1%, respectively. The reporting rates of insomnia of employees in the job burnout group and depressive symptoms group were higher than those in the non-job burnout group and non-depressive symptoms group (35.3% vs. 23.6%, 47.2% vs. 24.7%, P＜0.001). The results of hierarchical regression showed that job burnout explained 2.8% of the variation of insomnia (P

Renal fibrosis is a common pathological manifestation of chronic kidney disease （CKD）. Since the process of renal drug delivery is rather complex, there is currently no effective remedy for reversing renal fibrosis （RF）. Nanotechnology has been widely applied in the field of medicine and its targeting applications bring new hopes for managing RF. Currently numerous studies are aimed at developing delivery systems of targeting specific renal regions, cells or proteins. This review summarized the current diagnoses of RF, different targeting strategies and potential nano-preparations of plant extracts for treating RF.

Objective To explore the correlation between serum level of immunoglobulin G4 （IgG4）, renal function and micro inflammatory status in patients with IgG4-related nephropathy. Methods From January 2018 to August 2022, 60 patients hsopiatlized with IgG4-related nephropathy were selected as study group while another 60 healthy volunteers chosen as control group in 1∶1 ratio based upon propensity matching. Serum level of IgG4, renal function parameters of serum creatinine （Scr）, blood urea nitrogen （BUN）, estimated glomerular filtration rate （eGFR） and 24 h urinary total protein quantification （24 hUTP） and micro inflammatory status [including interleukin-6 （IL-6）, high-sensitivity C-reactive protein （hs-CRP） and tumor necrosis factor-α （TNF-α）] were detected in both groups. Serum level of IgG4, renal function and micro inflammatory status were compared between two groups. Pearson’s method was employed for examining the correlation between serum level of IgG4, renal function and micro inflammatory status in study group. Logistic regression analysis was performed for determining the risk factors for renal insufficiency. Results Serum level of IgG4 [（67.75 ± 18.63） mg/L vs （6.54 ± 1.19） mg/L], Scr [（182.75 ± 32.69） μmol/L vs （75.40 ± 15.61） μmol/L], BUN [（10.15 ± 2.90） mmol/L vs （5.28 ± 1.04） mmol/L], IL-6 [（5.18 ± 1.04） ng/L vs （0.40 ± 0.05） ng/L], hs-CRP [（24.69 ± 5.06） mg/L vs （4.58 ± 0.92） mg/L], TNF-α [（6.85 ± 1.79） μg/L vs （1.18 ± 0.21） μg/L] and 24 hUTP [（182.75 ± 32.69） mg vs （89.75 ± 12.36） mg] were higher in study group than those in control group （P＜0.05）; eGFR was lower than that in control group [（90.10 ± 9.87） mL·min−1·（1.73 m2）−1 vs （104.36 ± 20.15） mL·min−1·（1.73 m2）−1] （P＜0.05）. Serum level of IgG4 was correlated positively with Scr, BUN, 24 hUTP, IL-6, hs-CRP and TNF-α （r = 0.586, 0.543, 0.575, 0.602, 0.596, 0.574, P＜0.05） and negatively with eGFR in study group （r = −0.602, P＜0.05）. The incidence of renal insufficiency was 78.33% in study group. Course of disease, hypertension and serum level of IgG4 were the influencing factors of renal insufficiency （OR = 3.190, 2.401, 3.466, P＜0.05）. Conclusions An elevated serum level of IgG4 in patients with IgG4-related nephropathy is correlated with renal function and micro inflammatory status. And course of disease, concurrent hypertension and serum IgG4 level are the influencing factors for renal insufficiency.

This is an essay in the field of mineral processing engineering. In addition to the valuable elements copper and tungsten, there are still valuable fluorite resources in the newly discovered ore bodies of Kafang Branch of Yunnan Tin Group. The grade of fluorite in copper and tungsten flotation tailings is as high as 31.98%, the fluorite is coarse medium grain embedded, and the liberation degree is more than 95%. Besides quartz and feldspar, the gangue minerals are mainly hedenbergite with weak magnetism. During beneficiation tests, magnetic separation has been first conducted to remove the hedenbergite into magnetic gangue minerals, which reduces the interference on fluorite flotation process. Then flotation tests have been conducted using “one roughing- two scavenging- six cleaning” process, during which acidified sodium silicate as collector, sodium oleate as collector and return the middlings to scavenging 1, and a fluorite concentrate assaying 96.27% CaF2 with operation recovery of 88.85% has been obtained, which realized the efficient and comprehensive utilization of fluorite resources in Kafang mining area.

The etiology of primary biliary cholangitis （PBC） is unclear， which may be associated with genetic， hereditary and environmental factors， etc. Ursodeoxycholic acid （UDCA） is the first-line drug for the treatment of PBC. Eosinophilic granulomatous with polyangiitis （EGPA） is a systemic vascular inflammatory disease characterized by necrotizing vasculitis， infiltration of eosinophils in tissues and organs， and formation of extravascular granulomas. In this report， a 65-year-old male patient presented with recurrent rashes on four limbs， recurrent abnormal liver function， asthma-like wheezing， microscopic hematuria， abnormal renal function， and eosinophilia. He was finally diagnosed with PBC complicated with EGPA. This case suggests that the possibility of rheumatic immune system disease should be considered for patients with unexplained eosinophilia complicated with multiple organ damage， such as skin， lung， liver， kidney， and immune system.

BackgroundWith the rise and deepening of positive psychology research, theoretical research on job burnout is also deepening worldwide, and some new theoretical models are proposed, such as the burnout-engagement continuum, but there is still a lack of empirical research and application in China. ObjectiveTo analyze the current situation and influencing factors of five profiles in the burnout-engagement continuum in working populations of China: job engagement, ineffective, overextended, disengaged, and burnout. MethodsFrom August to October 2019 and June to September 2020, a total of 27344 subjects of key occupations in six typical industries, including teachers, firefighters, manufacturing workers, medical staff, flight attendants, and traffic police, were selected from 10 provinces (cities) in the eastern, middle, and western regions of China by multistage stratified cluster sampling method for cross-sectional investigation. Maslach Burnout Inventory-General Survey and Core Occupational Stress Scale were used to evaluate job burnout and occupational stress respectively. χ2 test was used to compare rates of count data. Binary logistic regression was used for multivariate analysis of the five profiles. ResultsAmong the subjects, 24.4%, 61.9%, 31.9%, 12.7%, and 11.8% were the prevalence rates of job engagement, ineffective, overextended, disengaged, and burnout, respectively. Flight attendants (35.7%), firefighters (29.0%), traffic police (28.5%), and manufacturing workers (26.5%) had high prevalence rates of job engagement profile. Medical stuff (62.9%) and manufacturing workers (61.8%) had high prevalence rates of ineffective profile. Teachers (39.2%), traffic police (37.2%), and medical stuff (35.5%) had high prevalence rates of overextended profile. Traffic police (17.9%), medical staff (14.3%), and teachers (13.4%) had high prevalence rates of disengaged profile. Traffic police (16.9%), medical staff (13.4%), and teachers (13.3%) had high prevalence rates of burnout profile. The results of multivariate analysis showed that gender, age, education level, marital status, weekly working hours, length of service, income per month, shift work, smoking, drinking, industry, and occupational stress entered into the regression equations of job engagement, ineffective, overextended, disengaged, and burnout. The risks of overextended (OR=1.456-2.970), disengaged (OR=1.306-4.092), and burnout (OR=1.302-4.102) among the high rating groups of the four factors of occupational stress were higher than those among the low rating groups. Flight attendants (OR=0.296) and firefighters (OR=0.329) had lower risks of burnout than teachers, and flight attendants (OR=0.392) and firefighters (OR=0.466) had lower risks of disengaged than teachers. ConclusionAmong the prevalence rates of the five profiles in the burnout-engagement continuum in the 6 typical occupational populations in China, ineffective profile is the highest, followed by overextended, and burnout is the lowest. Gender, age, education level, marital status, weekly working hours, length of service, income per month, shift work, smoking, drinking, industry, and occupational stress have different effects on the five profiles, but industry and occupational stress have greater impacts on job burnout.

BackgroundManufacturing industry is the main body of China's national economy, and manufacturing employees provide solid guarantee and support for the vigorous development of China's manufacturing industry. The research on job burnout of manufacturing employees is helpful to prevent or alleviate the health damage and economic loss caused by job burnout. ObjectiveTo investigate the status and influencing factors of job burnout among manufacturing employees in China, and evaluate the potential mediating effect of job burnout between job stress and depressive symptoms. MethodsA cross-sectional study was performed from August to October 2019 and from June to September 2020 in seven provinces of China. Study participants were recruited from 21 manufacturing companies covering 11 manufacturing subdivisions using multistage stratified cluster sampling. General Burnout Scale, Core Occupational Stress Scale, and Patient Health Questionnaire-9 were used to evaluate job burnout, job stress, and depressive symptoms. Mann-Whitney U test and Kruskal-Wallis H test were used to compare data between two independent samples and multiple independent samples of measurement data; Pearson χ2 test was used to compare the rate of enumeration data; Spearman rank correlation analysis was used to evaluate correlation between selected variables; binary logistic regression was used for multivariate analysis; stepwise regression and bias-corrected Bootstrap method were used to test potential mediating effect. ResultsA total of 10973 valid questionnaires were collected. The M (P25, P75) scores of exhaustions, cynicism, professional efficacy, job burnout, job stress, and depressive symptoms were 1.6 (0.4, 3.0), 1.0 (0.2, 2.2), 4.8 (3.2, 5.7), 1.6 (0.8, 2.5), 45.0 (40.0, 50.0), and 7.0 (4.0, 11.0), respectively. The positive rates of job burnout, job stress, and depressive symptoms were 53.4% (5865/10973), 28.4% (3116/10973), and 29.4% (3231/10973), respectively. The influencing factors of job burnout were gender (versus male; OR for female=0.852), age (versus≤25 years old; ORs for 26-30, 31-40, 41-50, 51-60 years old=0.824, 0.819, 0.738, 0.677), education level (versus junior high school or below; ORs for senior high school/technical secondary school, junior college/vocational college, graduate school or above=1.119, 1.345, 1.331), income per month (versus＜3000 yuan; ORs for 3000-4999, 5000-6999, 7000-8999, 9000-10999, ≥11000 yuan=0.513, 0.470, 0.430, 0.375, 0.411), position (versus assembly line; OR for non-assembly line=0.814), average weekly working hours (versus ≤40 h; ORs for 61-70, ＞70 h=1.199, 1.519), and drinking (versus non-drinking; OR for drinking=1.261). Job burnout was positively correlated with job stress and depressive symptoms (r=0.556, 0.508, P

Objective To explore potential correlation between liver inflammatory response and viral infection index in patients with hepatitis B virus(HBV). Methods Totally 198 serum samples from HBV infected patients and healthy subjects were collected. Patients were divided into different groups according to alanine transaminase/aspartate transaminase(ALT/AST), HBV-DNA, hepatitis B E Antigen(HBeAg) and liver cirrhosis situation; ELISA was used to determine the B cell-attracting chemokine 1(BCA-1) and stem cell factor(SCF) level; the relationship between BCA-1, SCF and other clinical indicators, including ALT/AST, HBV-DNA, HBeAg and cirrhosis condition, were analyzed in different groups; the data was analyzed either with unpaired t test, or with Mann-Whitney U test according to normal distribution, and Spearman method was used for correlation analysis. Results The levels of serum BCA-1 and SCF in HBV infected patients were significantly higher than those in healthy controls(P＜0.001). The serum SCF level was significantly higher in cirrhosis patients than patients without cirrhosis(P＜0.01). The BCA-1 level was significantly different between HBV-DNA+ and HBV-patients, as well as between alpha-fetoprotein(AFP) normal and abnormal patients(P＜0.05). BCA-1 was significantly higher in HBV-DNA+ patients than that in HBV-DNA-patients and was lower in AFP abnormal patients than in normal patients. Furthermore, BCA-1 was positively relate to HBV-DNA and HBeAg level(R=0.314, R=0.456,P＜0.01). Conclusions BCA-1 was significantly related to HBV DNA, while SCF is upregulated in cirrhosis patients with HBV infection, which may be the potential candidate of clinical indicators for HBV infection.

Gut microbiota is a large number of microorganisms that colonized in human intestinal tract. The “gut lung” axis is a two-way axis connecting the intestine and the lung. Gut microbiota and “gut lung” axis are involved in the occurrence and development of sepsis. When sepsis occurs, the gut mucosal barrier is damaged, the gut microbiota is imbalance, and bacterial translocation occurs. The lung is the first organ to be effected, and the pulmonary infection may lead to intestinal dysfunction.

According to observation of cores and thin sections, as well as analyses of fluid pressure features and geochemical indexes, the cause of fluid overpressure and the mechanism of shale oil enrichment in the Lucaogou Formation, Malang Sag, Santanghu Basin, were discussed. The results show that the shale oil of the Lucaogou Formation is generated in the low mature–premature stage of the source rocks and has the features of high density and high viscosity. The low-permeability and thick source rocks lead to high start-up resistance of fluid, which made it difficult for oil and gas to expel, so the retainment of oil and gas in source rocks is the major cause of formation overpressure. Excellent generation potential and well developed reservoir space are the basis for the oil retention; the pressure produced by hydrocarbon generation is not high enough to overcome the resistance of oil migration, which leads to the enrichment of shale oil. The enrichment degree of shale oil is controlled by hydrocarbon generation and storage capacity of lithofacies at various evolution stages. Key words: shale oil, overpressure, enrichment mechanism, Malang Sag

Background: The behavior of mentors impacts the quality and experience of nursing students who are studying in clinical placement. Accurately assessing the behavior of mentors is fundamental to training, regulating, guiding, and improving their behavior and quality of teaching. Purpose: To test the validity and reliability of the Clinical Nursing Mentors' Behavior Scale (CNMBS) among mentors. Methods: This study included three stages. During the first stage, seven Chinese experts were invited to evaluate content validity. During the second stage, the test-retest reliability was examined with 63 mentors. During the third stage, a cross-sectional study was conducted. Seven hundred and sixty-six nursing mentors from five hospitals in Beijing, Shenzhen, and Sichuan completed the survey either online or in hard copy form. The data collected from the questionnaire were analyzed using item analysis, construct validity, internal consistency and discriminant validity, with the results used to determine the psychometric characteristics of the CNMBS. Results: The content validity index for the CNMBS was .91. The intra-class correlation coefficient was .89; the range of the item discrimination critical ratio was 9.42--22.43 (p < .001), and the item-total correlation was .35- .70 (p < .001). The three factors of "guiding personal growth", "promoting professional development", and "providing psychosocial support" and a total of 23 items were identified, with item factor loadings ranging from .51 to .79. The three factors explained 50.99% of total variance. The internal consistency of the CNMBS earned a Cronbach's α coefficient of .92, while those of the three subscales were .89, .86 and .75, respectively. Conclusion: The Clinical Nursing Mentors' Behavior Scale demonstrated high validity and reliability, supporting the CNMBS as a valid tool for assessing the teaching behavior of mentors. [ABSTRACT FROM AUTHOR]

Objective: To investigate the normal value of six parameters of head and eye in Chinese children, including interorbit distance (IOD), interpupillary distance (IPD), superior otobasion-ectocochion distance (obs-ec), intersuperior otobasion distance (obs-obs), exophthalmos and nasal basis angle, for stipulating the sizes of children spectacle frames., Methods: The value of these six parameters in 10 171 children ages 5 to 17 years old were measured with caliper in four cities and the results were analyzed., Results: The IOD, IPD, obs-ec and obs-obs were increased and positively correlated with the age. The differences of these parameters among different ages were statistically significant (F = 0.97, P < 0.01), especially in IPD before 15, IOD before 13, obs-ec and obs-obs before 12 and exophthalmos before 12 years old. The fastest growth age in IPD, IOD, exophthalmos, obs-ec and obs-obs was 10, 11, 5, 7 and 11 years old, respectively. The growth period of IPD, IOD, exophthalmos, obs-ec and obs-obs was 5 - 15, 5 - 13, 5 - 8, 5 - 12 and 5 - 15 years old. The difference of these six parameters among children in 4 cities were statistically significant (t = 3.1, P < 0.01)., Conclusions: The most active growth period of IPD, IOD, obs-obs, obs-ec and exophthalmos lies between 5-15 years old in Chinese children 5-17 years old. Although the differences of these six parameters between male and female and among children in four cities are statistically significant, practically they are not important for stipulating the sizes of children's spectacle frames.