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Objective To investigate the impact of propofol on angiogenesis in postmenopausal osteoporosis (PMOP) rats and the role of Wnt/β-catenin signal pathway in this process. Methods Female Wistar rats were randomly grouped into sham operation group, PMOP group (bilateral ovariectomy), groups of propofol 2.5 mg/kg and of 5.0 mg/kg and propofol+Wnt inhibitor group (propofol 2.5 mg/kg + Wnt inhibitor 2 mg/kg), with 10 rats in each. The serum level of bone alkaline phosphatase (BALP), osteoprotegerin (OPG), nuclear factor κB receptor activating factor ligand (RANKL), vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1) was detected by enzyme linked immunosorbent assay (ELISA); bone mineral density (BMD) of femur was measured by dual-energy X-ray absorptiometry; hematoxylin-eosin (HE) staining microscopy was applied to observe pathological changes of bone tissue; the expression of CD31 in bone tissue was detected by immunohistochemistry; Western blot was applied to detect the expression of bone morphogenetic protein-2 (BMP-2), runt-related transcription factor 2 (Runx2), VEGFA, CD31, Wnt2, phosphorylated glycogen synthase kinase-3 (p-GSK-3) and β-catenin in bone tissue. Results Compared with the sham operation group, the serum RANKL level of PMOP group increased, the level of BALP, OPG, VEGF, Ang-1, expression of CD31 and protein level of BMP-2, Runx2, VEGFA, CD31, Wnt2, p-GSK-3, β-catenin all decreased (P＜0.05), the bone trabecula was damaged and the medullary cavity was enlarged; compared with the PMOP group, the changes of the above indexes in the propofol groups and the propofol+Wnt inhibitor group were obviously relieved(P＜0.05); compared with the propofol 5.0 mg/kg group, the propofol+Wnt inhibitor group showed inhibition in the activation of Wnt/β-catenin signal pathway, and weaken the promotion of propofol on angiogenesis, bone metabolism regulation and bone tissue morphology improvement in PMOP rats(P＜0.05). Conclusions Propofol may promote angiogenesis and regulate bone metabolism in PMOP rats by activating Wnt/β-catenin signal pathway as the potential mechanisms involved in anti-PMOP role process.

ObjectiveTo promote the implementation of the food safety strategy and strengthen the integration and application of food safety risk data in agriculture， market regulation， health， and other departments， and solve the problems of inconsistent data and interface standards， difficulties in data reporting and sharing， as well as information fragmentation， business fragmentation， and work segmentation among others.MethodsUsing data encoding techniques， a standardized system for basic information collection of food safety risk was established， which contains the basic data sets for food safety risk information， data dictionaries， and technical specifications for data exchange， among others.ResultsThe proposed system will promote consistent， trusted collection and connectivity of food safety risk basic data across domains from agriculture， market regulation， health， and other departments.ConclusionThe proposed system could help in comprehensive analysis， provide decision support based on food safety big data， accelerate the implementation of food safety strategy， and implement the Healthy China Strategy.

Promoting big data， artificial intelligence and other digital technologies to empower smart supervision is the only way to achieve the informatization of supervision in the new era， and to promote the modernization of national governance systems and capabilities. This article explores the development process and construction ideas of the market supervision informatization project （part of the National Health Commission）； analyzes the economic and social benefits of the project； some countermeasures and suggestions for reference are put forward for the problems exposed in network and data security， business collaboration and data sharing， and digital technology empowerment supervision services. The goal of the research is to point out the right and scientific guidance for the project， and make the project really useful and helpful for the market supervision. The final target is to improve the level of supervision informatization and promote the capacity building of supervision modernization， strengthen the modernization level of the governance system and capabilities， and improve the level of services for improving and guaranteeing people’s livelihood.